Session Details
[3P]Poster Presentation 3
Fri. Dec 5, 2025 5:00 PM - 7:00 PM JST
Fri. Dec 5, 2025 8:00 AM - 10:00 AM UTC
Fri. Dec 5, 2025 8:00 AM - 10:00 AM UTC
Poster & Exhibition Venue (Pacifico Yokohama Exhibition Hall)
[3P-001(3AS-02-09)]NMR-based structural characterization of a parallel-stranded DNA–RNA hybrid G-quadruplex
○kensei horie1,2, yudai yamaoki1,2, taisei masunaga1,2, chihiro nakayama1,2, keiko kondo1, takashi nagata1,2, masato katahira1,2 (1. Inst. Adv. Energy, Kyoto Univ., 2. Graduate School of Energy Science, Kyoto Univ.)
[3P-002]Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method
○Ryota Miyachi1, Keiko Masuda2, Yoshihiro Shimizu2, Norikazu Ichihashi1,3,4 (1. The University of Tokyo, 2. RIKEN Center for Biosystems Dynamics Research (BDR), 3. Komaba Institute for Science, The University of Tokyo., 4. Research Center for Complex Systems Biology, Universal Biology Institute, The University of Tokyo.)
[3P-003]Development of hybrid lines with truncated CaMBD region in rice GADs (OsGAD1 & OsGAD4 and OsGAD3 & OsGAD4)and Evaluation of Their Stress Tolerance.
○WENJIE GAO1, Ummey Kulsum2, Nadia Akter3, Kazuhito Akama4 (1. Grad. Sch. of Natural Sci. and Technol., Div. of Agricultural and Life Sci., Shimane Univ., 2. Grad. Sch. of Natural Sci. and Technol., Shimane Univ., 3. Genetic Resources and Seed Division,Bangladesh Rice Research Institute,Gazipur 1701, 4. Fac. of Life and Environmental Sci.,Shimane Univ.)
[3P-004]Exploring cell-free synthesis of Human Artificial Chromosomes using bacterial replication proteins
○Kazuyuki Fujimitsu1, Masayuki Su’etsugu1 (1. Rikkyo University)
[3P-005]Regulation of N-acetylglucosamine metabolism by transcriptional factor NagR in Clostridium paraputrificum
○Nodoka Kuwahara1, Gunji Nakano1, Emi Kunitake1, Tetsuya Kimura1 (1. Mie University Graduate School)
[3P-006]Cannot trust without Comparison - PCR Proficiency Test -
○Hiroki Nakae1,4, Michie Hashimoto1,4, Mari Onishi2, Reona Takabatake3, Satoshi Futo1,2 (1. Japan Biotechnology Cirtification Organization, 2. Fasmac Co., Ltd., 3. National Agriculture and Food Research Organization, 4. Japan bio-Measurmeent Consortium)
[3P-007]Analysis of allele-specific expression at gene loci in F1 hybrid mice between the inbred mice with different genetic backgrounds
○Hagumi Suzuki1, Ayaka Saito2, Takanori Amano2, Atsushi Yoshiki3, Hidenori Kiyosawa1 (1. Lab. for Genomic Sci., Dept. of Life Sci., Chiba Tech., 2. Next Generation Human Disease Model Research Team, RIKEN BRC, 3. Experimental Animal Division, RIKEN BRC)
[3P-008]Analysis of the relationship between enhancer polymorphism and allele-specific gene expression using inter-subspecific F1 hybrid mice
○Yukinori Ookubo1, Hidenori Kiyosawa1 (1. Lab. for Genomic Sci., Dpet. of Life Sci. Chiba Tech.)
[3P-009]Analysis of rare variants in RNU2-1 gene in tissue of lung adenocarcinoma
Marina Tanaka1, Makiko Ueda2, ○Toshiko Aiso1 (1. Kyorin Univ Grad School, 2. Kyorin Univ)
[3P-010]Characterization of Biomolecular Dynamics by NMR under Macromolecular Crowding
○Shohei Yamamoto1,2, Yudai Yamaoki1,2, Keiko Kondo1, Takashi Nagata1,2, Masato Katahira1,2 (1. Institute of Advanced Energy, Kyoto University, 2. Graduate School of Energy Science, Kyoto University)
[3P-011]Elucidation of the intracellular and nuclear transport mechanisms of a nuclear translocation aptamer
○Kaito Nitatouge1,2, Kenta Ishida1,2, Hidekazu Hoshino1,2, Yoichi Miyamoto2, Satoshi Obika1,3, Yuuya Kasahara1,2 (1. Grad. Sch. Pharm. Sci., UOsaka, 2. NIBN, 3. OTRI, UOsaka)
[3P-012]Integrative Omics Approaches to Elucidate Genetic Factors of Immune Responses in Humans
○Akari Suzuki1, Kazuhiko Yamamoto1 (1. RIKEN)
[3P-013]Establishment of High-Efficiency Genome Editing in Two-Cell Stage Mouse Embryos Using a Modified CRISPR/Cas Electroporation
○Marina Hayashi1, Norio Takei3, Yangxuan Wei4, Akiko Kamiyoshi1,2, Megumu Tanaka2, Yuka Ichikawa-Shindo1, Jiake Li1, Jun Duan1, Satoshi Watanabe5, Masahiro Sato6, Takayuki Shindo1,2, Takayuki Sakurai1,2 (1. Shinshu Univ., 2. Shinshu Univ. Institute for Biomedical Sciences, 3. Hokkaido University, 4. Hebei Medical University, 5. National Agriculture and Food Research Organization, 6. National Center for Child Health and Development)
[3P-014]Improvement of antisense oligonucleotide sequence design system for efficient development of 2′-MOE modified gapmers
○Natsumi Kameoka1, Harumi Yamaguma1, Tojo Nakayama2, Satoshi Obika3,4, Takanori Yokota2, Yuuya Kasahara1,2,3 (1. NIBN, 2. TIDE, Science Tokyo, 3. Grad. Sch. Pharm. Sci., UOsaka, 4. OTRI, UOsaka)
[3P-015]Establishment of a yeast-based assey for evalating engineered zinc finger recombinase activity
○Hikaru Kamimura1, Kiyomi Nigorikawa1, Wataru Nomura1 (1. Hiroshima University Graduate School of Biomedical and Health Sciences)
[3P-016]A Novel Gene Involved in Intracellular pH in Escherichia coli under Acidic Conditions
○Sakumi Teranaka1, Hiroko Fukuda1, Masahiro Mizuno1, Mikio Nakazima3, Hirotada Mori2, Masakazu Kataoka2 (1. Sinshu Univ., 2. Sinshu University, 3. freelance)
[3P-017]Construction of an evaluation system for development of aptamer-based protein degraders
○Yoko Senga1, Kenta Ishida1,2, Hidekazu Hoshino1,2, Yuuya Kasahara1,2 (1. NIBN, 2. Grad. Sch. Pharm. Sci., UOsaka)
[3P-018(3PS-04-03)]Toward understanding of functionality of the human genome sequences by megabase-scale region minimization
○Taichi Akase1,2, Hikaru Kurasawa1,2, Riho Yamane2, Eri Kawakami2, Hinata Hashimoto2, Yuta Matsuura2, Ayumi Horikawa1,2, Shota Yamazaki2, Shinya Kaneko2, Tomoyuki Ohno3, Yasunori Aizawa1,2,3 (1. Kanagawa Institute of Industrial Science and Technology, 2. Sch. Life Sci. Technol., Science Tokyo, 3. Logomix, Inc.)
[3P-019]Selective Regulation of mRNA Stability by Human CCR4-NOT Subunit CNOT3
○Hideaki Takeda1, Satoshi Hashimoto2, Toshihumi Inada1,2 (1. The University of Tokyo, Department of Biological Sciences Graduate School of Science, 2. The Institute of Medical Science, The University of Tokyo)
[3P-020]Development of gapmer-type antisense oligonucleotides targeting host factors involved in viral replication
○Yuuya Kasahara1,2, Harumi Yamaguma1, Natsumi Kameoka1, Hina Miyazaki3, Kosuke Takada3, Kida Yurie3, Itsuki Anzai3,4, Tokiko Watanabe3,4,5, Satoshi Obika2,4,5,6 (1. NIBN, 2. Grad. Sch. Pharm. Sci., UOsaka, 3. RIMD, UOsaka, 4. CiDER, UOsaka, 5. CAMaD, UOsaka, 6. OTRI, UOsaka)
[3P-021]Identify the optimum cultivation temperature by plasmodium area of Myxomycetes
○Chihana Kikuchi1,2, Mana Masui2,3, Nobuaki Kono1,2,3 (1. Dept. Environ. Info. Stud., Keio Univ., 2. Inst. Adv. Biosci., Keio Univ., 3. Syst. Biol. Program, Grad. Sch. Media Gov., Keio Univ.)
[3P-022]Comprehensive identification of recipient genes involved in conjugative transfer mediated by the RP4 system
○YOSHIHIRO MURATA1, Taiki Kanzaki1, Takeru Kurakawa1, Masahiro Mizuno1,3, Mikio Nakajima4, Hirotada Mori2,3, Masakazu Kataoka2,3 (1. Grad. Sch. Sci. Technol., Shinshu Univ., 2. Eng. Fac. Eng., Shinshu Univ., 3. RCAM., Shinshu Univ., 4. freelance)
[3P-023]Development of G4L-PROTACs for the Degradation of G-Quadruplex Binding Proteins in Cells
○Rena Nohara1, Yuma Tanaya1, Kazuo Nagasawa1, Masayuki Tera1 (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology)
[3P-024]Mechanism underlying gRNA-dependent variation in CRISPR-Cas9 cleavage efficiency
○Kanae Aoki1, Yusuke Kamachi1 (1. Sch. of Eng. Sci., Kochi Univ. of Tech.)
[3P-025]Analysis of the relationship between the function of unknown gene KWMTBOMO05087 (No. 118) and UPR in BmN cells
○Ryota Tanaka1, Natsuki tani1, Hiroaki Mon2, Jae Man Lee2, Akitsu Masuda2, Masato Hino2, Ryosuke Fujita2, Takahiro Kusakabe2 (1. Grad.Sch.of Biores.Bioenv.Sci.,Univ.of Kyushu, 2. Fac.Agr.,Univ.of Kyushu)
[3P-026]Identification and functional characterization of lncRNAs in dendritic cell differentiation and infection
○Jordan A. RAMILOWSKI1, Sakura Eri MAEZONO1 (1. YOKOHAMA CITY UNIVERSITY)
[3P-027]Relationship Between Binding Properties of Stem-Loop–Targeting Antisense Oligonucleotides to an mRNA Model and Regnase-1 Negative Feedback Inhibition
○Teru Biwata1, Kanade Nisikawa1, Kurumi Hasei1, Nae Sakimoto2, Junji Kawakami1,2 (1. FIRST Kounan university , 2. KOLOT)
[3P-028]Mismatch recognition ability of a DNAzyme modified high-affinity LNA
○Natsuki Doi1, Teru Biwata1, Nae Sakimoto2, Shigenori Iwai2, Junji kawakami1,2 (1. FIRSR, Konan University, 2. KOLOT)
[3P-029]Approach to Elucidating Metabolic Mechanisms through Single-Cell Distribution Analysis of Ionized Lipid SM-102 in Mouse Liver Using MS Imaging
○Kaoru Nakagawa1, Keiko Kajihara2, Sachiko Sakamoto2, Qiuyi Wang1, Ayako Matsunawa2, Hiroyuki Tanaka2, Masashi Sugimoto2, Hirofumi Ebe2, Kenjiro Minomi2, Manami Kobayashi1, Naoki Morita1, Tadayuki Yamaguchi1, Junko Iida1 (1. Shimadzu Corp., 2. Nitto Denko Corp.)
[3P-030]TASL Regulates Keratinocyte Differentiation by Linking Lysosomal Function to Calcium Signaling
○Soyoung Jang1 (1. Gyeongsang National University)
[3P-031]Kanade; Disentanglement of batch effects from conditional signals in single-cell omics
○Shunta Sakaguchi1,2, Masato Tsutsumi1,2, Kentaro Nishi2, Honda Naoki1,2 (1. Nagoya Univ., 2. Hiroshima Univ.)
[3P-032(3AS-13-03)]Hypermethylated CpG-rich regions identified by whole-genome bisulfite analysis in a monotreme genome
○Saki Aoto1, Kohji Okamura2 (1. Med. Gen. Ctr., NCCHD, 2. Dept. of Sys. Dev. Biol., NCCHD)
[3P-033]Comparative analysis of genomes de novo assembled using long-read sequencing in Japanese sugar beet breeding lines.
○Kazuyoshi KITAZAKI1, Kotaro HIROKI1, Kana TAKAYASU1, Akira NAITO1, Tsubasa NARIHIRO2, Hiroaki MATSUHIRA2, Tomohiko KUBO1, Yosuke KURODA2 (1. Hokkaido University, 2. NARO HARC)
[3P-034]Cell type–specific functions of nucleic acid-binding proteins revealed by deep learning on co-expression networks
○Naoki Osato1, Kengo Sato1 (1. Institute of Science Tokyo)
[3P-035]Comprehensive Evaluation of Mutation Tolerance at Each Coordinate on the Circular Bacterial Genome
○Yuto Fujimoto1,3, Nobuaki Kono1,2,3 (1. Graduate School of Media and Governance, Keio University, 2. Faculty of Environment and Information Studies, Keio University, 3. Institute for Advanced Biosciences, Keio University)
[3P-036]Genomic and Phylogenetic Characterization of Neobacillus nitrireducens sp. nov., a Novel Soil-Derived Denitrifier
○JinWoo Ahn1, Jeonghwan Jang1 (1. Jeonbuk National University)
[3P-037]Comprehensive extraction of plant allele sequences using an improved AlleleMiner and verification of transmission based on parent-child relationships
○Yukinari Kiryu1, Yoshihiro Kawahara2, Tomoko Endo3, Tokumasa Horiike1, Kenta Shirasawa4, Sachiko Isobe4, Takehiko Shimada3, Hiroshi Fujii5 (1. Graduate School of Integrated Science and Technology, Shizuoka University, 2. Research Center for Advanced Analysis, NARO, 3. Institute of Fruit Tree and Tea Science, NARO, 4. Kazusa DNA Research Institute, 5. Faculty of Agriculture, Shizuoka University)
[3P-038]Influence of Ploidy and Genomic Complexity on the Accuracy of Variant Detection with Long-Read Sequencing
○Yoshinori Fukasawa1 (1. Utsunomiya Univ.)
[3P-039(3PS-01-07)]Comparative Genomic Analysis of the Hattan Lineage of Hiroshima Sake Rice
○Ryo Nozu1,2, Miyuki Kanda2, Zennosuke Katsuba3, Ayane Fujita3, Shuji Matsushita3, Hidemasa Bono1,2 (1. Grad. Sch.Integ. Sci. Life, Hiroshima Univ., 2. Genome Editing Innovation Center, Hiroshima Univ., 3. Hiroshima Pref. Tech. Res. Inst.)
[3P-040]Genomic and Transcriptomic Insights into Aerobic Denitrification in Neobacillus sp. OS1-2 Isolated from Orchard Soil
○Changwoo Lee1, Jeonghwan Jang1 (1. Jeonbuk National University)
[3P-041]Uncovering Functional Potential of Repeat-Derived Genomic Elements
○Chao Zeng1, Hamada Michiaki1,2,3 (1. Waseda University, 2. AIST, 3. Nippon Medical University)
[3P-042]Screening of a Gata4 enhancer for fetal gonad expression.
○Maiho Sasa1 (1. National Center for Child Health and Development)
[3P-043]Comprehensive analysis of immune niches in breast cancer tissue through integration of spatial transcriptomics data
○Nagomi Kurogi1, Koreeda Tatsuya2 (1. Yokohama City University , 2. CRINIC FOR GROUP)
[3P-044]Cost-effective genomic library construction using TGN and its application to fission yeast
○Keito Abe1, Hisao Moriya1 (1. Okayama University)
[3P-045]Haplotype-resolved genome assembly of three human cell lines and gene comparison between haploids
○Taiki Ideguchi1, Sangwan Kim2, Yoshinori Hasegawa3, Hideki Hirakawa2 (1. Fac.Agr, Kyushu Univ., 2. Grad.Sch.Agr, Kyushu Univ., 3. Kazusa DNA Res.Inst.)
[3P-046]Temporal expression of nifH and high-level ammonium production in the diazotrophic bacterium Clostridium iksanensis sp. nov.
○Soyeon Park1, Jeonghwan Jang1 (1. Jeonbuk National University)
[3P-047]Development of a Scalable Pangenome Graph Browser
○Hiroaki Kamada1, Masahiro Kasahara1 (1. The University of Tokyo)
[3P-048]Novel transcript discovered unexpectedly from public data
○Shoichiro Tange1, Masashi Idogawa1, Issei Imoto2, Takashi Tokino3 (1. Sapporo Medical Univ., 2. Aichi Cancer Center, 3. Sapporo Univ. of Health Sci.)
[3P-049]Structure of venom protein gene clusters revealed by chromosome-scale genome assembly of a Japanese endemic pit viper, habu, Protobothrops flavoviridis
○YINRUI SUN1, Kazuaki Yamaguchi2, Takahito Chijiwa3, Naoko Oda-Ueda4, Shigehiro Kuraku2,5, Ogawa Tomohisa6, Hiroki Shibata1 (1. Div. Genomics, Med. Inst. Bioreg., Kyushu Univ., 2. RIKEN BDR, 3. Dept. Appl. Life Sci., Fac. Biotech. & Life Sci., Sojo Univ., 4. Dept. Pharmacy, Fac. Pharm. Sci., Sojo Univ., 5. Mol. Life Hist. Lab., Dept. Genomics & Evol. Biol., Natl. Inst. Genet., 6. Lab. Enzymol., Grad. Sch. Agri. Sci., Tohoku Univ.)
[3P-050]Phylogenetic Relationships and Genetic Structure of the Ryukyu Mouse (Mus caroli) Inferred from Whole-Genome Sequences
○Xiaolin Li1, Hitoshi Suzuki2, Kazumichi Fujiwara3, Toshinori Endo4, Naoki Osada4 (1. info.Biol.Lab.,Grad.Sch. of IST,Hokkaido Univ., 2. Hokkaido Univ., 3. NIG., 4. info.Biol.Lab.,Faculty of IST,Hokkaido Univ.)
[3P-051]Analysis of TP53 gene expression regulation associated with large structural variations
○Kumi Sakoe1, Gou Yamamoto1, Tomokazu Wakatsuki1, Chie Matsue1, Reiko Yoshida1 (1. Saitama Prefectural Cancer Center)
[3P-052]A chromosome-scale genome assembly of the field cricket Teleogryllus emma to uncover the molecular basis of obligatory egg diapause.
○Ramon Nagahama1, Kazuya Hirata2, Ryuto Sanno2, Kazuhiro Satomura3, Takeshi Suzuki4,5, Tsuyoshi Tanaka1,4,5,6, Kosuke Kataoka1,4,5,6,7 (1. Dept. Eng., Tokyo Univ. Agri. Tech., 2. Grad. Sch. Adv Sci. Eng., Waseda Univ., 3. Dept. Bio-Sci., Nagahama Inst. Bio-Sci. Tech., 4. Grad. Sch. Bio-App. Sys. Eng., Tokyo Univ. Agri. Tech., 5. Grad. Sch. Adv. Interdiscip. Sci., Tokyo Univ. Agri. Tech., 6. Grad. Sch. Eng., Tokyo Univ. Agri. Tech., 7. Comp. Res. Org., Waseda Univ.)
[3P-053]Regulatory mechanisms governing DNA replication timing through plant-specific histone modifications
○Masaaki Umeda1, Kar Yee Moo1, Shiori Aki2, Hirotomo Takatsuka3, Chikage Umeda1 (1. Nara Institute of Science and Technology, 2. Yamato University, 3. Nara Women's University)
[3P-054]The G-quadruplex-binding activity of human ORC1 may be involved in ORC-chromatin association before the initiation step of DNA replication
○Shou Waga1, Minami Takano1 (1. Japan Women's Univ.)
[3P-055]Unexpected Role of Nucleosides in the Robustness of ES Cell DNA Replication
○Kiminori Kurashima1,2, Praveen Pandy3, Andrei Chabes3, Sergio Acebrón1, Tomomi Tsubouchi2,4 (1. COS, Heidelberg Univ., 2. NIBB, NINS, 3. Dept. of Med. Biochem. and Biophysics, Umeå Univ., 4. Dept. of Agric., Shizuoka Univ.)
[3P-056]Stability of Sld3 is regulated by the complex formation with Cdc45 in the budding yeast Saccharomyces cerevisiae
○HONG NGOC NGUYEN1, Seiji Tanaka1,2 (1. Graduate School of Engineering, Kochi University of Technology, 2. School of Engineering Science, Kochi University of Technology)
[3P-057]Genome-wide analysis identifying lagging-strand synthesis and replication stress bypass functions of DNA polymerase δ in human cells.
○Takahiro Yamaguchi1,2, Yuji Masuda3, Lewis Bainbridge1, Tamiko Minamisawa1, Mami Takahashi1, Shu Kondo2, Chikahide Masutani3, Yasukazu Daigaku1 (1. Japanese foundation for cancer research, 2. Graduate School of Advanced Engineering, Tokyo university of science, 3. Research Institute of Environmental Medicine, Nagoya University)
[3P-058]Phosphorylation-Dependent Regulation of the Checkpoint Mediator Claspin
○Zhiying You1, Mikihiro Shibata2, Katsuhiko Kamada3, Chi-Chun Yang1, Hiroyuki Sasanuma1, Hisao Masai1 (1. Genome Dynamics, Dept. of Basic Med. Sci., Tokyo Metro. Inst. Med. Sci., 2. Nano Life Science Institute, High-speed Bio-AFM Research Unit, Kanazawa University, 3. Glycometabolic Biochemistry Laboratory, RIKEN)
[3P-059]Fission Yeast Rif1 Regulates DNA Replication via C-terminal Oligomerization and G4 DNA Binding
○Yutaka Kanoh Kanoh1, kaho Takasawa1, Hiroyuki Sasanuma1, Hisao Masai1 (1. TMiMS, Dept.of Basic Med. Sci., Genome Dynamics)
[3P-060]Function of Mcm10 for the initiation of DNA replication in Xenopus egg extract
○Shota Ueki1, Yumiko Kubota1 (1. Osaka University)
[3P-061]Mechanistic understanding of Timeless-Tipin-dependent sister chromatid cohesion establishment.
○Hiroto Goto1, Yukito Aiba2, Tomoko Nishiyama1 (1. Kyoto University, 2. Nagoya University)
[3P-062]Comparison of Cellular Responses to Interstrand DNA Crosslinks in Elephant and Human Fibroblasts
Taisuke Kitano1, Zida Zhu1, Naoya Minami1, Koichi Orino1, ○Yasunaga Yoshikawa1 (1. Kitasato Univ.)
[3P-063(3AS-02-08)]BET family, BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop–mediated Homologous recombination
Jianghao Qian1, Tomoko Watanabe2, Reiko Watanabe3, Shin-ichiro Kanno1, Akiko Takahashi4, Shinji Kohsaka2, Yuki Yoshino1, Natsuko Chiba1, Kozo Tanaka1, Takashi Kohno2, Akira Yasui1, ○Ayako Ui1 (1. Tohoku university, 2. National Cancer Center Research Institute, 3. Osaka University, 4. Japanese Foundation for Cancer Research)
[3P-064]Investigating age-related genes by combining genome stability analyses and bioinformatics methods
○Guimaraes Nunes Itamar Jose1,2, Takehiko Kobayashi1 (1. Institute of Quantitative Biosciences, Laboratory of Genome Regeneration, 2. Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo)
[3P-065]In silico screening of redox molecular chaperon HslO associated protein molecules with alphafold 3 in Escherichia coli
Ryouta Fujita1, Takumi Sakurada1, Yuxin Ran1, ○Akihiro Kaidow1 (1. Tokai Univ.)
[3P-066]Werner helicase and MutLα endonuclease control the fidelity of single-strand annealing
○Yoshitaka Kawasoe1, Satomi Oda2, Aya Sakazume3, Taisei Miyata3, Tatsuro Takahashi1 (1. Fac. of Sci., Kyushu Univ., 2. Grad. Sch. of Sci., The Univ. of Osaka, 3. Grad. Sch. of Systems Life Sci., Kyushu Univ.)
[3P-067]Time-course analysis of DSB end resection in the rad50-C47 mutant deficient in Mre11 exonuclease activity
○Haruka Nishida1, Kenichiro Matsuzaki1, Miki Shinohara1,2 (1. Advanced Bioscience, Graduate School of Agriculture, Kindai University, 2. Agricultural Technology and Innovation Research Institute, Kindai University)
[3P-068]Proteomic Analysis of DNA-PKcs-Dependent Responses to Ionizing Radiation in Human Cells
○Muhammad Aljiedi1, Akiie Honda1, Raito Muramatsu2, Natsuki Kondo2, Sing Ying Wong1, Yoshihisa Matsumoto2, Nobuhiro Hayashi1 (1. School of Life Science and Technology, Institute of Science Tokyo, Ookayama, Meguro-ku, Tokyo, Japan, 2. Laboratory for Zero-Carbon Energy, Institute of Integrated Research, Institute of Science Tokyo, Ookayama, Meguro-ku, Tokyo, Japan)
[3P-069]RNAOffScan: Prediction software for CBE-Induced RNA Off-Target Risks using DNA Language Model
○Kazuki Nakamae1, Takayuki Suzuki2, Sora Yonezawa2, Kentaro Yamamoto3, Taro Kakuzaki4, Hiromasa Ono1,5, Yuki Naito5, Hidemasa Bono1,2,5 (1. Genome Editing Innovation Center, Hiroshima University, 2. Graduate School of Integrated Sciences for Life, Hiroshima University, 3. Genome Analytics Japan Inc., 4. Independent Researcher, 5. Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems)
[3P-070]Development of a novel analytical framework for investigating mutation signature formation mechanisms using the Shuttle Vector (SV)-NGS method
○Chiho Fujiwara1, Hidehiko Kawai1, Hiroyuki Kamiya1 (1. Grad. Sch. Biomed. Hlth. Sci., Hiroshima Univ.)
[3P-071]Development of novel Shuttle Vector (SV) -NGS mutation analysis methods for high-precision, high-sensitivity, and high-throughput mutation analysis techniques
○Miho Fujiwara1, Hidehiko Kawai2, Hiroyuki Kamiya2 (1. Sch. Pharm. Sci., Hiroshima Univ., 2. Grad. Sch. Biomed. Hlth. Sci., Hiroshima Univ.)
[3P-072]Molecular mechanism analysis of action-at-a-distance mutations induced by oxidatively damaged base with Shuttle Vector (SV)-NGS using supF gene and 256tetra sequence
○Anna Tachibana1, Hidehiko Kawai1, Hiroyuki Kamiya1 (1. Hiroshima Univ.)
[3P-073]Precise genomic deletion using the unique genome editing tool, TiD-X
○Naoki Wada1, Emi Murakami1, Kazuya Marui1, Yuriko Osakabe2, Keishi Osakabe1 (1. Tokushima University, 2. Science Tokyo)
[3P-074]The Role of Homologous Recombination in Normally Proliferating Cells
Goki Taniguchi1, Alexander May1, Hiroshi Iwasaki1,2, ○Hideo Tsubouchi1,2 (1. IIR, Science Tokyo, 2. Life Sci., Science Tokyo)
[3P-075]Developing PET Degradation System in BHET-Degrading Bacteria
○Yusaku Kobayashi1, Masahiro Mizuno1, Kenji Miyamoto2, Masakazu Kataoka1 (1. Shinshu University, 2. Keio University)
[3P-076]Quantitative assay of MutSalpha(MSH2/MSH6) binding to base mismatches using oligo DNA trapping
○Shinya Oda1, Seijiro Shioi1, Isao Kuraoka2, Yoshimichi Nakatsu1 (1. NHO Kyushu Cancer Center, 2. Fukuoka Univ.)
[3P-077]Molecular mechanism of mismatch-repair-dependent DNA damage induced by replication across O6-methylguanine
○Reihi Sakamoto1, Karin Ueno1, Tetsusaburo Suganuma2, Tatsuro Takahashi3 (1. Graduate School of System Life Sciences, Kyushu University, 2. School of Science, Kyushu University, 3. Faculty of Science, Kyushu University)
[3P-078]Visualization of the chromatin containing histone H2A.X by ChIP-CryoEM structural analysis
○Haotong Zhuang1,2, Suguru Hatazawa1, Cheng-Han Ho1, Yoshimasa Takizawa1,2, Hitoshi Kurumizaka1 (1. Institute for Quantitative Biosciences, The University of Tokyo, Japan, 2. Graduate School of Frontier Sciences, The University of Tokyo)
[3P-079]Molecular characterization of MutS7 from Mimivirus shirakomae
○Satoshi Yoshioka1, Kenji Fukui2, Taisuke Wakamatsu1 (1. Grad. Sch. Int. Arts Sci., Kochi Univ., 2. Dept. Food Sci. Nutri., Nara Women’s Univ)
[3P-080]Molecular mechanism of copy number fluctuation of CUP1 region in S. cerevisiae
○Tatsuki Toriyama1, Kazuki Ikezawa2, Shiho Ogawa33, Seiji Tanaka1,4 (1. Grad. Sch. Eng., Kochi Univ. Tech., 2. Sch. Env. Sci. Eng., Kochi Univ. Tech., 3. Sch. Biol. Env. Sci., Kwansei Univ., 4. Sch. Sci., Kochi Univ. Tech.)
[3P-081]The effect of THO2 on the rDNA region and lifespan
○Takenobu Yasumura1, Syuichi Yanagi2, Takehiko Kobayashi1,2 (1. Tokyo Univ, 2. IQB)
[3P-082]Development of mutagenicity tests for the purpose of transcription coupled repair (TCR) evaluation.
○Yuto Ouchi1, Kazuhiro Shiizaki1 (1. Grad. Sch. Life Sci., Toyo Univ.)
[3P-083]Pathways and Structural Analysis of Aberrant DNA Structures in Aged Budding Yeast
○Kohshiroh Sakamoto1,2, Takehiko Kobayashi2 (1. Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2. IQB., Univ. of Tokyo)
[3P-084]Development of a FRET-based D-loop Formation Assay for Human RAD52
○Takumi Ichinose1, Chiaki Kinoshita1, Kazuki Kamoi1, Mika Saotome1, Wataru Kagawa1 (1. Meisei University)
[3P-085]Optimized recombinase-mediated knock-in method in human iPS cells
○Shogo Shibue1,2, Knut Woltjen1 (1. The Center for iPS Cell Research and Application, 2. Graduate School of Medicine, Kyoto University)
[3P-086]Processing of DNA topoisomerase II-DNA protein crosslink associated with etoposide-induced DNA double-strand breaks via VCP-proteasome pathway
○Ryo Sakasai1, Yumi Sunatani1, Tadashi Matsui1, Kuniyoshi Iwabuchi1 (1. Biochem. I, Kanazawa Med. Univ.)
[3P-087]Analyzing nucleolar localization of the cytidine deaminase AID
○Hidetaka Shimizu1, Ahmed Mohamed Refaat1, Takaaki Yasuhara1 (1. Graduate School of Biostudies, Kyoto University)
[3P-088]Analysis of the DNA damage-induction mechanisms of genistein
○Kokona Uehara1, Mahiro Fujita2, Shigeki Takeda1,2, Noritaka Adachi3, Aya Kurosawa1,2,3,4 (1. Sch. Sci. Tech., Gunma Univ., 2. Grad.Sch.Sci.Tech.,Gunma Univ., 3. Grad. Sch. Nanobiosci., Yokohama City Univ., 4. GUCFW, Gunma Univ.)
[3P-089]Analysis of the cytotoxic mechanisms of luteolin
○Yuzuki Arai1, Noritaka Adachi2, Aya Kurosawa1,2,3 (1. Sch. of Sci. Tech., Gunma Univ., 2. Grad. Sch. Nanobiosci., Yokohama City Univ., 3. GUCFW, Gunma Univ.)
[3P-090]Preparation of complexes for elucidating the function of UHRF1 in oocytes and early embryos
○Shuhei Kawaguchi1, Nao Nakamura2, Amika Kikuchi2, Kyohei Arita2 (1. School of Science, Yokohama City University, 2. Graduate School of Medical Life Science, Yokohama City University)
[3P-091(3AS-11-02)]Structural and biochemical analyses of SOX2 binding to genomic sequences in nucleosomes
○Kenta Echigoya1, Yoshimasa Takizawa1, Tomoya Kujirai1,2, Mitsuo Ogasawara1, Yohei Hayashi3, Hitoshi Kurumizaka1,2 (1. Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 2. RIKEN Center for Integrative Medical Sciences, 3. Research and Development Center, CiRA Foundation)
[3P-092]The relationship between changes in plant DNA methylation status and salt stress response
○Risa Kawashima1, Sayaka Tominaga1, Taiko To1 (1. Institute of Science Tokyo)
[3P-093(3AS-18-07)]Cryo-EM structure of plant MET1 reveals a similar but distinct DNA methylation maintenance mechanism from animals.
○Amika Kikuchi1, Atsuya Nishiyama2, Yoshie Chiba2, Makoto Nakanishi2, Taiko Kim To3, Kyohei Arita1 (1. Grad. Sch. of Med Life Sci., Yokohama City Univ., 2. Inst. of Med. Sci., Univ. of Tokyo., 3. Dept of Life Science and Technology, Institute of Science Tokyo.)
[3P-094(3PS-08-02)]DPPA3 interacts with the UHRF1 SRA domain via zinc-coordination and inhibits hemimethylated DNA binding of UHRF1
○Ayana Ota1, Shota Tanimoto1, Christopher B. Mulholland3, Yoshie Chiba1, Kyohei Arita2, Heinrich Leonhardt3, Atsuya Nishiyama1, Makoto Nakanishi1 (1. Div. Cancer Cell Biol., Inst. Med. Sci., Univ. Tokyo, 2. Grad. Sch. Med. Life Sci., Yokohama City Univ., 3. Fac. Biol. & Ctr. Mol. Biosyst. (BioSysM), Human Biol. & BioImaging, LMU Munich)
[3P-095]Investigating the genome-wide contribution of short tandem repeats to cell-type-specific gene expression in neurological disorders
○Takuya Suzuoka1,2, Hirofumi Aso1,3, Satoshi Ohno1, Hideyuki Shimizu1,2 (1. Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 3. Karolinska Institute)
[3P-096]Functional Analysis of Histone H3 Proteins in Paramecium
○Takayuki Kawaguchi1,3, Reiko Nakagawa2, Jun-ichi Nakayama1,3 (1. NIBB, 2. BDR, RIKEN, 3. Sch. of Life Sci., SOKENDAI, NIBB)
[3P-097(3AS-15-06)]LINE-1–repressive lamina-associated domain functions as a dynamic regulatory environment for neuronal genes
○Yuki Kitanishi1,2, Yuka Nakamura2, Sakurako Ishikawa2, Hiroaki Oshiro2, Hiroki Sugishita2, Daichi Kawaguchi2, Yukiko Gotoh1,2 (1. International Research Center for Neurointelligence(IRCN), 2. Graduate School of Pharmaceutical Sciences, The University of Tokyo)
[3P-098(3PS-18-04)]Structural analysis of nuclear lamina-associated proteins bound to nucleosomes
○Naoki Horikoshi1, Yoshimasa Takizawa1, Hitoshi Kurumizaka1 (1. The Univ. of Tokyo, IQB)
[3P-099]Sample preparation for observing the nanodynamic behavior of histone tails using High-Speed AFM
○Ryota Imada1, Quynh Pham2, Yusuke Miyanari3, Shoko Sato4, Hitoshi Kurumizaka4, Mikihiro Shibata3,5 (1. Grad. Sch. Math. & Phys., Kanazawa Univ., 2. Grad. Sch. NanoLS., Kanazawa Univ., 3. WPI-NanoLSI, Kanazawa Univ., 4. Institute for Quantitative Biosciences, Tokyo Univ., 5. InFiniti, Kanazawa Univ.)
