Presentation Information
[15a-PA1-2]Plasma treatment of MF and IL-4 alters M1/M2 differentiation and immune function
〇(M2)Hinako Nakamura1, Yoshihito Yagyu1, Nobuya Hayashi1,2, Reona Aijima3, Yoshio Yamashita3 (1.Kyushu Univ., 2.Kyushu Univ. i-SPES, 3.Saga Univ.)
Keywords:
porous plasma device,cytokine,immune cells
To explore the potential of immune network regulation via plasma irradiation, oxygen plasma was applied to a co-culture system of macrophages (J774.1) and the cytokine IL-4. The results revealed that plasma irradiation decreased macrophage phagocytic activity compared to the non-irradiated control. This reduction is likely attributed to the oxygen plasma promoting macrophage polarization from the pro-inflammatory M1 phenotype toward the tissue-repairing M2 phenotype, leading to the suppression of M1-type activity in the presence of IL-4.