Session Details
[1PS-03]【J】Integrated Understanding of Life, Aging, Disease, and Death Unraveled from the Cellular and Molecular Perspectives
Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 3(Pacifico Yokohama Conference Center 3F, 302)
Organizer: Tomoaki Tanaka (Chiba University), Tohru Minamino (Juntendo University)
Aging signals and metabolic stress form intricate networks that extend beyond cellular senescence, shaping aging at organ and organismal levels and contributing to the onset and progression of various diseases. Homeostatic mechanisms within cells and molecules are closely tied to aging, immune responses, and cancer, and their failure underlies many pathological conditions. Advances in single-cell analysis, spatial transcriptomics, and proteomics now offer dynamic, multidimensional insights into these complex networks across cells and organs. This symposium convenes researchers investigating aging, disease, and life processes from neuroscience, metabolism, immunology, and genetics perspectives. By exploring innovative studies on the interactions between aging, disease progression, and homeostatic regulation, we aim to enhance our understanding of these interconnected phenomena.
Introduction
[1PS-03-01]The role of cellular senescence in the pathologies of age-related diseases
○Yohko Yoshida1,2, Tohru Minamino2 (1. Juntendo University, Dept of Adv Senotherapeautics, 2. Juntendo University, Dept of Cardiovasc Biol and Med)
Q & A for Each Presentation
[1PS-03-02]Approaches to Age-Related Sleep Disorders via Senescent Cell Clearance
○Arisa Hirano1, Yasutaka Niwa2, Takeshi Sakurai1 (1. University of Tsukuba, 2. Hirosaki University)
Q & A for Each Presentation
[1PS-03-03]Understand the mechanism underlying the cancer immunotherapy-associated adverse events: Findings from aged mice.
○Hirotake Tsukamoto1 (1. Kyoto Univ.)
Q & A for Each Presentation
[1PS-03-04(1P-725)]Single-Cell Transcriptomic Analysis Reveals Aging-Associated Microglial Subpopulations, Their Dynamics, and Disease Relevance
○Hinase Moridono1,2, Ayaka Sugai1,3, Merve Bilgic1, Yukiko Gotoh3, Yusuke Kishi1,3 (1. Institute for Quantitative Bioscience, 2. Faculty of Pharmaceutical Sciences, 3. Graduate school of Pharmaceutical Sciences)
Q & A for Each Presentation
[1PS-03-05(1P-706)]Involvement of innate immunity in age-dependent memory impairment in Drosophila
○Momoko Hoshi1, Akari Yuki2, Kotomi Onuki1, Aoi Yanagihara2, Motoyuki Itoh1, Ayako Tonoki1 (1. Graduate School of Pharmaceutical Sciences, Chiba University, 2. Faculty of Pharmaceutical Sciences, Chiba University)
Q & A for Each Presentation
[1PS-03-06]Potential of Autonomic Nervous System Regulation in the Treatment of Kidney Diseases
○Tsuyoshi Inoue1 (1. Nagasaki University)
Q & A for Each Presentation
[1PS-03-07(1P-508)]The mechanism of cellular senescence induction by lysosomal membrane damage
○Taiichi Osumi1,2, Takayuki Shima1,2, Makoto Horikawa1,2, Shuhei Nakamura1,2 (1. Department of Biochemistry, Nara Medical University, 2. Center for Autophagy and Anti-Aging Research, Nara Medical University)
Q & A for Each Presentation
[1PS-03-08]Single-Cell Analysis of Endothelial Responses to Aging and Obesity Across Organs
○Masataka Yokoyama1, Akitoshi Nakayama1, Tomoaki Tanaka1 (1. Chiba University Graduate School of Medicine)