[3P-100]The impact of RNA on chromatin modification activities of NSD2 in vitro
○Chiaki Ichimura1, Hiroto Isobe1, Akira Sassa1, Naoki Horikoshi2, Hitoshi Kurumizaka2, Masaki Kikuchi3, Takashi Umehara4, Kiyoe Ura1 (1. Graduate School of Science, Chiba University, 2. Institute for Quantitative Biosciences, The University of Tokyo, 3. Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 4. College of Pharmaceutical Sciences, Ritsumeikan University)
[3P-101]Structural analysis of nucleosome reconstituted by Cell-free protein expression system and analysis of related chaperone function.
○Taiki AZUMA1, Keiichi OKIMUNE1, Junko HAGA1, Petra Banko2, Katsumi MAENAKA3, Syunsuke KITA3, Daisuke KIHARA4, Ryo MORISHITA5, Taichi TAKASUKA2,1 (1. Hokkaido Univ., Grad. Sch. of Global Food Resources, 2. Hokkaido Univ., Res. Fac. of Agric., 3. Hokkaido Univ., Res. Fac. of Pharm., 4. Purdue Univ., West Lafayette, 5. CellFree Sciences Co., Ltd)
[3P-102(3PS-08-03)]Histone H3K27 mono-methylation by PRC2 complex and G9a/GLP in mammalian cells
○Yuto Iwaya1,2, Ayumi Yamada1, Yoichi Shinkai1 (1. RIKEN, Shinkai cellular memory laboratory, 2. Institute of Science Tokyo)
[3P-103]Isolation and Cryo-EM Analysis of Chromatin Rich in Histone H3 and H4 from Living Cells
○Osamu Kawasaki1, Hitoshi Kurumizaka2, Kayo Nozawa1 (1. Institute of Science Tokyo, School of Life Science and Technology, 2. The University of Tokyo, Institute for Quantitative Biosciences)
[3P-104(3PS-09-07)]An approach to acylation analysis from the perspective of data science.
○Naoshi Dohmae1 (1. RIKEN CSRS)
[3P-105]Structural and functional analysis of a unique subnucleosome containing centromere-specific histone variant CENP-A
○Iori Kiyokawa1, Osamu Kawasaki1, Yoshimasa Takizawa2, Hitoshi Kurumizaka2, Kayo Nozawa1 (1. Institute of Science Tokyo , 2. The University of Tokyo)
[3P-106]Epigenetic Priming and Establishment of Transposable Element-Derived Enhancers during Mouse Oogenesis
○Yasuhisa Munakata1,2, Mengwen Hu2, Raissa G Dani2, Richard M Schultz2,3, Satoshi H Namekawa2 (1. Fukushima Med Univ., 2. University of California, Davis, 3. University of Pennsylvania)
[3P-107]Linking chromatin hub formation to epigenetic dynamics via single-molecule multiway chromatin conformation assay
○Akira Hirota1, Takumi Wada1, Takuya Yamamoto1,2,3, Taro Tsujimura1 (1. Kyoto Univ., ASHBi, 2. Kyoto Univ., CiRA, 3. Riken, AIP)
[3P-108]Unraveling the Molecular Pathogenesis of Muscular Dystrophy Caused by Epigenetic Dysregulation
Using Patient-Derived iPS Cells and Early Developmental Models
○Takumi Kishimoto1,2, Mitsuru Honda2, Satomi Mitsuhashi3, Mio Iwasaki2, Hidetoshi Sakurai2 (1. Kyoto University, 2. CiRA, Kyoto University, 3. St. Marianna University School of Medicine)
[3P-109]Live-cell imaging analysis of histone modification dynamics in Arabidopsis thaliana
○Sora Oshima1, Hikaru Sato1, Megumi Matsuoka1, Mio Shibuta2, Takuya Sakamoto3, Nanami Ito1, Tatsuaki Goh4, Yuko Sato5, Hiroshi Kimura6, Sachihiro Matsunaga1 (1. Dept. Integrated Biosci., Grad. Sch. Frontier Sci., Univ., 2. Fac. Sci., Yamagata Univ., 3. Dept. Sci., Fac. Sci., Kanagawa Univ., 4. Div. Biol. Sci., Grad. Sch. Sci. Tech., NAIST, 5. MIB, Kyushu Univ., 6. IIR, Science Tokyo)
[3P-110(3PS-04-06)]In Vitro Reconstitution and Analysis of Ubiquitin-Mediated Regulation in Plant DNA Methylation Maintenance
○Nao Yoshida1, Yoshie Chiba1, Kyouhei Arita2, Yichen Li2, Akihisa Osakabe3, Taiko To4, Atsuya Nishiyama1, Makoto Nakanishi1 (1. Graduate School of Frontier Sciences, The University of Tokyo, 2. Graduate School of Medical Life Science, Yokohama City University, 3. Institute for Advanced Academic Research, Chiba University, 4. Department of Life Science and Technology, Institute of Science Tokyo)
[3P-111]Toward Intracellular Single Molecule Analysis Using Cryogenic Ultrathin Sections of Cells.
○Kanta Naruse1, Saeko Aoyama2, Yusuke Hirabayashi2, Daiki Sakamoto1, Takuma Yorita1, Michio Matsushita1, Syota Matsumoto3, Yoshimasa Takizawa3, Hitoshi Kurumizaka3, Haruaki Yanagisawa4, Masahide Kikkawa4, Satoru Fujiyoshi1 (1. Deparment of Physics, Institute of Science Tokyo, 2. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 3. Institute for Quantitative Biosciences, The University of Tokyo, 4. Graduate School of Medicine and Faculty of Medicine, The Unibersity of Tokyo)
[3P-112]Involvement of histone tails in the in vitro reconstitution efficiency of nucleosome core particles on the 601 DNA sequence
○Kyohnosuke Shimada1, Masahiro Kawasaki1, Noriyuki Suka1,2 (1. Dep. of Chem., Grad. Sch. of Sci. Eng., Meisei Univ. Tokyo, Japan, 2. Prog. in Chem. Life Sci., Sch. of Sci. Eng., Meisei Univ. Tokyo, Japan)
[3P-113(3PS-08-07)]Nucleosome stability safeguards cell identity and stress resilience and promotes healthy aging
○Hiroshi Tanaka1, Brenna McCauley2, Clara Guida1, Sha Li1, Xue Lei1, Weiwei Dang2, Michael Petrascheck3, Rolf Bodmer1, Peter Adams1 (1. Sanford Burnham Prebys Medical Discovery Institute (USA), 2. Baylor College of Medicine, 3. The Scripps Research Institute)
[3P-114]Plastic epigenome in early-life stage due to chromatin accessibility dynamics and stem cell diversity
○Yuyu Yuyu Liu1, Chihiro Takeuchi1, Toshikazu Ushijima1 (1. Hoshi University)
[3P-115]Mechanistic insights into chromatin remodeling during post-replicative DNA mismatch repair
○Eiichiro Kanatsu1, Riki Terui2, Tamiko Minamisawa4, Reihi Sakamoto1, Megumi Sato3, Yasukazu Daigaku4, Tatsuro Takahashi2 (1. Grad. Sch. of Sys. Life Sci., Kyushu Univ., 2. Fac. of Sci, Kyushu Univ., 3. Sch. of Sci, Kyushu Univ., 4. Cancer Institute, JFCR)
[3P-116]De novo incorporating H3.3 during late mouse spermatogenesis ensure offspring health
○Jianxi Li1,2, Masashi Hada1, Yuko Fukuda1, Erina Inoue1, Yuki Okada1,2 (1. University of Tokyo, IQB, 2. Univ. of Tokyo, Department of Pharmaceutical Science)
[3P-117]Specificity Modification of H4K20me1-Specific Intracellular Single-Strand Variable Region Antibodies
○Takumi Kanai1, Kimura Hirosi1 (1. Institute of Science Tokyo)
[3P-118]Rapid sensing of global DNA methylation levels using a methyl-CpG-binding domain–fused luciferase and fluorescent protein
○Yuto Shoji1, Koichiro Doi1, Masayoshi Tanaka2, Wataru Yoshida1 (1. Grad. Sch. of Bionics, Tokyo Univ. of Tech., 2. Dep. of Chem. Sci. Eng., Science Tokyo)
[3P-119]Development of DNA methylation levels detection method using MBD fused luciferase and fluorescently labeled methylated probe DNA
○Ayumu Hokamura1, Wataru Yoshida1 (1. Tokyo Univ. of Tech)
[3P-120]The role of H3K9 methylation in cardiomyocytes
○Ryo Okubo1, Kyohei Oyama1, Yoshitaka Tateishi1, Hiroyuki Kamiya1 (1. Asahikawa medical university)
[3P-121]Light-induced changes in Cytochrome b5 reductase (Cyb5r2) activity and expression levels
○Miyu Tsukada1, Yukana Tomoda1, Takashi Yoshikado1, Satofumi Iida1, Koji Chiba1, Makoto Takehana1, Mikako Oka1 (1. Yokohama University of Pharmacy)
[3P-122]Structural basis of CDCA7:HELLS in DNA methylation maintenance: Establishment of a method for Cryo-EM using complexes derived from Xenopus egg extracts
○Nao Nakamura1, Atsuya Nishiyama2, Yoshie Chiba2, Makoto Nakanishi2, Kyohei Arita1 (1. Graduate School of Medical Life Science, Yokohama City University, 2. Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo)
[3P-123]Artificial DNA methylation induced on centromeres and peri-centromeres changes cell cycle, histone modifications and offspring production in mouse early embryos.
○Sakiko Katagiri1, Haruka Jyougan1, Taiga Yamazaki2, Yu Hatano3, Kazuo Yamagata1 (1. Kindai University, 2. Kitasato Univ, 3. Kwansei Gakuin Univ)
[3P-124]Functional Role of SETX in R-loop Regulation and Transcriptional Maintenance during Meiotic Prophase I
○Yasuhiro Fujiwara1,2, Yuko Fukuda2, Chizuko Koga2, Erina Inoue2, Yuki Okada2 (1. Chiba Univ., 2. Univ. Tokyo, IQB)
[3P-125]Dynamics of transcription-coupled de novo DNA methylation
○Tatsuya Ohhata1, Kazuki Yamazawa2, Satoshi Sakai1, Hiroyuki Niida1, Soichiro Yamanaka1 (1. Hamamatsu University School of Medicine, 2. Tokyo Med. Center)
[3P-126]Induction of Modification-Dependent Histone Degradation Using a Modification-Specific Intracellular Antibody and the Trim-Away System
○Oki Endo1, Hiroshi Kimura1 (1. Institute of Science Tokyo)
[3P-127]Identification of bookmarking factors associated with meiotic chromosomes in mouse oocytes
○YUTO SEKIOKA1,2, KOSHI IMAMI1, AZUSA INOUE1,2 (1. RIKEN IMS, 2. Dept. of Biol. Sci., Grad. Sch. of Sci. Tokyo Metro. Univ)
[3P-128]Molecular Mechanism of Exclusivity Controlled Repressive Histone Modifications H3K27me3 and H3K9me3
○Aya Kimoto1, Hiroshi Kimura2 (1. Institute of Science Tokyo, 2. Cell Biology Center, IIR, Institute of Science Tokyo;)
[3P-129]Development of an information infrastructure for RNA splicing variants using single-cell RNA-Seq data
○Tetsuya Sato1, Susumu Goto2 (1. Saitama Medical University, 2. Database Center for Life Science)
[3P-130]The role of SUMO isopeptidase USPL1 in snRNA Transcription
○Natsuaki Kawamata1, Keiko Horiuchi1, Hidehisa Takahashi1 (1. Yokohama City University)
[3P-131]Analysis of Heat Shock response mechanism by Mediator complex and HSF1
○KEXIN LI1, Kazuki Furugori1, Shun Sawatsubashi2, Hidefumi Suzuki1, Hidehisa Takahashi1 (1. Yokohama City University , 2. Tokushima University)
[3P-132(3AS-02-07)]Structural basis of co-transcriptional histone H3K36 methylation by Set2
○Haruhiko Ehara1, Tomoya Kujirai1,2, Tomoko Ito2, Masami Henmi1, Eriko Oya2, Takehiko Kobayashi2, Hitoshi Kurumizaka1,2, Shun-ichi Sekine1 (1. RIKEN IMS , 2. IQB, Tokyo Univ.)
[3P-133]MORE-RNAseq: the pipeline and references for quantifying retrotransposition-capable LINE-1 expression using RNA-seq data
○Yutaka Nakachi1, Jianbin Du1,2, Risa Watanabe1,3, Yutaro Yanagida1, Tomonari Miyatake1, Daisuke Okamoto1, Miki Bundo1, Kazuya Iwamoto1 (1. Dept. of Mol. Brain Sci., Grad. Sch. of Med. Sci, Kumamoto Univ., 2. Dept. Geriatric Psychiat, Mental Health Ctr., Jiangnan Univ., 3. Dept. Psychiat, Icahn Sch. Med. at Mount Sinai)
[3P-134]Decoding the regulatory activity of transcription factor clustering in Drosophila
○Toshiki Nakanishi1, Koji Kawasaki1, Takashi Fukaya1,2 (1. Laboratory of Transcription Dynamics, Research Center for Biological Visualization, Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo)
[3P-135]Roles of FKBP12 for the transcriptional regulation of ribosomal protein gene in the pathogenic yeast Candida glabrata
○Kaita Suzuki1, Miharu Nakamura1, Naoki Shimamura1, Koji Kasahara1 (1. Tokyo University of Agriculture)
[3P-136]Functional analysis of the phosphorylated CTD-binding RNA methyltransferase PCIF1 in the Type I IFN Response
○Chihiro Ikeda1, Ryoya Kano1, Chihiro Oyama1, Shiho Ito1, Aki Tanaka1, Akiko Inujima2, Shinichiro Akichika3, Tsutomu Suzuki3, Yoshiaki Ohkuma4, Yutaka Hirose1 (1. Grad. Sch. of Med. & Pharma. Sci., Univ. of Toyama, 2. Div. of Med. Oncology, Cancer Res. Inst., Kanazawa Med. Univ., 3. Grad. Sch. of Eng., Univ. of Tokyo, 4. Grad. Sch. of Biomed. Sci., Nagasaki Univ.)
[3P-137]DNA binding analysis of the paralogous transcription factors regulating mannanase genes in Aspergillus nidulans
○Haruno Watanabe1, Nuo Li2, Kyoko Kanamaru2, Makoto Kimura2, Tetsuo Kobayashi2, Tetsuya Kimura1, Emi Kunitake1 (1. Grad. sch. Biores. Mie Univ., 2. Grad. sch. Bioagric Sci., Nagoya Univ.)
[3P-138]Alveolar Epithelial Cell Dynamics and Their Contribution to Tuberculosis Lung Damage Revealed by Single-Cell Transcriptomics
○HENDA AGENG RASENA1, Yiwei Ling1, Shujiro Okuda1 (1. Medical AI Center, Niigata University School of Medicine)
[3P-139]SUMOylation regulates snRNA transcription in the Cajal Body
○Keiko Horiuchi1, Motomi Ogasawara1, Natsuaki Kawamata1, Shunta Kobayashi1, Hiroko Hirose1, Tomoko Akiyama2, Yayoi Kimura2, Hidehisa Takahashi1 (1. Molecular Biology, Yokohama city university, 2. Advanced Medical Research Center, Yokohama city university)
[3P-140]Molecular basis of transcription regulation by Cohesin complex
○Ryunosuke Odaka1, Yasuto Murayama2, Naruhiko Adachi3, Kayo Nozawa1 (1. Institute of Science Tokyo, 2. National Institute of Genetics, 3. University of Tsukuba)
[3P-141]Identification and functional analysis of the initiation element that enables an adequate transcription start site selection on the HIS3 promoter in budding yeast
○Kiyoshi Watanabe1, Tetsuro Kokubo1 (1. Grad. Sch. of Med. Life Sci., Yokohama City Univ.)
[3P-142]Elucidation of the mechanism of pancreatic cancer progression by the transcription factor Bach1
○Shunichi Tsuge1, Hiroki Shima2, Mitsuyo Matsumoto3, Shin Hamada4, Atsushi Masamune4, Kazuhiko Igarashi1 (1. Department of Biochemistry, Tohoku University Graduate School of Medicine, 2. Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 3. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 4. Division of Gastroenterology, Tohoku University Graduate School of Medicine)
[3P-143]Interaction of hypoxia-inducible factors with beta-catenin
○Shun Takemoto1, Showa Komatsu1, Mebae Koike1, Kazuhiro Shiizaki1,2 (1. Grad. Sch. Life Sci., Toyo Univ., 2. Dept. Life Sci., Toyo Univ.)
[3P-144]Development of a CRISPRi system using TiD-X
○Takeki Ito1, Kugo Goto1, Tadaomi Furuta1, Satoshi Kidokoro1, Naoki Wada2, Keishi Osakabe2, Yuriko Osakabe1 (1. Sch. Of Life Sci. & Tech., Science Tokyo., 2. Grad. Sch. Of Tech., Ind. & Soc. Sci., Tokushima Univ.)
[3P-145]Observation of mitochondrial transcription dynamics via tanscription initiation complex visualization
○Shigeru Matsuda1, Fan-Yan Wei1 (1. Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University)
[3P-146]Analysis of n-Butyric Acid-Induced Activation of the Human ATM Gene Promoter
○Shigeru HANAMATA1, Yuka KAZUMA1, Takahiro ODA1, Hikaru TAKENO1, Yuriko UMIHARA1, Yoko OGINO1, Fumiaki UCHIUMI1 (1. Laboratory of Gene Regulation (Uchiumi Lab) Department of Medicinal and Life Sciences Faculty of Pharmaceutical Sciences, Tokyo University of Science)
[3P-147(3PS-16-05)]TFIID–Mediator complex interaction regulates transcriptional switching from initiation to elongation
○Kazuki Furugori1, Hidefumi Suzuki1, Ryota Abe1, Hidehisa Takahashi1 (1. Yokohama City Univ.)
[3P-148]Live imaging analysis of transcriptional repression dynamics
○Tetta Hiranuma1,2, Koji Kawasaki1, Takashi Fukaya1,2 (1. Laboratory of Transcription Dynamics, Research Center for Biological Visualization, Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo)
[3P-149]Elucidation of the Liquid-Liquid Phase Separation Mechanism Regulating Gluconeogenic Gene Expression via HNF4α
○Takumi Kouketsu1, Ayana Hozawa1, Shun Sawatsubashi2, Atsushi Yokoyama1, Akira Sugawara1 (1. Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2. Research and Innovation Liaison Office / Lab. of Integrative Nuclear Dynamics, Tokushima University)
[3P-150]Clustering Analysis of Transcriptional Dynamics at DNA Replication Sites in Early Zebrafish Embryos
○Mika Saotome1, Ngoc Thi Bich Nguyen3, Yuuko Sato2, Hiroshi Kimura1,3 (1. Cell Biology Center, Science Tokyo, 2. Medical Institute of Bioregulation Kyushu Univ., 3. School of Life Science and Technology, Science Tokyo)
[3P-151]Tracking the dynamics of RNA polymerase II using fluorescent RPB1 and Ser2ph-specific intracellular antibody
○Chihiro Takayama1, Hiroshi Kimura1,2 (1. Institute of Science Tokyo, School of Life Science and Technology, 2. Institute of Science Tokyo, Institute of Integrated Research, Cell Biology Center)
[3P-152]Transcriptional Repression of the Estrogen Receptor Gene Esr2 Mediated by DMRT1
○Naoki Nick Ishikawa1, Kei Tamura1, Daisuke Tsukamoto1, Arisa Suto2, Yuta Takahashi2, Takashi Matsui2, Yoshio Kodera2, Takuya Matsuo1, Michihiko Ito1 (1. Lab. Mol. Biol., Grad. Sch. Sci., Kitasato Univ., 2. Lab. Life Phys., Grad. Sch. Sci., Kitasato Univ.)
[3P-153]Precision Modulation of REST/NRSF: The Trade-off Between Neuroprotection and Regeneration during Spinal Cord Injury
○Laalitya Kandala1 (1. Cambridge Centre for International Research)
[3P-154]Elucidation of the interaction network of reprogramming factors
○Kazuya Kudo1,2, Marino Akamatsu2,3, Shunsuke F Shimobayashi2 (1. Kyoto Univ., Graduate School of Medicine, Department of Medical Science, 2. Center for iPS Cell Research and Application, 3. Kyoto Univ., Faculty of Medicine, Department of Medicine)
[3P-155]ModScore and nanoDoc3: Enhanced Nanopore Based Detection of RNA Modifications in mRNA and non-Coding RNAs
○Ueda Hiroki1, Bo-yi Yu1, Keisuke Yamada2, Norikazu Ichihashi3, Akihide Yoshimi4, Takeshi Chujyo5, Genta Nagae2, Hiroyuki Aburatani2 (1. Advanced Data Science,RCAST, The University of Tokyo, 2. Genome Science And Medicine, RCAST, The University of Tokyo, 3. Department of Life Science, Graduate School of Arts and Science, Komaba Institute for Science, The University of Tokyo, 4. Division of Cancer RNA Research, National Cancer Center Research Institute, 5. Division of Molecular Physiology, Faculty of Life Science, Kumamoto UniversityFaculty of Life Science, Kumamoto University)
[3P-156]Protective role of yeast RNA-binding protein Puf5 in cell growth and survival under replication stress.
○Sato Megumi1,2, Kenji Irie2 (1. University of Tsukuba, 2. Mol Cell Biol Lab, University of Tsukuba.)
[3P-157(3PS-07-03)]Aberrant Splicing in NIPBL-deficient Embryoid Bodies and Its Impact on Cardiac and Neural Lineages
○Eiko Saijou1, Masashige Bando1, Yuki Okada1, Katsuhiko Shirahige1, Heiko Peters2, Ryuichiro Nakato1 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Newcastle University)
[3P-158]Quantitative Analysis of Intercellular Heterogeneity in siRNA-Mediated Gene Silencing Using smFISH.
○Tomoko Hayakawa1, Mika Shirato1, Junko Sakagami1 (1. NIKON CORPORATION)
[3P-159(3AS-16-07)]Single-nucleus RNA-seq Analysis of First-trimester Human Placentas to Elucidate Early Pathogenesis of Preeclampsia
○Akihito Sagara1,2, Tomoaki Koga1, Munekage Yamaguchi2, Osamu Shimokawa3, Hiroyasu Ohashi3, Ritsuko Pooh4, Eiji Kondoh2, Mitsuyoshi Nakao1 (1. Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2. Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, 3. CRIFM Prenatal Medical Clinic, 4. Department of Clinical Genetic Research, Ritz Medical Co., Ltd)
[3P-160]Analysis of molecular mechanisms involved in HSP90 inhibitor-induced abnormalities in mRNA metabolism
○Riki Tamai1, Kumiko Takemori1, Seiji Masuda1 (1. Kindai Univ.)
[3P-161]Nuclear Transport of Segmented Genome during Influenza A Virus Cell Entry
○Yasuyuki Miyake1,2, Takuto Washizawa3, Ko-ichi Inagaki3, Atzin Bolanos-Ceron1, Yuya Hara1, Kentaro Hiraka4, Kazuyoshi Murata4, Takayuki Uchihashi5, Yohei Yamauchi6 (1. Nagoya Univ. Grad. Sch. Med., 2. Nagoya Univ. IAR, 3. Nagoya Univ. Med., 4. NINS, ExCELLS, 5. Nagoya Univ. Grad. Sch. Sci., 6. ETH Zurich)
[3P-162]Chromatin-associated intronic RNAs form RNA clouds and may regulate transcription in endocrine-resistant breast cancer cells
○Masaki Kato1, Yuichi Ichikawa2, Xufeng Shu1, Maierdan Palihati2, Noriko Saitoh2, Piero Carninci1,3 (1. RIKEN IMS, 2. Cancer Inst., JFCR, 3. Human Technopole)
[3P-163(3PS-16-06)]A Germ Cell-Specific RNA-Binding Protein Mediates Specific RNA Accumulation into Membraneless Organelles : The Molecular Mechanism and Functional Co-option in Cancer
○Mizuki Fukuda1, Hiroya Yamazaki1, Hideto Ito1, Yurika Namba1, Mikiko C Siomi1 (1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
[3P-164]Precursor tRNA maturation mechanism by the star-shaped oligomeric bacterial minimal protein RNase P
○Takeshi Koyasu1, Takamasa Teramoto1, Takashi Yokogawa2, Naruhiko Adachi3, Kouta Mayanagi1, Takahiro Nakamura1, Toshiya Senda3, Yoshimitsu Kakuta1 (1. Kyushu Univ., 2. Gifu Univ., 3. High Energy Accelerator Research Organization (KEK))
[3P-165]The role of RNA-binding protein Whi3 in cell cycle and checkpoint regulation in Saccharomyces cerevisiae
○Varsha Rana1, Kenji Irie1 (1. University of Tsukuba)
[3P-166]Development of Manufacturing Processes and Analytical Methods for Active Targeting mRNA-LNP
○Masato Amano1, Masahiro Hashimoto1, Kana Tanabe1 (1. AGC Inc.)
[3P-167(3PS-16-08)]Deciphering the RNA blueprint for a new principle of membraneless organelle assembly
○Sota Umezaki1, Tomohiro Yamazaki1, Sylvie Souquere2, Ichiro Taniguchi1, Hiro Takakuwa1, Gerard Pierron2, Tetsuro Hirose1,3 (1. FBS, Univ Osaka, 2. CNRS, 3. OTRI, Univ Osaka)
[3P-168]Transcriptome Analysis of the Cultivated Rush Variety "Suzukaze"Using Long-Read RNA-Seq
○Yuki Teramae1, Tomoko Kuriyama2, Masaharu Kawauchi2, minami matsui2, Kumiko Kihara3, Yuko Makita1,2 (1. Maebashi Inst. of Tech., 2. RIKEN CSRS, 3. NIT, Kumamoto College)
[3P-169]The relationship between nuclear export of murine leukemia virus full-length mRNA and RNA secondary structure
○Miyu Kamano1, Keisuke Yonebayashi 1, Tsukasa Koreeda1, Sachie Torii 1, Sayaka Sayaka Takase-Yoden 1,2 (1. Department of Biosciences, Graduate School of Science and Engineering, Soka University, 2. Glycan and Life Systems Integration Center (GaLSIC), Soka University)
[3P-170]Structural study of CCA terminal sensitivity of tRNA 3'-rocessing enzyme RNase PH
○Takamasa Teramoto1, Takeshi Koyasu1, Yoshimtsu Kakuta1 (1. Kyushu University)
[3P-171]Improved In Vivo Stability of EGF-mRNA Through Optimization of Chemical Modifications in the Poly(A) Tail
○Ittoku Kikuchi1, Atsushi Hashimoto1, Yuma Kunitomo1, Hiroki Yamada1, Keiko Kobayashi1, Kazuhiro Soshiroda1, Hiromi Aman1, Masakazu Honma1, Yasuaki Kimura4, Junichiro Yamamoto1, Yasuhisa Shiraishi1, Satoshi Uchida2,3, Hiroshi Abe4,5,6,7, Hiroto Iwai1 (1. Research Division, Kyowa Kirin Co., Ltd. , 2. Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 3. Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 4. Department of Chemistry, Graduate School of Science, Nagoya University, 5. Research Center for Materials Science, Nagoya University, 6. CREST, Japan Science and Technology Agency, 7. Institute for Glyco-core Research (iGCORE), Nagoya University)
[3P-172]RBM20 regulates the expression ratio of isoforms involved in the generation of passive tension in the cardiomyocytes by skipping the exon cluster of Ttn transcripts
○Yuri Yamasu1,2, Mahoko Ueda2, Yuta Kochi2, Hidehito Kuroyanagi1 (1. University of the Ryukyus, 2. Institute of Science Tokyo)
[3P-173]Characterization of sbRNA and ROP-1 interactions in Caenorhabditis elegans
○Miki Saito1, Takehiro Chiba1, Sayuri Kuroda1, Kyosuke Imaizumi1, Chisato Usida1 (1. Hirosaki Univ.)
[3P-174]Molecular mechanisms by which small heat shock proteins interact with mRNAs
○Kotaro Yoshida1, Tsukumi Miwa2, Yajie Cheng1, Hideki Taguchi1,2 (1. School of Life Science and Technology, Science Tokyo, 2. Cell Biology Center)
[3P-175]Elucidation of the Relationship Between the Cell Cycle and Newly Synthesized tRNA
○Wakako Tsunekuni1, Futa Konishi2, Ryota Yamagami2, Takashi Ohtsuki1, Kazunori Watanabe1 (1. Grad school of Interdis Sci and Eng in Health Sys, Okayama University, 2. Grad school of Sci and Eng, Ehime University)
[3P-176]Optimized tRNA Sequencing Improved Mapping of Tissue-Specific tRNA-Derived Small RNAs.
○Daisuke Ando1,3,4, Sherif Rashad1,5, Kuniyasu Niizuma1,2,4,5 (1. Dept. Translational Neuroscience, Tohoku Univ., 2. Dept. Neurosurgery, Tohoku Univ., 3. Dept. Neurology, Tohoku Univ., 4. Div. Development and Discovery of Interventional Therapy, TUH, 5. Dept. Neurosurgical Engineering, Tohoku Univ.)
[3P-177]Development of a Pipeline for Optimizing Virtual Screening Using RNA–Ligand Docking Simulations
○Kazuki Hamada1, Ikuo Kurisaki2, Michiaki Hamada1,3,4 (1. Faculty of Science and Engineering, Waseda University, 2. Waseda Research Institute for Science and Engineering, Waseda University, 3. The National Institute of Advanced Industrial Science and Technology, 4. Nippon Medical School)
[3P-178]Tolerance of a Caenorhabditis elegans rop-1 mutant against UVB irradiation
○Arisa Tanji1, Shusei Sugita1, Kyousuke Imaizumi1, Aoi Yamaguchi1, Chisato Ushida1 (1. Graduate School of Agriculture and Life Science, Hirosaki University)
[3P-179]Exploring Target Recognition Sites in Aptamer Sensors for DNA Detection
○Emily Matsusaka1, Nae Sakimoto2, Shigenori Iwai2, Junji Kawakami1,2 (1. FIRST, Konan University, 2. KOLOT)
[3P-180]Mechanism of Chiral-Selective Aminoacylation of an RNA Minihelix
Tadashi Ando1, Hiromi Mutsuro-Aoki1, Yusuke Saga1, ○Koji Tamura1 (1. Tokyo University of Science)
[3P-181]Translation inhibition of the transcribed intron of CDK5RAP2 gene by YTH family proteins.
○Yuka Araki1, Kensuke Hayashi1 (1. Sophia University)
[3P-182]UFMylation-deUFMylation cycle of ribosome is required for ER-RQC activity
○Sota Ito1, Gaoxin Mao2, Ryosuke Ishimura2, Jun-ichi Sakamaki2, Ryohei Sasaki3, Nobuo N. Noda3, Masaaki Komatsu2, Toshifumi Inada1,4 (1. The University of Tokyo, 2. Juntendo University, 3. Hokkaido University, 4. IMSUT)
[3P-183]Human PURE system–based reconstitution of N-glycosylation
○Mayumi Sunagawa1, Mizuki Okabayashi1, Akari Okinaka1, Yuki Matsuda1, Rintaro Yamamoto1, Kodai Machida1, Hiroaki Imataka1 (1. University of Hyogo)
[3P-184(3PS-16-09)]Visualization of Nop56-Repeat Associated Non-AUG translation in living cells at single mRNA level
○AYAMU NOGUCHI1, Hayato Ito1, Timothy Stasevich2, Yoshitaka Nagai3, Hideki Taguchi1,4 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Biochem. and Mol. Biol., Colorado State University, 3. Faculty of Medicine, Kindai University, 4. Institute of Integrated Research, Institute of Science Tokyo)
[3P-185]Molecular basis of mammalian ribosome quality control
○Shuhei Ebine1, Ivan Penchev2, Takuya Tomita1, Chisato Kikuguchi1, Satoshi Hashimoto1, Toru Suzuki1, Thomas Becker2, Yasushi Saeki1, Roland Beckmann2, Toshifumi Inada1 (1. IMSUT, The Univ of Tokyo, 2. LMU, Univ of Munich)
[3P-186]Elucidation of molecular mechanism of arrest peptides from Clostridia
○Yuki Harada1, Keigo Fujiwara2, Shinobu Chiba1 (1. Kyoto Sangyo University, 2. National Institute of Genetics)
[3P-187]Functional analysis of an arrest peptide from Caulobacter crescentus
○Ayano Takeda1, Chiba Shinobu1 (1. Kyoto Sangyo University)
[3P-188]Selenium modification of bacterial tRNA promotes stop codon mistranslation and readthrough, resulting in regulation of the stress response.
○Kazuyasu Kanazawa1, Xu Yue 1, Raja Norazireen Raja Ahmad 1, Haruna Tnai1, Shigeru Matsuda 1, Akiko Ogawa 1, Shintaro Iwasaki 2, Qing Cheng 3, Elias Arnér 3, Fan-Yan Wei 1 (1. Dept. Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, 2. RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, 3. Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet)
[3P-189]Development of a Method for Monitoring Mitochondrial Translation via Amino Acid Analogue Uptake
○Yuna Miyaji1,2, Shigeru Matsuda2, Fan-Yan Wei2 (1. tohoku university, 2. IDAC, tohoku university)
[3P-190]Translation repression through the inactivation of Ded1 and eIF2B in yeast cells under acetic acid stress
○Miyu Terashima1, Haruka Yoshiyama2, Shingo Izawa1 (1. Grad. Sch. Sci. Technol., Kyoto Institute of Technology, 2. Kyoto Institute of Technology)
[3P-191]Identification of inhibitors of the association between eIF5A2 and ribosomes adopted cancer progression
○Masato Suzuki1, Ayuna Miwa1, Masahiro Komeno1, Hitoshi Kotani2, Ken Matsumoto3, Chiaki Takahashi4, Kazunori Akimoto1, Kazuei Igarashi5, Kyohei Higashi1 (1. Fac. Pharm. Sci., Tokyo Univ. Sci., 2. Fac. Med., Shimane Univ., 3. RIKEN CSRS, 4. Cancer Res. Inst., Kanazawa Univ., 5. Amine Pharm. Res. Inst.)
