The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[1AS-06]【E】Regulation of Cellular Collective Dynamics Dependent on Intercellular Material Transport and Adhesion-mediated Interactions

Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 6(Pacifico Yokohama Conference Center 3F, 311+312)
Organizer: Shiro Suetsugu (Nara Institute of Science and Technology), Tetsuya Takeda (Okayama University)
Cells form collectives to create an individual organism, often clustering with the same type. While intercellular adhesion via adhesion molecules is well known for signal transduction, material transfer through cellular protrusions, tunneling nanotubes, and extracellular vesicles also play a key role. This symposium explores adhesion, morphogenesis, and signaling in collective cell behavior based on recent findings.
9:00 AM - 9:15 AM JST(12:00 AM - 12:15 AM UTC)

[1AS-06-01]Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Artem Fokin1, Yueying Lin2, Dmitry Guschin1, Hsiang-Ying Chen3, John James1, Jie Yan2, Pascal Silberzan3, ○Alexis Gautreau1 (1. CNRS Institut Polytechnique de Paris, France, 2. MBI, NUS, Singapore, 3. Institut Curie, Paris, France)
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9:15 AM - 9:28 AM JST(12:15 AM - 12:28 AM UTC)

[1AS-06-02]A sliding puzzle of keratocytes to expand their sheet maintaining the same shape

○Chika Okimura1 (1. Yamaguchi Univ.)
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9:28 AM - 9:41 AM JST(12:28 AM - 12:41 AM UTC)

[1AS-06-03]Pacsin 2 regulates collective cell migration by controlling N-cadherin endocytosis

○Tetsuya Takeda1 (1. Okayama University)
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9:41 AM - 9:54 AM JST(12:41 AM - 12:54 AM UTC)

[1AS-06-04]Regulation of multimodal cell communication via cell-cell adhesion and extracellular vesicles in epithelial tissue

○Kenji Matsuzawa1 (1. Kyushu University Graduate School of Medical Sciences)
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9:54 AM - 10:03 AM JST(12:54 AM - 1:03 AM UTC)

[1AS-06-05(1P-419)]Macropinocytosis promotes collective cell migration by driving cell shape changes through membrane transport

○Kaede Nakasato1, Sayaka Sekine2,1, Mayuko Sato3, Satoko Okayama4, Kenta Onoue4, Shigenobu Yonemura4, Kiminori Toyooka3, Hiroyuki Uechi1,5, Erina Kuranaga1,5 (1. Lab. of Organ Morphogenesis, Grad. Sch. of Life Sci., Tohoku Univ, , 2. Science Tokyo, 3. RIKEN CSRS, 4. RIKEN BDR, 5. Lab. for Histogenetic Dynamics., Grad. Sch. of Pharm. Sci., Kyoto Univ.)
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10:03 AM - 10:12 AM JST(1:03 AM - 1:12 AM UTC)

[1AS-06-06(1P-420)]Vertex remodeling by PAK4 and Afadin maintains epithelial integrity and barrier function

○Tomohito Higashi1, Babli Adhikary2, Alexander Chang2, Atsuko Y Higashi1, Hideki Chiba1, Ann L Miller2 (1. Fukushima Medical University, 2. University of Michigan)
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10:12 AM - 10:21 AM JST(1:12 AM - 1:21 AM UTC)

[1AS-06-07(1P-416)]Characterization of Zonula occludens-1 in invadopodia

○Ngoc Phuong Pham1,2,3, Sayuki Hirano2, Kazuhiro Aoki2,3 (1. Basic Biology Program, Department of Advanced Studies, Graduate Institute for Advanced Studies, The Graduate University for Advanced Studies, SOKENDAI , 2. Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University, 3. Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University)
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10:21 AM - 10:34 AM JST(1:21 AM - 1:34 AM UTC)

[1AS-06-08]Protein transfer for intercellular communication and cell manipulation through the protrusion-derived extracellular vesicles

○Tamako Nishimura1, Shiro Suetsugu1 (1. NAIST)
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10:34 AM - 10:47 AM JST(1:34 AM - 1:47 AM UTC)

[1AS-06-09]Immune evasion through mitochondrial transfer in the tumor microenvironment

○Hideki Ikeda1,2, Yosuke Togashi2,3,4 (1. Chiba University, 2. Chiba Cancer Center Research Institution, 3. Okayama University, 4. Okayama University Hospital)
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10:47 AM - 11:00 AM JST(1:47 AM - 2:00 AM UTC)

[1AS-06-10]Phenotypic synchronization of cells with direct intercellular vesicle exchange

○Jun K. Yamashita1 (1. Univ. of Tokyo, Grad. Sch. of Med.)
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