[17a-K503-1~6] 6.6 Probe Microscopy

11:00 AM - 11:15 AM JST(2:00 AM - 2:15 AM UTC)

[17a-K503-5] Development of the t-SPESI Measurement System for High-sensitivity Single-Cell Mass Spectrometry Imaging

〇(B)Takao Yasuda¹, Yoichi Otuka², Shuichi Shimma³, Michisato Toyoda² (1.School of Science, Osaka Univ., 2.Graduate School of Science, Osaka Univ., 3.Graduate School of Engineering, Osaka Univ.)

Keywords:

Mass Spectrometry Imaging

To apply high-sensitivity single-cell mass spectrometry imaging to biological tissues, we developed a miniaturized new Tapping-mode Scanning Probe Electrospray Ionization (t-SPESI) measurement system to enhance ion detection sensitivity. In this presentation, we report the changes in ion detection sensitivity achieved with the new system and the results of mass spectrometry imaging of mouse brain tissue sections.