[3P-192]A new approach for studying the specificity of translation inhibitors to the nucleotide sequence of mRNA.
○Arina Nikandrova1,2, Ekaterina Komarova2, Petr Sergiev1,2, Olga Dontsova1,2,3 (1. Skolkovo Institute of Science and Technology, 2. Lomonosov Moscow State University, 3. Shemyakin-Ovchinnikov Institute of bioorganic chemistry)
[3P-193]Regulation of HAV IRES translation by hepatocyte-specific factors
○Hiyori Iba1, Kaiki Noguchi1, Takumi Tomohiro1, Akira Fukao1, Yoshinori Funakami1, Toshinobu Fujiwara1 (1. Kindai University)
[3P-194]Theoretical study of the bioluminescent reaction of Aequorin by QM/MM hybrid free energy method
○Tomohiro Ando1, Shigehiko Hayashi1, Toru Nakatsu2, Toshiya Funahashi3 (1. Grad. Sch. of Sci. Kyoto Univ., 2. Wakayama Med. Univ., 3. Grad. Sch. of Pharm. Sci. Kyoto Univ.)
[3P-195]Ligand-induced conformational changes in the adenosine A2a receptor revealed by ATRFTIR spectroscopy
○Shuma Tajima1, Kento Watanabe1, Shota Nakamura2, Mika Hirose2, Akitoshi Inoue3, Takayuki Kato2, Ryoji Suno3, Hideki Kandori1,4, Kota Katayama1,4 (1. Graduate School, Nagoya Institute of Technology, 2. Institute for Protein Research, Osaka University, 3. Kansai Medical University, 4. OptoBioTechnology Research Center, Nagoya Institute of Technology)
[3P-196]Development of a novel method to detect structural changes in DPBB/DZBB folds: insights into early protein evolution
○Yui Tanaka1, Riddhi Gondhalekar2, Sota Yagi3,4, Shunsuke Tagami4,5, Kosuke Fujishima2,6 (1. LST., Science Tokyo, 2. ELSI., Science Tokyo, 3. Faculty of Human Sciences, Waseda Univ., 4. RIKEN IMS, 5. WPI-SKCM Hiroshima Univ., 6. Grad.sch. of Media and Governance., Keio Univ.)
[3P-197]An attempt to reconstitute the baseplate complex of bacteriophage Mu
○Kosei Koyama1, Shigeki Takeda1 (1. Interfaculty Initiative in Regulatory Science of Biomedical Science and Engineering, Graduate School of Gunma University)
[3P-198]NMR analysis of the interactions of the MyD88 TIR domain in innate immune signaling
○Shiho Nukui1, Yudai Ito1, Shion Masuda1, Kazuki Kasai1, Hidehito Tochio1 (1. Graduate School of Science, Kyoto University)
[3P-199]What does DARUMA, a prediction model for intrinsically disordered regions, focus on?
○Shunsuke Masuda1, Itsuki Shimizu1, Satoshi Fukuchi1 (1. Maebashi institute of technology)
[3P-200]NMR Analysis of E2~Ubiquitin Dynamics and Its Interaction with the Linear Ubiquitin Chain Synthase
○Marina Koga1, Kazuki Kasai2, Kayo Imamura1, Kazuhiro Iwai4, Takayuki Kato3, Mika Hirose3, Keiichi Namba2, Tomoko Miyata2, Hidehito Tochio1 (1. Kyoto Univ. Graduate School of Science, 2. Osaka Univ. Graduate School of Frontier Biosciences, 3. Osaka Univ. Institute for Protein Research, 4. Kyoto Univ. Graduate School of Medicine)
[3P-201]An artificial cell-based approach for visualizing nuclear peripheral chromatin
○Gen Kumakura1, Yutetsu Kuruma2, Kayo Nozawa1 (1. Institute of Science Tokyo, 2. Japan Agency for Marine-Earth Science and Technology)
[3P-202]Dynamic Structural Basis of Ligand Recognition and Activation Modulating Muscarinic Receptor Subtype Selectivity
○Kento Watanabe1, Yuya Sugiura1, Moeka Mizuno1, Yuji Sumii1, Akitoshi Inoue3, Chiyo Suno3, Ryoji Suno3, Norio Shibata1, Hideki Kandori1,2, Kota Katayama1,2 (1. Grad. Sch. Eng., Nagoya Inst. , 2. OptoBio Technology Research Center., 3. Kansai Medical University. Medical.)
[3P-203]Structure changes in monomer and oligomer of protein arginine methyltransferase 1 induced by the cofactor binding
○Nobuyuki Endo1, Sachiko F-Toma2,3, Hinako Koshimura2, Akihiro Kawamoto1, Mika Hirose1, Akiko Ikegami2, Miwa Kuzuhara2, Hiroaki Daitoku3,4, Koichiro Kako5, Jun-dal Kim3,6, Takayuki Kato1, Hironari Kamikubo2, Susumu Uchiyama7, Toshiyuki Shimizu8, Atsushi Nakagawa1, Akiyoshi Fukamizu3,4, Genji Kurisu1 (1. UOsaka, IPR, 2. NAIST, 3. AMED-CREST, 4. Univ. of Tsukuba, TARA, 5. Univ. of Tsukuba, 6. Univ. of Toyama, 7. UOsaka, 8. UTokyo)
[3P-204]Structural basis of passport sequence recognition in the secretory pathway of glycoproteins
○Kazuya Sunagawa1, Maho Yagi-Utsumi1,2, Hirokazu Yagi1,2, Koichi Kato1,2 (1. Nagoya City Univ., 2. ExCELLS, NINS)
[3P-205]Solution NMR analysis of thermostabilizing variants of the proton-pumping rhodopsin TR
○Yusuke Abe1, Chika Hoyano1, Toshio Nagashima2, Keiichi Kojima3, Toshio Yamazaki2, Takeshi Murata4, Yuki Sudo3, Hideo Takahashi1 (1. Graduate School of Yokohama University, 2. RIKEN, Center for Biosystems Dynamics Research, 3. Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 4. Graduate School of Science, Chiba University)
[3P-206]Making X-ray crystallographic refinement accessible for non structural biologists
○Miki Senda1, Toshiya Senda1 (1. High Energy Accelerator Research Organization (KEK))
[3P-207]Structural and functional study of protein degradation mechanism by mitochondrial inner membrane proteases
○Sayuka Kanayama1, Yuta Imai1, Nanako Kobayashi1, Shiho Kawai1, Atsuyuki Ito2, Yuri Hariki3, Satoshi Ogasawara3, Noriyuki Kodera4, Takeshi Murata3, Yuhei Araiso1 (1. Div. of Health Sci., Kanazawa Univ., 2. Grad. Sch. of Med., Chiba Univ., 3. Grad. Sch. of Sci., Chiba Univ., 4. WPI Nano Life Science Institute, Kanazawa Univ.)
[3P-208]Structural and functional analysis of the membrane protein Multigene family 110-12L of African swine fever virus
○Yuma Nakamura1, Hayato Masutani1, Shiho Saito1, Shibo Wei1, Peng Lu1, Kenta Tsutsumi1, Suguru Okuda1, Ken Okamoto1, Hiroshi Kawakami1, Suzuki Michio1, Tomoya Kitamura2, Kentaro Masujin2, Takehiro Kokuho2, Hideaki Itoh1, Koji Nagata1 (1. The University of Tokyo, 2. NIAH NARO)
[3P-209]Analysis of the molecular basis of drug efflux by AcrB
○Sakaguchi Wataru1, Astuki Nakano2, Yuto Muto1, Kaoru Mitsuoka3, Ken Yokoyama1 (1. Kyoto Sangyo university, 2. App. Chem.,Univ.of Tokyo, 3. Research Center for Ultra-High Voltage Electron Microscopy, Osaka University)
[3P-210]Structural analysis of the C-Terminal Domain of Orexin Receptor Type 2 by solution NMR spectroscopy
○Yuki Kanazaki1, Misato Tsutsumi1, Riki Kato1, Naotaka Sekiyama1, Kayo Imamura1, Hidehito Tochio1 (1. Graduate School of Science, Kyoto University)
[3P-211(3PS-02-05)]Experimental-method dependence hidden in the structure data of the Protein Data Bank
○Kaori Chiba1, Mahan Kunii1, Toshiyuki Chatake2, Takashi Ohhara3 (1. Nat. Inst. Tech, Ibaraki Coll., 2. KURNS, Kyoto Univ., 3. J-PARC, JAEA)
[3P-212]Structural and Functional Study of the circadian output protein SasA
○Sota Suzuki1, Yuki Hirato2, Takahiro Iida2, Masaru Goto2, Risa Mutoh2 (1. Grad of Sci Toho Univ. , 2. Fac of sci Toho Univ.)
[3P-213]Structural analysis of FoF1-ATPase in SMP membranes of bovine heart mitochondria
○Katsuya Matsuki1, Kyosuke Sugawara1, Atsuki Nakano1, Masatoshi Murai2, Takahiro Masuya2, Kaoru Mitsuoka3, Ken Yokoyama1 (1. Department of Molecular Biosciences, Kyoto Sangyo University, 2. Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, 3. Research Center for Ultra-High Voltage Electron Microscopy, Osaka University)
[3P-214]The potential of Viral entry Pathways Blockade of SARS-CoV-2 and Influenza Entry by Centella asiatica Triterpenoids: In Silico Validation for Co-infection Therapeutics
○Pauline Kiatmetha1, Nattaya Chutikamoltham2 (1. Navamindradhiraj University, 2. Mahidol University)
[3P-215]Identification of the DNA-binding recognition sequence of the clock protein Pex
○Momoka Kodama1, Hiroshi Sato2, Masahiro Ishiura2, Risa Mutoh3 (1. Toho University Graduate School , 2. Center for Gene Research, Nagoya University, 3. Toho University)
[3P-216]Extraction of cis-Peptide Bonds Based on Cα–Cα Distances Between Adjacent Amino Acid Residues
○Santo Arakizeki1, Takayuki Nagae2, Tetsuji Okada2, Fumiaki Tomoike1 (1. Hokkai-Gakuen Univ., 2. Gakushuin Univ.)
[3P-217]Structural analysis of the extracelluar region of Drosophila E-cadherin using cryo-EM
○Taiichi Tsuyama1, Masayuki Niwa2, Kazuki Kasai3,4, Tomoko Miyata3,4, Fumiaki Makino3,4,5, Keiichi Namba3,4, Hiroki Oda1,2 (1. JT Biohistory Research Hall, 2. Graduate School of Science, The University of Osaka, 3. Graduate School of Frontier Biosciences, 4. JEOL YOKOGUSHI Research Alliance Laboratories, The University of Osaka, 5. JEOL Ltd.)
[3P-218]Development of subunit vaccines against African swine fever virus (ASFV)
○Yurina Kondo1, Akitsu Masuda2, Daiki Kaneko1, Keigo Ebata1, Kaori Wada1, Hiroaki Mon2, Takahiro Kusakabe2, Jae Man Lee2 (1. Grad. Sch. Bioresour. Bioenviron. Sci., Kyushu Univ., 2. Faculty of Agriculture, Kyushu Univ.)
[3P-219]Effects of Nanoparticles with Different Chemical Composition on Secondary Structure of Lysozyme
○Kota Saito1, Yuta Takahashi1, Ryo Nagasawa1, Hamsini Bharat2, Naoya Sakaguchi2, Naoya Sakaguchi1, Masakazu Umezawa1 (1. Tokyo University of Science, 2. SRM Institute of Science and Technology)
[3P-220]Protection of protein crystals with hydrogels
○Kyosuke Okada1, Shun Morita2, Haruna Muroyama2, Takayuki Nagae2, Tetsuji Okada2, Fumiaki Tomoike1 (1. Hokkai Univ., 2. Gakushuin Univ.)
[3P-221]Development of a method to predict interaction membrane protein pairs
○Takahiko Tsutsumi1, Hiroto Narushima1, Wataru Nemoto1,2 (1. Tokyo Denki Univ., 2. Grad. Sch. of Tokyo Denki Univ.)
[3P-222]Design of thermostable proteins with a desired melting temperature
○Shuichi Wada1, Wataru Nemoto2,1 (1. Tokyo Denki Univ., 2. Grad. Sch. of Tokyo Denki Univ.)
[3P-223]Elucidation of the mechanism by which Escherichia coli Curli formation inhibitor CsgI represses csgD expression via the EnvZ/OmpR two-component regulatory system
○Nozomi Matsuyoshi1,2,3, Chuta Hirotaka2,3, Hiroaki Kobayashi2,3, Hiroshi Ogasawara3,4,5,6 (1. Grad. Sch. Med. Sci. Tech., Shinshu Univ., 2. Grad. Sch. Sci. Tech., Shinshu Univ., 3. Res. Ctr. Adv. Sci. Tech., Shinshu Univ., 4. Acad. Assy. Sch. Hum. SoSci. Inst. Hum., Shinshu Univ., Shinshu Univ., 5. RCAM, Shinshu Univ., 6. IFES, Shinshu Univ.)
[3P-224]Biochemical characterization of monocatalytic FtsH2 protease from Arabidopsis thaliana
○Toyoki Amano1, Urara Okamoto1 (1. Shizuoka University)
[3P-225]Structural analyses of Charcot-Marie-Tooth disease-associated
variants of the extracellular domain of myelin protein zero
○Kosei Kandori1, Emika Neriki2, Kotaro Okamura2, Mikio Tanabe3, Kazuhiro Mio4, Masayoshi Sakakura1,2 (1. Sch. of Sci., Yokohama City Univ., 2. Grad. Sch. of Med. Life Sci., Yokohama City Univ., 3. KEK, IMSS, SBRC, 4. AIST-UTokyo operando OIL)
[3P-226]Molecular Basis of Mitochondrial Quality Control via the Matrix Peptidases
○Hiroki Kinefuchi1,2, Naru Suzuki1, Noriyuki Matsuda1, Koji Yamano2 (1. Department of Biomolecular Pathogenesis, Medical Research Laboratory, Institute of Science Tokyo, 2. Intracellular Quality Control Project, Tokyo Metropolitan Institute of Medical Science)
[3P-227(3PS-13-07)]Conversion of mitochondrial inner structure during heart development
○Yuto Ishikawa1, Shun Hirose1, Misaki Emori1, Isshin Shiiba1, Shigeru Yanagi1 (1. Gakushuin University)
[3P-228(3AS-04-04)]The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders
○Ryohei Sakai1,2, Shu Aizawa2, Hyeon-Cheol Lee-Okada3, Chihana Kabuta2, Tatsuo Mano2, Tadafumi Hashimoto2, Ikuko Koyama-Honda4, Tomohiro Kabuta2 (1. Nippon Medical School, 2. National Center of Neurology and Psychiatry, 3. Juntendo University Graduate School of Medicine, 4. The University of Tokyo)
[3P-229]Toward Elucidation of the SUMOylation Network Supporting Chromosome Segregation in Fission Yeast
○Yusuke Nishimura1, Nonoka Tamaoki1,2, Hidetaka Kosako3, Kohei Nishino3, Shiho Ogawa1,2, Katsunori Tanaka1,2 (1. Dept. of Bioscience, Kwansei Gakuin Univ., 2. Dept. of Biosciences, Kwansei Gakuin Univ., 3. Inst. Adv. Med. Sci., Tokushima Univ)
[3P-230(3AS-04-03)]ESCRT-III-mediated lysosomal micronucleophagy mitigates the STING inflammatory signaling
○Asuka Kodaira1, Fuma Sunayama1, Shiori Hamano1, Yoshihiko Kuchitsu1, Tomohiko Taguchi1 (1. Graduate School of Life Sciences, Tohoku University)
[3P-231]Amino acid sequence generation by a phylogenetic tree-based method for metaproteomic data analysis of unknown species
○Nobuaki MIURA1,2, Koki Ishino2, Akiyasu C. Yoshizawa2, Tsuyoshi Tabata3, Yasushi Ishihama3, Shujiro Okuda2 (1. Toyama University of International Studies, 2. Medical AI Cemter, Niigata University School of Medicine, 3. Graduate School of Pharmaceutical Sciences)
[3P-232]Spermidine and spermine downregulate ISG15 modification
○Fumihiko Okumura1, Haruka Etori1, Riko Asoshina1, Takayuki Obita2 (1. Fukuoka Women's University, 2. Faculty of Pharmaceutical Sciences, University of Toyama)
[3P-233]Oxidized Albumin Mediates Pathological Organ-Gut Crosstalk by Disrupting Gut Barrier Function
○Jie Cheng1, Yang Sui1, Jian Yao1 (1. University of Yamanashi)
[3P-234]Analysis of the impact of CPEB3 ubiquitination on translational regulation
○Keiju Osumi1, Harunobu Saito1, Masatomo So1, Ayako Furukawa1, Hiromi Imamura2, Kenji Sugase1 (1. Kyoto Univ., 2. Yamaguchi Univ.)
[3P-235]Liquid-Liquid Phase Separation Analysis of VAPB, a Familial ALS-Associated Protein
○Rion Komuro1, Mayu Enomoto1, Kyoko Furuita2, Takashi Kodama2, Yohei Miyanoiri2, Chojiro Kojima1 (1. Yokohama National University, 2. Institute for Protein Research, The University of Osaka)
[3P-236]Regulation mechanism of specific immune induction by flagellin from Acidovorax avenae
○Masami Ohno1 (1. Nagahamabaiodaigakuinn)
[3P-237]Analysis of Structural Transition and Dimerization in Plk1 Activation
○Chang Liu1,2, Motoko Takahashi1, Yasuhiro Hirano1,3, Toru Hirota1,2 (1. Div. Exp. Pathol., Cancer Inst., JFCR, 2. Grad. Sch. of Med., Univ. Tokyo, 3. Grad. Sch. of Frontier Biosci., Univ. Osaka)
[3P-238]Peptidomics-based identification of endogenous substrates for evaluating aminopeptidase A activity in human body
○Akari Ikeda1, Yusuke Masuo1, Yukiko Yamaguchi1, Yukio Kato1 (1. Faculty of Pharmacy, Kanazawa University)
[3P-239]Investigation of the Relationship Between Reproductive Dysfunction and Endoplasmic Reticulum-Associated Degradation (ERAD)
○Sayaka Miura1, Moka Yoshimura, Katsuko Sudo2, Katsuyoshi Kumagai3, Hidetoshi Fujita1 (1. Osaka Institute of Technology, 2. Tokyo Medical University, 3. University of Human Arts and Sciences)
[3P-240]Optimization of Malonyl Coenzyme A Biosensors in a Reconstituted Cell-Free System for Detecting Acetyl-CoA Carboxylase Activity
○Shohei Ito1,3, Shota Nishikawa2, Naohiro Terasaka3, Kosuke Fujishima3,4 (1. Science Tokyo. , 2. RIKEN., 3. Science Tokyo. ELSI., 4. Keio Univ.)
[3P-241]Design of F2Pmp peptide probes for large-scale functional analysis of tyrosine phosphatases
○Fumika Mori1, Tomoya Niinae1, Kosuke Ogata1, Eisuke Kanao1,2, Yasushi Ishihama1,2 (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. NIBIOHN)
[3P-242]allerSTAT+: A robust high-precision weighted-ensemble model for food allergenicity prediction
○Kazunari Kondo1, Honoka Yamanaka1, Remi Kawano1, Naho Akiba1, Maki Sasaki1, Hinata Shimizu1 (1. Showa Women's University)
[3P-243]Mechanism of Grp170-mediated regulation of protein–protein interactions in the ER.
○Shinya Aso1, Kazutoshi Matshushita2, Satomi Nadanaka3, Hiroshi Kitagawa3, Andrew Emili4, Koichi Kato5,6,7, Hirokazu Yagi5,6, Kazutoshi Mori2, Satoshi Ninagawa1,8 (1. Grad Sch of Agr, Kobe Univ, 2. Grad Sch of Sci, Kyoto Univ, 3. Grad Sch of Pharm Sci, Kobe Pharm Univ, 4. Knight Cancer Inst, Oregon Health & Sci Univ, 5. Ctr. for Life Creation, Natl. Inst. of Nat. Sci., 6. Grad. Sch. of Pharm. Sci., Nagoya City Univ., 7. Natl. Insts. of Nat. Sci., Inst. of Mol.Sci, 8. Biosig Res Ctr, Kobe Univ)
[3P-244]Sul7d Family DNA-Binding Proteins-Fused High-Fidelity Thermostable DNA Polymerases
○Mashio Watanabe1, Toshiki Saito1, Koko Nakata1, Shunsuke Takahashi1 (1. Tokyo Denki University)
[3P-245]Interaction between SOCS3 and NOD2 in lung cancer tumorigenicity
○JeongMi Park1, Inho Jeong1, Peter C. W Lee1 (1. Department of Biochemistry & Molecular Biology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea)
[3P-246]Activity-based Kinase Enrichment Using Artificial Substrate Peptides
○JUNQI LIANG1, Saki Toi1, Naoyuki Sugiyama1,2, Yasushi Ishihama1,3 (1. Kyoto University, 2. Omics Research Center, National Cerebral and Cardiovascular Center Hospital, 3. National Institute of Biomedical Innovation, Health and Nutrition)
[3P-247]Search for novel ligands such as vitamins for human L-PGDS
○Soichiro Kotani1, Miki Kurata3, Kazuki Mitani1, Koichi Uegaki2, Shigeru Shimamoto 3 (1. Grad. Sch. Sci. & Eng. Res., The Univ. of Kindai , 2. Agri., The Univ. of Kindai, 3. Sci. & Eng., The Univ. of Kindai)
[3P-248]Establishment of an Insect Cell Expression System for Cardiac Myosin via Co-expression with UNC45B and Auxiliary Factors.
○Yuki Takano1, Takeshi Haraguchi1,2, Hiroki Fukunaga3, Mitsuhiro Iwaki3,4,5, Kohji Ito1,2 (1. Grad. Sch. Sci., Univ. Chiba, 2. Sch. Sci., Univ. Chiba, 3. NICT, 4. Grad. Sch. Sci., Univ. Osaka, 5. Sch. Sci., Univ. Osaka)
[3P-249]Investigation of Human Skeletal Muscle Myosin Purification Using an Insect Cell Expression System
○Yuki Tonsho1, Takeshi Haraguchi1,2, Yuki Hukunaga3, Mitsuhiro Iwaki3,4,5, Koji Ito1,2 (1. Grad. Sch. Sci. Univ. Chiba, 2. Sch. Sci. Univ. Chiba, 3. Advanced ICT. NICT, 4. Grad. Sch. FBS. Univ. Osaka, 5. IFReC. Univ. Osaka)
[3P-250]Chiral curve motion inverted on lipid membranes: Toward elucidating the mechanism of chiral curve motion
○Aruto Nagata1, Takeshi Haraguchi1,2, Yusei Sato3, Junichiro Yajima3, Kohji Ito1,2 (1. Grad. Sch. Sci. Univ. Chiba, 2. Grad. Sci. Univ. Chiba, 3. Univ. Tokyo)
[3P-251(3AS-12-05)]Identification of a membrane-spanning degron governing CFTR ER quality control
○Yuka Kamada1, Saori Kato1, Kenta Kashiwagi1, Tsukasa Okiyoneda1 (1. Dept. of Biomed. Sci., Sch. of Biol. and Env. Sci., Kwansei Gakuin Univ.)
[3P-252]Enhancing Yield and Solubility of Marine-Derived Proteins through Multifactorial Optimization
○Seungmin Shin1,2, Hyung-Soon Yim1, Ji-Soo Yu Yu 1,3, Se-Jin Ji1,3, Kyeong Won Lee1, Hak Jun Kim2, Jung-Hyun Lee1, Young Jun An1 (1. Korea Institute of Ocean Science and Technology, 2. Department of Chemistry, Pukyong National University, 3. Department of Biomedical Engineering, Pukyong National University)
[3P-253]UCHL1 Promotes Gastric Cancer Progression by Regulating the Degradation of CIP2A
○GAYE LEE1, Inho Jeong1, Peter Chang Whan Lee1 (1. Department of Biochemistry & Molecular Biology, University of Ulsan College of Medicine)
[3P-254]BAP1-Mediated Stabilization of BIRC5 Promotes 5-FU Resistance in Gastric Cancer
○YU JIN PARK1, Inho Jeong1, Peter Chang Whan Lee1 (1. Department of Biochemistry & Molecular Biology, University of Ulsan College of Medicine)
[3P-255]Nanopore-based characterization of functional perforin pores and their molecular permeability
○Sotaro Nakamura1, Kazuhiro KOBAYASHI2, Koya Saji1, Ryo IIZUKA1, Hideaki Kato2,1,3,4, Sotaro Uemura1 (1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2. Research Center for Advanced Science and Technology, The University of Tokyo, 3. Depatment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 4. Department of Advanced Interdisciplinary Studies, Graduate school of engineering, The University of Tokyo)
[3P-256]Development of a Secretion-Based Production and Immobilization System for GRP-tag Fusion Proteins Using Diverse Curdlan Carriers in Mammalian Cells
○Masataka Horiuchi1, Rumi Horiuchi2, Taiichi Sakamoto3, Takashi Nagata4, Masanori Ochiai5 (1. Sch. Dent., Health Sci. Univ. Hokkaido, 2. Grad. Sch. Dent. Med., Hokkaido Univ., 3. Dept. Life Sci., Chiba Inst. Tech, 4. Inst. of Adv. Energy, Kyoto Univ., 5. Inst. Low Temp. Sci., Hokkaido Univ.)
[3P-257]Functional switching of protein complexes driven by isoform localization changes: Precise control mechanism of neural differentiation by Meis1
○Tomoo Owa1, Toma Adachi1, Ryo Shiraishi1, Satoshi Miyashita1, Kentaro Ichijo2, JI KAIYUAN1, Minami Mizuno1, Kyoka Suyama1, Nishioka Tomoki3, Daisuke Kawauchi4, Shinichiro Taya1, Kozo Kaibuchi3, Mikio Hoshino1 (1. National Center of Neurology and Psychiatry, 2. Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 3. Institute for Comprehensive Medical Science, Fujita Health University, 4. Institute of Brain Science Nagoya City University Graduate School of Medical Science)
[3P-258]Elucidation of the physical properties and function of light-driven sodium-pumping rhodopsin BeNaR for solution NMR analysis
○Yui Shiozawa1, Keiichi Kojima2, Yuki Sudo2, Hideo Takahashi1 (1. Graduate School of Medical Life Science, Yokohama City University, 2. Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
[3P-259]The membrane division site accumulation of the division execution factor Drp1 mediated by the outer membrane receptor Fis1
○Moka Uetani1, Chise Kiriyama1, Shintaro Kita1, Noriyuki Kodera2, Yuhei Araiso1 (1. Dept. of Clin. Lab. Sci., Div. of Health Sci., Kanazawa Univ., 2. WPI Nano Life Science Institute, Kanazawa Univ.)
[3P-260]Analysis of a BAG6-independent degradation pathway for the Rab39b non-stop mutant
○Kanako Tsuchiya1, Naoto Yokota1, Hiroyuki Kawahara1 (1. Tokyo Metropolitan University)
[3P-261]Hybrid platform for purification of membrane proteins using Nanodisc and silkworm–BEVS
○KEIGO EBATA1, Akitsu Masuda2, Takahiro Kusakabe2, Hiroaki Mon2, Masato Hino2, Jae Man Lee2 (1. Grad. Sch. of Biores Bioenv.Sei.,Univ. of Kyushu, 2. Fac. Agr., Univ. of Kyushu)
[3P-262]Molecular analysis of microtubule serving ATPase katanin and its interaction with microtubule polymerase Mor1.
○Nao Sato1, Marina Ohno1, Ikuko Hayashi1 (1. Yokohama City University Graduate School)
[3P-263]Disruption of Uba6-Dependent Ubiquitin Signaling Alters Neurodevelopment via UBE3A–Smad2 Axis
○Eunju Lee1, Ji-Min Kim1, Peter C.W. Lee1 (1. Department of Biomedical sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea)
[3P-264]Analysis of thermal stability in α-synuclein fibrils disaggregated by molecular chaperone Hsp104
○Fuka Soga1, Natsumi Hirota1, Kentaro Noi2, Kyosuke Shinohara1 (1. Tokyo University of Agriculture and Technology, 2. Kobe University)
[3P-265]Investigation of the functional significance of PTK2B exon 31
○Masahide Kato1, Ayaka Isazawa1, Makoto Araki1, Ai Ohki1, Motoaki Yanaizu1, Yoshihiro Kino1 (1. Grad. Sch. Pharm. Sci., Meiji Pharmaceutical Univ.)
[3P-266]UBE3A control GBM proliferation through Ubiquitin-dependent regulation of SV2A
○Dae Hui LEE1, Min-Jee KIM1, Mi-Sun YUM2, Peter C. W. LEE1 (1. Department of Biochemistry & Molecular Biology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea, 2. Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, South Korea)
[3P-267]Interaction analysis of prostaglandin binding protein from medaka with riboflavin derivatives
○Kazuki Mitani1, Uegaki Koichi2, Shimamoto Shigeru3 (1. Graduate School of Science and Engineering, Kindai University, 2. Faculty of Agriculture, Kindai University, 3. Faculty of Science and Engineering, Kindai University)
[3P-268]Phylogenetic and Functional Analysis of Lipocalin-type Prostaglandin D Synthase
○Kodai Nakamoto1, Chitatsu Noma1, Kei Iida1, Shigeru Shimamoto1 (1. Graduate School of Science and Engineering, Kindai University)
[3P-269]Thermodynamic studies of the binding reactions between three flavin derivatives and apoFMN-binding protein using three analytical method
○REN TABATA1, Yuto Tukada2, Takeshi Nakanishi1,2, Masaya Kitamura1,2 (1. Osaka Metropolitan University, 2. Osaka City University)
[3P-270]The relationship between vesicular trafficking and thermotolerance in fission yeast
○Ami Matsuo1, Jia Xin Soong1, Yukiko Nakase1,2, Daisuke Watanabe1, Kazuhiro Shiozaki1,3, Yuichi Morozumi1,4 (1. NAIST, 2. Yamato Univ., 3. California Univ., 4. Yamanashi Univ.)
[3P-271]Do the main chain structural models of proteins in PDB depend on the program for analysis?
○Mahan Kunii1, Chatake Toshiyuki2, Ohhara Takashi3, Chiba Kaori1 (1. National Institute of Technology, Ibaraki College, 2. KURNS, Kyoto Univ., 3. J-PARC, JAEA)
[3P-272]Physiological roles of supersulfide production by cysteinyl-tRNA synthetase CARS1 in skeletal muscle.
○Mei Omata1, Yusuke Kusano1,2, Shohei Murakami1, Masanobu Morita3, Tomoaki Ida3,4, Keitaro Umezawa5, Tomoyoshi Soga6, Yukio Katori2, Takaaki Akaike3, Hozumi Motohashi1,7 (1. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2. Department of Otolaryngology-Head & Neck Surgery, Tohoku University Graduate School of Medicine, 3. Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, 4. Organization for Research Promotion Osaka Metropolitan University, 5. Tokyo Metropolitan Institute for Geriatrics and Gerontology, 6. Institute for Advanced Biosciences, Keio University, 7. Department of Gene Expression Regulation, IDAC, Tohoku University)
[3P-273]Evaluation of Thermostability of Structural Domains of DNA methyltransferase M.ApeKI from Hyperthermophilic Archeon
○Mao Hayashi1, Yasuhiro Iida1 (1. Kanagawa institute of technology)
[3P-274]Analysis of the Effect of the Chloroplast Ribosome Hibernation Factor PSRP1 on Ribosome Distribution in vivo
○Airi Moronuki1, Kenta Tanaka1, Daiki Suzuki1, Akira Shishido1, Yasuhiko Sekine1 (1. Rikkyo university)
[3P-275]Computational analysis of GPCR heterodimer ligands and their binding residues
○Wataru Nemoto1,2, Ryota Takishima1,2 (1. Tokyo Denki Univ., 2. Grad. Sch. of Tokyo Denki Univ.)
[3P-276]Development of Peroxidase-Based Cancer Detection and Therapy Using Bacterial P450 Enzymes
○ENKHTUUL ERDENEBAT1, Christopher J. Vavricka1 (1. Department of Biotechnology and Life Science)
[3P-277]Computational Workflow for the Rational Design of Artificial Phosphonate Ester Hydrolases
○Rin Kunisada1, Christopher J. Vavricka1 (1. Tokyo University of Agriculture and Technology, Faculty of Engineering, Department of Biotechnology and Life Sciences)
[3P-278]Systematic discovery of a luminol-active peroxidase that can be produced in E. coli as a basic enzyme.
○e.g. Manaka e.g. Taguchi1, Christopher John Vavricka1 (1. Tokyo University of Agriculture and Technology)
[3P-279]Development of the cytokine-embedded silkworm sericin cocoon applicable as a scaffold for the proliferation of embryonic stem cells
○Yuta Yamada1, Keiko Takaki1, Lye Ping Ying1, Kouki Kajiwara, Eiji Kotani1 (1. Kyouto Institute of Technology)
[3P-280]Kinetical Carbon Isotope Fractionation with CODH
○Akira Miyatani1, Ueno Yuichiro1, Gilbert Alexis , Nakagawa Mayuko1, Shawn McGlynn1 (1. Institute of Science Tokyo)
[3P-281]Did enzymatic thioester and thioacid formation precede phosphorylation in evolution?
○Hayato Tazaki1, Shawn McGlynn1 (1. Science Tokyo)
[3P-282]Large-scale membrane fusion assay with L-OPA1 expressed in E. coli
○Yuta Maeda1, Reo Tomotake1, Tadato Ban2, Naotada Ishihara1 (1. The University of Osaka, 2. Kurume University)
[3P-283]Establishment of a Baculoviral Essential Gene Rescue System for Enhancing the Silkworm–Baculovirus Expression System
○Misaki Shibuya1, Hiroaki Mon2, Takeru Ebihara1, Masato Hino2, Tsuguru Fujii2, Jaeman Lee2, Ryosuke Fujita2, Takahiro Kusakabe2 (1. Grad. Sch. of Biores. Bioenv. Sci., Univ. of Kyushu, 2. Fac. Agr., Univ. of Kyushu)
[3P-284]Elucidation of the Mechanism of hypochlorite Response by the Salmonella Two-Component Regulatory System CopS/CopR
○Tomoki Ito1,2,3, Rumine Taniguti1,2,3, Hirosi Ogasawara3,4,5 (1. Grad. Sch. Sci. Tech., Shinshu Univ, 2. Grad. Sch. Sci. Tech., Shinshu Univ., 3. Acad. Assy. Sch. Hum. SoSci. Inst. Hum., Shinshu Univ., Shinshu Univ., 4. IFES, Shinshu Univ., 5. Res. Ctr. Adv. Sci. Tech., Shinshu Univ.)
