The 48th Annual Meeting of the Molecular Biology Society of Japan
Advanced Search

Session Details

Symposium

[1PS-08]【E】New insights into the metal transporters: structure, functions, disease, and drug development

Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 8(Pacifico Yokohama Conference Center 3F, 315)
Organizer: Toshiyuki Fukada (Tokushima Bunri University ), Taiho Kambe (Kyoto University)
Metals, such as zinc, iron, copper and manganese, etc, play fundamental roles to regulate various proteins, and their homeostasis is controlled by metal transporters. Dysfunction of metal transporters causes human diseases, further highlighting metal transporters as important drug target molecules. In this symposium, we will discuss and share the recent advances of metal transporters from structures and functions, and their biological relevance in molecular basis.
2:20 PM - 2:23 PM JST(5:20 AM - 5:23 AM UTC)

Introduction

2:23 PM - 2:42 PM JST(5:23 AM - 5:42 AM UTC)

[1PS-08-01]Efforts towards altering the substrate preference of a transition metal transporter

○Jian Hu1 (1. Michigan State University)
Comment()
2:42 PM - 3:01 PM JST(5:42 AM - 6:01 AM UTC)

[1PS-08-02]Discovery of a first-in-class ZIP14 inhibitor with therapeutic potential for cancer-associated cachexia

○Toshiyuki Fukada1, Takafumi Hara1, Gen Tanaka2, Tomonori Tamura3, Masaomi Terajima4, Kengo Hamamura5, Yuya Yoshida5, Yusuke Kasai1, Toru Kimura6, Kazuto Nunomura8, Taguchi Hiroki1, Yuta Nakayama1, Takumi Umeyama1, Hitomi Fujishiro1, Naoya Matsunaga5, Mitchell D Knutson7, Shigehiro Ohdo5, Hiroshi Imagawa1, Itaru Hamachi3, Hiroyuki Sakurai2 (1. Tokushima Bunri Univ., 2. Kyorin Univ., 3. Kyoto Univ., 4. Astellas Pharma Inc., 5. Kyushu Univ., 6. Josai Univ., 7. Univ. of Florida, 8. Osaka Univ.)
Comment()
3:01 PM - 3:20 PM JST(6:01 AM - 6:20 AM UTC)

[1PS-08-03]Regulation of Muscle Stem Cell Quiescence and Activation by the Metal Transporter ZIP13: Implications for Skeletal Muscle Regeneration

○Emi Yoshigai1,2, Takafumi Hara2, Masaki Hashimoto2, Hidenao Tsuzuki2, Ayaka Noguchi2, Takuto Ohashi2, Toshiyuki Fukada2 (1. Univ. of Occup. & Environ. Health, 2. Tokushima Bunri University)
Comment()
3:20 PM - 3:39 PM JST(6:20 AM - 6:39 AM UTC)

[1PS-08-04]ZIP13 coordinates lipid metabolism in response to changes in intracellular iron and zinc balance

○Ayako Fukunaka1, Gun Tanaka2, Toru Kimura3,2, Kowit Hengphasatporn4, Yasuteru Shigeta4,5, Hirotaka Watada5, Toshiyuki Fukada6, Yoshio Fujitani1 (1. Gunma University, 2. Kyorin University, 3. Josei University, 4. Tsukuba University, 5. Juntendo University, 6. Tokushimabunri University)
Comment()
3:39 PM - 3:58 PM JST(6:39 AM - 6:58 AM UTC)

[1PS-08-05]Structural basis of copper shuttling by the human Golgi-resident copper ion transporter ATP7A

○QIAN XIAOLIN1,2, WATANABE SATOSHI2, KENJI INABA2 (1. Graduate School of Life Sciences, Tohoku Univ, 2. Division of Trans-Scale Structural Life Science, Kyushu Univ)
Comment()
3:58 PM - 4:17 PM JST(6:58 AM - 7:17 AM UTC)

[1PS-08-06]The Zinc–MTF-1–Metallothionein axis contributes to ferroptosis resistance in human cells

○Taiho Kambe1 (1. Kyoto University)
Comment()
4:17 PM - 4:20 PM JST(7:17 AM - 7:20 AM UTC)

Conclusion

Back to Category List