[17p-K402-1~11] 12.6 Nanobiotechnology

1:30 PM - 1:45 PM JST(4:30 AM - 4:45 AM UTC)

[17p-K402-3] Detailed analysis of ipid bilayer under applied electric fields using FMO

〇Koji Okuwaki^1,2, Ryota Nakajima¹, Hideo Doi¹, Koji Sumitomo³, Yuji Mochizuki^1,4 (1.Rikkyo Univ., 2.JSOL Corp., 3.Univ. Hyogo, 4.Univ. Tokyo)

Keywords:

Electroporation,Lipid bilayer,Molecular simulation

In the field of electroporation technology, which involves applying a electric fields to a lipid bilayer to increase membrane permeability and insert molecules, molecular simulations are expected to elucidate phenomena at the nano level. We have analyzed pore formation in POPC membranes using non-empirical parameters by utilizing FMO-DPD technology, which applies the interactions obtained using FMO to dissipative particle dynamics (DPD). In this study, we report on the results of a detailed analysis of the intermolecular interactions in the pores using FMO by reverse-mapping technology.