[3P-285]The Role of Lrtm2 and its potential binding partners in Striatal Neurons
○Misato Ichise1, Minoru Hatayama1, Jun Aruga1 (1. nagasaki university)
[3P-286]The Effect of E. coli IEE on the CRISPR-Cas system
○Haruto Yamazaki1, Ren Kishino1, Yasuhiko Sekine1 (1. Rikkyo Univ.)
[3P-287]Molecular Basis of Alkane Biosynthesis in Cyanobacteria and Enhanced Production in Recombinant Strains
○Misato Nagao1,3, Takato Ozaki1, Hirofumi Fukuda1, Yu Kanesaki2, Munehiko Asayama1,3 (1. Practical Agricultural and Food Science Course, Graduate School of Agriculture at Ibaraki University, 2. Department of Laboratory Sciences, Graduate School of Health Sciences at Gunma University, 3. Department of Applied Life Science, United Graduate School of Agricultural Science at Tokyo University of Agriculture and Technology)
[3P-288]Characterization and Functional Evaluation of the Green Algal Extracellular Polysaccharide amiEPS for Next-Generation Biomaterials
○Reo Yamane1, Reiya Ishida1, Yuuya Uejima1, Akari Takagi1, Akihiro Nakamura1,2, Munehiko Asayama1,2 (1. Practical Agricultural and Food Science Course, Graduate School of Agriculture at Ibaraki University, 2. Department of Applied Life Science, United Graduate School of Agricultural Science at Tokyo University of Agriculture and Technology)
[3P-289]Novel biopolymers in the extracellular substance skECS from a filamentous cyanobacterium
○Runa Koshikawa1, Kotaro Kido2, Rise Katoh1, Nguyen Thi Thuy Quynh1, Yu Kanesaki3, Morifumi Hasegawa1,4, Akihiro Nakamura1,4, Munehiko Asayama1,4 (1. Practical Agricultural and Food Science Course, Graduate School of Agriculture at Ibaraki University, 2. Department of Food and Life Sciences, College of Agriculture at Ibaraki University, 3. Department of Laboratory Sciences, Graduate School of Health Sciences at Gunma University, 4. Department of Applied Life Science, United Graduate School of Agricultural Science at Tokyo University of Agriculture and Technology)
[3P-290]Precision Hydroxytyrosol Biosynthesis in Engineering E.coli
○Ryunosuke Sano1, Tomohiro Nawata1, Koko Nakata1, Toshiki Saito1, Shunsuke Takahashi2 (1. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ., 2. Dept. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ.)
[3P-291]Role of autophagy-related protein for regulation of high-fat diet induced metabolic dysfunction in skeletal muscle.
○Mami Yamada1, Miu Yasutake1, Eiji Warabi2, Hisashi Oishi3, Mitsuharu Okutsu1 (1. Grad. Sch. of Sci., Nagoya City Univ., 2. Inst. of Med., Tsukuba Univ., Tsukuba, 3. Grad. Sch. of Med. Sci., Nagoya City Univ.)
[3P-292]Ammonia-driven metabolic reprogramming in pancreatic ductal adenocarcinoma
○Feifei Feifei CAI1, Chisato Iwabuchi1, Runmei Cui1, Tsuyoshi Osawa1 (1. The University of Tokyo)
[3P-293]Impact of BST1 on nucleoside metabolism
○Yoshimitsu Suzuki1, Takashi Nakagawa1, Keisuke Yaku1 (1. Toyama Univ.)
[3P-294]Comprehensive identification of proteins proximal to vitamin K-dependent carboxylase GGCX
○Yuki Kubota1,2, Toshihiko Takeiwa2, Kyojiro Kawakami3, Yuri Miura3, Yoshihisa Hirota1, Satoshi Inoue2 (1. Grad. Sch. Eng. Sci., Shibaura Inst. Technol., 2. Dept. of Syst. Aging Sci. and Med., Tokyo Metropolitan Inst. for Geriatr. and Gerontol., 3. Dept. of Proteome Res., Tokyo Metropolitan Inst. for Geriatr. and Gerontol.)
[3P-295(3MS-11-06)]Environmental adaptability of the eubacterium Ralstonia sp. NT80, which possesses lipase superinducing ability
○Morio Ishizuka1, Shu Katsuragi1, Genki Akanuma2, Kazutoshi Ushio3 (1. Chuo University, 2. Josai University, 3. Niihama National College)
[3P-296]GlycoFish: a comprehensive database for fish glycobiology
○Nobuki Tsukada1, Kiyoko Flora Kinoshita1, Kazuhiro Aoki2 (1. Soka University, 2. Medical College of Wisconsin)
[3P-297]Elucidation of the unique glycolipid biosynthetic pathway constitutes the cell membrane of the extreme thermophile Thermus thermophilus HB8
○Masahiko Kawaguchi1, Haruo Shimada2, Yoshitaka Bessho3, Naoki Nemoto4 (1. Dept. of Eng., Grad. Sch. of Eng., Chiba Ins. of Tec., 2. BioChromato Inc., 3. RIKEN SPring-8 Center, 4. Dept. of Life Sci., Grad. Sch. of Adv. Eng., Chiba Ins. of Tec.)
[3P-298]Elucidation of a unique carotenoid biosynthetic pathway in the extreme thermophile Thermus thermophilus HB8
○Aone Nakamura1, Masahiko Kawaguchi2, Naoki Nemoto1 (1. Dept. of Life Sci., Adv. Eng., Chiba Ins. of Tec., 2. Dept. of Eng., Grad. Sch. of Eng., Chiba Ins. of Tec.)
[3P-299]Identification of candidate molecules for disease glycobiomarkers by data-driven analysis
○Hidemi Arakawa1, Kiyohiko Angata2, Kiyoko Flora Kinoshita2, Akiko Tozawa3, Akira Togayachi1,2 (1. Graduate school of Science & Engineering, Soka University, 2. Glycan & Life Systems Integration Center / GalSIC, 3. Department of Obstertrics and Gynecology, St.Marianna University School of Medicine)
[3P-300]Chloroplast Genome Variations and NDH Complex-Related Gene Loss in Brown Algae
○Akane Nakajima1, Hikaru Sugita1, Yoshinori Fukasawa1 (1. Utsunomiya University)
[3P-301(3PS-12-05)]Unraveling Genome Scrambling in a Miniature Chordate Genome Using Multiple Chromosome-Level Assemblies
○Johannes Nicolaus Wibisana1, Yongkai Tan1, Nicolas Dierckxsens1, Kian L Murray1, Andrew Liu1, Aki Masunaga1, Ana Klarkowska1, Michael J Mansfield1, Alfonso Ferrandez-Roldan2, Charles Plessy1, Cristian Canestro2, Nicholas Luscombe1 (1. OIST, 2. Univ. Barcelona)
[3P-302]Evaluation of phylogenetic analysis using 3D structural information of proteins
○Yuina Oishi1, Tokumasa Horiike1 (1. Shizuoka University)
[3P-303(3AS-10-04)]Evolution of cis-regulatory landscapes in limb bone elongation: a comparative genomics approach focusing on bipedal rodents
○Alexander Y Liu1, Alexander J Weitzel1, Aditya Saxena1, Daniel Richard2, Terence D Capellini2, Michael Hiller3,4,5, Kimberly L Cooper1 (1. University of California, San Diego, 2. Harvard University, 3. LOEWE Centre for Translational Biodiversity Genomics, 4. Senckenberg Research Institute, 5. Goethe-University)
[3P-304]Identification of positive selection in the insulin gene of the Gekko japonicus species group and its implications for receptor binding properties
○Genki Yamagishi1, Teppei Jono2, Shinichi Miyagawa3, Naoko Hattori1 (1. Gunma University, 2. Kyoto University, 3. Tokyo University of Science)
[3P-305]Functional characterization of gene regulatory sequences associated with mammalian frugivory
○Mai Nobuhara1,5, Wei Gordon1,5, Maggie Liang1,5, Kelly An1,5, Varda Singhal1,5, Beniamin Krupkin1,5, Yien-Ming Kuo6, Jeremie Rispal7, Hai Nguyen1,5, David Ray2, Lisa Noelle Cooper4, Tony Schountz3, Nadav Ahituv1,5 (1. Dept. of Bioengineering and Therapeutic Sciences, UCSF, 2. Dept. of Biological Sciences, Texas Tech University, 3. Dept. of Microbiology, Immunology & Pathology, Colorado State University, 4. Dept. of Anatomy and Neurobiology, Northeast Ohio Medical University, 5. Institute for Human Genetics , UCSF, 6. Dept. of Ophthalmology, UCSF, 7. Craniofacial Biology, UCSF)
[3P-306]Testing the pinniped biphyletic hypothesis through bitter taste receptor analysis
○Mit Ebihara Ebihara1 (1. Kanto-gakuin University)
[3P-307]Discovery of ancient endogenous bornavirus-like elements showing high sequence similarity to modern bornaviruses
○Hana Sasaki1, Masayuki Horie1,2,3, Mai Kishimoto1,2,3 (1. School of Veterinary Science, Osaka Prefecture University., 2. Graduate School of Veterinary Science, Osaka Metropolitan Univ., 3. Osaka international Research Center for Infectious Diseases, Osaka Metropolitan Univ.)
[3P-308]Solubility screening from variants of aggregation-prone proteins using in vivo folding sensor
○Atsuhiro Kanazawa1, Tatsuya Nojima2, Tsukumi Miwa2, Hideki Taguchi1,2 (1. Sch of Life Sci Tech, Science Tokyo, 2. CBC, IIR, Science Tokyo)
[3P-309]Reconstruction of ancient β-barrel proteins with primitive cationic amino acids.
○Sota Yagi1,2, Khushboo Bhagat3, Aditya Kumar Padhi3, Kam Zhang4, Shunsuke Tagami2,5 (1. Waseda Univ., 2. RIKEN IMS, 3. IIT (BHU) BE, 4. RIKEN BDR, 5. Hiroshima Univ.)
[3P-310]Correlation between Functional Changes in E. coli GroE and Robustness During Thermo-Adaptive Evolution
○Yudai Terashima1, Takeshi Masuda2, Moe Matsuo1, Nobuaki Kono3,2, Toshihiko Kishimoto1 (1. Toho Univ., 2. Keio Univ., 3. IAB, Keio Univ.)
[3P-311]Uric Acid Transporter Gene SLC22A12 is a Chimera of Multiple Ancestral Genes
○Kazuharu Misawa1,2 (1. Graduate School of Data Science, Yokohama City Univ., 2. RIKEN, AIP)
[3P-312]Evolutionary Conservation and Genomic Context of MER130 Elements in Tetrapod Species
○Ngoc Hung Nguyen1 (1. Graduate School of Frontier Sciences, The University of Tokyo)
[3P-313]Genotypic diversification and phenotypic convergence in the thermally adapted RNA phage Qβ
○Minori Sato1, Sawako Takahashi1, Md. Tanvir Hossain2, Akiko Kashiwagi1 (1. Hirosaki Univ., 2. Noakhali Science and Technology Univ.)
[3P-314]2D Cultures of New World Monkey Intestinal Organoids toward Understanding Dietary Adaptation of Nutrient Absorption Mechanisms
○Arisa Ishimura1, Ken Iwatsuki2, Hiroo Imai3 (1. Kyoto Univ., 2. Tokyo Univ. Agric., 3. Kyoto Univ. EHUB)
[3P-315]in silico Identification of specific genes and those functions on Microbiota
○Kazuki Arita1, Yoshio Nakano1, Satoru Miyazaki1 (1. Tokyo University of Science)
[3P-316]Cross-species Enhancer Prediction AI: A Novel Approach to Cancer Resistance and Longevity in Mammals
○Naoya Minami1, Takumi Ito2,3, Hideyuki Shimizu2,3, Yasunaga Yoshikawa1 (1. Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University, 2. Department of AI Systems Medicine, M&D Data Science Center, Institute of integrated research, Institute of Science Tokyo, 3. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[3P-317]Laboratory evolution of Escherichia coli under two-drug combinations with sulfamethoxazole/trimethoprim
○Ryu Goto1, Hazuki Kotani2, Satoru Fukiya1, Chikara Furusawa2,3, Tomoya Maeda1,2 (1. Hokkaido Univ., 2. RIKEN, 3. UTokyo)
[3P-318]Development of a gene duplication analysis tool and comprehensive search for human-specific duplicated genes
○Yosuke Nakano1, Ikuo K Suzuki1 (1. The University of Tokyo)
[3P-319]Evolutionary Dynamics of the Mammalian Sex-Determining Gene Sry: A “Gekokujō (Jump-Decline)” Model from Functional Enhancement under Positive Selection to Tolerated Functional Decline
○Honoka Okuyama1, Ayuka Tokunaga1, Shiori Inazumi1, Yusaku Ogita2, Shunsuke Iguchi1, Shuuji Mawaribuchi3, Shun Hayashi4, Kosuke Suda1, Daisuke Tsukamoto1, Takuya Matsuo1, Kei Tamura1, Iku Tsuchiya5,6, Mika Hirabayashi5, Shuji Takada5,6, Shuta Uehara7, Takashi Matsui7, Yoshio Kodera7, Michihiko Ito1 (1. Lab. Mol. Biol., Grad. Sch. Sci., Kitasato Univ., 2. Res. Cent. Integr. Evol. Sci., SOKENDAI, 3. Cell. Mol. Biotech. Res. Inst., AIST, 4. Amphibian Res. Center, Hiroshima Univ., 5. Dept. of Systems BioMed., NCCHD, 6. Dept. of NCCHD, Grad. Sch. of Med. and Dent. Sci., Science Tokyo, 7. Lab. Life Phys., Grad. Sch. Sci., Kitasato Univ.)
[3P-320]Simple and efficient method enabling one-antigen-based production of high-affinity, stereo-specific monoclonal antibodies, and evaluation of its effectiveness
○Atsumi Sakaguchi1, Mei Kawamura2, Fujino Kuba2, Yasuyuki Kurihara3 (1. Bioscience Center, Science Tokyo, 2. Grad Sch Sci Eng, Yokohama Natl Univ., 3. Fac Eng Sci, Yokohama Natl Univ.)
[3P-321]Development of antibody-like proteins binding to N-terminal amino acid of a peptide for single-molecule peptide sequencing method
○Shun Umemoto1, Naoki Kobayashi1, Izumi Takayanagi1, Yuta Kabeya1, Haruto Kosugi1, Gosuke Hayashi1, Hiroshi Murakami1,2,3 (1. Graduate School of Engineering, Nagoya University, 2. Institute of Nano-Life Systems, Institutes of Innovation for Future Society, Nagoya University, 3. Research Institute for Quantum and Chemical Innovation, Institutes of Innovation for Future Society, Nagoya University)
[3P-322(3AS-13-07)]The impact of "gene acquisition" from viruses on the evolution of viviparity and sophisticated brain function in mammals
○Fumitoshi Ishino1, Masahito Irie2, Hirosuke Shiura3, Moe Kitazawa3, Yoshifumi Fujioka4, Tomoko Kaneko-Ishino5 (1. Inst. Sci. Tokyo (IST), 2. Nonprofit Org. Gene Info. Bank, 3. Fac. Life Environ. Sci., Univ. Yamanashi, 4. RIKEN Cent. Integ. Med. Sci. (IMS),, 5. Tokai Univ. Sch. Med.)
[3P-323]Regulatory mechanism underlying topological change of Vap33/VAPB
○Kanako Tamai1, Mizuki Tando1, Kosuke Kamemura2,1, Riyo Imamura3, Misako Okumura1,4, Takahiro Chihara1,4 (1. Hiroshima Univ. Program of Biomedical Science, 2. UT Southwestern Medical Center, 3. Drug Discovery Initiative, 4. Hiroshima Univ. Program of Basic Biology)
[3P-324]Gamma Radiation Response of Limnobacter thiooxidans Isolated from the Torus Room of the Fukushima Daiichi Nuclear Power Plant and Characterization of a Novel Stress Response Gene, LT3126
○Tomoro Warashina1,2, Asako Sato2, Takeshi Masuda2, Yuma Dotsuta3, Toru Kitagaki3, Ayumi Hashiguchi4, Teppei Morita2, Kataoka Masakazu5, Akio Kanai1,2,6 (1. Syst. Biol. Prog. Grad. Sch. Media & Governance, Keio Univ., 2. Institute for Advanced Biosciences, Keio University., 3. Japan Atomic Energy Agency, 4. Faculty of Environmental, Life, Natural Science and Technology, Okayama University, 5. Department of Chemistry and Material Engineering, 6. Bachelor of Arts in Environmental Information)
[3P-325]Isolation for phages specific to sex-pili and sterilization of drug-resistant Inc plasmid-carrying bacteria
○Mitsuoki Kawano1, Nene Takada1, Ayano Izumi1, Sakura Sana1, Kotaro Oda1, Fuka Nakamura1, Riko Nakanishi1, Sayaka Maeda1 (1. Nakamura Gakuen University)
[3P-326]Validation of Visual Reporters in an Optimized Screening Platform for Selecting Highly Expressible Marine Proteins.
○ji se jin1, Yim Hyung Soon1, Yu Ji Soo 1, An Young Jun 1, Jung Won Kyo 2, Lee Jung Hyun 1, Lee Kyeong Won 1 (1. Korea Institute of Ocean Science & Technology, 2. Pukyong National University)
[3P-327]Development of inhibitory peptides for the small GTPase Arf6
○Risa Sato1,2, Naohiro Katagiri2, Yuji Funakoshi2, Kazusa Kimoto3, Daisuke Fujiwara3, Ikuo Fujii3, Atsushi Kawaguchi2, Yasunori Kanaho2 (1. Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2. Institute of Medicine, University of Tsukuba, 3. Graduate School of Science, Osaka Metropolitan University)
[3P-328]Protective Role of Sulforaphane via Nrf2 Activation in Polystyrene Nanoplastic-Induced Myoblast Senescence
○JaeHun Cheong1, Chae Rin Jung1, Ye Bin Kim1, Yoon Hee Lee1, Yu Kyeong Kim1, Da In Yang1 (1. Department of Molecular Biology, Pusan National University)
[3P-329]Characterization of a DNA aptamer which recognizes CD4 and its applications to CD4 detection
○Pengpeng Xue1, Koichi Takakura1, Maiko Okada1, Kazuyoshi Yano1 (1. Grad. Sch. of Bionics, Tokyo Univ. of Tech.)
[3P-330]The Biorepository Technical Administrator (BiTA) Certification Examination: Advancing Quality in Biobanking
○Junko Ikeda1, Keiko Misawa1, Kazuhiro Okano3, Soichi Ogishima4, Tomoyo Takeuchi5, Hiroki Nakae2,1, Yoshihito Nakajima6, Kotaro Hattori7, Shinichiro Fujii8, Kazuyuki Matsushita9, Yohei Miyagi10, Mizuki Morita11, Takayuki Morisaki12 (1. Council for Industrial use of Biological and Environmental Repositories (CIBER) , 2. Japan bio Measurement and Analysis Consortium, 3. Agilent Technologies Japan, Ltd., 4. Tohoku University Advanced Research Center for Innovations in Next-Generation Medicine / Tohoku Medical Megabank Organization, 5. Tsukuba Human Tissue Biobank, University of Tsukuba Hospital, 6. Thermo Fisher Scientific K.K., 7. Medical Genome Center, National Center of Neurology and Psychiatry, 8. National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, 9. Chiba University Hospital, 10. Kanagawa Cancer Center Research Institute, 11. Graduate School of Interdisciplinary Science and Engineering in Health Science, Okayama University, 12. BioBank Japan, The Institute of Medical Science, The University of Tokyo)
[3P-331]Real-time visualization of nanoscale functional accessibility of immune checkpoints in tumor-derived extracellular vesicles at the single-particle level
○Reon Imakawa1, Kee Siang Lim2, Takeshi Yoshida2,3, Tomoyoshi Yamano3, Tsunaki Hongu4, Noriko Goto4,5, Rikinari Hanayama2,3, Richard W. Wong1,2,5,6,7 (1. Div. of Nano Life Sci., Kanazawa Univ., 2. WPI-Nano Life Sci. Inst., Kanazawa Univ., 3. Dept. of Immunol., Kanazawa Univ. Grad. Sch. of Med. Sci., 4. Div. of Cancer Cell Biol., Cancer Res. Inst., Kanazawa Univ., 5. Inst. for Frontier Sci. Initiative, Kanazawa Univ., 6. WISE Program for Nano-Precision Med., Sci. & Tech., Kanazawa Univ., 7. Cell-Bionomics Res. Unit, INFINITI, Kanazawa Univ.)
[3P-332]Molecular Mechanisms Involved in Fetal Growth Delay in DGKθ-Deficient Mice
○Emi Inoue1, Shuji Ueda1, Kazuki Ito1, Xiaoya Li1, Mako Yamaguchi1, Nao Koizumi1, Itsuko Fukuda1, Yasuhito Shirai1 (1. Graduate School of Agricultural Science, Kobe University)
[3P-333]Cell-Free Upcycling of Bioplastics for Amino Acid Synthesis via the Gluconeogenic Serine Pathway
○I Tang1, Shota Nishikawa2,3, Po-Hsiang Wang4, Kosuke Fujishima2 (1. LST., Science Tokyo, 2. ELSI., Science Tokyo, 3. RIKEN, 4. GIEE., NCU)
[3P-334]Development of an Estimation Method for Enzyme Reaction Networks Using Interaction Information
○Shinsuke Uda1 (1. Yamaguchi university)
[3P-335]Screening of hydrogen-producing bacteria and evaluation in bacterial immobilization capsules
○Ayako Suzuki1, Ayaka Syutou1, Takanori Inoue1 (1. oita universitiy)
[3P-336]Analysis of zebrafish chromosome characteristics and the mechanism of fish chromosome maintenance in a human-derived cell line.
○Ohira Takahito1,2, Kugoh Hiroyuki1,2 (1. Dept. of Chr Bio Eng., Sch. of Med., Univ. of Tottori, 2. Chr. Eng. Res. Cen., Univ. of Tottori)
[3P-337]Generation of FXS model animals using mouse artificial chromosome with FXS fragile site
○Rin Ushida1, Ryoma Ichikawa1, Haruto Kitase2, Yuji Nakayama3,4, Yasuhiro Kazuki1,2,4, Hiroyuki Kugoh1,2,4 (1. Dept. of Chr. Bio Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. Sch. of Lifesci., Fac. of Med., Tottori Univ., 3. RIC., Res. Init. & Prom., Tottori Univ., 4. Chr. Eng. Res. Cen., Tottori Univ.)
[3P-338]Regulatory Role of Akt Signaling in hTERT expression in Oral Squamous Cell Carcinoma
○Haruka Ooi1, Miyu Murata1, Takahito Ohira2,3, Hiroyuki Kugoh2,3 (1. Dept. of Chr. Eng., Grad. Sch. Of Med. Sci., Univ. of Tottori, 2. Dept. of Chr Bio Eng., Sch. of Med., of Tottori , 3. Chr. Eng. Res. Cen., Univ. of Tottori)
[3P-339]A novel regulatory mechanism of hTERT mRNA transcription in human oral squamous cell carcinoma cells
○Miyu Murata1, Haruka Ooi1, Takahito Ohira2,3, Hiroyuki Kugoh2,3 (1. Dept. of Chr. Eng., Grad. Sch. Of Med. Sci., Univ. of Tottori, 2. Dept. of Chr Bio Eng., Sch. of Med., Univ. of Tottori, 3. Chr. Eng. Res. Cen., Univ. of Tottori)
[3P-340]Analysis of mutant strains of fission yeast that exhibit hyper-condensed chromosome during stationary phase.
○Naoki Kotani1, Airi Sonokawa1, Sharmin Sultana Shirin1, Kazuto Takizawa2, Hideo Dohra1,3,4, Ayumu Yamamoto1,2,5 (1. Grad. Sch. Int. Sci. Tech., Shizuoka Univ., 2. Dept. Chem., Fac. Sci., Shizuoka Univ., 3. Shizuoka Inst. Anal. Ctr, Shizuoka Univ., 4. Res. Inst. Green Sci. Technol., Shizuoka Univ., 5. Grad. Sch. Sci. Tech.)
[3P-341]Genome-wide dynamics of acetylated cohesin mediating sister chromatid cohesion
○Takashi Sutani1, Mai I Shimizu1,2, Masashige Bando1, Atsunori Yoshimura1, Toyonori Sakata1,3, Katsuhiko Shirahige1,3 (1. The Univ. of Tokyo, 2. Tokyo Women's Med. Univ., 3. Karolinska Inst.)
[3P-342(3PS-12-07)]Application of chromosome engineering technology (1): Development of Mb-scale chromosomal engineering technology using human iPS cells
○Narumi Uno1, Hitomaru Miyamoto2, Masaya Egawa1, Shino Okado1, Jukiya Kitazawa1, Yuki Ishizu1, Yusaku Okano1, Ayami Seno1, Kyotaro Yamazaki3, Hiroaki Kobayashi2, Nanami Kishima2, Teruhiko Suzuki4, Satoshi Abe2,5, Kanako Kazuki5, Yasuhiro Kazuki2,3, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm and Life Sci., 2. Div. of Chromo. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 3. Chr. Eng. Group, ExCELLS, 4. Immunomed., Tokyo Metropol. Inst. Med. Sci. , 5. CERC, Tottori Univ.)
[3P-343]Application of chromosome engineering technology (2): Mechanism for maintaining chromosomes in different species and their manipulation
○Junichiro Ohzeki1, Jia Xiam Lee2, Kyotaro Yamazaki3, Yasuhiro Kazuki1,2,3,4 (1. CERC, Tottori Univ., 2. Sch. of Life Sci., Facul. of Med., Tottori Univ., 3. Chr. Eng. Group, ExCELLS, 4. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ.)
[3P-344]Application of chromosome engineering technology (3): Development of Versatile Chromosome Transfer Technology and Exploration of Novel Reagents
○Hiroaki Kobayashi1, Hitomaru Miyamoto1, Kanako Kazuki2, Masaharu Hiratsuka2, Yasuhiro Kazuki1,2,3,4 (1. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. CERC, Tottori Univ., 3. Sch. of Life Sci., Facul. of Med., Tottori Univ., 4. Chr. Eng. Group, ExCELLS)
[3P-345]Application of chromosome engineering technology (13):Functional Analysis of Insulator Sequences Located in the Upstream Region of the Human UBC Gene
○Daiki Fukushima1, Aina Ichikawa1, Rio Suzuki1, Yuki Ishizu1, Natsumi Yamazaki1, Narumi Uno1, Yasuhiro Kazuki2,3, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm and Life Sci., 2. CERC, Tottori Univ., 3. Div. of Chromo. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ)
[3P-346]Application of chromosome engineering technology (5):Search for new insulator sequences that enhance the expression of introduced genes
○Aina Ichikawa1, Daiki Fukushima1, Rio Suzuki1, Yuki Ishizu1, Natumi Miyazaki1, Narumi Uno1, Shin Kaneko2, Yasuhiro Kazuki3,4,5, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2. CiRA Kyoto Univ., 3. CERC, Tottori Univ., 4. Div. of Chr. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ., 5. Chr. Eng. Group, ExCELLS)
[3P-347]Application of chromosome engineering technology (6): Loading human chromosome regions onto human artificial chromosomes via genome editing-induced translocations in iPS cells
○Jukiya Kitazawa1, Shino Okado1, Eriko Noguchi1, Miwa Fujitani1, Narumi Uno1, Masaya Egawa1, Akihiro Ishikawa2, Masaharu Hiratsuka3, Yusuke Ogame3, Shin Kaneko2, Yasuhiro Kazuki3,4,5, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2. CiRA, Kyoto Univ., 3. CERC, Tottori Univ., 4. Div. of Chr. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ., 5. Chr. Eng. Group, ExCELLS)
[3P-348]Application of chromosome engineering technology (7): Development of a human artificial chromosome-based expression system for CAR genes and multiple functional enhancement factors toward iPSC-derived CAR-T cell therapy
○Shino Okado1, Jyukiya Kitazawa1, Miwa Fujitani1, Eriko Noguchi1, Narumi Uno1, Akihiro Ishikawa2, Masaharu Hiratsuka3, Yusuke Ohkame3, Shin Kaneko2, Yasuhiro Kazuki3,4,5, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2. CiRA, Kyoto Univ., 3. CERC, Tottori Univ., 4. Div. of Chr. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ., 5. Chr. Eng. Group, ExCELLS)
[3P-349]Application of chromosome engineering technology (8): Construction and functional analyses of human artificial chromosome vectors for gene therapy of ataxia telangiectasia
○Hitomi Sakano1, Kanako Kazuki2, Satoshi Abe2, Yasuhiro Kazuki1,2,3,4 (1. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. CERC, Tottori Univ., 3. Chr. Eng. Group, ExCELLS, 4. Sch. of Life Sci., Facul. of Med., Tottori Univ.)
[3P-350]Application of chromosome engineering technology (9):Minimization of chromosome 21 using partial monosomy human iPS cells
○Ayami Seno1, Yusaku Okano1, Rina Komazaki1, Momoko Hayashi1, Yuki Ishizu1, Masaya Egawa1, Yusuke Ohkame2, Kyorato Yamazaki5, Teruhiko Suzuki4, Uno Naru1, Yasuhiro Kazuki2,3,5, Kazuma Tomizuka1 (1. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci.,, 2. CERC, Tottori Univ.,, 3. Div. of Chr. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ.,, 4. Stem Cell Proj., Tokyo Metropol. Inst. Med. Sci.,, 5. Chr. Eng. Group, ExCELLS)
[3P-351]Application of chromosome engineering technology (10): Minimization of chromosome 21 in human iPS cells: functional complementation by synthetic expression units for essential genes
○Momoko Hayashi1, Ayami Seno1, Yusaku Okano1, Rina Komazaki1, Yuki Ishizu1, Masaya Egawa1, Yusuke Ohkame1, Kyotaro Yamazaki2, Teruhiko Suzuki4, Narumi Uno1, Yasuhiro Kazaki2,3,5, Kazuma Tomizuka1 (1. Tokyo University of Pharmacy and Life Sciences, 2. CERC, Tottori Univ., 3. Div. of Chr. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ., 4. Stem Cell Proj., Tokyo Metropol. Inst. Med. Sci, 5. Chr. Eng. Group, ExCELLS)
[3P-352]Application of chromosome engineering technology (11): Histological analysis of cerebellar Purkinje cells in Down syndrome model rats
○Manami Yamamoto1, Ayano Taguchi1, Masaharu Hiratsuka2, Yasuhiro Kazuki1,2,3,4 (1. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. CERC, Tottori Univ., 3. Sch. of Life Sci., Facul. of Med., Tottori Univ., 4. Chr. Eng. Group, ExCELLS)
[3P-353]Application of chromosome engineering technology (12): Generation of immune-humanized mice via megabase region deletion method
○Yui Moriguchi1, Nanami Kishima1, Satoshi Abe2, Akane Okada2, Hitomaru Miyamoto1, Wakana Nakagawa1, Kyotaro Yamazaki3, Takashi Moriwaki4, Kanako Kazuki2, Narumi Uno5, Kazuma Tomizuka5, Yasuhiro Kazuki1,2,3,4 (1. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. CERC, Tottori Univ., 3. Chr. Eng. Group, ExCELLS, 4. Sch. of Life Sci., Facul. of Med., Tottori Univ., 5. Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci.)
[3P-354]Application of chromosome engineering technology (13):Analysis of trans-chromosomic mice with full-length human immunoglobulin loci expressing both kappa and lambda antibodies
○Yuana Masuda1, Kazuto Shimoya1, Takashi Moriwaki2,3, Akane Okada3, Satoshi Abe3, Yasuhiro Kazuki1,2,3,4 (1. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2. Sch. of Life Sci., Facul. of Med., Tottori Univ., 3. CERC, Tottori Univ., 4. Chr. Eng. Group, ExCELLS)
[3P-355]Application of chromosome engineering technology (14): Establishment of a platform technology for generating humanized pharmacokinetic rat models
○Satoshi Abe1, Kaoru Kobayashi2, Genki Minegishi2, Kanako Kazuki1, Atsushi Miyajima2, Masumi Hirabayashi3, Tetsushi Sakuma4, Takashi Yamamoto5, Yasuhiro Kazuki1,3,6,7 (1. CERC, Tottori Univ., 2. Dept. of Biopharmaceutics, Grad. Sch. of Clin. Pharm., Meiji Pharm. Univ., 3. CERG, ExCELLS., 4. Grad. Sch. Of Agri., Kyoto Univ., 5. Genome Edit. Innov. Ctr., Hiroshima Univ., 6. Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 7. Sch. Of Life Sci., Facul. of Med., Tottori Univ.)
[3P-356]Application of chromosome engineering technology (15): Research to elucidate the antiviral immunity mechanisms played by bat MHC-I
○Nanami Kishima1, Yasuhiro Kazuki1,2,3 (1. Graduate School of Medical Sciences, Tottori University, 2. CERC, Tottori Univ., 3. Chr. Eng. Group, ExCELLS.)
[3P-357]Differential Modes of EP Interaction by Cohesin and Condensin: Evidence for a Diffusion Capture-Based Transcriptional Control
○Hideki Tanizawa1, Yik-Lok Claire Chung1, Ken-ichi Noma1 (1. Institute for Genetic Medicine, Hokkaido University)
[3P-358]Regulation of dual pathways maintaining centromere position in vertebrates
○Tetsuya Hori1, Yutaka Mahana1, Mariko Ariyoshi1, Tatsuo Fukagawa1 (1. FBS, Osaka Univ.)
[3P-359]KPNA1 associates with nucleolar components involved in rRNA processing.
○Osamu Kutomi1,2, Katsutoshi Mizuno1,2, Takafumi Itoh3, Masami Yamada1,2 (1. Facul. of Medical Sciences, University of Fukui, 2. Life Science Innovation Center, University of Fukui, 3. Dept. Biosci. Biothech., Fukui Prefectural University)
[3P-360]An interpretation of heterochromatin and euchromatin based on a novel classification method for A/B compartments from Hi-C data
○Takashi Sumikama1,2, Hisashi Miura3, Ichiro Hiratani3, Takeshi Fukuma2 (1. Kyoto University, 2. Kanazawa University, 3. RIKEN BDR)
[3P-361]Effect of phosphorylation of budding yeast DNA polymerase Pol1 on telomere length regulation
Chinami Shoji1, Yuuta Takahashi1, Mao Kamioka1, Takuya Iwata1, ○Hidetaka Torigoe1 (1. Dept. Chem., Grad. Sch. Sci., Tokyo Univ. Sci.)
