Session Details
[1S-Cm][JST-MOONSHOT] Molecular, cellular, and interorgan networks controlling "natural history of cancer"
Wed. Jul 17, 2024 9:00 AM - 11:30 AM JST
Wed. Jul 17, 2024 12:00 AM - 2:30 AM UTC
Wed. Jul 17, 2024 12:00 AM - 2:30 AM UTC
Venue C 2F Conference Room 201
Organizers:Shizue Ohsawa(Nagoya University), Miho Sekai(Kyoto University)
There are growing evidence showing that the development and progression of cancer are governed not only by the accumulation of multiple genetic mutations but also by the interaction between cancerous cells and their surrounding environment. Understanding this complicated mechanism has become an urgent challenge toward intractable cancers. In this symposium, we present the latest insights into systemic signals, including cellular interactions and metabolism controlling the "natural history of cancer" from precancerous stages to malignancy. We will discuss about the principles of cancer regulation through molecular, cellular, and interorgan networks.
[1C01]Engulfing Macrophage regulates Non-autonomous Tumor Growth in Drosophila
*Shizue Ohsawa1 (1. Division of Natural Science, Nagoya University)
[1C02]Tumor-suppressive cell competition driven by a "kick-me-out" signal, FGF21
*Motoyuki Ogawa1,2,3, Isao Naguro1,2,3, Hidenori Ichijo3 (1. Bioresponse Signaling, Faculty of Pharm., Juntendo Univ., 2. Cell Signaling, Grad. Sch. Pharmaceut. Sci., Univ. of Tokyo, 3. Cell Signaling and Stress Responses Laboratory, TMDU Advanced Research Institute)
[1C03]Functional analysis of senescent cells controlling the natural history of cancer
*Akiko Takahashi1,2 (1. Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, 2. Cancer Cell Communication Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research)
[1C04]Understanding Cancer Progression through Regulation of Amino Acid Metabolism
*Ayuna Hattori1, Yoshiki Yamamoto1, Makoto Nakagawa2, Takahiro Ito1 (1. Kyoto Univ. Institute for Life and Medical Sciences, 2. Duke Univ.)
[1C05]Identification of a marker for pancreatic precancerous lesions: diagnostic implication for early detection
*Miho Sekai1, Kenta Sugie1, Yasuyuki Fujita1 (1. Department of Molecular Oncology, Graduate School of Medicine, Kyoto University)
[1C06]Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.
*Akihisa Fukuda1, *Tomonori Masuda1, Hiroshi Seno1 (1. Kyoto University Graduate School of Medicine, Dept. of Gastroenterology & Hepatology)