Session Details
[1AS-04]【J】Physiological functions of RNA Epicodes and their regulation
Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 4(Pacifico Yokohama Conference Center 3F, 303)
Organizer: Kuniaki Saito (National Institute of Genetics), Ogawa Akiko (Tohoku University)
RNA modifications found in various RNA species, including mRNA, tRNA, and rRNA, add new chemical properties to nucleic acids. Disruptions in these modifications have been linked to diseases such as neurological disorders and cancer. In this symposium, we will collectively refer to these modifications as the "RNA epicode" and provide an overview of the latest advancements. Discussions will focus on key areas, including (i) regulatory mechanisms, (ii) roles in physiology and pathology, (iii) detection technologies, and (iv) nucleic acid chemistry and engineering. Through these discussions, we aim to explore new directions for future research.
Introduction
[1AS-04-01]RNA Epicode metabolism regulates defense mechanisms
○Akiko Ogawa1 (1. Graduate School of Pharmaceutical Sciences, Tohoku University)
Q & A for Each Presentation
[1AS-04-02]Cytoplasmic and extracellular functions of tRNA halves and their implications in diseases
○Yohei Kirino1 (1. Thomas Jefferson University)
Q & A for Each Presentation
[1AS-04-03]Pathogenic mechanism of kidney failure upon dysfunction of a tRNA modification enzyme, CDKAL1
Hiroko Nagata1, Yu Nagayoshi1, ○Takeshi Chujo1, Hitomi Kaneko1, Kayo Nishiguchi1, Yutaka Kakizoe1, Hiroko Ijima1, Korin Sakakida1, Takeshi Masuda1, Sumio Ohtsuki1, Fan-Yan Wei2, Yukie Takahashi1, Takaichi Fukuda1, Hideaki Jinnouchi3, Ryosuke Yamamura1, Koki Matsushita1, Masataka Adachi1, Hideki Yokoi1, Kimitoshi Nakamura1, Hitoshi Nakazato1, Kazuhito Tomizawa1 (1. Kumamoto Uni., 2. Tohoku Univ., 3. Jinnouchi Hospital)
Q & A for Each Presentation
[1AS-04-04]Discovery and Functional Characterization of Novel tRNA Methyltransferases in Higher Eukaryotes
○Shinichiro Akichika1, Akira Mineo1, Mariangela Spagnuolo2, Vishwaja Jhaveri3, Keita Miyoshi4,5, Shunya Kaneko4,5, Shintaro Iwasaki6,7, Takeo Suzuki1,8, Kuniaki Saito4,5, Jean-Yves Roignant2,3, Tsutomu Suzuki1 (1. Dept. of Chembio., Grad. Sch. of Eng., Univ. of Tokyo, 2. Inst. of Pharm. and Biomed. Sci., JGU Mainz, 3. Center for Int. Gen., Facl. of Biol. and Med., Univ. of Lauassnne, 4. Invertebrate Genetics Lab., Nat. Inst. of Genetics, ROIS, 5. Dept. of Genetics, SOKENDAI, 6. RIKEN CPR, 7. Dept. of Comp. Biol. and Med. Sci., Grad. Sch. of Front. Sci., Univ. of Tokyo, 8. Present address: Dept. of Med. Biochem., Grad. Sch. of Med., Univ. of the Ryukyus)
Q & A for Each Presentation
[1AS-04-05(1P-181)]Biogenesis mechanism and significance of intronic polycistronic H/ACA snoRNAs in Drosophila melanogaster
○Mitsunaga Hamashima1, Tomohiro Yamano1, Shigeki Hirakata1, Takashi Fukaya2, Mikiko C. Siomi1 (1. Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2. IQB, Univ. of Tokyo)
Q & A for Each Presentation
[1AS-04-06]Noncanonical Translation of the AUA Codon in Lactobacillus casei
○Chie Tomikawa1, Satoshi Okura1, Gakuto Uesugi1, Kazuyuki Takai1 (1. Graduate School of Science and Engineering, Ehime University)
Q & A for Each Presentation
[1AS-04-07]Disruption of the tRNA epicode triggers degradation: Molecular mechanisms and cell-specific sensitivity
Keita Miyoshi1,2, Kiito Otsubo1,2, Shunya Kaneko1, Makoto Terauchi3, Yuki Hatoyama4, Hideki Noguchi3, Masato T Kanemaki2,4,5, ○Kuniaki Saito1,2 (1. Inverte Genet Lab, Dept of Chr Sci, Natl Inst Genet, ROIS, 2. SOKENDAI, 3. ROIS-DS, 4. Mol Cell Engineering Lab, Dept of Chr Sci, Natl Inst Genet, , ROIS, 5. Dept Biol Sci, Grad Sch Sci, Univ Tokyo)
Q & A for Each Presentation
[1AS-04-08]Development of Gene Expression Control Technology through Functional Enhancement of Triplex-Forming Oligonucleotide
○Yu Mikame1, Asako Yamayoshi1 (1. Institute of Science Tokyo)