[3P-362]CENcyclopedia: dynamic landscape of kinetochore architecture throughout the cell cycle
○Aussie Suzuki1,2,3, Yu-Chia Chen1,2,3 (1. McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 2. Carbone Cancer Center, University of Wisconsin-Madison, 3. Molecular and Cellular Pharmacology Graduate Program, University of Wisconsin-Madison)
[3P-363]Analysis of the effects of chromosome length and spindle position on chromosome dynamics during metaphase
○Karen Nagase1, Kinue Kuniyasu1, Kenji Iemura1, Kozo Tanaka1 (1. Dept. of Mol. Oncol., IDAC, Tohoku Univ.)
[3P-364]One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures
○Yu-Chia Chen1,3, Roshan Norman1,4, Mark Burkard1,2,4, Aussie Suzuki1,2,3 (1. McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 2. Carbone Cancer Center, University of Wisconsin-Madison, 3. Molecular and Cellular Pharmacology Graduate Program, University of Wisconsin-Madison, 4. Department of Medicine, University of Wisconsin-Madison)
[3P-365(3MS-15-09)]The Malignant Evolution Illuminated Based on Karyotypic and Transcriptomic Tracing
○Shengyue Lei1,2, Minji Jo1, Utako Kato1, Toru Hirota1,2 (1. Cancer Institute, Japanese Foundation for Cancer Research, 2. Dept. JFCR., Institute of Science Tokyo)
[3P-366]Impact of Age-related Hormonal Changes on CITI Formation during Meiosis
○Soma Ishikawa1, Guiying Chen1, Takaaki Yasuhara1 (1. Kyoto University)
[3P-367]Chromosome segregation machinery involves centromeric DNA transcription
○Anna Suzuki1,2, Saho Matsui1,2, Toru Hirota1,2 (1. Div. Exp. Pathol. Cancer Inst. JFCR, 2. Dept. JFCR., Science Tokyo)
[3P-368]Structural Analysis of Condensin-Dependent Organization of Ribosomal DNA Repeats in Budding Yeast
○Hinako Uno1,2, Shuichi Yanagi1, Yutaro Hori1, Takehiko Kobayashi1,2 (1. IQB, The University of Tokyo, 2. Department of Biological Sciences Graduate School of Science The University of Tokyo)
[3P-369]Mechanistic analysis of Perinucleolar Compartment formation driven by cancer-associated non-coding RNA
○Gideon Kipkemoi1, Fan Kaidi1, Wang Wenhao1, Yutaka Kikuchi1, Haruko Takahashi1 (1. Grad. Sch. Integrated Sci. for Life, Hiroshima University)
[3P-370]DNA condensation mechanism of mycobacterial intrinsically disordered histone-like protein
○Akihito Nishiyama1, Mika Shioya1, Noriyuki Kodera2, Tsuyoshi Shirai3, Masahiro Shimizu4, Yuriko Ozeki1, Amina Kaboso Shaban1, Toru Abe1, Sohkichi Matsumoto1 (1. Bacteriology, Niigata Univ Sch Med., 2. NanoLSI, Kanazawa Univ., 3. Biosci, Nagahama Inst Bio-Sci & Technol., 4. Inst Integr Radiat Nuclear Sci, Kyoto Univ.)
[3P-371]Heat stress-induced nuclear Stress Bodies formation via Ca2+-phosphatidic acid signaling
○Yuji Furutani1, Kyohei Matono1, Takashi Ohtsuki1, Kazunori Watanabe1 (1. Okayama University)
[3P-372(3PS-16-07)]The role of the intrinsically disordered region of Coilin in Cajal body formation and recruitment of its constituent factors
○Ryota Yokoyama1, Shinichi Nakagawa1, Hiroshi Maita1 (1. Hokkaido University)
[3P-373]Characterization of Phase-Separated Droplets Formed by Escherichia coli HU Protein and DNA
○Koichi Yano1, Hironobu Fujita1, Kenta Ichinoe1, Erin Kariya1, Masayuki Suetsugu1 (1. Rikkyo Univ., Coll. Sci., Dept. Life Sci.)
[3P-374]Molecular basis of U-body assembly, a cytoplasmic membrane-less organelle accumulating snRNA, and its contact with p-bodies
○Kantaro Sugi1, Shinichi Nakagawa1,2, Hiroshi Maita1,2 (1. Grad. Sch. of Life Sci., Hokkaido Univ. , 2. Fac. of Pharm. Sci., Hokkaido Univ.)
[3P-375(3AS-07-03)]Oncoproteins as "accelerants": how cancer transcription factors can disrupt higher-order interactions to accelerate target diffusion and stimulate activity
Andrej Paluda1, ○Donald Cameron1 (1. Institute for Quantitative Biosciences, University of Tokyo)
[3P-376]Computational Framework for Automated Detection and Quantification of Phase Separation in Nuclear Bodies
○Atefeh Joudaki1, Makiko Tsutsumi1, Hiroki Kurahashi1 (1. Division of Molecular Genetics, Fujita Health University)
[3P-377]Spatial regulation of ribosomal RNA transcription by phase separation and transition
○Satoru Ide1, Yasuto Murayama2, Hiroshi Kimura1, Kazuhiro Maeshima2 (1. Science Tokyo, 2. National Institute of Genetics)
[3P-378]Evaluation of an improved fluorescent probe to detect phase-separated biomolecules
○Koki Matsumoto1, Sora Kitai2, Kei Makiyama1, Dini Kurnia Ikliptikawati3, Yata Kozuka4, Maho Tobita4, Yoshio Nishiyama2, Shogo Amemori2,3,5, Shih-Cheng Chen6,7, Chien-Hung Yu7,8, Wei-Min Liu9, Motohiro Mizuno2,3,5, Kazuma Ogawa10, Koichi Ogami Ogami11, Kenji Takahashi4, Hiroshi Suzuki11,12,13,14, Richard W Wong3,4,15, Takahiro Soeta2, Masaharu Hazawa3,4,15 (1. Division of Transdisciplinary Sciences, Graduate School of Frontier Science Initiative, Kanazawa University, 2. Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, 3. Institute for Frontier Science Initiative, Kanazawa University, 4. Division of Biological Science and Technology, Graduate School of Natural Science and Technology, Kanazawa University, 5. NanoMaterials Research Institute, Kanazawa University, 6. National Institute of Cancer Research, National Health Research Institutes, 7. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 8. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 9. Department of Chemistry, Fu Jen Catholic University, 10. Graduate School of Medical Sciences, Kanazawa University, 11. Division of Molecular Oncology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 12. Institute for Glyco-Core Research (iGCORE), Nagoya University, 13. Center for One Medicine Innovative Translational Research (COMIT), Nagoya University, 14. Inamori Research Institute for Science (InaRIS), 15. WPI Nano Life Science Institute, Kanazawa University)
[3P-379]Elucidation of Novel Functions of the IQGAP3–MYOVI–Nuclear Actin Complex in Transcriptional Regulation
○Shinya Taniguchi1, Atsushi Kobayashi1, Sunmin Lee1, Takeru Torii1, Satsuki Kawashima1, Goto Toshiyuki1,2, Takahito Nishikata1, Daisuke Miyoshi1, Keiko Kawauchi1 (1. FIRST, Konan Univ., 2. Graduate School of Science, Technology and Innovation, Kobe Univ.)
[3P-380]Regulation of mitotic chromosome dynamics by the interaction between condensin I and RNA.
○Hkaru Nishiguchi1, Kazashi Kato1, Kazuya Kudo1,3, Motoko Takahashi2, Noriko Saito2, Toru Hirota2, Keiji Kimura1 (1. University of Tsukuba, 2. Cancer Institute of the Japanese Foundation for Cancer Research, 3. Kyoto University)
[3P-381]Development of a novel method to artificially degrade target proteins based on chaperone-mediated autophagy and single-chain Fv
○Masami Shiobara1, Yuuma Miyamoto1, Tatsuro Seike2, Tetsuro Watanabe2, Miki Hara-Yokoyama2, Hidetaka Torigoe1 (1. Dept. Chem., Grad. Sch. Sci., Tokyo Univ. Sci., 2. Grad. Sch. Med. Dent. Sci., Inst. Sci. Tokyo)
[3P-382]Surface Discharge Gene Delivery for Ex Vivo Gene Therapy: Regulation of Insulin Expression and In Vivo Response in a Type 1 Diabetes Model
○Nozomu Nishiura1, Takuya Saiki1, Tomoya Otsuka1, Masafumi Jinno1,2, Yoshihisa Ikeda1, Susumu Sato2, Satomi Ihara3 (1. Ehime University, 2. i-Gene Corp, 3. Pearl Corp)
[3P-383]Mechanistic analysis of Msp1-mediated regulation of peroxisomal matrix protein import
○Yoshiki Kogure1, Tomoyuki Numata1, Shunsuke Matsumoto1 (1. Department of Bioscience and Biotechnology, Graduate School Bioresource and Bioenvironmental Sciences, Kyushu University)
[3P-384]The mechanism by which α-arrestin Rod1 recognizes transporters for their glucose-induced endocytosis in budding yeast.
○Seia Naka1, Shoki Fujita1, Masayuki Nakazawa1, Katsuya Gomi1, Takahiro Shintani1 (1. Graduate School of Agricultural Science, Tohoku University)
[3P-385]Heat acclimation alters water transport function in mouse skeletal muscle
○Yuka Kudo1, Nozomi Yazawa1, Keigo Murata1, Taku Nedachi1 (1. Toyo University)
[3P-386]Subcellular localization of Japanese eel endothelial cells-infecting virus Large T antigen
○Koichi Tateishi1, Tetsuya Mizutani1 (1. Tokyo university of Agriculture and Technology)
[3P-387]Protein quality control of thermosensitive nuclear transport factor Importin α
○Yutaka Ogawa1, Naoko Imamoto2 (1. RIKEN Center for Sustainable Resource Science (CSRS), 2. Jikei University of Health Care Sciences, Graduate School of Medical Safety Management)
[3P-388]The regulatory mechanism of endoplasmic reticulum-associated degradation of HMGCR by the vitamin K conversion enzyme UBIAD1
○Ryo Tomioka1, Sho Sano1, Yoshitomo Suhara1, Yoshihisa Hirota1 (1. Graduate School of Engineering and Science, Shibaura Institute of Technology)
[3P-389]Evaluation of SXR transcriptional activity and intracellular localization using NBD or DBD labeled vitamin K derivatives
○Kana Yamaguchi1, Yusei Ando2, Ayaka Yokoi1, Yoshitomo Suhara1,2, Yoshihisa Hirota1,2 (1. Department of System Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, 2. Department of Life Science, Shibaura Institute of Technology)
[3P-390]Mechanistic analysis of oxidative stress–induced lysosomal distribution mediated by the TRPML1 complex
○Shumpei Shimizu1, Yukiko Sasazawa1,2, Yoshiki Miura3, Shinji Saiki4, Nobutaka Hattori1 (1. Juntendo Univ. Dept of Neurology, 2. Juntendo Univ. Institute for Diseases of Old Age, 3. Juntendo Univ. Lab. of Proteomics & Biomolecular Sci., Biomed. Res. Core Facilities, 4. Tsukuba Univ. Dept of Neurology)
[3P-391]Hydroxyurea mitigates reductive stress in the endoplasmic reticulum of budding yeast
○Yuki Takano1, Yuki Kimata-Ishiwata2, Ryo Ushioda3,4, Yukio Kimata2, Kunio Nakatsukasa1 (1. Nagoya City Univ., 2. Nara Institute of Science and Technology, 3. Kyoto Sangyo Univ., 4. Institute for protein Dynamics Kyoto Sangyo Univ.)
[3P-392]Disulfide bond, ubiquitination, and HIF-1a affect the occludin stability, and it leads to regulates the cell proliferation
○Satoshi Tanaka1, Sari Iwasaki2, Koji Taniguchi2 (1. CCDI Hokkaido Univ. Faculty of Med., 2. Dep. Pathol, Hokkaido Univ. Faculty of Med.)
[3P-393]Analysis of HSPB5/PSMC3 Complex Formation Mechanism Induced by Proteasome Inhibition
○Yuzumi Saito1, Kenichi Yoshino2, Yuuki Hioka1, Itsuko Fukuda1, Yasuhito Shirai1, Shuji Ueda1 (1. Graduate School of Agicultural Science, Kobe University, 2. Graduate School of Medicine, Kobe University)
[3P-394]Cellular mechanisms controlling localization of ABCC2 to the apical plasma membrane in polarized epithelial cells.
○Yoshikazu Emi1, Masao Sakaguchi1 (1. University of Hyogo)
[3P-395]USP8 controls VAMP8 deubiquitination for SNARE recycling and cytokinesis
○Marsya Yonna Nurrachma1, Yuzuka Nishioka1, Faiza Ramadhani Rizqullah1,2, Rina Aoki1, Keijun Kakihara3, Masayuki Komada1,3, Toshiaki Fukushima1,3 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Department of Biology, University of Indonesia, 3. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)
[3P-396]Comparative Analysis of Stress Responsiveness among Importin α Family Members
○Hinata Sugasawa1, Takuma Ishikawa1, Noriko Yasuhara2 (1. Nihon University Graduate School of Comprehensive Basic Science Department of Interdisciplinary Science, 2. Nihon Univ. Bioscience)
[3P-397]Effects of anti-influenza activity of Mel56 on mitochondrial functions
○Kazuto Takegawa1,2, Masaki Shoji3, Takashi Kuzuhara3, Yasuo Shinohara1,2 (1. Institute of Advanced Medical Sciences, Tokushima University, 2. Graduate School of Pharmaceutical Sciences, Tokushima University, 3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University)
[3P-398]Deficiency of the peroxisomal protein Tysnd1 and branched-chain fatty acid metabolism
○YUMI MIZUNO1,2, Yosuke Mizuno1, Takeshi Kajihara2 (1. Saitama Med. Univ., Biomed. Res. Center, 2. Saitama Med. Univ., OB/ GYN)
[3P-399]Identification of Mitochondrial SELENOP mRNA-Binding Proteins in the Liver
○Ailesi Nuer1, Hiroaki Takayama1,2, Hein Ko Oo1, Galicia Medina Monserrat Cynthia1, Toshinari Takamura1 (1. Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, 2. Life Science Division, Engineering and Technology Department, Kanazawa University)
[3P-400]Spatial profiling of Golgi-localized glycosyltransferases by comprehensive quantitative analysis
○Katsuki Takagi1, Seigo Tateo1,2, Maho Yagi-Utsumi1,2, Hirokazu Yagi1,2, Koichi Kato1,2 (1. Nagoya City Univ., 2. ExCELLS, NINS)
[3P-401(3PS-03-06)]Regulation of the canonical Wnt signalling pathway by mitochondria-endoplasmic reticulum tethering
○Yui Sakurai-Saito1, Hiroki Sugishita1, Masafumi Tsuboi1, Yukiko Gotoh1, Yusuke Hirabayashi1 (1. The University of Tokyo)
[3P-402]Establishment of the ER-resident protein quality control
○Masaki Matsuo1, Kazuya Tsumagari2, Akiha Kagehira3, Kinnosuke Yahiro4, Makoto Kashima3, Koshi Imami2, Satoshi Ninagawa5,1 (1. Dept. of Bioresour. Sci., Grad. Sch. of Agric. Sci., Kobe Univ. , 2. IMS, RIKEN, 3. Fac. of Sci., Toho Univ., 4. Lab. of Microbiol. & Infect. Control, Kyoto Pharm. Univ., 5. Biosig. Res. Ctr., Kobe Univ.)
[3P-403]"Development of Electron Microscopy Image Analysis Methods for Cryogenic Correlative Light and Electron Microscopy (Cryo-CLEM)
○Yuki Masudomi1, Masahide Kikkawa2, Haruaki Yanagisawa2 (1. Institute of Science Tokyo, 2. University of Tokyo)
[3P-404]Exploring inter-organelle communication at Nucleus–Vacuole Junction in fission yeast
○Akika Murayama1, Shintaro Fujimoto1, Yasushi Tamura2 (1. Graduate School of Science and Engineering, Yamagata University, 2. Faculty of Science, Yamagata University)
[3P-405(3PS-15-06)]A Novel Role of Organelle Contact Sites in the Regulation of Mitochondrial Iron Dynamics
○Hijiri Oshio1, Isshin Shiiba1, Shigeru Yanagi1 (1. Gakushuin university)
[3P-406]Analysis of the activation state of the small GTPase ARFRP1 by a fluorescence-based HPLC assay
○Yukika Kasuya1, Kaho Yoshimoto1, Makoto Araki1, Kenji Kontani1 (1. Meiji Pharmaceutical University)
[3P-407]Functional analysis of Syntaxin6-like protein in vascular plant (SYLK)
○Sara Tode1, Emi Ito2, Yoko Ito2, Yutaro Shimizu3, Wataru Yamori4, Naoya Katsuhama4, Kei Hiruma5, Akihiko Nakano6,7, Tomohiro Uemura1,8 (1. Grad. Sch. Humanities and Sciences, Ochanomizu Univ., 2. IHLS., Ochanomizu Univ., 3. LBM, UMR5200 CNRS/Bordeaux Univ.,, 4. ISAS, Univ. Tokyo, 5. Grad.Sch.Arts and Sciences, Univ. Tokyo, 6. Institute of Integrated Research, Science Tokyo, 7. RIKEN Center for Advanced Photonics, 8. Faculty of Core Research, Natural Science Div., Ochanomizu Univ.)
[3P-408]Control of Mutant mtDNA Heteroplasmy Using DdCBE in Mitochondrial Disease Model Cells
○Hiroki Kameya1, Issei Nakazato2, Kazuto Nakada3, Shin-ichi Arimura2, Fan-Yan Wei1, Haruna Tani1 (1. Institute of Development, Aging and Cancer, Tohoku University, 2. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 3. Faculty of Life and Environmental Sciences, University of Tsukuba)
[3P-409]Membrane Ordering Mediates Ice-Binding Protein Protection: A Design Framework for Non-Freezing Cold Tolerance
○Tamami Kosaka1, Masahiro Kuramochi1,2 (1. Ibaraki Univ., 2. Univ. of Tokyo)
[3P-410]Development of Hepatitis B Virus-Like Particle (VLP)
○Manami Nagae1, Akito Kawase1, Eri Takayama1, Mari Horita1, Masahiro Fujimuro1 (1. Dept. of Cell Biology)
[3P-411]Functional study of a novel MAM protein in mitochondrial dynamics and mitophagy
○Harshini Sheeja Prabhakaran1 (1. National University of Singapore)
[3P-412]Development of gel device and tissue manipulation methods using laser fabrication/manupration.
○Sohei Yamada1, kouga Fujita1, Takuma kureha2, Yasutaka Hanada1 (1. Hirosaki University Mechanical Science and Engineering, 2. Hirosaki University Frontier Materials Chemistry)
[3P-413]The role of lncRNA-Y in osteogenic differentiation through a ceRNA mechanism with microRNAs
○Hiroyuki Yano1, Yano Mami2,6, Ryoji Hamanaka4, Mariko Hida2,3, Noritaka Matsuo2, Hidekatsu Yoshioka2,5 (1. Faculty of Health Sciences, JUNSHIN GAKUEN University, 2. Faculty of Medicine, Oita University, 3. Institute for Research Management, Oita University, 4. Department of Human Sciences, Oita University of Nursing and Human Sciences, 5. Department of Clinical Examination, Shinbeppu Hospital, 6. Department of Health and Medical Sciences, Nippon Bunri University)
[3P-414]Evaluation of Plant Extracts Containing Flavonoids with Regulatory Activities of Tight Junction
○Koki Okada1, Miyu Ito1, Yuri Emoto1, Takeshi Tenno1,2, Natsuko Tenno1, Hidekazu Hiroaki1,2,3 (1. Nagoya Univ., 2. BeCellbar, 3. COMIT)
[3P-415]Exploration and analysis of physical conditions that cause cell destruction in model cartilage tissue
○Shotaro Tanaka1, Fumio Nakamura1 (1. Tokyo Women's Medical University)
[3P-416]Motion Control of the Liposome-Based Biohybrid Swimmer “Chlamy-Lipo” by Modulating Membrane Deformation
○Koichiro Akiyama1, Sota Hamaguchi2, Hiromasa Shiraiwa1, Shunsuke Shiomi1, Daiki Matsunaga2, Masahito Hayashi1,3, Tomoyuki Kaneko1 (1. Grad. Sch. Eng. Sci., Univ. Hosei, 2. Grad. Sch. Sci. Eng., Univ. Osaka, 3. Dept. Biotech. Life Sci., Tokyo Univ. Agri. Tech.)
[3P-417]Induction of smooth muscle cell differentiation of human myofibroblasts using type I collagen gel matrix
○Yuta Shimizu1, Takanori Kihara1 (1. The University of Kitakyushu)
[3P-418]Effects of TGF-β on the modes of epithelial collective migration
○Tomoaki NAGAI1, Hirokazu Kaji2, Michiru Nishita1 (1. Fukushima Medical University School of Medicine, 2. Institute of Science Tokyo)
[3P-419]Long-range transport and path control of micro-objects using Chlamydomonas-Encapsulated Liposomes.
○Hiromasa Shiraiwa1, Koichiro Akiyama1, Masahito Hayashi2,1, Tomoyuki Kaneko1 (1. Hosei Univ., 2. Tokyo Univ.Agri.Tech)
[3P-420]Exploring the in vivo functions of Sorbs family proteins, Sorbs1 (CAP) and Sorbs2 (ArgBP2), using medaka
○Kentaro Kawai1, Yasuhisa Kimura1, Masato Kinoshita2, Noriyuki Kioka1 (1. Kyoto Univ., 2. Kyoto University)
[3P-421]Effect of FBS on protein expression in cultured cell
○Natsuko Goda1, Yuri Emoto1, Koki Okada1, Takeshi Tenno1,2, Hidekazu Hiroaki1,2,3 (1. Grad. Sch. Pharm. Sci., Nagoya Univ., 2. BeCellbar. LCC, 3. NU-COMIT)
[3P-422]KAT-Dependent Energy Partitioning Governs Contraction-Induced Fatigue Resistance: Isoform Mapping in Primary Mouse 3D Muscle
○Hiroaki Takada1, Shion Osana2, Ryoichi Nagatomi1 (1. Tohoku University, 2. Kokushikan University)
[3P-423]Evaluation of Host Intestinal Cell Interactions with Microbial Adhesion
Wei-Hsuan Hsu2, Cheng-Hao Huang2, Xiao-Yang Chu2, ○Bao-Hong Lee1 (1. National Chiayi University, 2. National Cheng Kung University)
[3P-424]Dissecting Epithelial Folding Mechanism via Lateral Constriction
○Haruka Yoshizawa1, Kazuki Kuroda1, Yu Watanabe2, Erina Kuranaga1,2 (1. Kyoto University, 2. Tohoku University)
[3P-425]Midbody-dependent polarization of the C. elegans germline lineage
○Kazunori Yamamoto1, Fumio Motegi1 (1. Hokkaido Univ. Institute for Genetic Medicine)
[3P-426]MTCL1 stabilizes microtubules by promoting repair of microtubule lattice defects
○Kentaro Ito1, Atsushi Suzuki1 (1. Graduate School of Medical Life Science, Yokohama City University)
[3P-427]Regulation of microtubules by mitochondrial protein phosphatase PGAM5 during mitophagy
○Akimi Inoue1, Taiki Baba1, Jun Takouda1, Suga Hiroyuki1, Hirakawa Ayano1, Kohsuke Kakeda1, Susumu Tanimura1 (1. Cell Regulation, Grad. Sch. Biomed. Sci., Nagasaki Univ.)
[3P-428(3PS-18-06)]ESCRT III-Driven Repair of Nuclear Rupture Lifts Transcriptional Arrest in Lamin-Related Cardiomyopathy
○Atsuki En1,2, Melanie Gucwa1, Cara Barnett1, Nicole Weaver1, Kohta Ikegami1 (1. Cincinnati Children's Hospital Medical Center, 2. Yokohama City Univ.)
[3P-429(3AS-01-08)]Elucidating the mechanisms regulating cell shape through photochemical manipulation
○Shohei Yamamoto1 (1. The University of Tokyo)
[3P-430]Spatial map of protein-protein binding based correlation analysis of molecular localization by multiplexed super-resolution imaging, IRIS
○Tai Kiuchi1, Dimitrios Vavylonis3, Naoki Watanabe2 (1. Kyoto University Faculty of Medicine, 2. Kyoto Univ. Graduate School of Biostudies, 3. Lehigh Univ. Physics Department)
[3P-431]Programmed cell death regulation by α-tubulin detyrosination during influenza A virus infection.
○Joyeeta Kar1, Kotono Nakayama2, Mikako Hirohama3, Atsushi KAWAGUCHI1,2,3 (1. Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2. School of Medicine, University of Tsukuba, 3. Institute of Medicine, University of Tsukuba)
[3P-432]FKBP–FRB System-Based Analysis of Cellular Protrusions in the I-BAR Domain Proteins
○Ryouma Kitade1, Hiroki Kawana1, Shiro Suetsugu1 (1. Division of Biological Science Graduate School of Science and Technology, Nara Institute of Science and Technology)
[3P-433]Exploring molecular mechanisms regulating cholesterol accumulation in the plasma membranes of focal adhesions
○Hirofumi Ichinose1, Yasuhisa Kimura1, Noriyuki Kioka1 (1. Kyoto University)
[3P-436]Centrosome protein CEP169 regulates proper orientation of the mitotic spindle axis
○Kousei Yamamoto1, Shunsuke Imai1, Yasuhiko Terada1 (1. Dept. of Chem. and Biochem., Grad. Sch. of Adv. Sci. and Eng., Univ. of Waseda)
[3P-437(3AS-07-04)]A genome-wide screen reveals novel regulators of centriole-independent spindle assembly
○Muhammad Hamzah1, Midori Ohta1, Franz Meitinger1 (1. Okinawa Institute of Science and Technology)
[3P-438]p53 prevents multipolar spindle formation induced by inhibition of CEP169 expression
○Kanako Terada1, Midori Ishige1, Anju Haeno1, Shunsuke Imai1, Misaki Nakayama1, Yasuhiko Terada1 (1. Dept. of Chem. and Biochem., Grad. Sch. of Adv. Sci. and Eng., Univ. of Waseda)
[3P-439]Functional genetics with a hypomorphic CENP-C mutant reveals a regulatory system for chromosome congression
○JIAHANG MIAO1, Masatoshi Hara1,2, Kuan-Chung Su3, Heather R. Keys3, Weixia Kong1, Yusuke Takenoshita1, Iain M. Cheeseman3,4, Tatsuo Fukagawa1 (1. The University of Osaka, 2. The University of Tokyo, 3. Whitehead Institute for Biomedical Research, 4. Massachusetts Institute of Technology)
[3P-440]Ultradian oscillations of Hes1 regulate proliferation of mouse neural stem cells
○Satomi Tsukamoto1, Taimu Masaki1, Ayumi Goto1, Yuki Maeda1, Ryoichiro Kageyama1 (1. RIKEN BDR)
[3P-441(3AS-01-07)]Development of an Optogenetic Tool for Controlling the Spindle Assembly Checkpoint (Opto-SAC) in Eukaryotic Cells
○Chijun An1, Yuhei Goto1, Kazuhiro Aoki1 (1. Graduate School of Biostudies, Kyoto University)
[3P-442]GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer
○Yuki Kito1, Tania González-Robles1,2,3, Sharon Kaisari1,3, Juhee Pae1, Sheena Faye Garcia1, Juliana Ortiz-Pacheco1,5, Beatrix Ueberheide1,5, Ruth Lehmann4, Antonio Marzio1, Gergely Rona6, Michele Pagano1,3 (1. Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, 2. Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, 3. Howard Hughes Medical Institute, New York University Grossman School of Medicine, 4. Department of Cell Biology, New York University Grossman School of Medicine, 5. Proteomics Laboratory, New York University Grossman School of Medicine, 6. Research Centre for Natural Sciences)
[3P-443]Development of a Food-Grade Culture Medium for Plant Cell-Based Food Production and Achievement of Stable Cell Proliferation
○Moeto Matsumoto1, Keisuke Igarashi1 (1. Tohoku Univ.)
[3P-444]The impact of intracellular GTP synthesis on cell proliferation and migration
○Taiki Ashizawa1, Masashi Oshima2, Kazuma Tada3, Atsuo T Sasaki2, Yoshihisa Hirota1,2,3 (1. Grad. Sch. Eng. and Sci., Shibaura Inst. of Tech., 2. University of Cincinnati College of Medicine, 3. Dep. Life. Sci., Shibaura Inst. of Tech.)
[3P-445]The role of Cdh1 in the regulation of larval muscle cell number during Halocynthia roretzi embryogenesis
○Takuya Setoguchi1 (1. Graduate school of Tokyo Metropolitan University)
[3P-446]The molecular function of PABPN1 in spindle bipolarization
○Saito Akatsu1, Hina Nishino1, Hideki Yokoyama1 (1. National Insutitute of Technology, Ibaraki College)
[3P-447(3AS-01-02)]Vulnerable regulation of chromosome segregation in cancers
○Nana Kamakura1,2, Toru Hirota1,2 (1. Japanese Foundation of Cancer Research, 2. Institute of Science Tokyo)
[3P-448]Induction of stationary phase entry from G1 and spore formation by inositol in fission yeast
○Ryu Sawai1, Ema Inaba1, Kohei Yamada1, Shunsuke Shimazaki1, Ayumu Yamamoto1 (1. Shizuoka Univ.)
[3P-449]5-Aminolevulinic acid-Mediated Growth Inhibition and the Underlying Molecular Mechanisms in an Early Oncogenesis Model.
○Katsumi Saito1, Seiya Watanabe1, Taku Chibazakura1 (1. Dept. Biosci., Tokyo Univ. Agric.)
[3P-450]Mechanism of Cell Proliferation Suppression via Sustained ERK Activation by Catfish Egg Lectin
○Kohtaro Kikuchi1, Shigeki Sugawara1, Hazuki Kanno1, Takeo Tatsuta1, Masahiro Hosono1 (1. Tohoku Medical and Pharmaceutial University)
[3P-451]Role of Prohibitin and Prohibitin 2 on the chondrocyte differentiation
○Yu Hiromoto1, Kana Fujimoto1, Ibuki Morimoto1, Ryota Hirose1, Ryuji Hara1, Ryo Igarashi1, Nobuyuki Shimohata2,1, Toshiya Hayano1 (1. Ritsumeikan university, 2. Kanagawa Univ. of Human Services)
[3P-452]Mechanism of skeletal muscle function regulation mediated by hypusination of proteins
○Satoshi Ohgiya1, Takashi Sasaki1, Ryuuitirou Satou1, Yoshio Yamauchi1 (1. The University of Tokyo)
[3P-453]Identification of specific substrates for PKC isoforms for measuring the intracellular activity of each isoform
○Saki Toi1, Junqi Liang1, Junna Nakazono1, Dai Sakamoto1, Naoyuki Sugiyama1,2, Yasushi Ishihama1,3 (1. Grad. Sch. Pharm.Sci., Kyoto Univ, 2. mics Research Center, National Cerebral and Cardiovascular Center, 3. National Institutes of Biomedical Innovation, Health and Nutrition)
[3P-454]Osmotic enhancement of the phosphorylation cascade in the yeast stress-responsive MAPK pathway
○Kazuo Tatebayashi1, Haruo Saito1 (1. Inst. Med.Sci, The Univ. of Tokyo)
[3P-455]Mechanism of selective degradation of E2 enzymes via TRIP12-dependent K29/K48 branched ubiquitin chain
○Ryotaro Chiba1,2, Asato Maeda3, Kosuke Ogata3, Yasushi Ishihama3, Fumiaki Ohtake1,2 (1. Graduate School of Pharmaceutical Sciences, Hoshi University, 2. Institute for Advanced Life Sciences, Hoshi University , 3. Graduate School of Pharmaceutical Sciences, Kyoto University)
[3P-456]p38 augments TAB1 tyrosine phosphorylation via Src activation
○Iimi Onuma1, Yusuke Iwata1, Mai Nakada1, Hiroyuki Iwahara1, Kanako Natori1, Arisa Kondo1, Yue Zhou1, Satoru Yokoyama1, Hiroaki Sakurai1 (1. Univ. Toyama.)
[3P-457]Regulation of Ephexin4 GEF activity by phosphorylation at Ser41 residue
○Mayu Murata1, Ryuji Yasutake, Ryuzaburo Yuki1, Yuji Nakayama1 (1. Kyoto Pharmaceutical University)
[3P-458]Analysis of DUBs regulating PROTAC-induced degradation of BRD4
○ICHIGO KATO1,2, Fumiaki Ohtake1,2 (1. Institute for Advanced Life Sciences, Hoshi University, 2. Graduate school of Pharmaceutical Sciences, Hoshi University)
[3P-459]The functional differences of genes for stress-activated protein kinases (SAPKs) in HeLa cells and THP-1 cells.
○Chihiro Ito1, Akane Tamura1, Mirei Yamamoto1, Mitsuki Tomita1, Nozomi Yokota1, Taichi Sato1, Nanoka Nakamura1, Shinobu Fujii1, Toshihiro Fujii1, Rikiro Fukunaga1 (1. Osaka Medical and Pharmaceutical University)
[3P-460]Deubiquitinating enzyme USP5 promotes stress granule disassembly by modulating the interaction of VCP with a SG protein G3BP1
○SUWIJAK MOOLCHUA1, Masayuki Komada1,2, Toshiaki Fukushima1,2 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)
[3P-461]Regulation of USP8 deubiquitinase activity and its dysregulation by Cushing's disease mutations
○Rina Aoki1, Yusuke Takehara1, Keijun Kakihara2, Kodai Kato1, Masayuki Komada1,2, Toshiaki Fukushima1,2 (1. Sch. Life Sci. Tech., Science Tokyo, 2. Cell Biol. Cent., Science Tokyo)
[3P-462]Functional Analysis of E3 Ubiquitin Ligases Encoded by Cancer Viruses
○ASUKA SHUKUYA1, TERUHISA KAMIYA1, KOHEI HOSOKAWA1, MASAHIRO FUJIMURO1 (1. Department of Cell Biology)
[3P-463]Regulation of the HOG pathway during adaptation tohyperosmolarity .
○Kotaro Satake1, Tsutomu Kishi2 (1. Graduate School of Engineering, Nihon University, 2. School of Engineering, Nihon University)
[3P-464]Fluorescence imaging of the heavy metal stress response mechanism in zebrafish
○Yuri Maekawa1, Hayato Eugene Morita1 (1. Department of Material Science, Graduate School of Science, Josai University)
[3P-465]Exploring genes involved in glorin signalling in Polysphondylium violaceum by restriction enzyme mediated-integration
○Tae Washizu1, Takaaki Narita2 (1. Grad. Sch. of Adv. Eng., Chiba Tech, 2. Dep. of Life Sci., Fac. of Adv. Eng., Chiba Tech)
[3P-466]Fluorescence imaging for the heavy metal stress response in Xenopus Tropicalis
○Takahiro Ishii1, Hayato Eugene Morita1 (1. Department of Material Science, Graduate School of Science, Josai University Graduate School)
[3P-467]The role of lipid mediators in cell membrane repair
○Yuan CHI1, Kazuko Saeki1, Takehiko Yokomizo1 (1. Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.)
