[17p-K209-1~9] 1.5 Instrumentation, measurement and Metrology

2:00 PM - 2:15 PM JST(5:00 AM - 5:15 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[17p-K209-3] Inspection of Small-Mass Medicines Using a Portable Nuclear Quadrupole Resonance Spectrometer

〇Yui Otagaki¹, Haruki Kanto¹, Atsuki Yoshida¹, Hiroshi Murata¹ (1.Mie Univ.)

Keywords:

nuclear quadrupole resonance,medicines authentication,portable spectrometer

Counterfeit medicines are a serious threat to human health. Therefore, the technique to detect counterfeit medicines at midsupply chain or point-of-dispensing is essential.
Nuclear quadrupole resonance (NQR) is a kind of magnetic resonance phenomena that detects the interaction between the nuclear spins and the electric field gradients inside the substance by irradiating RF magnetic field at the unique frequency according to the target. As the frequency used for NQR can penetrate most of the surface coatings of the medicines, NQR has the potential to be applied to medicines authentication because of its high specificity and ease of sample preparation.
In this presentation, we will report on our developed portable and highly-sensitive NQR spectrometer composed of a highly effective transmission class-D amplifier and a low noise receiver amplifier. The results showed that the developed system can quantitatively detect hexamethylenetetramine (HMT) samples in the range of 50-500mg.