[16p-WL1_201-1~14] Innovation in Physical Chemistry and Quantum Life Sciences via Photothermal Conversion

2:10 PM - 2:35 PM JST(5:10 AM - 5:35 AM UTC)

[16p-WL1_201-3] Emerging Diagnostic and Drug-Discovery Approaches for Neurodegenerative Diseases through Optical Condensation Technologies

〇Yu Nagashima¹, Masatoshi Kanoda^2,3,4, Masafumi Ohtsubo¹, Shiho Tokonami^2,3, Takuya Iida^4,3 (1.IPMed Hamai Univ., 2.Grad. Sch. Sci. OMU, 3.RILACS OMU, 4.Grad. Sch. Eng. OMU)

Keywords:

Optical Condensation,Neurodegenerative Disorders,Amyloid fibril

Aggregation-prone proteins that form amyloid fibrils in the central nervous system are important biomarkers of neurodegenerative diseases. Here, we present a rapid method for measuring protein aggregates using an optical condensation technique based on a nanobowl substrate. This approach has the potential to discriminate polymorphic forms of protein aggregates present in patient samples, making it valuable not only as a diagnostic technology for neurodegenerative diseases but also as a platform for drug target exploration.