[3P-468]Elucidation of the mechanism of Polycystic Ovary Syndrome (PCOS) onset mediated by nuclear receptors activation through PFAS
○Aiko Nakatsuka1, Azusa Kawai1, Kazuhiro Siizaki2, Jun Nakamura3, Masanobu Kawanishi1 (1. Graduate School of Science, Osaka Metropolitan University , 2. Graduate School of Life Science, Toyo University, 3. Graduate School of Veterinary Science, Osaka Metropolitan University)
[3P-469]Comparative analysis of AhR activity and cytotoxicity of tryptophan metabolites and tapinaroph —Revisiting the biological importance of endogenous ligands
○Emiri Yasuda1, Jun Nakamura2, Masanobu Kawanishi1 (1. Graduate School of Science, Osaka Metropolitan University, 2. Graduate School of Veterinary Science, Osaka Metropolitan University)
[3P-470]AhR Activity of Kynurenine, FICZ, and Tapinarof: A Comparative Analysis in Canonical and Non-canonical Pathways
○Azusa Kawai1, Jun Nakamura2, Masanobu Kawanishi1 (1. Graduate School of Science, Osaka Metropolitan University, 2. Graduate School of Veterinary Science, Osaka Metropolitan University)
[3P-471]Analysis of the mechanism of suppression of Selenoprotein P expression by the culture supernatant of SH-SY5Y cells
○Ari Honda1, Yuichiro Mita2, Kayoko Shimomura1, Noriko Noguchi1 (1. Doshisha University, 2. Doshisha Univ.)
[3P-472]Engneering E.coli Genome-integrated Synthetic Genetic Circuits using Cell-to-cell communication by Quorum-sensing
○Ayame Taira1, Tomohiro Nawata2, Toshiki Saito1, Koko Nakata2, Shunsuke Takahashi1 (1. Div. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ., 2. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ.)
[3P-473]Visualization of Steady-State Receptor Activity in Escherichia coli using Halo tag
○Fumitoshi Hirano1, Yumiko Uchida1, Akihiko Ishijima1, Hajime Fukuoka1 (1. Grad. Sch. Frontier Biosci. Osaka Univ.)
[3P-474]Correlation between methylation levels of chemoreceptors and repellent response of E. coli
○Tomoya Sumino1, Yoichi Kuroki1, Yumiko Uchida1, Akihiko Ishijima1, Hajime Fukuoka1 (1. Graduate School of Frontier Biosciences Osaka Univ.)
[3P-475]Regulation of myokine and extracellular vesicle-encapsulated microRNA expression in skeletal muscle by heat stress
○Nozomi Yazawa1, Yuka Kudo1, Yuho Mizuseki1, Keigo Murata1, Taku Nedachi1 (1. Toyo University)
[3P-476]NRK Kinase as a Regulator of Structural Stability and Autophagic Signaling in Cells
○Kimitoshi Denda1, Toshiaki Fukushima1,2, Beni Lestari1, Masayuki Komada1,2, Nobuhiro Hayashi1, Lingyan Fu2, Yoshihisa Matsumoto2, Mikio Shimada2,3 (1. Sch. of Life Sci. and Tech., Institute of Science Tokyo, 2. Inst. of Integrated Res., Institute of Science Tokyo, 3. Radiation Effects Research Foundation)
[3P-477]Analysis of the Mechanism of Cell-Specific Insulin Signal Activation via Persulfide
○Moe Hattori1, Yuichiro Mita2, Misuzu Nakamura1, Ririka Kamata1, Noriko Noguchi1 (1. Doshisha University, 2. Doshisha Univ.)
[3P-478]Comprehensive study on oxidative stress-promoted expression of inflammatory cytokine/cytokine receptor in fibroblast-like synoviocytes derived from mouse temporomandibular joint
○Kanna Asanuma1, Seiji Yokota2, Naoyuki Chosa2, Emiko Kikuchi1, Karen Abe1, Kazuro Satoh1, Akira Ishisaki2 (1. Division of Orthodontics, Department of Developmental Oral Health Science, School of Dentistry, Iwate Medical University, 2. Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University)
[3P-479]Deciphering DFz2/DFz4-mediated Wnt Signaling in Axon Guidance of the BLT Command Neuron in Drosophila Larvae
○Chunyang Zhang1 (1. The University of Tokyo)
[3P-480]Honokiol, a natural small compounds, effects on human leukemia cells
○MIKI TAKAHASHI1, Masato Ota1 (1. Japan Women's University)
[3P-481]Effects of excitatory amino acids on neurite outgrowth in PC-12 cells
○Ryuta Fujioka1, Akira Okamoto1, Takuya Morikawa2, Luoming Fan2, Shiroh Miura3, Hiroki Shibata2 (1. Department of Food and Nutrition, Beppu University Junior College., 2. Division of Genomics, Medical Institute of Bioregulation, Kyushu University., 3. Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine.)
[3P-482]Analysis of endocytosis dysfunction and lysosomal function in senescent cells
○Akira Mitsuishi1, Noriko Yano1, Rina Kunishige2, Masayuki Murata2,3, Fumi Kano2 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, 3. International Research Center for Neurointelligence, Institutes for Advanced Study, The University of Tokyo)
[3P-483]Screening for chemical compounds that specifically remove senescent cells accompanied by SASP
○Risako Uehara1, Koichi Kemmochi1, Nodoka Suzuki1, Yasuhiko Terada1 (1. Dept. of Chem. and Biochem., Grad. Sch. of Adv. Sci. and Eng., Univ. of Waseda)
[3P-484]Elucidation of the mechanism by which IFNγ responsiveness is attenuated in senescent cells
○Kiyotaka Oshikawa1, Atsushi Hatano1, Masaki Matsumoto1 (1. Dept. Omics and Systems Biology, Niigata Univ.)
[3P-485]Disturbed proteostasis is the key event that triggers cellular senescence through the regulation of chromatin organization and genome stability
○Keisuke Tanabe1, Yuki Takauji1, Haruna Miyashita1, Takuma Katakawa1, Saeri Fujii1, Atsuki En1,2, Michihiko Fujii1 (1. Yokohama city university , 2. Cincinnati Children's Hospital Medical Center)
[3P-486]Analysis of the Complex Mechanisms of Cancer Cell Death Induced by Synthetic Melanin
○Yoshiyuki Kawamoto1, Arisa Imoto1, Kanon Kaiho1, Kozue Takeda1 (1. Chubu Univ.)
[3P-488]Iron exacerbates congenital cholestatic liver injury via bile acid-induced ferroptosis
○Yudai Ohta1,2, Yohei Kanamori1, Toshiro Moroishi2 (1. Dept. of Mol. Pharmacol., Grad. Sch. of Life. Sci., Univ. of Kumamoto, 2. Div. of Cellular Dynamics, Med. Res. Lab., Inst. of Integr. Res., Inst. of Science Tokyo,)
[3P-489]Establishment of a Ferroptosis and ROS Detection System in HeLa Cells for GPx4 Inhibitor Evaluation
○Ibuki Nakamura1, Yuki Yoshiizumi1, Takashi Kodama2, Kyoko Furuita2, Miyanoiri Yohei2, Chojiro Kojima1 (1. Yokohama national university, 2. Institute for Protein Research, The University of Osaka)
[3P-490]Elucidation of the mechanism by which stress-responsive amino acid transporter SLC7A11 promotes oxidative stress-induced parthanatos
○Ryo Ito1, Yusuke Hirata1, Takuya Noguchi1,2, Atsushi Matsuzawa1 (1. Tohoku Univ., 2. Iwate Medical Univ.)
[3P-491]Neurotoxicity of adrenaline under oxidative stress conditions
○Kazuki Kozakai1, Tsai Cheng-Ta1,2,3, Chia Yuan Hsu1,3, Shion Osana4, Masaki Kaneko1,2,3, Masaru Sakurai1,2,4, Katsuhiko Hata1,2,3,4 (1. Research Center for Mathematical Medicine, 2. Graduate School of Physical Education, Kokushikan University, 3. Molecular Nutrition Institute, Inc., 4. Kokushikan University, Faculty of Physical Education, Department of Sports Medicine)
[3P-492]Overexpressing the ribosome collision sensor ZNF598 promotes cellular senescence in the human dermal fibroblast
○Tasuku Inaba1,2, Toru Suzuki2, Chisato Kikuguchi2, Yoshitaka Matsuo2, Toshifumi Inada1,2 (1. Graduate School of Science, The University of Tokyo, 2. Institute of Medical Science, The University of Tokyo)
[3P-493]A Unique Cell Death Mediated by Cyclo-Octasulfur
○YUJUE WANG1, Takaaki Akaike1, Hozumi Motohashi1 (1. TOHOKU UNIVERSITY)
[3P-494]The role of collagen processing in collagen fiber changes associated with cellular aging
○Ryo Onda1, Yuki Shibaike2, Katsura Sano2, Shogo Suzuki2, Toshiaki Tanaka1 (1. Institute of Science Tokyo, 2. ALBION Co., Ltd.)
[3P-495]The Contribution of FGF11 to Chemotherapeutic Response of cisplatin in Osteosarcoma
○ji soo Yu1,2, Hyung-Soon Yim1, Se-Jin Ji1,2, Seung Min Shin1,3, Young Jun An1, Won-Kyo Jung2, Jung-Hyun Lee1, Kyeong Won Lee1 (1. Korea Institute of Ocean Science & Technology, 2. Department of Biomedical Engineering, Pukyong National University, 3. Department of Chemistry, Pukyong National University)
[3P-496]Identification of Lifespan-Extending Factors via Cell–Cell Communication in the Schizosaccharomyces pombe mot1-1 Mutant
Miori Saito1, Yukiya Watanabe1, Taiga Nozawa1, Ayumu Iwaki1, Kenta Karasawa1, Shizuka Kariya1, Rikako Sato1, Hiroaki Takaku1, ○Harutake Yamazaki1 (1. Niigata University of Pharmacy and Medical and Applied Life Sciences)
[3P-497]Causes of Genomic Instability Leading to Cellular Senescence: Altered Localization of Sir2 by Extrachromosomal Circular DNA
○Yoshio Yamamuro1, Yuta Uneme1,2,3, Sihan Li4, Toshifumi Inada4, Takehiko Kobayashi1 (1. U Tokyo, IQB, Genome Reg., 2. U Tokyo, Grad. Sch. Sci., Biol. Sci., 3. JFCR, Cancer Epigenomics, 4. U Tokyo, IMSUT, Div. RNA & Gene Reg.)
[3P-498]Mitochondrial Hyper-Acetylation Induced by an Engineered Acetyltransferase Promotes Cellular Senescence
○Tadahiro Shimazu Shimazu1, Ayane Kataoka1, Takehiro Suzuki1, Naoshi Dohmae1, Yoichi Shinkai1 (1. RIKEN)
[3P-499]High Glucose Downregulates c-FLIP and Enhances TNFα-Induced Apoptosis in Monocytes
○Li-Wen Fang1, Hsin-Jen Tsai1,2 (1. Dept. of Nutr., I-Shou Univ., Kaohsiung, Taiwan., 2. Dept. of Health Manag., I-Shou Univ., Kaohsiung, Taiwan.)
[3P-500]Analysis of cell-death-mode fate determination mechanisms by long non-coding RNA Neat1_1
○Tetsuya Miyoshi1, Akira Sato1,2,3,4 (1. Department of Biochemistry and Molecular Biology, Tokyo University of Science, Graduate School of Pharmaceutical Sciences., 2. Department of Biochemistry and Molecular Biology, Tokyo University of Science, Faculty of Pharmaceutical Sciences., 3. Division of Biological Fluctuations, Research Institute for Science and Technology, Tokyo University of Science, 4. Divisiont of Medical Data Sciences, Research Institute for Science and Technology, Tokyo University of Science.)
[3P-501]The effect of nicotinamide on IGF2R gene expression during the differentiation induction of HL-60 leukemia cells.
○Chieri Ida1 (1. University of Toyama)
[3P-502]Genetic analysis of Eiger/TNF-mediated JNK activation in tumor-suppressive cell competition
○Asuka Catherine Kido1, Shuiwo Mach Mak2, Haolin Xie2, Tomoya Ueda2, Senri Sakaino3,2, Haruhiko Sato1,2, Shunki Takao1,2, Mai Nakamura2, Ryo Matsumoto2, Jiaqi Li2, Weiran Ye2, Tomoe Kobayashi4, Makoto Matsuyama4, Shu Kondo5, Keita Miyoshi6, Kuniaki Saito6, Kiichiro Taniguchi2, Tatsushi Igaki1,2 (1. Grad. Sch. and Fac. of Pharm. Sci., Kyoto Univ., 2. Grad. Sch. of Biostudies, Kyoto Univ., 3. Fac. of Sci., Kyoto Univ., 4. Div. of Mol. Genet. Shigei Med. Res. Inst., 5. Dept. of Biol. Sci. & Tech., Tokyo Univ. of Sci., 6. Invertbr. Genet. Lab, Natl. Inst. of Genet.)
[3P-503]Genetic analysis of the elimination mechanism of ER-stressed cells in cell competition
○Sakura Ishihara1, Rina Nagata1, Bungo Kakemura1, Mai Nakamura1, Shu Kondo2,3, Kuniaki Saito3, Tomoe Kobayashi4, Makoto Matsuyama4, Tatsushi Igaki1 (1. Kyoto University., 2. Tokyo Univ of Science., 3. National Inst of Genetics., 4. Shigei Medical Research Institute.)
[3P-504]Anti-aging effect of sulfated galactans from red seaweed Gracilaria fisheri extract on human dermal fibroblast
○Benjamart Pratoomthai1, Phennapa Promthale2, Warachin Gangnonngiw3, Thirawass Phumyoo1, Kanokpan Wongprasert4 (1. Navamindradhiraj University, 2. Rangsit University, 3. National Science and Technology Development Agency, 4. Mahidol University)
[3P-505]The Effect of Tuna Blood Hydrolysate with 1.5% Pepsin on Cell Apoptosis and Autophagy in SH-SY5Y Cells
○Veerawat Sansri1, Morakot Sroyraya2 (1. Navamindradhiraj University, 2. Mahidol University)
[3P-506]Inhibition of DHCR7 prevents ferroptosis via accumulation of 7-dehydrocholesterol
○Tadayoshi Karasawa1, Yamada Naoya1, Masafumi Takahashi1 (1. Division of Inflammation Researc, Center for Molecular Medicine, Jichi Medical University)
[3P-507]The role of DNA sensors in cellular responses to ectopic DNA
○Akiko Sakai1, Kanako Watanabe2, Hideaki Matsui1 (1. Niigata Univ. Brain Res. Inst., 2. Niigata Univ. Sch. Med. Dent.)
[3P-508]Mechanism of Cellular Dysfunction Induced by the Accumulation of Damaged NADH
○Yuto Hyakuda1, Kodai Takahashi1, Nobuhito Goda2 (1. Dept. of Life Sci. and Med Biosci., Adv. Sci. and Eng., Waseda Univ., 2. Fac. of Sci. and Eng., Waseda Univ.)
[3P-509]The responsiveness of various senolytic drugs to senescent bovine endometrial stromal cells and their potential for improving fertility.
○Kaede Ito1, Yosuke Sugino1, Kohei Kawano1, Suzuno Senda2, Rei Ichikawa2, Sho Nakamura2, Satoshi Kato3, shuichi Matsuyama2, Koji Kimura1 (1. Okayama University graduate school of Environmental, Life, Natural Science and Technology, 2. Nagoya University graduate school of Bioagricultural Science, 3. Gunma Prefectural livestock experiment station)
[3P-510]Induction of Partial Reprogramming to Human Senescent Cells by Frog Oocytes
○Kosei Kitayama1, Shuntaro Nishizaki1, Nao Koyabu2, Karin Fujiwara2, Nobuhiko Yamauchi1, Kei Miyamoto1 (1. Kyushu Univercity, 2. Kindai Univercity)
[3P-511]Drug sensitivity of tumor cells to topoisomerase I inhibitor irinotecan and topoisomerase II inhibitor etoposide under ARH3 deficiency
○mengting xu1, Yongkang Shao1, Ziqian Huang1, Ankitha Vadi Velu1, Barkha Saraswat1, Ying Tong1, Mitsuko Masutani1 (1. Nagasaki University)
[3P-512]Possible involvement of MacroD1 in DNA damage response in tumor cells through regulating PAR/Mar levels
○Ziqian Huang1, Yongkang Shao1, Mengting Xu1, Goutham Sivanandan1, Ankitha Vadi Velu1, Zongxiang Zhang1, Barkha Saraswat1, Ying Tong1, Mitsuko Masutani1 (1. Nagasaki University)
[3P-513]Decidualization failure in infertile women: impact on implantation and trophoblast differentiation
○Taishi Fujimura1, isao tamura1, Toshihide Yoneda1, amon shiroshita1, norihiro sugino1 (1. Department of Obstetrics and Gynecology Yamaguchi University Graduate school of Medicine)
[3P-514]Artificial reduction of ZNF746/PARIS transcriptional repressor expression by antisense oligonucleotide administration
○Eiko Yoshinaga1, Yuka Nozaki2, Yuhei Mizunoe2, Yoshikazu Higami2, Hidetaka Torigoe1 (1. Dept. Chem., Grad. Sch. Sci., Tokyo Univ. Sci., 2. Grad. Sch. Pharm. Sci., Tokyo Univ. Sci.)
[3P-515]Complementary roles of the lipoprotein receptor LRP1 in efferocytosis of ARPE-19 cells
○Hinami Sashi1, Hideki Hayashi1, Yasuto Hikima 1, Yui Iwatani1, Yoshiyuki Moriyama1, Norio Takagi1 (1. Dept. Appl. Biochem., Sch. of Pharm., Tokyo Univ. Pharm. Life Sci.)
[3P-516]Study on amino acid sensing system in the Pib2 pathway for TORC1 activation via ITC measurements
○Asako SAKAI1, Yasuhiro Araki2, Takeshi Noda2,1 (1. Graduate School of Frontier Biosciences, The University of Osaka, 2. Graduate School of Dentistry, The University of Osaka)
[3P-517]Photoinduced Control of Plasma Membrane Potential by Charge Separation of Spiropyran-Derivative
○Hayato Takagi1, Eri Sakuda2, Tomohiro Numata3, Tatsuya Murakami1,4 (1. Toyama Prefectural University, 2. Graduate School of Engineering, Nagasaki University , 3. Graduate School of Medicine, Akita University, 4. iCeMS, Kyoto University)
[3P-518]Cellular Iron, as an Epidermal Differentiation Regulator in Keratinocytes
○JUNYA ABE1, YOHEI HIRAI1 (1. Kwansei Gakuin University)
[3P-519]Effect of liquiritin on mucin production and secretion in human airway cell lines
○Jun Iwashita1, Ryoma Yoshio1 (1. Akita prefectural university)
[3P-520]Availability of single amino acid contiguous sequence (PolyX) unknown to language models
○Yukihiro Murase1, Hisao Moriya1 (1. Okayama Univ.)
[3P-521]A highly accurate method for quantitative measurement of fungal genomic DNA using the modified adenine-HPLC method
○yoshifumi ohyama1, Mamiko Shimamura1, Yuki Asami1, Dieter M Tourlousse2, Yuji Sekiguchi2, Naoyuki Togawa3, Koji Narita3, Naoki Hayashi3, Hiroko Kawasaki1, Takamasa Miura1 (1. National Institute of Technology and Evaluation, 2. National Institute of Advanced Industrial Science and Technology, 3. Japan Microbiome Consortium)
[3P-522]Label-Free Visualization of Stepwise Molecular Dynamics in Elastic Fiber Assembly by Raman Spectroscopy
○Keita Muraie1, Kaori Sugiyama2, Yusuke Oshima1 (1. Univ Toyama, 2. National Defense Medical College)
[3P-523]A red color fluorescence lifetime-based ATP biosensor working at 37 °C
○Tri Minh Phan1, B.M.K.D Basnayake1, Cong Quang Vu2, Satoshi Arai1,2 (1. Graduate School of Frontier Science Initiative, Kanazawa University , 2. WPI Nano Life Science Institute)
[3P-524]Development of the Smart Bioreactor “ACKNOS”
○Atsushi Yamada1, Yoshiaki Kinosita2, Takafumi Sakuma1, Tatsuya Iida2, Yosuke Hara1, Akira Takahira1, Masataka Shinogi2, Rikiya Watanabe2 (1. Seiko Future Creation Inc. , 2. PRI,RIKEN)
[3P-525]A novel effector downstream of p130Cas within the c-Src/p130Cas signaling axis regulates osteoclastic bone resorption
○AONAN LI1, JING GAO1, Eijiro JIMI1,2 (1. Lab. of Mol.Cell.Biochem., Fac of Dent. Sci., Univ. of Kyushu, 2. OBT Research Center, Fac of Dent. Sci., Univ. of Kyushu)
[3P-526]Is polyphosphate synthesis ‘in vacuoles’ important for cellular proliferation in Schizosaccharomyces pombe?
○Hiyori Takechi1, Kaho Fujiyama1, Kanon Tsukuda2, Rumi Okuyama1, Kaoru Takegawa3, Kojiro Takeda1,2 (1. Konan University Graduate School, 2. Konan University, 3. Kyushu university)
[3P-527]Functional characterization of the human phosphate exporter Xpr1 in fission yeast and development of a drug screening platform
○Nene Sakurai1, Kouta Yamamoto2, Hiyori Takechi1, Masahiro Takado3, Tomohiro Matsumoto3, Kojiro Takeda1,2 (1. Konan University Graduate School, 2. Konan University, 3. Kyoto University)
[3P-528]Cytotoxicity and Intracellular Dynamics of Polyphosphate Granules in Fission Yeast
○Rumi Okuyama1, Kaho Fujiyama1, Machika Hatori2, Aoi Miwatari2, Kojiro Takeda1,2 (1. Graduate School, Konan Univ., 2. Konan Univ.)
[3P-529]Identification of Novel Functions of the Phosphate Exporter Xpr1 in Schizosaccharomyces pombe
○RYOMA IKEGAWA1, Nene Sakurai1, Kouta Yamamoto2, Hiyori Takechi1, Masahiro Takado3, Tomohiro Matsumoto3, Kojiro Takeda1,2 (1. Konan University, Graduate School・Natural Sciences, 2. Konan University・Faculty of Science and Engineering・Department of Biology, 3. Kyoto University・Radiation Biology Center)
[3P-530]Screening for genes involved in the quantitative regulation of intracellular polyphosphate in Schizosaccharomyces pombe
○seita takeda1, sena oosima2, kojiro takeda1,2 (1. Konan University, Graduate school of Natural science, 2. Biology, Faculty of Science and Engineering, Konan University)
[3P-531]Evaluation of combined Mechano-bactericidal and photocatalytic sterilization system against Bacillus subtilis in water
○Yuuki Shibano1, Naoki Nemoto1, Nobuaki Negishi2 (1. Chiba Institute of Technology, Dep. Life Science, 2. National Institute of Advanced Industrial Science and Technology, Environmental Management Research Institute)
[3P-532]What Are Cells Doing?: Toward rule-based representations bridging Cell Behavior Database and PhysiCell
○Yukiko Sato1, Hiroyuki Kaneko1,2 (1. Research and Education Center for Natural Sciences, Keio Univ., 2. Faculty of Letters, Keio Univ.)
[3P-533]Control of intracellular crystal formation by ice-binding molecules
○Rin Iizuka1, Masahiro Kuramochi1,2 (1. Ibaraki Univ., 2. Univ. of Tokyo)
[3P-534]Properties of Fibroblast-Like Cells Derived from Postmortem Human Cardiac Tissue
○Atsushi Ueda1, Xeuting Guan1, Ikuto Takeuchi1, Motoo Yoshimiya1, Shotaro Isozaki1, Yu Kakimoto1 (1. Tokai Univ.)
[3P-535]Analysis of cytotoxicity induced by microalgae taken up by animal cultured cells
○Ryuya Kojima1, Tomoko Matsunaga1, Sachihiro Matsunaga1 (1. The University of Tokyo)
[3P-536]Regulatory Mechanisms of Cardiac Outflow Tract-Specific Transcription during Embryonic Development
○Airi Maeda1, Yukihiro Harada1,2, Saki Inami1, Yuichiro Onishi1, Yunce Wang1, Yoshiki Hisayasu1, Mizuki Arimoto1, Kano Suzuki1, Tomoe Ueyama2,3,4, Shirai Manabu5, Yusuke Watanabe6, Akiyasu Iwase7, Hiroki Kurihara7,8, Osamu Nakagawa2,3,9, Teruhisa Kawamura1,2 (1. Grad. Sch. of Life Sci., Ritsumeikan Univ., 2. Dept. of Biomed. Sci., Col. of Life Sci., Ritsumeikan Univ., 3. Res. Org. of Sci. and Tech., Ritsumeikan Univ., 4. Global Innov. Res. Org., Ritsumeikan Univ., 5. ORC, OIC, NCVC, 6. Dept. of Cardiac Regen. Biol., Res. Inst., NCVC, 7. Isotope Sci. Center, Tokyo Univ. , 8. IRCMS, Kumamoto Univ., 9. Dept. of Genom. Med., Res. Inst., NCVC)
[3P-537(3AS-11-08)]Arteriovenous Vascular Organoid Development to Investigate Angiogenic Dysregulation in Vascular Malformations Associated with Congenital Heart Disease
○Laura Yuriko González-Teshima1,2, Kozue Murata1, Masaya Hagiwara2, Hidetoshi Masumoto1 (1. Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2. Human Biomimetic System RIKEN Hakubi Research Team, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan)
[3P-538]Unraveling the genetic regulatory mechanism controlling L-R asymmetry formation of the anterior gut in Drosophila melanogaster
○Florian Lucas Neugebauer1, Takamasa Higashi1, Yi-Ting Lai1, Tomoki Ishibashi1, Mitsutoshi Nakamura1, Mikiko Inaki2, Daiki Umetsu1, Naoki Matsuda1, Kotomi Okano1, Akira Nakamura3, Kenji Matsuno1 (1. Osaka University, 2. Hyogo University, 3. Kumamoto University)
[3P-539]Skeletal abnormalities in zebrafish rhoq mutant
○Moeka Maruyama1, Toshiyasu Yanagisawa1, Kento Asaoka1, Hirotoshi Shibuya2, Keishin Takemura2, Masaru Tamura2, Shingo Koinuma3, Takeshi Nakamura3, Misaki Sakashita1, Naoyuki Wada1 (1. Tokyo Univ. Sci., App. Biol. Sci., 2. RIKEN BRC, 3. Tokyo Univ. Sci., Res. Inst. Biomed. Sci.)
[3P-540(3AS-14-05)]Decoupling of transcriptional and metabolic responses to regenerative signals in the aged liver
○Kenichi Horisawa1, Ryo Murayama1, Atsushi Suzuki1 (1. MIB, Kyushu Univ.)
[3P-541(3AS-13-04)]Molecular mechanisms for multicellularity evolution of animals - cell adhesion and signal transduction genes of unicellular holozoans
○Hiroshi Suga1, Seitaro Denbo1, Ayato Hino1, Rin Etoh1, Shion Shimizu1 (1. Prefectural University of Hiroshima)
[3P-542(3PS-13-04)]Human zebrafish chimeric heart
Jo Onozuka1, Issa Watanabe1, Riko Taira1, Shin Kadota2, Hajime Ichimura2, Yuji Shiba2, Chinmoy Patra3, ○Kiyoshi Ohnuma1 (1. Nagaoka University of Technology, 2. Shinshu University, 3. Agharkar Research Institute)
[3P-543]Role of endocardial-derived tissue macrophages in cardiac development and cardiac homeostasis
○LUO YIXUAN1, Atsushi Nakano2,3, Norika Liu1,2 (1. Kumamoto University, 2. University of California, Los Angeles, 3. The Jikei University School of Medicine)
[3P-544(3MS-10-04)]Identification and functional characterization of a potent inhibitor of insect steroid hormone biosynthesis
○Eisuke Imura1, Naoki Yamanaka1 (1. University of California, Riverside)
[3P-545]Regulatory Mechanisms of Cardiac Segment-Specific Enhancers during Embryonic Development
○Yukihiro Harada1,2, Akiyasu Iwase3, Yuichiro Onishi2, Airi Maeda2, Yunce Wang2, Yoshiki Hisayasu2, Mizuki Arimoto2, Saki Inami2, Kano Suzuki2, Tomoe Ueyama1,4,5, Manabu Shirai6, Yusuke Watanabe7, Hiroki Kurihara3,8, Osamu Nakagawa1,4,9, Teruhisa Kawamura1,2 (1. Dept. of Biomed. Sci., Col. of Life Sci., Ritsumeikan Univ., 2. Grad. Sch. of Life Sci., Ritsumeikan Univ., 3. Isotope Sci. Center, Univ. of Tokyo, 4. Res. Org. of Sci. and Tech. Ritsumeikan Univ., 5. Global Innov. Res. Org. Ritsumeikan Univ., 6. ORC, OIC, NCVC, 7. Dept. of Cardiac Regen. Biol., Res. Inst., NCVC, 8. IRCMS, Kumamoto Univ., 9. Dept. of Genom. Med., Res. Inst., NCVC)
[3P-546]Generation of Muscular Dystrophy Medaka and Phenotypic Evaluation
○Misato Shimoda1, Kiyoshi Naruse2, Rie Kusakabe1 (1. Kansai Univ., 2. NBRP)
[3P-547]An attempt to label a specific dorsolateral migrating pathway of the trunk neural crest cells in an ancienct fish Polypterus
○Yasuyo Shigetani1, Norifumi Tatsumi1, Masataka Okabe1 (1. The Jikei University School of Medicine)
[3P-548]Functional Analysis of Epigenetic Regulators Required for Shoot Regeneration through Epigenetic Priming in Arabidopsis thaliana
○Saida Yussupova1, Hikaru Sato1, Masako Migihashi1, Min Li1, Soichi Inagaki2, Takuya Sakamoto3, Sachihiro Matsunaga1 (1. Dept. Integrated Biosci., Grad. Sch. Frontier Sci., Univ. Tokyo, 2. Dept. Biol. Sci., Grad. Sch. Sci., Univ. Tokyo, 3. Dept. Sci., Fac. Sci., Kanagawa Univ.)
[3P-549]Planar cell polarity proteins localize asymmetrically in photoreceptor neurons in the visual columns
○Takumi Morita1, Haruka Yasuda1, Xujun Han2, Miaoxing Wang2, Makoto Sato2, Takashi Suzuki1 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Institute for Frontier Science Initiative, Kanazawa University)
[3P-550]Single-cell level analysis of Tmem100 expression specificity in vascular endothelial cells of mouse embryos
○Yuichiro Onishi1, Yukihiro Harada1,2, Kano Suzuki1, Yunce Wang1, Yoshiki Hisayasu1, Mizuki Arimoto1, Airi Maeda1, Tomoe Ueyama2,3,4, Daiki Hashimoto5, Osamu Nakagawa2,3,6, Teruhisa Kawamura1,2 (1. Grad. Sch. of Life Sci., Ritsumeikan Univ., 2. Dept. of Biomed. Sci., Col. of Life Sci., Ritsumeikan Univ., 3. Res. Org. of Sci. and Tech., Ritsumeikan Univ., 4. Global Innov. Res. Org., Ritsumeikan Univ., 5. Dept. of Physiol.Ⅱ,Wakayama Med. Univ., 6. Dept. of Genom. Med., Res. Inst., NCVC)
[3P-551]Development of Human Meningeal-Cerebral Hybrid Organoid
○Ryoma Ogihara1, Mototsugu Eiraku2 (1. Graduate School of Engineering, Kyoto university,, 2. Institute for Life and Medical Sciences, Kyoto University)
[3P-552]Contribution of blastema cells to the regeneration of zebrafish pectoral-fin endoskeleton
○Hakozaki Taichi1, Yoshida Keigo1, Uesaka Masahiro1, Tamura Koji1 (1. Tohoku university)
[3P-553]Quantification of morphological changes and differentiation processes in organoids toward elucidating the mechanism of eye cup formation
○Sakuya Shirosaki1, Nath Sristilekha1, Satoru Okuda1 (1. Kanazawa Univ.)
[3P-554]Formation of the caudal vasculature in medaka embryos
Rino Higuchi1, Yusuke Sato1, ○Misato Fujita1 (1. Kanagawa University)
[3P-555]Measuring Mammalian Facial Evolution: Upper Jaw Reorganization and the Rise of the "Nose"
○Hiroki Higashiyama1 (1. SOKENDAI)
[3P-556]Analysis of macrophage dynamics during amphibian skin regeneration in Xenopus tropicalis
○Reika Oyabu1, Yuuka Hiroaki1, Reika Wada1, Sayo Tozawa1, Akimasa Fukui1 (1. Chuo Univ.)
[3P-557]Approaches to a reporter gene knock-in method for cell-specific expression in Xenopus laevis
○Hitoha Hirayama1, Haruki Ochi2, Sayo Tozawa1, Akimasa Fukui1 (1. Chuo Univ., 2. Kobe Univ.)
[3P-558]Critical role of p130Cas in driving palatal mesenchyme proliferation and fusion for normal palatogenesis
○TAO HAN1, JING GAO1, EIJIRO JIMI1,2 (1. Lab.of Mol.Cell.Biochem.,Fac of Dent.Sci.,Univ.of Kyushu, 2. OBT Research Center.,Fac of Dent.Sci.,Univ.of Kyushu)
[3P-559]Next-generation human developmental research using a human pluripotent stem cell–derived pancreatic organoid model
○Soki Kimura1,2, Kenichiro Furuyama2, Yoshiya Kawaguchi2 (1. Kyoto University , 2. Kyoto University)
[3P-560]Elucidation of Bone Remodeling Mechanisms Using an In Vitro Bone Organoid Model
○Naoki Tsuji1,3, Tomoaki Sakamoto1, Takashi Nakamura2, Kazuto Hoshi3, Atsuhiko Hikita1,3 (1. Department of Clinical Stem Cell Biology,The University of Tokyo, 2. Department of Biochemistry,Tokyo Dental College, 3. Department of Oral-maxillofacial Surgery,The University of Tokyo)
[3P-561]Construction and Analysis of knockout lines with multiple Tweedle Genes deleted in Drosophila
○Marika Ota1, Haruka Nagao2, Sakizaki Sota1, Tajiri Reiko1 (1. Faculty of science Chiba University, 2. Graduate school of science and engineering Chiba University)
[3P-562]Morphogenesis of the median fin in Xenopus laevis larvae
○JINAN HU1, Kotomi Imura1, Kazue Mogi2, Ryuji Toyoizumi1 (1. Kanagawa Univ., 2. Res. Inst. Integr. Sci., Kanagawa Univ.)
