[1AO-B] Proliferation, Differentiation, and Cell Death I

11:14 AM - 11:26 AM JST(2:14 AM - 2:26 AM UTC)

[1AO-B-03] Real-Time Sensing of ATM Kinase Activity in Pancreatic Cancer Organoids Reveals Hypoxia-Driven Enhanced Stress Response

*HUAZE YE^1,2, Yukino Inomata¹, Weisheng Zhang^1,2, Akihito Machinaga³, Hiroshi Seno⁴, Seishi Ogawa^5,6,8, Nobuyuki Kakiuchi^4,7, Shigeki Higashiyama¹, Toru Hiratsuka^1,2 (1. Osaka International Cancer Institute, Next-Generation Precision Cancer Research Center, Frontier Exploratory Research Domain, Department of Oncogenesis and Growth Regulation, 2. The University of Osaka, Graduate School of Medicine, Department of Molecular Oncology, 3. OBG, Eisai Co. Discovery, Medicine Creation, Oncology Tsukuba Research Department, 4. Kyoto University, Graduate School of Medicine, Department of Gastroenterology and Hepatology, 5. Kyoto University, Graduate School of Medicine, Department of Pathology and Tumor Biology, 6. Kyoto University, Institute for the Advanced Study of Human Biology (WPI-ASHBi), 7. Kyoto University, The Hakubi Center for Advanced Research, 8. Kindai University, Faculty of Medicine, Department of Innovative Medicine)

Keywords:

Spatiotemporal dynamics,Live imaging,Förster resonance energy transfer,Tumor hypoxic microenvironment,Stress sensing

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