The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[1AS-03]【E】Multicellular Robustness revisited

Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 3(Pacifico Yokohama Conference Center 3F, 302)
Organizer: Tohru Ishitani (The University of Osaka), Tatsushi Igaki (Kyoto University)
Multicellular systems possess "robustness," the ability to overcome various disturbances and reproducibly create structures with the same shape and function. This concept was proposed by Waddington in the 1940s, but mechanisms ensuring robustness at multicellular levels, which is necessary to understand development and disease prevention, remain unclear. This symposium will introduce the latest understanding on multicellular robustness and will also serve as an opportunity to reconsider robustness.
9:00 AM - 9:01 AM JST(12:00 AM - 12:01 AM UTC)

Introduction

9:01 AM - 9:20 AM JST(12:01 AM - 12:20 AM UTC)

[1AS-03-01]Physiological cell competition ensure multicellular robustness.

○Tohru Ishitani1 (1. The University of Osaka)
Comment()
9:20 AM - 9:32 AM JST(12:20 AM - 12:32 AM UTC)

[1AS-03-02(1P-568)]Is the Dpp/BMP morphogen scaling required for scaling of wing vein patterns in the Drosophila wing?

○Shinya Matsuda1, Kaoru Sugimura1 (1. University of Tokyo)
Comment()
9:32 AM - 9:44 AM JST(12:32 AM - 12:44 AM UTC)

[1AS-03-03(1P-674)]Additional perturbations of Notch signaling rescue synchronized oscillations in the Lfng-knockout segmentation clock

○Ayumi Goto1,2, Akihiro Isomura1, Ryoichiro Kageyama1 (1. RIKEN, 2. Kyoto university)
Comment()
9:44 AM - 10:03 AM JST(12:44 AM - 1:03 AM UTC)

[1AS-03-04]Toward Understanding Size Robustness in Somitogenesis
Using Human Organoids

○Marina Sanaki-Matsumiya1, Maria Costanzo2, Mitsuhiro Matsuda3, Nicola Gritti2, Vikas Trivedi2, Hiromi Yanagisawa1, Miki Ebisuya3 (1. Tsukuba univ., 2. European Molecular Biology Laboratory (EMBL) Barcelona, 3. Physics of Life, TU Dresden)
Comment()
10:03 AM - 10:22 AM JST(1:03 AM - 1:22 AM UTC)

[1AS-03-05]Elucidating the molecular mechanisms that robustly maintain the proportions of cell types in the intestinal epithelium using Iterative Indirect Immunofluorescence Imaging for cryosections (Cryo-4i)

○Yumi Konagaya1 (1. RIKEN Center for Biosystems Dynamics Research (BDR))
Comment()
10:22 AM - 10:41 AM JST(1:22 AM - 1:41 AM UTC)

[1AS-03-06]A novel regulation of nuclear proteostasis (protein homeostasis) by cell competition regulator Mahjong (VprBP/DCAF1)

○Naoka Shiratsuchi1, Sakurako Nozaki1, Tomoki Kyo1, Riku Egami2, Kei Kozawa1, Yasuyuki Fujita1 (1. Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, 2. Department of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University)
Comment()
10:41 AM - 11:00 AM JST(1:41 AM - 2:00 AM UTC)

[1AS-03-07]Mechanisms that determine cellular fitness

○Tatsushi Igaki1 (1. Grad. Sch. of Biostudies, Kyoto Univ.)
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