Presentation Information
[25a-1BL-7]Dynamic Detection of Biomolecular Interactions with Infrared Plasmonic Metasurfaces
〇(DC)Tang Dang1, Jiaqi Yang1, Shuting Ma1, Hitoshi Tabata1, Hiroaki Matsui1 (1.Univ. of Tokyo)
Keywords:
surface-enhanced infrared absorptions,kinetic,metasurface
Utilizing surface-enhanced infrared absorption (SEIRA) techniques for biomolecular identification poses challenges, particularly in aqueous solutions where water's strong infrared absorption interferes with the process. In this investigation, we employed a distinctive metasurface structure (depicted in Figure 1a) featuring two dots of distinct sizes tailored to enhance the C-H and amide bonds, respectively. To address the hindrance posed by water's intrinsic absorption characteristics in the IR range, leveraging a single-layered gold structural array and the CaF2 substrate as an infrared window, the metasurface facilitates real-time monitoring of biomolecular binding events, enabling the calculation of dynamic parameters and affinity between biomolecules.