[3P-563]Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in teleost heart
Sho Matsuki1, Yusei Inoue1, Ryuta Watanabe1, Toshiyuki Mitsui1, ○Yuuta Moriyama1 (1. Aoyama Gakuin University)
[3P-564]Analysis of Pax7-positive cell dynamics in the development and regeneration of newt limbs
○Yuta Tsukamoto1,2, Mai Takehara1,2, Hiromi Ikuta1,2, Toshinori Hayashi1,2 (1. Hiroshima University Amphibian research center, 2. Hiroshima University Graduate school of integrated science for life)
[3P-565]Identification of the Juvenile Hormone Biosynthetic Organ and Visualization of Hormone-like Activities in Daphnia magna
○Hajime Watanabe1, Ohtani Yuka1, Noda Ayano1, Yoshioka Rin1, Iwasaki Tamon1, Kato Yasuhiko1 (1. The University of Osaka)
[3P-566]Analysis of ethanol effects on embryonic heart looping
○Ryuichiro Yamazaki1, Rikuto Noguchi1, Aimi Yamashita1, Taiyo Eguchi1, Yuuta Moriyama1, Toshiyuki Mitsui1 (1. Aogaku Univ.)
[3P-567]EMG1 cooperates with GRHL3 in β-catenin-mediated surface ectoderm differentiation to regulate neural tube closure
○Chiharu KIMURA-YOSHIDA1, Kyoko MOCHIDA1, Chihiro MATSUNO1, Keiko KANO2, Emi MISHIRO2, Isao MATSUO1 (1. Dept. Molecular Embryology, Research Institute, Osaka Women's and Children's Hospital, 2. Molecular Structure Center, Isnt. Transformative Bio-Molecules, Nagoya Univ.)
[3P-568]Development of monolayer and 3D tubular intestinal organoid models for epithelial cell functional analysis
○Shinsuke Matsui1, Ken Iwatsuki1, Marie Shinohara2, Ayane Arinaga (1. Tokyo University of Agriculture, 2. Tokyo University)
[3P-569]Development of Anterior Neural Plate Border Cells in Ascidian Embryos
○XIMAN REN1, BOQI LIU2, Yutaka Satou1 (1. Kyoto university, 2. Tsinghua University–Peking University Joint Center for Life Sciences, Tsinghua University)
[3P-570]3D shape formation by the integration of cell properties and force balance regulated by apical and basal ECM
○Shotaro Hiraiwa1, Tensho Terano1, Shumpei Takeshita1, Tianrun Ma1, Tetsuya Kojima1 (1. The University of Tokyo)
[3P-571(3AS-01-06)]Uncovering Novel Transcriptional Regulatory Mechanisms of Neural Stem Cells Using Optogenetic Tool
○Mayumi Yamada1, Itaru Imayoshi2 (1. Cell Biol, Inst Life Med Sci, Kyoto Univ., 2. Brain Dev Reg, Grad Sch Biostudies, Kyoto Univ.)
[3P-572]Capturing myonuclei turnover: Lineage tracing of muscle stem cell nuclei and pre-existing myonuclei in homeostasis
○Nour EL KHAZEN1, Minchul KIM1 (1. I.G.B.M.C. - Institut de génétique et de biologie moléculaire et cellulaire)
[3P-573]NN15-017 Promotes Human Pluripotent Stem Cell Proliferation and Generation
○Shizuka Fujigaki-Yamazaki1, Ryoko Nakatani1, Mai Fujii1, Hirofumi Suemori1, Eihachiro Kawase1 (1. Institute for Life and Medical Sciences, Kyoto University)
[3P-574]Reactivation of Mitophagy in Expanded MSCs Improves their Mitochondrial Quality and Therapeutic Efficacy
○Bunta Mizoguchi1, Yusuke Fujita1, Sogo Aoki1, Kiyoshi Sato1, Hiroyoshi Kawakami1 (1. Graduate School of Tokyo Metropolitan University)
[3P-575(3AS-11-06)]Dynamic rewiring of isoform switching during somatic cell reprogramming
○Satomi Masai Masai1, Yasuhiro Yunoki1, Weipeng Shi1, Yuki Sasaki1, Risa Kawaguchi1, Masato Nakagawa1 (1. Kyoto University)
[3P-576]Evaluation of the characteristics of F1 hybrid ES cell lines between inbred mice strains belonging to different subspecies and the differences originated from their genetic backgrounds
○Masaki Ota1, Hidenori Kiyosawa1 (1. Lab. for Genome Sci., Dept. of Life Sci., ChibaTech.)
[3P-577]Molecular mechanisms regulating the transition to the Zscan4-positive state in mouse ES cells
○Hideo Suzuki1, kana amagai2, Makoto Kashima2, Shinpei Yamaguchi1 (1. Toho Univ. Sci. Bio., 2. Toho Univ. Sci. Biomol.)
[3P-578]A novel flow-programmable kidney organoid-on-chip platform enabling enhanced glomerular vascularization and disease modeling through pulsatile perfusion
○Yuhei Higashi1,2, Shohei Kuraoka1,2,3, Honami Honjoh1,2, Ryuji Morizane1,2 (1. Massachusetts General Hospital, 2. Harvard Medical School Department of Medicine, 3. Kumamoto Daigaku)
[3P-579(3AS-11-05)]Establishment of iPS Cells from Peripheral Blood Mononuclear Cells Using Synthetic RNAs: Efficient Reprogramming via p53 Pathway Modulation
○Masato Nakagawa1,2, Mizuho Nogi1, Hatsuki Doi1, Hirohisa Ohno1, Megumi Mochizuki1, Karin Hayashi1, Hirohide Saito1 (1. Center for iPS Cell Research and Application (CiRA), Kyoto University, 2. Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka)
[3P-580]Inhibition of N-myristoyltransferase in Pluripotent Stem Cells Promotes the Naive State in Mice and Elicits Trophectoderm and Primitive Endoderm Markers in Humans
○Junko Yoshida1, Hitomi Watanabe2, Kaori Yamauchi2, Takumi Nishikubo1, Ayako Isotani3, Satoshi Ohtsuka4, Hitoshi Niwa5, Yuki Kawamoto1, Hidenori Akutsu6, Akihiro Umezawa6, Hirofumi Suemori2, Yasuhiro Takashima7, Hideo Matsuda8, Gen Kondoh2, Junji Takeda9, Kyoji Horie1 (1. Dept. Physiol. II, Nara Med. Univ., 2. Inst. Front. Life Med. Sci., Kyoto Univ., 3. Div. Biol. Sci., NAIST, 4. Lab. Exp. Animal, Kyoto Pref. Univ. Med., 5. IMEG, Kumamoto Univ., 6. Center Reg. Med., NCCHD, 7. Cira., Kyoto Univ., 8. Bioinfo. Eng., IST, Osaka Univ., 9. Lab. Immunoglycobiology, RIMD, Osaka Univ.)
[3P-581]The Lineage Analysis of CD73-Positive Cells Contributing to Osteochondrogenesis
○Kenichi Kimura1, Nao Hosomi1, Marina Matsumiya1, Hiromi Yanagisawa1 (1. University of Tsukuba)
[3P-582]Identification of pluripotent factor in pluripotent stem cells
○Chunhua Wang1, Motoharu Sarubo1, Yasusei Kudo1 (1. Tokushima University)
[3P-583]Development of a new culture condition for rabbit pluripotent stem cells
○Akiyumi Tashiro1, Tomoki Chiba2,1, Masakazu Machida3,1, Kazuhiro Takekita1 (1. Hyperion Drug Discovery Co. Ltd., 2. The University of Tokyo, 3. National Center for Child Health and Development)
[3P-584]Loss of the nuclear envelope phosphatase Ctdnep1 in periosteal cells causes osteochondroma
○Takuto Konno1, Chisato Sampei1, Yasuhiro Arasaki1, Kanon Otsuka1, Takashi Nakamura2, Shigeaki Kato3, Yoshinori Asou4, Yoichi Ezura5,6, Ryuichi Nishinakamura7, Tadayoshi Hayata1 (1. Pharmaceutical Sciences, Tokyo University of Science, 2. Biochemistry, Tokyo Dental College, 3. Life Science and Engineering, Iryo Sosei University, 4. Orthopaedic Surgery, Science Tokyo, 5. Occupational Therapy, Teikyo Heisei University, 6. Joint Surgery and Sports Medicine, Science Tokyo, 7. Kidney development, Kumamoto University)
[3P-585]Activation of the growth for hair follicle stem cells with the stem cell conditioned media
○shuhei mori1, Yuki Tanaka2, Maki Sato2, yukio Mitui2, Hayato Eugene Morita1 (1. Material Sci. Grad. Sch. Sci., Josai Univ. , 2. Horus Co., Ltd.)
[3P-586]IQGAP3-MYC axis commonly regulates stomach tissue repair and carcinogenesis
○Junichi Matsuo1, Takaomi Sanda1,2, Mitsuhiro Shimura1,3, Jungwon Lee1, Nawaphat Jangphattananont1, Wei Peng Yong1,4, Linda Shyue Huey Chuang 1, Yoshiaki Ito 1 (1. National University of Singapore, 2. Nagoya City University , 3. Tohoku University , 4. National University Health System, Singapore)
[3P-587]Establishment of Bovine Pituitary Stem Cell Lines for Elucidating Cell Differentiation Mechanisms
Chihiro Iwamoto1,2, Ai Oguchi3,4, ○Masashi Higuchi1,4 (1. Laboratory of Veterinary Biochemistry, Faculty of Agriculture, Tottori Univ., 2. Chausuyama Zoo, 3. Tottori Livestock Hygiene Service Center of Tottori Prefecture, 4. Joint Graduate School of Veterinary Sciences, Tottori Univ.)
[3P-588]Resolving Human MSC Heterogeneity via Differentiation Assays and scRNA-seq/CAGE Integration analysis
○SUZUKA YAMAGUCHI1,2,4, Masaki Suimye Morioka2,4, Takumi Miura3, Megumi Takano3, Takeya Kasukawa2, Satoshi Yasuda3, Yoji Sato3 (1. Yokohama City University Graduate School of Medical Life Science, 2. RIKEN Center for Integrative Medical Science, 3. National Insutitute of Health Sciences, 4. Life Science Technology Project, Kanagawa Institute of Industrial Science and Technology)
[3P-589]From Myoblasts to Myotubes: Insights into Muscle Cell Differentiation and Fusion
○Motoshi Kaya1, Yoshizuki Fumoto1, Kyogo Kawaguchi1, Tsukasa Oikawa2, Shingo Takada3, Yasuhito Onodera2 (1. University of Tokyo, 2. Hokkaido University, 3. Hokusho University)
[3P-590]Development of a Novel Temperature-Sensitive Sendai Virus Vector
○Koichi Saeki1, Sakiyo Asada1, Yumi Horie1 (1. Repli-tech Co., Ltd.)
[3P-591]Evaluation of Sendai Virus Vector Concentration using Polyethylene Glycol (PEG) Precipitation
○Hiroki Matsuda1, Ying Yang1, Aya Hara1, Yumi Horie1, Koichi Saeki1 (1. Repli-tech Co., Ltd.)
[3P-592]Development of a Real-time PCR Kit for Quantification of Sendai Virus Vectors
○YING YANG1, Matsuda Hiroki1, Hara Aya1, Saeki Koichi1 (1. Repli-tech Co., Ltd.)
[3P-593]Transcriptomic analysis of region-specific glial differentiation from mouse embryonic stem cells
○Takuma Shinozuka1, Noriaki Sasai1 (1. NAIST)
[3P-594]Study on the Impact of Butyric Acid on 3T3-L1 Cell Differentiation into Adipocytes.
○Fu Ya Chu1, Chuang Yu Ren2, Fang Li Wen1 (1. Dept. of Nutr., I-Shou Univ., Kaohsiung, Taiwan., 2. Dept. of Med. Res., E-Da Hosp., Kaohsiung, Taiwan.)
[3P-595]Heterogeneous activation of Wnt/β-catenin signaling during thymic epithelial cell development
○Sayumi Fujimori1, Yousuke Takahama2, Shinji Takada3, Izumi Ohigashi1 (1. IAMS, Tokushima Univ., 2. CCR, NCI, NIH, 3. NIBB, NINS)
[3P-596]Promotion of Functional Maturation during Pancreatic β-Cell Differentiation by Short-Chain Fatty Acids
○Kengo Matsuzawa1, Sara Takaishi1, Tomomi Sugiyama1, Keisuke Hirota1, Kana Amagai2, Makoto Kashima2, Takuji Yamada1, Nobuaki Shiraki1, Shoen Kume1 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Department of Biomolecular Science, Faculty of Science, Toho University)
[3P-597]Investigating the Effects of Propionate on Adipocyte Differentiation in 3T3-L1 Cells
○Yu Ting Kuo1, Yu Ren Chuang2, Li Wen Fang1 (1. Dept. of Nutr., I-Shou Univ., Kaohsiung, Taiwan., 2. Dept. of Med. Res., E-Da Hosp., Kaohsiung, Taiwan.)
[3P-598(3PS-13-03)]Derivation of human post-mitotic cardiomyocyte from tetraploid induced pluripotent stem cells
○Ittetsu Nakajima1,2, Shimane Mitsuyoshi3, Grace Holmstrom4, Yuichiro Miyaoka1,2,5 (1. Tokyo Metropolitan Institute of Medical Sciece, 2. Institute of Science Tokyo, 3. Nanion Technologies Japan K.K., 4. Pitzer College, 5. Ochanomizu University)
[3P-599(3PS-02-04)]Transcriptome-based prediction of small molecules that replace transcription factors for direct reprogramming
○Momoko Hamano Hamano1, Yoshihiro Yamanishi2 (1. Kyutech, 2. Nagoya Univ.)
[3P-600]Functional analysis of Prdm genes in the neural cell differentiation process of mouse embryonic tumor cells
○Ran Misaka1, Akira Baba1, Sakiko Terano1, Juri Tashima1, Hideki Hirakawa1, Kosuke Tashiro1 (1. Kyushu Univ.)
[3P-601(3MS-10-02)]Phosphoinositide-mediated regulation of steroidogenic cell fate
○Shogo Yanai1, Yuto Kikuchi1, Katsuya Yuguchi1, Hiroaki Kajiho1, Junko Sasaki1, Takehiko Sasaki1 (1. Science Tokyo, MRL, Biochemical Pathophysiology)
[3P-602]The role of FGF in early EMT regulation
○Tsuyoshi Takagi1, Rie Terada1, Masato Asai1 (1. Aichi Developmental Disability Center)
[3P-603]Effects of co-culture with glial cells on neuronal differentiation of mouse iPS cells
○YUTO SUGAYA1, Ikuroh Ohsawa1,2, Hideo Kawaguchi1 (1. Grad Sch Life Sci, Toyo Univ, 2. TMIG)
[3P-604]Reduction of transcription of RNA sensors and RNA catalyzing enzymes during osteoclast differentiation.
○Kazuhisa Nakashima1, Hisashi Ideno1, Teruhito Yamashita2, Akira Nifuji1 (1. Department of Pharmacology, Tsurumi University School of Dental Medicine, 2. Department of Chemistry, Matsumoto Dental University)
[3P-605]Gene regulatory network analysis aimed at predicting fate-conversion factors for pancreatic β cells
○Hiroyuki Fukuda1, Ruslan Deviatiiarov1, Kenji Kamimoto4,5, Oleg Gusev1, Yasushi Okazaki1,2,3, Masahito Matsumoto1,2,3 (1. Juntendo University Intractable Disease Research Center, 2. Direct Cell Reprogramming for Regenerative Medicine, 3. Diagnostics and Therapeutics of Intractable Diseases, 4. Research Institute for Microbial Diseases, Osaka University, 5. Osaka University’s Premium Research Institute for Human)
[3P-606]Efficient generation of mouse lymphoid progenitors.
○Nozomi Katsuya1, Yasuda Tomoharu1, Kawano Yohei1 (1. Hiroshima Univ.)
[3P-607]The artificial transcription factor protein system can engineer human fibroblasts into hepatic stem cells within five days
○Tomoki Takashina1, Tetsushi Sakuma2, Takashi Yamamoto3, Yukihito Ishizaka1 (1. Japan Institute for Health Security, 2. Graduate School of Agriculture, Kyoto University, 3. Genome Editing Innovation Center, Hiroshima University)
[3P-608]In silico design of transcription factor cocktails for cardiac reprogramming based on multi-omics analysis
○Riona Katoh1, Masaki Hirose1, Kawasaki Ryota1, Hamano Momoko2 (1. Kyushu Institute of Technology Graduate School of Computer Science and Systems Engineering, 2. Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology)
[3P-609]Spatial transcriptomics reveal lineage complexity of gastric incomplete intestinal metaplasia and its association with gastric cancers
○Hyesung Kim1,2, Bogun Jang1,4,3 (1. Jeju National University College of Medicine, 2. Department of Biomedical Science, 3. Department of Pathology, 4. Jeju National University Hospital)
[3P-611]ER-resident peptidyl prolyl isomerase Fkbp11 regulates osteoclast differentiation
○Koki Nakamura1, Kanon Otsuka1, Masamichi Li1, Takuro Akiya1, Yasuhiro Arasaki1, Tadayoshi Hayata1 (1. Tokyo University of Science)
[3P-612]Exploration of Natural Substances Promoting Muscle Differentiation by Targeting PPARδ Activation
○Manaka Furusawa1, Reina Hayashi1, Rumana Mahzabin2, Yukako Tokutake1,2, Shinichi Yonekura1,2 (1. Shinshu Univ. Fac. of Agr., 2. Shinshu Univ. Grad. Sch. Med. Sci. Tech.)
[3P-613]Cortical Actin Flow Drives Epithelial Geometry
○Kazuko Okamoto1,2, Shuya Fukamachi3, Aki Teranishi3, Makoto Sato4, Satoru Okuda1,5 (1. Nano Life Science Institute, Kanazawa University, 2. Amphibian Research Center, Hiroshima University, 3. Graduate School of Frontier Science Initiative, Kanazawa University, 4. Institute for Frontier Science Initiative, Kanazawa University, 5. Sapiens Life Sciences, Evolution and Medicine Research Center, Kanazawa University)
[3P-614]Functional analysis of Interstitial Cells of Cajal during smooth muscle development
○Hana Hashiguchi1, Saki Egashira2, Takeru Fujii3, Yuko Sato3, Mako Nakamura4, Yasuyuki Ohkawa3 (1. Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 2. Graduate School of Medical Sciences, Kyushu University, 3. Division of transcriptomics, Medical institute of bioregulation Kyushu university, 4. Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University)
[3P-615]Cell-level dosage-compensation dynamics and its transcriptional regulons in the early chicken embryo
○Ilya Rubinshteyn1, Ruslan Deviatiiarov2, Guojun Sheng3, Oleg Gusev4,2,1 (1. Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, Ufa, 2. Life Improvement by Future Technologies (LIFT) Center, Molecular Biomimetics, Moscow, 3. Kumamoto University, The International Research Center for Medical Sciences (IRCMS), Kumamoto, 4. Juntendo University, Intractable Disease Research Center, Tokyo)
[3P-616(3AS-13-06)]Impact of the Retroelement-Derived PEG10 Gene on the Evolution and Establishment of the Mammalian Placenta
○Hirosuke Shiura1, Mayuko Fujii1, Takashi Kohda1, Tomoko Kaneko-Ishino2, Fumitoshi Ishino3 (1. Fac. of Life and Env. Sci., Univ. of Yamanashi, 2. Sch. of Med., Tokai Univ., 3. Res.Inst., Science Tokyo)
[3P-617]Functional analysis of Plk4 in translational regulation during mouse and zebrafish oocyte maturation
○Shoji Saito1, Anyu Suginishi1, Takahiro Sanada1, Tomoya Kotani2 (1. Hokkaido University・Life science, 2. Hokkaido University・Science)
[3P-618]Understanding the reguration system of tissue heterogeneity in cell competition through mathematical simulation
○Seiya Nishikawa1 (1. Kyoto University)
[3P-619(3AS-11-04)]Active WNT/β-Catenin signalling derails the naïve to primed state transition in human pluripotent stem cells
○Connor Ross Ross1, Takuya Azami2, Peter Rugg-Gunn3, Stefan Hoppler1 (1. Institute of Medical Sciences, University of Aberdeen, 2. Human Genetics Unit, University of Edinburgh, 3. Babraham Institute, University of Cambridge)
[3P-620(3AS-03-04)]Lysosome-mediated RNA degradation fosters zygotic genome activation in Drosophila
○Shiho Makino1, Yoshinori Ohsumi2, Takashi Fukaya1,3 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Cell Biology Center, Institute of Innovative Research, Institute of Science Tokyo, 3. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo)
[3P-621]Hydrogen peroxide dynamics during Xenopus early development
○Yoshiyuki Anchi1, Arata Imamura1, Jihoon Kim1, Takayuki Teramoto1, Kanji Okumoto1, Naho Okano1, Minoru Watanabe2, Nobushige Nakajo1 (1. Grad. Sch of Sys. Life Sci., Kyushu Univ., 2. Inst. Lib. Art. Sci., Tokushima Univ.)
[3P-622]Impact of epigenetic modifications downstream of TGF-β signaling underlying expression of 5'Hox genes
○Ayana Tatsumi1, Miku Takabayashi2, Syun Tomooka2, Takayuki Suzuki1 (1. Osaka Metropolitan University, 2. Nagoya University)
[3P-623(3PS-05-06)]Extracellular presentation of the type IV membrane protein syntaxin4 as a potential trigger for region-specific gastrulation during early embryogenesis.
○Sae Nozaki1, Yohei Hirai1 (1. Kwansei Gakuin University)
[3P-624]A synthetic integrin-activating peptide promotes embryo-endometrium attachment and implantation
○Tam Thi Pham1, Toru Matsu-ura1, Naoko Yoshida1, Yoshiki Ikeda2, Tatsuya Kobayashi3, Keizo Tokuhiro4, Yoshiko Hashimoto5,6, Hidetaka Okada5, Koji Tsuta1 (1. Department of Pathology,Kansai Medical University, 2. Institute for Integrated Cell-Material Sciences, Kyoto University, 3. Department of Regulatory Science, The Center for Advanced Reproductive Medicine, Fujita Medical Innovation Center Tokyo, Fujita Health University, 4. Department of Genome Editing, Kansai Medical University, 5. Department of Obstetrics and Gynecology, Kansai Medical University, 6. Department of Obstetrics and Gynecology, Suita Tokushukai Hospital)
[3P-625]Insights into the Evolution of Mammalian Placentas from the Analysis of Yolk Sac Placentation in Marsupials
○Moe Kitazawa1,2, Shiura Hirosuke1, Kohda Takashi1, Kaneko-Ishino Tomoko3, Ishino Fumitoshi4, Renfree Marylin 2 (1. University of Yamanashi, 2. Melbourne Unversity, 3. Tokai University, 4. Institute of Science Tokyo)
[3P-626]Comparative study of mesodermal gene expression during gastrulation in Pleurodeles waltl and Xenopus laevis
○Taro Kansha1, Nana Harada1, Saki Fujii1, Moe Kasai1, Sayo Tozawa1, Akimasa Fukui1 (1. Chuo University)
[3P-627]Genome-wide Mapping of CNOT9 Binding Reveals Transcriptional Control of Developmental Genes in Mouse ESCs
○Haytham Mohamed Aly Mohamed1, Hemanta Sarmah1,2, Atsuko Sato1, Tadashi Yamamoto1 (1. Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, 2. Columbia Stem Cell Initiative, Stem Cell Core, Columbia University Irving Medical Center)
[3P-628]Disruption of the endocytic recycling pathway causes mouse early embryonic dysgenesis
○Michihiko Sugimoto1, Masaki Ohmuraya1, Kuniya Abe2 (1. Hyogo Medical University, 2. RIKEN BioResource Research Center)
[3P-629]Development of methods to deliver proteins into Ciona robusta embryos.
○Haruki Sakuragi1, Shigeki Fujiwara1 (1. Kochi Univ.)
[3P-630]Effects of Pyruvate removal from Embryo culture medium on early mouse embryonic development and Mitochondrial Distribution.
○Haruto Tanaka1, Ryo Suenaga1, Saaya Koizumi2, Takayuki Torisawa2, Akatsuki Kimura2, Tatsuma Yao3, Kazuo Yamagata1 (1. BOST., Kindai Univ., 2. DCS., NIG., 3. R&D, Fuso Pharma., Ltd.)
[3P-631]SOX2 closes trophectoderm enhancer of Gata3 to abolish responsiveness to TEAD-YAP
○Naoki Hirono1, Masanori Uchikawa1, Hiroshi Sasaki1 (1. Graduate School of Frontier Biosciences, The University of Osaka)
[3P-632]H3K9me3 Is Dispensable for Parental Asymmetric Transcription in Mouse Zygotes.
○Sana Nakamae1, Masatoshi Ooga1 (1. Azabu Univ.)
[3P-633]Loss of the maternal amino acid transporter impairs development by disrupting metabolic homeostasis and mitosis during early embryogenesis in Drosophila
○Hinano Iijima1, Takaomi Sakai1, Toshiro Aigaki1, Satomi Takeo1 (1. Tokyo Metropolitan University)
[3P-634]Functional analysis of DMRT1 in male germ cell differentiation in chickens
○Mashiro Mitsufuji1, Tenkai Watanabe1, Ryo Ezaki1, Mei Matsuzaki1, Hiroyuki Horiuchi1,2 (1. Graduate School of Integrated Sciences for Life, 2. Genome Edit. Innov. Ctr, Hiroshima Univ.)
[3P-635]Development of a rat sperm cryopreservation and IVF method using a chemically defined preservation solution
○Kohtaro Morita1,2, Keiji Mochida1, Ayumi Hasegawa1, Shunya Ihashi2, Kento Morita2, Saki Wajima2, Miho Kohara3, Tadashi Sankai3, Kimiko Inoue1, Atsuo Ogura1, Masahide Asano2 (1. RIKEN BRC, 2. Inst. of Lab. Anim., Grad. Sch. of Med., Kyoto Univ., 3. NIOBIHN)
[3P-636]Investigation of the effects of exogenous pressure on the in vitro growth of mouse preantral follicles
○Tomohiro Kohama1, Go Nagamatsu1 (1. Yamanashi Univ.)
[3P-637]The effect of in vitro culture of bovine oviduct smooth muscle cells on contractile gene expression
○Sayaka Kubota1, Yui Iwamoto1, Kohei Kawano1, Koji Kimura1 (1. Okayama Univ.)
[3P-638]Physiological role of the HUSH complex in spermatogenesis
○Yoshifumi Fujioka1, Yuka W Iwasaki1 (1. RIKEN)
[3P-639]Towards deciphering germ cell regulatory mechanisms underlying lifelong fertility in the Naked Mole-Rat
○So Shimamoto1, Yoshimi Kawamura2, Kyoko Miura2, Tomoya Kitajima1 (1. RIKEN Center for Biosystems Dynamics Research, 2. Graduate School of Medical Sciences, Kyushu University)
[3P-640]Transcriptomic Analysis of Age-Related Gene Expression Changes in Zebrafish Oocytes
○shiho nagata1, Soichiro Kumamoto2, Moka Uetani1, Sayuka Kanayama1, Kayo Sugitani1, Johmura Yoshikazu2, Yuhei Araiso1 (1. Dept. of Clin. Lab. Sci, Div. of Health Sci., Kanazawa Univ., 2. Cancer Research Institute,Knazawa Univ.)
[3P-641]Importin13 is required for the germ cell development in mice
Yasuka L Yamaguchi1, Tam PL Patrick2, Hiroshi Kiyonari3, ○Satomi S Tanaka1 (1. Kumamoto Health Sci. Univ., 2. CMRI, Univ. of Sydney, Australia, 3. RIKEN BDR)
[3P-643]Establishment of an In Vitro Culture System for Reconstructed Primordial Follicles
○Riku Yamashita1, Go Nagamatsu1 (1. University of Yamanashi)
[3P-644]Spatiotemporal Analysis of Oocyte Dynamics Using Reconstituted and Fetal Mouse Ovary Culture Systems
○Yui Muraki1, Katsuhiko Hayashi1 (1. Graduate School of Medicine, Osaka Univ.)
[3P-645]Functional analysis of the DND1-DAZL complex
○Itaru Takayama1, Atsushi Suzuki1 (1. Grad.Sch.Sci Eng,Yokohama Natl. Univ.)
[3P-646]Establishment of a simple and efficient in vitro oocyte induction system
○Kana Mizuno1, Ami Banno1, Mizuki Sakamoto1, Sota Komatsubara1, Kenjiro Shirane2, Katsuhiko Hayashi2, Koshi Imami3, Shigenobu Yonemura4, Takashi Ishiuchi1 (1. Faculty of Life and Environmental Sciences, University of Yamanashi, 2. Department of Genome Biology, Graduate School of Medicine, Osaka University, 3. Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, 4. Laboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research)
[3P-647]Analysis of mouse embryonic abnormalities caused by the extracellular matrix defects in the uterus
○Ami Matsumoto1, Kimika Miyahara1, Rika Takeuchi1, Arisa Fukumoto1, Yuki Miyanohara1, Hidetaka Shiratori1 (1. Kyoto Sangyo University)
[3P-648]Sry deficiency impairs oocyte competence and early embryonic development in sex-reversed female mice
○Xiaohan Chen1, Hiroaki Funahashi1, Takuya Wakai1 (1. Okayama University)
[3P-649]Functional analysis of Gm614, a novel causative gene for asthenozoospermia
○Arisa Tanigawa1, Yoshiki Miyasaka1, Tomoko Tokunaga1, Manami Nishimura1, kazuki nakao1 (1. The University of Osaka)
[3P-650]Pin1 regulates follicular development and ovulation in mice
○Yumi Hoshino1, Joshua Johnson2, Evelyn Llerena Cari2, Takafumi Uchida3 (1. Institute of Science Tokyo, 2. University of Colorado Denver, 3. Tohoku University)
[3P-651]Redox Dynamics of the Epididymis During Reoxygenation in Mouse Sperm Maturation
○Tomoya Sugiyama1, Kosei Oishi1, Atsumi Sakaguchi2, Masanobu Morita3, Minkyung Jung4, Takaaki Akaike3,4, Yasuyuki Kurihara5 (1. Grad. Sch. Sci. Eng., Yokohama Natl. Univ., 2. Bioscience Center, Institute of Science Tokyo, 3. Dept. Env. Med. and Mol. Toxicology, Tohoku Univ. Grad. Sch. Med., 4. Dept. Redox Mol. Med., Tohoku Univ. Grad. Sch. Med., 5. Fac. Eng. Sci., Yokohama Natl. Univ.)
[3P-652]Elucidation of the male germ cell–specific Heat Shock Response mechanism
○Yusuke Osato1, Momoka Miyabe1, Yuka Karato1, Tomoko Sagi1, Kai Otsuka1, So Maezawa1 (1. Tokyo Univ. of Sci.)
[3P-653]Toward cloning of genes regulating developmental speed
○Kaho Ieda1, Kotaro Kimura1 (1. Nagoya City Univ. Grad. Sch. of Science)
[3P-654]Growth-promoting effects of D-serine in the hemimetabolous cricket Gryllus bimaculatus
○Kota Kinoshita1, Kohyoh Murata2, Masashi Mita4, Takeshi Suzuki2,3, Tsuyoshi Tanaka5, Kosuke Kataoka5,6 (1. Dept. Eng., Tokyo Univ. Agri. Tech., 2. Grad. Sch. Bio-App. Sys. Eng., Tokyo Univ. Agri. Tech., 3. Grad. Sch. Adv. Interdiscip. Sci., Tokyo Univ. Agri. Tech., 4. KAGAMI Inc., 5. Grad. Sch. Eng., Tokyo Univ. Agri. Tech., 6. Comp. Res. Org., Waseda Univ.)
[3P-655]Three-Dimensional Imaging Analysis of Neovessel Morphology in a Mural Cell Co-cultured Microvessel-on-a-Chip
○Hedele Zeng1,2, Makoto Kondo1,2, Yukiko T. Matsunaga1,2 (1. Institute of Industrial Science, The University of Tokyo , 2. Department of Bioengineering, School of Engineering, The University of Tokyo)
[3P-656(3PS-06-06)]Development of novel cell therapies for AKI and CKD using human iPS cell-derived nephron progenitor cells
○Toshikazu Araoka1 (1. Center for iPS cell research and application, Kyoto university)
[3P-657]Therapeutic effects of transplanting chemically induced cells in a rat model of spinal cord injury
○Toshihiro Kurahashi1, Yoshinori Harada2, Ping Dai1 (1. Department of Cellular Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 2. Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine)
[3P-658]A 3D bioprinted tissue-engineered skin fabricated by
incorporating GelMa-laden cells into a scaffold composed of
gelatin and sodium alginate
○TSENG YICHEN1, KAI-CHIEH CHOU1, YI-WEN WANG1, KUANG-LING OU1 (1. National Defense Medical University, Taiwan)
[3P-659]Discovery of novel cell-surface markers for specific identification of mature beta cells
○Wing Sing Wong1, Haruki Odaka2, Hiroaki Tateno2, Nobuaki Shiraki1, Shoen Kume1 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology)
[3P-660]Pattern formation by interacting fibers
○Keisuke Matsuda1,4, Yanru Li2, Ueli Grossniklaus2, Shigeru Kondo3,4 (1. Kyushu Univ., 2. Univ. of Zurich, 3. Natl. Inst. Genet., 4. Osaka Univ.)
[3P-661]Regulation of Liver Regeneration by NAXD
○Hiroki Yamamoto1, Takahashi Kodai1, Goda Nobuhito1 (1. Waseda University)
[3P-662]Survival of Campylobacter jejuni in the Acanthamoeba polyphaga
Mako Kitade1, Reima Yamazaki1, ○Takaaki Shimohata1 (1. Fukui Prefectural University)
[3P-663]Green hydra symbiosis sheds light on the photosymbiotic potentials and sugar secretion of green algae.
○Hinako Kawano1, Daisuke Yamagishi1, Mayuko Hamada2, Shinichiro Maruyama1 (1. Tokyo Univ., 2. Okayama Univ.)
[3P-664]Elucidating the Role of Gut Microbiota in Cecal Enlargement of Germ-Free Mice
○Karin Ninomiya1,2, Runa Aoyagi2, Kento Omotegawa2,3, Tsukasa Oda2, Eiji Miyauchi2, Takayuki Saitoh1, Nobuo Sasaki2 (1. Grad. Sch. of Health Sci., Gunma Univ., 2. Lab. of MED, IMCR, 3. Dept. of Medicine, Sch. of Medicine, Gunma Univ.)
