[16a-WL1_301-1~11] 12.7 Biomedical Engineering and Biochips

9:30 AM - 9:45 AM JST(12:30 AM - 12:45 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[16a-WL1_301-3] Functional Interface Design and Characterization of Graphene FET-Based Biosensors for High-Sensitivity DNA Detection

〇Shunya Takahashi¹, Kazuaki Okada², Tatsuya Yuhki², Kenzo Maehashi¹ (1.TUAT, 2.Nissan Chem. Corp.)

Keywords:

Graphene Field Effect Transistor,DNA,sensor

This study aims to develop a novel linker that resolves the various issues inherent in PBASE and to form an optimally functionalised interface for this linker. Using the developed linker, probe DNA was modified onto a graphene surface, and target DNA concentration dependence was determined. The results fitted well with the Langmuir adsorption isotherm, yielding a dissociation constant of ~3 nM. This value was nearly equivalent to the dissociation constant obtained via optical detection.