Session Details
[2AS-06]【J】Replication Stress and Robustness: A Balancing Act in Genomes
Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC
Room 6(Pacifico Yokohama Conference Center 3F, 311+312)
Organizer: Bunsyo Shiotani (Tokyo Medical University), Tatsuro Takahashi (Kyushu University)
DNA replication is a highly accurate process; nevertheless, it also enables evolution by "tolerating errors." This symposium will discuss how cells adapt to DNA replication stress derived from fluctuations in the chromatin environment and exhibit replication robustness by regulating repair and alternative replication systems. We will also focus on how replication robustness prioritizes replication completion and contributes to the "trade-off" between cell survival and genome/epigenome integrity under replication stress.
[2AS-06-01]Roles of DNA polymerase dynamics in maintaining genome replication robustness
○Yasukazu Daigaku1 (1. Japanese Foundation for Cancer Research)
[2AS-06-02]Mechanism of DNA replication stress tolerance regulation by HMGA1 phosphorylation
○Syoju Endo1,2, Bunsyo Shiotani2 (1. Science Tokyo, 2. Tokyo Medical Univ.)
[2AS-06-03]Analysis of mechanisms of DNA damage tolerance in human cells
○Rie Kanao1,2, Chikahide Masutani1,2 (1. Res. Inst. Environ. Med., Nagoya Univ., 2. Nagoya Univ. Grad. Sch. Med.)
[2AS-06-04(2P-060)]REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
○Masaoki Kohzaki1, Katarzyna Sobkowiak2,3, Rafael Böhm4,5, Jonathan Mailler2, Florian Huber2,6, Soheila Emamzadah2, Laurence Tropia2, Sebastian Hiller4, Thanos D Halazonetis2 (1. University of Occupational and Environmental Health, Japan, 2. University of Geneva, 3. Merck Biotech Development Center, 4. University of Basel, 5. NUVISAN Innovation Campus, Berlin , 6. Ludwig Institute for Cancer Research, Lausanne)
[2AS-06-05]Smarcad1 facilitates the mismatch-repair-dependent O6-methylguanine response during DNA replication
○Karin Shigenobu Ueno1, Reihi Sakamoto1, Tetsusaburo Suganuma1, Eiichiro Kanatsu1, Tatsuro Takahashi2 (1. Grad. Sch. of System Life Sciences., Kyushu Univ., 2. Fac. of Sci., Kyushu Univ.)
[2AS-06-06]ATR-dependent phosphorylation of INO80 complex plays a crucial role in genome integrity maintaining
○Jiying Sun1, Yoshitaka Kamimura1, Yasunori Horikoshi1, Emi Kawabata1, Bunsyo Shiotani2,3, Roland Kanaar4, Satoshi Tashro1 (1. Hiroshima Univ., 2. Tokyo Med. Univ., 3. Natl Cancer Ctr Res. Inst., 4. Erasmus MC Cancer Inst.)
[2AS-06-07(2P-064)]DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
○Kaima Tsukada1, Liudmyla Lototska1, Aya Tsukada2, Ipek Ilgin Gönenç1, Charlotte Sherlaw-Sturrock3, Manil Kanade1, Antony Oliver4, Samuel Jones5, Satpal Jhujh3, Julius Bannister5, Zafar Iqbal6, Thomas Miller1, Grant Stewart3, Fena Ochs2, Andrew Blackford1,5 (1. Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2. Biotech Research & Innovation Centre, University of Copenhagen, 3. Department of Cancer and Genomic Sciences, Birmingham, University of Birmingham, 4. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, 5. Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, 6. Department of Neurology, Oslo University Hospital)
[2AS-06-08]DNA methylation maintenance through replication protects cancer cells from senescence
○Kosuke Yamaguchi1,2, Xiaoying Chen2, Fumihito Miura3,4, Brianna Rodgers2, Delphine Goehrig5, David Vindrieux5, Takashi Ito3, Masato T Kanemaki1, David Bernard5, Pierre Antoine Deffossez2 (1. National Institute of Genetics, 2. University Paris Cite, CNRS, 3. Graduate School of Medical Sciences, Kyushu University, 4. Graduate School of Frontier Sciences, the University of Tokyo, 5. Equipe Labellisee La Ligue Contre Le Cancer, Inserm U1052, CNRS UMR 5286)