Session Details
[1PS-11]【E】Deciphering Fibroblast Molecular Biology: A Lineage and Multipotency Perspective
Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 11(Pacifico Yokohama Conference Center 4F, 414+415)
Organizer: Takashi Nishina (Toho University), Yosuke Kurashima (Chiba University)
Traditionally viewed as structural support cells, fibroblasts have emerged as key players in diverse physiological and pathological processes, including stem cell niche maintenance, tissue repair, tumor microenvironment formation, and organ fibrosis progression. Elucidating the molecular mechanisms that regulate this multifunctional nature of fibroblasts represents a critical challenge for understanding homeostatic regulation and developing novel therapeutic strategies. This symposium brings together leading researchers to share cutting-edge findings on fibroblasts present in various tissues and those originating from different cellular lineages, aiming to deepen our fundamental understanding of these enigmatic cells and their complex regulatory networks.
[1PS-11-01]Fibroblasts as the Initiating Cells of Mucosal Repair and Their Intercellular Interactions
○Yosuke Kurashima1 (1. Institute for Advanced Academic Research, Department of Innovative Medicine, Chiba University)
[1PS-11-02]Constitutively high levels of endogenous soluble ST2 inhibit food allergic responses in mice
○Kumi Izawa1, Mayuki Kojima1, Tomoaki Ando1, Keiko Maeda1, Ayako Kaitani1, Nobuhiro Nakano1, Akie Maehara1, Susumu Nakae2, Ko Okumura1, Jiro Kitaura1 (1. Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2. Graduate School of Integrated Sciences for Life, Hiroshima University)
[1PS-11-03(1P-973)]FoxO3a Promotes Scarless Wound Healing
○Saki Asada1, Mariko Moriyama1, Shoji Imamichi2, Kurumi Ogata1, Ryoichi Mori2, Hiroyuki Moriyama1 (1. Kindai Univ., 2. Nagasaki Univ.)
[1PS-11-04(1P-967)]Pregnancy-responsive fibroblast controls physiological skin remodeling as a mechano-to-chemical signaling hub
○Yoshihiko Kobayashi1,2, Kazunori Sunadome3,4, koichiro Maki2,5, Hiroki Fukunaga6, Hitomi Matsubara7, Taiji Adachi2,5, Ken-ichi Matsumoto8, Mitsuhiro Iwaki6,9,10,11, Takuya Yamamoto3,4,12, Fumiko Toyoshima1,2 (1. MRL, Science Tokyo, 2. LiMe, Kyoto Univ, 3. CiRA, Kyoto Univ, 4. ASHBi, Kyoto Univ,, 5. Graduate School of Engineering, Kyoto Univ, 6. Adv ICT Res Inst, NICT, 7. IMS, RIKEN, 8. Interdisciplinary Center for Science Research, Shimane Univ, 9. BDR, RIKEN, 10. IFReC, Univ Osaka, 11. FBS, Univ Osaka, 12. AIP, RIKEN)
[1PS-11-05]The identification of tumor-infiltrating fibrocytes and their multiple roles in the tumor microenvironment
○Atsushi Mitsuhashi1, Aito Yoshida1, Kazuya Koyama1, Hirokazu Ogino1, Yasuhiko Nishioka1 (1. Tokushima University)
[1PS-11-06]MIKE-1 Phase 1-2 Trial of Tamibarotene (AM80) plus gemcitabine and nab-paclitaxel: Stromal Reprogramming Therapy for Pancreatic Cancer via Induction of Meflin-positive tumor-restraining CAFs
○Yasuyuki Mizutani1, Atsushi Enomoto2 (1. Dept. Gastroenterol., Nagoya Univ. Hosp., 2. Dept. Tumor Pathol., Nagoya Univ. Grad. Sch. Med.)
[1PS-11-07]Single-Cell and Spatial Transcriptomic Dissection of Stromal Niches in the Stomach
○Miwako Kakiuchi1, Ayumu Tsubosaka1, Kyohei Sano1, Daisuke Komura1, Hiroto Katoh1,2, Shumpei Ishikawa1,2 (1. the University of Tokyo, 2. National Cancer Center)
[1PS-11-08]Unraveling the Role of Inflammatory Fibroblasts in Intestinal Homeostasis and Cancer Development
○Takashi Nishina1, Yutaro Kumagai2, Tamami Suto1, Takao Seki1, Soh Yamazaki1, Yutaka Suzuki3, Tetuo Mikami1, Masaki Ohmuraya4, Masahide Okunishi1, Hiroyasu Nakano1 (1. Toho University, 2. AIST, 3. University of Tokyo, 4. Hyogo College of Medicine)