Presentation Information
[24a-P06-17]Super-Resolution Imaging of Amyloid Fibrils by Near-Field Infrared Absorption Spectroscopy with Wavelength Swept Quantum Cascade Laser
〇(M1)Yuta Hamada1, Toshiaki Hirose1, Tatsuo Dougakiuchi2, Gen Takebe2, Yoichi Kawada2, Yoshimasa Kawata1, Atsushi Ono1 (1.Shizuoka Univ., 2.Hamamatsu Photonics K.K.)
Keywords:
Near-Field Infrared Absorption Spectroscopy,Quantum Cascade Laser,Protein
The purpose of our research is to spectroscopically observe the aggregation process of proteins with nanoscale resolution. Deposition of amyloid fibrils formed by protein misfolding is a cause of diseases such as Alzheimer's disease, but the process of amyloid fibril formation is still unknown. We have demonstrated super-resolution imaging of amyloid fibrils by near-field infrared absorption spectroscopy with a wavelength-swept quantum cascade laser, and have shown that this technique is useful for structural analysis of amyloid fibrils.