[16p-WL1_301-1~9] Next-Generation Biomedical Applications: Pioneered by Magneto-Science and Medical-Engineering Integration

4:00 PM - 4:30 PM JST(7:00 AM - 7:30 AM UTC)

[16p-WL1_301-5] Magnetic Sensing Techniques in Biomedical Engineering

〇Shin Yabukami¹ (1.Tohoku Univ.)

Keywords:

magnetic nanoparticle,Bacteria detection,protein detection

We reported a simple bacteria detector based on the magnetic signal of aggregates formed between magnetic nanoparticles (MNPs) and bacteria, suitable for point-of-care testing (POCT). This method detects microbial concentration by evaluating the magnetic flux change of aggregates of MNPs and antigens, and is useful as a POCT method. In this study, the small differential pickup coil, about 1 mm in diameter, was fabricated to evaluate the magnetic flux change of magnetic nanoparticle aggregates with a high signal-to-noise ratio. Saliva samples collected from 28 subjects (including esophageal cancer patients) were analyzed for Fusobacterium Nucleatum without a wash process. From the evaluation of 28 samples, the concentration of Fusobacterium Nucleatum obtained from the flux change of magnetic nanoparticle aggregates correlated well with the PCR evaluation results, with a correlation coefficient of 0.69 (p<0.0001).