The 47th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Open-call Symposium : [1PS-12] Molecular basis of the nuclear and mitochondrial DNA maintenance

[1PS-12]【E】Molecular basis of the nuclear and mitochondrial DNA maintenance

Wed. Nov 27, 2024 4:45 PM - 7:00 PM JST
Wed. Nov 27, 2024 7:45 AM - 10:00 AM UTC
Room 12(Fukuoka International Congress Center, 2F 203)
Organizer: Kazutoshi Kasho (Kyushu University), Bunsyo Shiotani (National Cancer Center Research Institute)
Genomic DNA in nucleus and mitochondria must be inherited properly. However, DNA replication is often compromised by obstacles stems from intrinsic and extrinsic stimuli, leading to genome instability and various diseases including cancer. In this symposium, we will discuss the latest findings on the cellular strategy to maintain genome stability or to tolerate genome stress from the aspect of molecular mechanism and cancer biology, focusing on PrimPol.
4:45 PM - 4:48 PM JST(7:45 AM - 7:48 AM UTC)

Introduction

4:48 PM - 5:13 PM JST(7:48 AM - 8:13 AM UTC)

[1PS-12-01]The pillars of the human DNA primase/Polymerase, PrimPol

○María Isabel Martínez-Jiménez1, Marcos Jiménez-Juliana1, Cristina Veláquez-Ruiz1, Susana Guerra-González1, Luis Blanco1 (1. CSIC- Centro de Biologia Molecular Severo Ochoa)
Comment()
5:13 PM - 5:33 PM JST(8:13 AM - 8:33 AM UTC)

[1PS-12-02]The regulations of ATR-dependent tolerance mechanisms in response to oncogenic KRAS-induced replication stress

○Bunsyo Shiotani1 (1. Lab. Genome Stress Signaling, Natl. Cancer Ctr. Res. Inst.)
Comment()
5:33 PM - 5:53 PM JST(8:33 AM - 8:53 AM UTC)

[1PS-12-03]Targeting the POLD4-PRIMPOL axis in non-small cell lung cancer

○Atsuko Niimi1, Siripan Limsirichaikul1, Toshiyuki Takeuchi1, Patinya Sawangsri1, Dat Quoc Tran 1, Yasuyoshi Mizutani1, Motoshi Suzuki1 (1. Mol. Oncol, Fujita Health Univ. Sch. Med.)
Comment()
5:53 PM - 6:18 PM JST(8:53 AM - 9:18 AM UTC)

[1PS-12-04]Mitochondrial DNA (mtDNA) metabolism alterations promote inflammatory gene expression in senescent cells.

○Sjoerd Wanrooij1, Valentin L'Hote1, Lisa Marchhart1, Alma Vennberg1, Maxime Donzel1, Erik Chorell1 (1. Umea university, Sweden)
Comment()
6:18 PM - 6:38 PM JST(9:18 AM - 9:38 AM UTC)

[1PS-12-05]Mitochondrial transcription elongation factor facilitates the transition from RNA synthesis to DNA synthesis at the H-strand replication origin of human mitochondrial DNA

○Takehiro Yasukawa1,2, Shigeru Matsuda2,3, Masunari Nakayama2, Yura Do2, Takashi Ishiuchi5,6, Mikako Yagi2,4, Sjoerd Wanrooij7, Kazuto Nakada8, Fan-Yan Wei3, Kenji Ichiyanagi6,9, Hiroyuki Sasaki6, Dongchon Kang10 (1. Juntendo Univ., 2. Kyushu Univ. Dept CCLM, 3. Tohoku Univ., 4. Kyushu Univ. Dept Health Sci, 5. Univ. Yamanashi, 6. Kyushu Univ. MIB, 7. Umea Univ., 8. Univ. Tsukuba, 9. Nagoya Univ., 10. Kashiigaoka Rehabilitation Hosp.)
Comment()
6:38 PM - 6:58 PM JST(9:38 AM - 9:58 AM UTC)

[1PS-12-06]The dynamics of mitochondrial DNA regulate respiratory function

○Takaya Ishihara1,2, Naotada Ishihara1 (1. Osaka University, 2. Shimane University)
Comment()
6:58 PM - 7:00 PM JST(9:58 AM - 10:00 AM UTC)

Conclusion

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