Presentation Information
[15a-M_110-5]Verification of circularly polarized light scattering method
for invasion depth measurement of epithelial cancers
〇(M2)Asato Esumi1, Mike Raj Maskey1, Koki Kasama1, Miyu Kimura1, Nozomi Nishizawa1 (1.Kitasato Univ.)
Keywords:
Circularly polarized light,Optical biopsy,Light scattering
By irradiating circularly polarized light onto turbid media containing dispersed particles such as biological tissues and investigating the degree of polarization removal in scattered light, information regarding cell nucleus size, shape, and density can be measured. Since the nuclei of many cell types become enlarged when they become cancerous, the use of circularly polarized light enables non-invasive, non-staining cancer evaluation. In this study, numerical analysis and experimental investigations using computational models and phantoms with systematically varied tumor layer thickness were conducted to evaluate the effectiveness of measuring the depth of invasion in epithelial carcinoma.