[16p-WL1_301-1~9] Next-Generation Biomedical Applications: Pioneered by Magneto-Science and Medical-Engineering Integration

6:00 PM - 6:30 PM JST(9:00 AM - 9:30 AM UTC)

[16p-WL1_301-9] Hyperthermia using functional magnetic nanoparticles

〇Akira Ito¹ (1.Nagoya Univ.)

Keywords:

magnetic nanoparticles,Cancer therapy

Magnetic nanoparticles composed of magnetite, a highly biocompatible iron oxide, generate heat under an alternating magnetic field and can be used as heating elements in cancer hyperthermia. However, a technical bottleneck in hyperthermia using magnetic nanoparticles is how to efficiently accumulate magnetic nanoparticles in tumor tissue. We recently investigated an approach to improve blood stability by polymerizing the highly biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on the surface of magnetic nanoparticles, thereby enabling their accumulation in tumor tissue. We evaluated whether this approach could simultaneously achieve tumor MRI contrast (diagnosis) and hyperthermia (treatment) via exposure to an alternating magnetic field. In this presentation, we will focus on this research and introduce our previous research on cancer hyperthermia using functional magnetic nanoparticles.