[3P-665]Scalp Commensal Bacteria and Their Association with Chronic Scalp Inflammation
○KOSUKE WATANABE1, TAKASHI SUTANI1, KATSUHIKO SHIRAHIGE1 (1. Institute for Quantitative Biosciences, The University of Tokyo)
[3P-666]Construction of an artificial secondary endosymbiotic system between microalgae and cultured human cells
○Kaisei Chujo1, Yayoi Inui1, Yoji Okabe1, Tomoe Kodama1, Sachihiro Matsunaga1 (1. The Univ. of Tokyo)
[3P-667]Generation of Ustilago esculenta strains expressing fluorescent proteins
○Nanoka Sasahara1, Moemi Watanabe2, Shigeyuki Tanaka4, Takashi Motobayashi3, Nobumitsu Sasaki1 (1. Grad. Sch. of Agr., Tokyo Univ. of Agr. & Tech., 2. Fac. of Agr., Tokyo Univ. of Agr. & Tech., 3. FS center., Tokyo Univ. of Agr. & Tech., 4. Fac. of Agr., Setsunan Univ.)
[3P-668]The impact of immune changes induced by bone marrow transplantation on the colonization of gut microbiota following fecal microbiota transplantation
○Ryoha Ichimura1,2,3, Kazuki Tanaka1,2,3,4, Isaiah Song 2, Eisuke Shimizu5, Yoko Ogawa55, Kazuo Tsubota5, Shinji Fukuda1,2,3,4,6 (1. Keio University, Graduate School of Media and Governance, Systems Biology Program, 2. Keio University, Institute for Advanced Biosciences, 3. Kanagawa Institute of Industrial Science and Technology, Gut Environmental Design Group, 4. Juntendo University Graduate School of Medicine, Innovative Microbiome Therapy Research Center, 5. Keio University School of Medicine, Department of Ophthalmology, 6. University of Tsukuba, Transborder Medical Research Center)
[3P-669]Wnt/β-catenin signaling pathway-mediated regulation of sleep-like behavior in Hydra vulgaris
○Shogo Hamagami Hamagami1, Aya Sato2, Taichi Itoh1,2 (1. Graduate School of Systems Life Sciences, Kyushu University, 2. Faculty of Arts and Science, Kyushu University)
[3P-670]Screening of natural compounds with sleep control effects using hydra and identification of new candidate compounds
○Asa Kimoto1, Taichi Itoh1,2 (1. Kyushu Univ., 2. Kyushu Univ)
[3P-671]The regulation of the circadian clock on physiological activities of human epidermal melanocytes and its photoentrainment response
○Yanyan Chen1,2, Yuyun Xiong1,2, Hengheng Fan1,2, Yunwen Zheng1,2,3,4, Yumei Li1,2 (1. Department of Dermatology, Affiliated Hospital of Jiangsu University, 2. Jiangsu University Institute of Regenerative Medicine, 3. Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Chinese Academy of Medical Sciences, 4. Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
[3P-672]Relationship between prefrontal synaptic potentiation and NREM sleep-inducing SIK3 pathway
○Motoki Juichi1,4,5, Yusuke Iino4,5, Miyo Kakizaki4,5, Shinnosuke Nomura4,5, Shinya Nakata4,5, Takeshi Sawada2, Hiromasa Funato3,4,5, Shoi Shi4,5, Masashi Yanagisawa4,5 (1. University of Tsukuba, 2. University of Tokyo, 3. Toho University, 4. TIAR, 5. WPI-IIIS)
[3P-673]Rational engineering of XCaMP-C, a versatile genetically-encoded Ca2+ indicator for all-optical interrogation, multiplex imaging, and quantitative Ca2+ imaging
○Hajime Fujii1, Keisuke Ota1, Yayoi Kondo1, George Cai1,2, Richard Song3, Haobo Song1, Michiko Okamura1, Hayato Kondo1, Masatoshi Inoue1,4, Haruhiko Bito1 (1. Deptartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, 2. Neuroscience Program, Harvard University, 3. Department of Neuroscience, Vanderbilt University, 4. Biophotonics Res Cntr, Mallinckrodt Inst of Radiology, Univ Wash St. Louis)
[3P-674]Spatio-temporal model of neural dynamics in C. elegans considering its local connectome
○Yuishi Iwasaki1 (1. Grad. Sch. Sci. Eng., Ibaraki Univ.)
[3P-675]Subcellular and Regional Localization of the Autism-Associated IL-17A Receptors
○Kentaro Itagaki1,2, Kenyu Nakamura1,3, Asumi Kubo1,4, Sae Sanaka1,3, Sara Kamiya1,4, Kyoko Kishi1, Momo Morikawa1, Suguru Iwata1, Tetsuya Sasaki1,4, Takei Yosuke1,4 (1. Laboratory of Anatomy and Neuroscience, Division of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Tsukuba, 2. School of Medical Sciences, Faculty of Medicine, University of Tsukuba, 3. School of Medicine, Faculty of Medicine, University of Tsukuba, 4. Degree Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba)
[3P-676]Transmembrane Protein Crosstalk Directs Accurate Axonal Targeting in the Drosophila Visual System
○Yufan Jin1, Yuichi Ishiwata1, Hiroki Takechi1, Tomoyuki Yoshida2, Tatsuya Niwa1, Takashi Suzuki 1 (1. Graduate School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan., 2. Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.)
[3P-677]Apoptosis inducing effects of neurotoxin MPP+ on SH-SY5Y neuroblastoma cells, the protective actions of estrogen, and the potential involvement of CRMP4
○Asumi Kataoka1, Masaomi Tomita1, Takuto Kudo2, Ritsuko Ohtani-Kaneko1,2 (1. Toyo University Graduate School of Life Science, 2. Toyo University of Life Science)
[3P-678(3PS-08-06)]Elucidation of epigenetic changes underlying axon regeneration in a hypoglossal nerve injury model
○Yudai Nishiyama1,2, Sumiko Kiryu3, Yusuke Kishi1,2 (1. Institute for Quantitative Biosciences in The University of Tokyo, 2. Graduate School of Pharmaceutical Sciences in The University of Tokyo , 3. Nagoya University Graduate School of Medicine)
[3P-679]Exploration of the molecular mechanisms underlying the reprogramming barriers in cortical projection neurons
○Ryusei Kurashita1, Koji Oishi1, Yukiko Gotoh1,2 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study, The University of Tokyo)
[3P-680]A Metabolic-Epigenetic Axis Regulates Species-Specific Cortical Developmental Tempo
○Quan Wu1, Taeko Suetsugu1, Ryo Yoshita2, Hideya Sakaguchi2, Fumio Matsuzaki1 (1. KYOTO UNIVERSITY, 2. RIKEN BDR)
[3P-681]Physiological significance of the interaction between NBCe1-C andSNX-27
○Goto Yasuaki1, Masahiro Hukaya3, Naomi Hasegawa2, Koichi Hamada1, Hiroyuki Sakagami4, Akihiro Mizutani1 (1. Showa Pharm. Univ., 2. Natl. Inst. of Ment. Health., Natl. Ctr. of Neurol. & Psychiat., 3. Kitasato Univ. AHS., 4. Kitasato Med.)
[3P-682]How neurons adapt their migratory behavior to different extracellular environments
○Noriko Takeda1, Naotaka Nakazawa2, Vadim Doucet3, Mineko Kengaku1,4 (1. Kyoto Universiry, 2. Kinki University, 3. Sorbonne University , 4. Kyoto University)
[3P-683]Changes in ubiquitination of microtubule-cleaving enzyme, Katanin-like, during vertebrate evolution
○Tomoki Shigemura1, Kensuke Hayashi1 (1. Sophia Univ.)
[3P-684]Building a Zebrafish Phenotype Analysis Platform Using a Whole-body 3D Anatomical Atlas
○Tomoya Shiraki1,2, Koichi Kawakami2 (1. National Institute of Occupational Safety and Health, Japan, 2. National Institute of Genetics)
[3P-685]Activity-dependent Regulation of the Adhesion-GPCR Cirl in Synaptic Plasticity of Drosophila Visual System
○Shogo Akino1, Jiro Osaka1, Yannick Carrier2, Filipe Pinto-Teixeira2, Takashi Suzuki1 (1. Institute of Science Tokyo, 2. MCD team, Centre de Biologie Intégrative (CBI), CNRS, Université Toulouse III)
[3P-686]Mechanisms of mTORC1 signaling regulation dependent on neuronal cell adhesion
○Koichi Hashizume1, Yoneko Hayase1, Shigehiro Ogata1, Yukiko Ueno-Inoue1, Takayoshi Inoue1, Yu-ichi Goto1, Shinichiro Taya1,2, Mikio Hoshino1 (1. National Center of Neurology and Psychiatry, 2. Fujita Health Univ.)
[3P-687]Cystin regulates axonal regeneration after injury in central nervous system
○Rei Miyamoto1, Makoto Sunano1, Masahiro Fujimuro1, Yuichi Sekine1 (1. Kyoto Pharmaceutical University)
[3P-688]Analysis of synaptic remodeling in the adult mouse retina by focusing on the synapse organizer Pikachurin
○Hitoshi Sumihiro1, Hung-Ya Tu1, Takahisa Furukawa1 (1. Lab for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka)
[3P-689]Evolutionarily Conserved Interhemispheric Remodeling: Collagen Degradation at the Telencephalic Midline
○Ryota Noji1,4, Anna Yasunaga2, Takaya Abe2, Yukihiro Nishikawa3, Hiroshi Kiyonari2, Tadashi Nomura4,5 (1. Kyoto Prefectural University of Medicine, 2. Laboratory for Animal Resources and Genetic Engineering, RIKEN BDR, 3. Material’s Properties Control, Kyoto Institute of Technology, 4. Applied Biology, Kyoto Institute of Technology, 5. Center for Social and Biomedical Engineering, Kyoto Institute of Technology)
[3P-690]The Effect of Sex Hormones on the Survival and Differentiation of Oligodendrocytes in Vitro
○Hitomi Misawa1, Sakurako Abe2, Yuichi Hiraoka3, Nobuharu Suzuki1,2 (1. Department of Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Science, Institute of Science Tokyo , 2. Medical Technology Major, School of Health Care Sciences, Faculty of Medicine, Institute of Science Tokyo, 3. Center for Disease Biology and Integrative Medicine, Graduate School of Medi cine, The University of Tokyo)
[3P-691]Spatial multi-omics mapping of molecular pathology in the 22q11.2 deletion mouse model
○Yusuke Mizuno1, Masahide Seki1, Akinori Kanai1, Junko Zenkoh1, Daisuke Mori2, Yuko Arioka2, Hiroki Okumura2, Takuyo Matsuda2, Norio Ozaki2, Yutaka Suzuki1 (1. Dept. of Comp. Biol. and Med. Sci., Grad. Sch. of Front. Sci., Univ. of Tokyo, 2. Pathophysiol. Mental., Grad. Sch. of Med., Nagoya Univ.)
[3P-692]Distinct contributions of calmodulin-encoding genes to the development of layer 4 sensory recipient neurons in the mouse neocortex
○Naoto Ohte1,2, Yuta Furusho1,2, Pei-Shan Hou1,3,4, Yusuke Sugita2,5, Hiroaki Kobayashi6, Carina Hanashima1,2,3 (1. Waseda Univ., 2. Grad. School of Waseda Univ., 3. RIKEN, 4. National Yang Ming Chiao Tung Univ., 5. TMIMS, 6. Osaka Univ.)
[3P-693]Spatial diversity of cortical progenitor cells contributes to the expansion of the neocortex
○Yuta Furusho1,2, Koichiro Irie2, Koyomi Shimamoto1,2, Kimura Takayuki1,2, Shoko Yoshizawa1,2, Miyu Watanabe1, Carina Hanashima1,2 (1. Waseda Univ. , 2. Grad. School of Waseda Univ.)
[3P-694]Generation of SETD1A and SETD1B Mutant Marmosets as Non-human Primate Models for Neuropsychiatric and Neurodevelopmental Disorders
○Zefeng Wei1, Harumi Nakao1, Yukiko Abe1, Motoki Goto1, Moe Tamano1, Atsu Aiba1 (1. The University of Tokyo)
[3P-695]Identification of neuronal populations expressing an extra ocular opsin Ci-opsin2 in the ascidian larva
○Iori Den1, Kouhei Onuma2, Ayana Maruo1, Nanako Okawa3, Fuki Gyoja1, Keiichi Kojima4, Takahiro Yamashita3, Yoshinori Shichida3,5, Zeng Xin6,7, Yutaka Suzuki6, Kenta Nakai7, Takehiro G Kusakabe1 (1. Grad. Sch. of Nat. Sci. Konan Univ., 2. Grad. Sch. of Nat. Sci. & Tech., Shimane Univ., 3. Grad. Sch. of Sci., Kyoto Univ., 4. Grad. Sch. of Med. Dent. Pharm. Sci., Okayama Univ., 5. Res. Org. Sci. & Tech., Ritsumeikan Univ., 6. Grad. Sch. of Front. Sci., the University of Tokyo., 7. Inst. of Med. Sci., the University of Tokyo.)
[3P-696]Analysis of mice with reduced diversity of clustered protocadherin Pcdhb
○Haruya Iwasaki1, Ryuon Higuchi1, Makoto Sanbo2, Takeshi Yagi1 (1. Osaka University, 2. National Institute for Physiological Sciences)
[3P-697]Molecular basis of dendritic bundling formation in the retrosplenial cortex
○Tatsuki Nakano1,2, Misano Sirasaka1,2, Naoto Ohte1,2, Carina Hanshima1,2 (1. Waseda Univ., 2. Waseda uni.)
[3P-698]Nwd1 regulates the assembly of purinosomes and stress granules
○Miona Funato1, Shinichi Sakakibara1 (1. Waseda University)
[3P-699]Analysis of the Mechanisms Underlying Behavioral Choice in C. elegans
○Keichiro Mukouya1, Asuka Takeishi1 (1. Kobe University)
[3P-700]Sex-dependent regulation and role of R-loops in cocaine-conditioned place preference in mice
○Rei Nishimoto1,2, Mary Claire Herrington2, Siera Simmerson2, Rose Marie Akiki2, Caila Worley2, Makoto Taniguchi2 (1. National Organization Hospital Fukuyama Medical Center, 2. Medical University of South Carolina)
[3P-701]Octopamin signaling in clock neurons is required for two distinct memory processes in Drosophila
○Yuto Kurata Kurata1, Takaomi Sakai1 (1. Tokyo Metropolitan University)
[3P-702(3AS-09-05)]A GPCR conserved from human to nematode functions as thermo-receptor and is involved in heat acclimation of C. elegans
○Hiromu Ueka1,2,3, Chinatsu Morimoto1,2,3, Chie Miyazaki2, Kohei Ohnishi1,2,3, Tohru Miura1,2,3, Ohta Akane1,2,3, Atsushi Kuhara1,2,3,4 (1. Graduate school of Natural Science, Konan Univ., 2. Faculty of Science and Engineering, Konan Univ., 3. nstitute for Integrative Neurobiology, Konan Univ., 4. AMED-PRIME)
[3P-703]Investigating the molecular mechanisms underlying the integration of temperature and odor cues in C. elegans
○Yanshu Zhang1, Kristina Galatsis1, Zhenhua Shao1, Asuka Takeishi1,2 (1. Center for Brain Science, RIKEN, 2. Graduate School of Science, Kobe University)
[3P-704]Neural mechanism underlying motivation to approach humans in mice showing Active tameness
○Bharathi Venkatachalam1,2, Mao Nemoto3, Yasushi Shimoda3, Tsuyoshi Koide1,2 (1. National Institute of Genetics, 2. The Graduate University for Advanced Studies, SOKENDAI, 3. Department of Materials Science and Bioengineering, Nagaoka University of Technology)
[3P-705]N-NOSE Cancer Screening Technology: A Comprehensive Analysis of Clinical Efficacy and Validation
○Masayo Morishita1, Takaaki Hirotsu1, Eric di Luccio1, Aya Hasan Alshammari1, Hideyuki Hatakeyama1, Kazuko Matsubara1, Takuya Oshiro1, Umbhorn Ungkulpasvich1, Junichi Yamaguchi1, Gus Wanto1, Nobuaki Kondo1 (1. HIROTSU BIO SCIENCE Inc.)
[3P-706]Real-time monitoring of CREB transcriptional activity in Drosophila using the luminescent reporter Akaluc
○Sota Anzawa1, Takehito Satoh1, Takahiro Chihara2, Takaomi Sakai1 (1. Tokyo Metropolitan University, 2. Hiroshima University)
[3P-707]Evaluation of the response sensitivity of C. elegans to volatile substances.
○Suzuki Michiyo1 (1. National Institutes for Quantum Science and Technology)
[3P-708]Analysis of the molecular and neural mechanisms by which an immediate early gene Hr38 regulates dopaminergic neural functions in long-term courtship memory of Drosophila melanogaster
○Aya Nishikawa1, Seika Kiya1, Taketoshi Kiya1 (1. Div. of Life Sci., Grad. Sch. of Nat. Sci & Tech., Kanazawa Univ.)
[3P-709]Roles of serotonin in sleep impairments induced by confinement stress in a small space in Drosophila
○Momoka Ogawa1, Takaomi Sakai1 (1. Tokyo Metropolitan University Graduate School)
[3P-710]Measurement and Analysis for the Automated Detection of Mouse Foot Faults
○Ryudai Yokokawa1, Ryodai Oda1, Chikako Hara-Miyauchi1, Itsuki Ajioka1, Shingo Maeda1 (1. Institute of Science Tokyo)
[3P-711]Analysis of sex differences in behavioral phenotypes of C57BL/6J mice
○Ikuko Yamada1, Tomoko Kushida1, Tamio Furuse1, Masaru Tamura1 (1. RIKEN BioResource Research Center)
[3P-712]Split-GAL4 based screening identified a pair of descending neurons that drives C-bending in the Drosophila larval SEZ
○LIYAN SHI1 (1. The University of Tokyo)
[3P-713]Behavioral analysis using mice with reduced clustered protocadherin expression diversity
○Rikuto Kimura1, Tomoki Osuka1, Ryuon Higuchi1, Makoto Sanbou2, Takeshi Yagi1 (1. The University of Osaka, 2. National Institute for Physiological Sciences)
[3P-714]Specific haplotypes formed by HTRA1 pathogenic mutation and SNP rs2672592 increase MRI white matter lesion volume in HTRA1-related cerebral small vessel disease
○SHIN KOIDE1,2, Taisuke Kato1, Shoichiro Ando2, Osamu Onodera1,2 (1. Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 2. Department of Neurology, Brain Research Institute, Niigata University)
[3P-715]Development of an assay system for the analysis of Alzheimer's disease pathology using transparent fish.
○Masahiro Inui1, Kunihiro Matsumoto1, Naoki Hisamoto1, Tsubasa Itou1 (1. Nagoya Univ.)
[3P-716]Investigating the Association between Supersulfides and Alzheimer's Disease
○Ayaka Kinno1, Shingo Kasamatsu1, Takahiro Katsuki1,2, Tomoaki Ida3,4, Takaaki Akaike4, Hideshi Ihara1 (1. Dept. of Biol. Chem., Grad. Sch. of Sci., Osaka Metropolitan Univ., 2. Toyo Inst. of Food Tech., 3. Organ. for Res. Prom., Osaka Met. Univ., 4. Dept. of Red. Mol. Med., Tohoku Univ. Grad Sch of Med.)
[3P-717]Reprogramming Müller glia in the injured adult mammalian retina to induce de novo neurogenesis for retinal regeneration
○Taimu Masaki1,2, Ryoichiro Kageyama1,2 (1. RIKEN BDR, 2. Graduate School of Medicine, Kyoto University)
[3P-718]The regulatory mechanism of microglia by astrocytes in an in vitro stress model using dexamethasone
○Astrella Devina1, Shigeo Uchino2, Takae Hirasawa2 (1. Graduate School of Science and Engineering, Teikyo University, Japan, 2. Department of Biosciences, School of Science and Engineering, Teikyo University, Japan)
[3P-719]LPS or PG uniquely affects neuronal differentiation through TLRs
○Kaito Yamada1, Junji yamauchi1, Yakon hideji1 (1. Tokyo University of Pharmacy and Life Sciences)
[3P-720]Development of Nucleic Acid Targeting Technology for Inflammatory Astrocytes
○Yogo Sakakibara1, Kyohei Okahara1, Kenji Ohba2 (1. Eisai Co. Ltd., 2. Jichi Medical University)
[3P-721]Drosophila VPS13 cooperates with VPS35 to maintain mitochondrial homeostasis in dopaminergic neurons
○Kahori Fukushima1, Yuzuru Imai1, Nobutaka Hattori1 (1. Juntendo University)
[3P-722]Biological impact of CRMP1 de novo variants identified in neurodevelopmental disorders on neuronal response to Sema3A
○HIROKO MAKIHARA1, YUMI YANO1, SUZUNA SATO1, FUMIO NAKAMURA1 (1. Tokyo women's medical university)
[3P-723(3PS-08-09)]Analysis of Mitochondrial Dysfunction Induced by MBD5 and MBD6 Deficiency
○Shin-ichi Horike1, Keiko Iwata3, Yoko Hashimoto1, Hideo Matsuzaki2, Makiko Meguro1 (1. Kanazawa Univ., 2. Fukui Univ., 3. Wakayama Med Univ.)
[3P-724(3PS-07-02)]TENM4-related familial epilepsy caused by imbalance in splicing variant expression
○Yasuyo Suzuki1, Yasushi Enokido2, Noriko Nomura1, Kenichiro Yamada1, Jun-ichi Takanashi3, Hiroaki Miyahara4, Johji Inazawa5, Shin Hayashi1,5 (1. Dept. of Genet., Inst. for Develop. Res., Aichi Develop. Disability Ctr., 2. Dept. of Cell Pathol., Inst. for Develop. Res., Aichi Develop. Disability Ctr., 3. Dept. of Pediatr., Tokyo Women's Med. Univ. Yachiyo Med. Ctr., 4. Inst. for Med. Sci. of Aging, Aichi Med. Univ., 5. Dept of Mol Cytogenetics, Med. Research Inst. and Grad. Sch. of Med. and Dental. Sci.)
[3P-725]Neurodegeneration and Phosphorylated Tau Accumulation in the Chronic Phase of EAE Mice
○Ryosuke Oda1, Naotoshi Iwahara1, Takayuki Nonaka1, Masanobu Tanemoto1, Atsushi Kuno2, Shin Hisahara1 (1. Department of Neurology, Sapporo Medical University, 2. Department of Pharmacology, School of Medicine, Sapporo Medical University)
[3P-726]Effects of social stress on CSF penetration into periventricular regions
○Hana Konno1, Takumi Taketomi2, Megumi Uno1, Tsuruta Fuminori2,3 (1. MS Prog Biol, Deg Prog in Life and Earth Sci, Grad Sch Sci and Tech, Univ of Tsukuba, 2. PhD Prog in Human Biol, Univ of Tsukuba, 3. Inst of Life and Env Sci, Univ of Tsukuba)
[3P-727]Observations of Gut Microbiota and Polyamine Metabolism in an App Knock-In Mouse Model.
○Sofia Tomomi Carletti1, Shion Akagi1, Mayumi Minamisawa1 (1. Chiba Institute of Technology)
[3P-728]Mutations in the Autism-associated Gene Hevin/SPARCL1 Lead to Secretion Defects and Reduced Social Behaviors
○Hirone Kikukawa1, Taketomi Takumi2, Tsuruta Fuminori3 (1. MS Prog Biol, Deg Prog in Life and Earth Sci, Grad Sch Sci and Tech, Univ of Tsukuba, 2. Ph. D. Program in Human Biology, University of Tsukuba, 3. Inst of Life and Env Sci, Univ of Tsukuba)
[3P-729]Ninjinyoeito enhances social interaction via Fgf21/Isotocin neuron
○Yukiko Nishi1, Yuko Futagami2, Momoko Kawabe3, Seiwa Michihara3, Shigeki Chiba3, Akio Inui4, Kazuhiro Shiozaki1,2 (1. Grad. Sch. Agricult. Forest. Fish., Kagoshima Univ., 2. Fac. Fish., Kagoshima Univ., 3. Kracie, 4. Grad. Sch. Med. Den. Sci., Kagoshima Univ.)
[3P-730]Pathogenic TDP-43 mutation impairs RNA binding and disrupts RNA quality control pathways.
○Yuki Oshima1,2, Hidefumi Suzuki1, Hiroaki Yaguchi2, Ryota Abe3, Yoko Ike1, Keiko Horiuchi1, Tomohiko Akiyama1, Tomonori Hirose1, Ichiro Yabe2, Hidehisa Takahashi1 (1. Department of Molecular Biology, Yokohama City University, 2. Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, 3. Department of Neurology and Stroke Medicine, Yokohama City University)
[3P-731]Identification of Age-associated Pathogenic Factors in the Brain Vascular Endothelium of Down Syndrome
○Shintaro Funasaki1, Sayaka Ogusa1, Shunsuke Kamei1, Shingo Itoh2, Kazuhiro Takara3, Sumio Ohtuki2, Hiroyasu Kidoya3, Takashi Minami1 (1. IRDA, Kumamoto Univ., 2. Pharm.Microbiol., Kumamoto Univ., 3. Integr. Vasc. Biol., Fukui Univ.)
[3P-732]Molecular pathology of inclusion body myositis with one-to-one correspondence to cellular pathology within tissue sections through high-quality single-cell spatial transcriptomics
○Kazuki Kurimoto1, Nanami Yamada1, Hiroki Ikeda1, Kazuma Sugie1 (1. Nara Med. Univ.)
[3P-733]A trial to develop an alpha-synuclein fibril-based Drosophila model of synucleinopathy
○Yoshiki Takamatsu1, Genjiro Suzuki1, Masami Masuda-Suzukake 1, Shin-Ichi Hisanaga2,1, Masato Hasegawa1 (1. TMIMS.Dept.Clin.Med.Sci.Dem., 2. TMU.Dept.Biol.Sci.)
[3P-734]Reparative function in brain cells after ischemic stroke by single cell analysis
○AYAKA NAKAMURA1,2, Seiichiro Sakai1, Koji Hase2, Takashi Shichita1 (1. Insitute of ScienceTokyo, 2. Keio University)
[3P-735]Therapeutic possibility of Kleefstra syndrome by CRISPRa-mediated EHMT1 activation
○Ayumi Yamada1, Kayako Nishimura1, Yoichi Shinkai1 (1. Shinkai Cellular Memory lab, RIKEN)
[3P-736(3MS-15-05)]Elucidating the Molecular Mechanisms of Epilepsy through Single-Cell Spatial Transcriptomic Analysis
○Satoshi Miyashita1, Nao Tabe1, Keiya Iijima2, Kaoru Yagita3, Kazumi Shimaoka1, Shuyu He1, Minami Mizuno1, Ayane Hosaka1, Masaki Takao3, Tomoki Nishioka4, Tomoo Owa1, Masaki Iwasaki2, Mikio Hoshino1 (1. Department of Biochemistry and Cellular biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, 3. Department of Clinical Laboratory and Internal Medicine, , National Center Hospital, National Center of Neurology and Psychiatry, 4. Division of Cell Biology, International Center for Brain Science, Fujita Health University)
[3P-737]Involvement of microglial xCT in the pathology of Alzheimer’s disease model mouse
○Yugo Kato1, Yosuke Horikoshi1, Kazuhiro Nakaso1 (1. Division of Biochemistry, Faculty of Medicine, Tottori University)
[3P-738]Optically enhanced plasticity in interneuron clears amyloid beta plaques in Alzheimer’s disease.
○Mariia Ivanova1, Lotta Esselström1, Delight Degu1, Lisa Rampazzo1, Rashid Giniatullin1, Riikka Martikainen1, Heikki Tanila1, Tarja Malm1, Juzoh Umemori1 (1. A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland)
[3P-739]Genetic Analysis of the Regulation of Avoidance Distance to Odor Stimuli
○Keitaro Tobe1, Kotaro Kimura1 (1. Nagoya City Univ. Grad. Sch. of Science)
[3P-740]Characterization of gene regulatory networks in neural differentiation in Down syndrome
○Kanako Ikeuchi1,2, Masaki Suimye Morioka1,3, Tomoe Nobusada1,2, Takeya Kasukawa1,2 (1. Laboratory for Large-Scale Biomedical Data Technology RIKEN IMS, 2. Graduate school of Medical life science Yokohama City University, 3. Database Center for Life Science)
[3P-741]Reversal of axonal swelling in primary neurons following transient autophagy suppression
○Kazuma Kita1, Tomoya Eguchi1, Noboru Mizushima1 (1. Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo)
[3P-742]Detection and Analysis of Early Brain Abnormalities in Alzheimer's Disease Model Mice Using an ATP Visualization System
○Takahito Ayano1,2, Masamichi Yamamoto1 (1. Dept. Research Promotion and Management, National Cerebral and Cardiovascular Center, 2. JSPS Research Fellowship)
[3P-743]Spatial omics analysis for Pcdh15 null bipolar disorder model mouse
○Kanta Yoneyama1, Masahide Seki1, Akinori Kanai1, Junko Zenko1, Yusuke Mizuno1, Daisuke Mori2, Yuko Arioka2, Hiroki Okumura2, Norio Ozaki2, Yutaka Suzuki1 (1. Tokyo Univ., 2. Nagoya Univ.)
[3P-744]Intracellular amyloid-β disrupts lysosomal homeostasis and influences tau phosphorylation in Alzheimer’s disease
○NAZERE KEYOUMU1, Takahashi Tetsuya2, kuwano yuki1, morino hiroyuki1 (1. Department of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences,, 2. Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences,)
[3P-745]Improvement of neuroinflammation and sensorimotor gating impairment through brain-gut interaction by green Algae ingestion in Cuprizone short-term treated mice
○Kentaro Nakashima1,3,4, Kyoka Tsukuda1,2,4, Ayaka Onishi3, Aoi Chiba4, Taku Nagamatsu4, Takashi Kubota4,5, Yasushi Kishimoto4,6 (1. Inst. Neurosci., Tokushima Bunri Univ., 2. Lad. Pharmacotherapy, Dept. Pharm., Fac. Pharm., Kindai Univ., 3. Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ., 4. Lab. Biophysics, Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ., 5. Dep. Pharm. Sci., Fac. Pharm. Sci., Teikyo Heisei Univ., 6. Lab. of Phys. Chem., Fac. Pharm. Sci., Teikyo Univ.)
[3P-746]Mitochondria-Driven Pathogenic Mechanisms in Retinitis Pigmentosa Associated with Hexokinase1:p.Glu847Lys
○Takumi Tateno1, Shigeru Sato1,2, Ryusei Ogawa1, Keita Kawagoe1, Aoi Ichikawa3, Keisuke Takeda3, Emi Ogasawara3, Naotada Ishihara3, Motokazu Tsujikawa1,2 (1. Department of Health Science, Graduate School of Medicine, The University of Osaka, 2. Department of Ophthalmology, Graduate School of Medicine, The University of Osaka, 3. Graduate School of Science, The University of Osaka)
[3P-747]Analysis of intercellular transfers between motor neurons and microglia in ALS
○Hiroko Kushige1, Kagistia Hana Utami1, Hirotaka Watanabe2, Satoru Morimoto1, Hideyuki Okano1,2 (1. keio University, 2. Fujita Health University)
[3P-748]Effects of Autotaxin expressed in follicular dendritic cells on B cell activation
○Mikoto Nakashima1, Satomi Ohtsuka1, Hiroshi Tokumitsu1, Masaki Magari1 (1. Okayama University)
[3P-749]Elucidation of the role of BAFF in the differentiation of monocytic cells with B cell-activating ability.
○Norika Mori1, Risa Nakatsuka2, Satomi Ohtsuka1, Hiroshi Tokumitsu1, Masaki Magari1 (1. Grad. Sch. Interdiscip. Sch. and Eng. in Health Syst. Okayama Univ., 2. Fac. Eng., Okayama Univ.)
[3P-750]Analysis of the post-transcriptional modification of membrane-bound IL-34 that is important for monocytic cell differentiation induced on follicular dendritic cells.
○Shiori Oyama1, Chisato Okamoto1, Sayaka Ogawa1, Satomi Ohtsuka1, Hiroshi Tokumitsu1, Masaki Magari1 (1. Okayama Univ.)
[3P-751]Identification of the novel biomarker and therapeutic target in endothelial cells for lymphocytic myocarditis
○Satofumi Takaoka1, Ken Matsuoka1,2, Takatsugu Segawa1,3, Seiji Takashima1,2 (1. Department of Medical Biochemistry, Graduate School of Frontier Biosciences Osaka University, 2. Department of Medical Biochemistry, Osaka University Graduate School of Medicine, 3. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)
[3P-752]Mast cell–neutrophil interactions regulate allergic inflammation
○Saki Toyama1, Yuka Nagata1, Atsushi Furukawa1, Ryo Suzuki1 (1. Kanazawa Univ.)
[3P-753]Allergen affinity regulates IgE receptor desensitization without inducing secretory responses
○Sota Iwami1, Yuka Nagata1, Atsushi Furukawa1, Ryo Suzuki1 (1. Kanazawa Univ.)
[3P-754]The effects of quercetin metabolites on T cell activation
○Nao Ishizaki1, Risa Yanagi1, Kaeko Murota2, Haruko Hayasaka1,3 (1. Dept. Life Sci., Grad. Sch. Sci. and Eng., Kindai Univ., 2. Dept. Life Sci., Grad. Sch. Nat. Sci. and Tech., Shimane Univ., 3. Res. Inst. Sci. and Tech., Kindai Univ.)
[3P-755]Foundational study on immune responses induced by Organ-Targeted mRNA-LNP Delivery
○Yuya Akahane1, Kazuto Shimoya2, Hiroki Tanaka2, Hidetaka Akita2 (1. Laboratory of DDS Design and Drug Disposition, Faculty of Pharmaceutical Sciences, Tohoku University , 2. Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Tohoku University)
[3P-756]Phocaeicola dorei and Phocaeicola vulgatus inhibit atherosclerosis via gut immune responses
○Hitomi Nakashima1, Takuo Emoto2, Ryohei Shinohara2, Hiroshi Mori4, Tomoya Yamashita2,3 (1. Division of Development & Research, Noster inc., 2. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 3. Department of Advanced Medical Science, Kobe University Graduate School of Science, Technology and Innovation, 4. Advanced Genomics Center, National Institute of Genetics)
[3P-757]Effects of Antibody Isotype–Specific ER Stress Responses on Plasma Cell Differentiation
○Kunie Obayashi1, Tomomitsu Doi1, Sumida Kazuhiro1, Endo Motoyoshi1 (1. University of Occupational and Environmental Health, Japan)
[3P-758]Innovative Antibody Therapy Targeting Refractory Inflammatory Disorders
○Rie Kinoshita1, Nahoko Tomonobu1, Yuma Gohara1, Ken-ichi Yamamoto1, Hitoshi Murata1, Tomoko Honjo2, Junichiro Futami2, Kazumi Sagayama3, Masakiyo Sakaguchi1 (1. Okayama Univ., Grad. Sch. Med., Dent. & Pharm. Sci., 2. Okayama Univ., Grad. Sch. Interdisc. Sci. & Eng. in Health Systems, 3. Okayama Univ., Fac. Educ. & Res. Mgmt.)
[3P-759]Runx/Cbfβ regulates the development of tolerogenic Thetis cells
○Chihiro Ogawa1, Ichiro Taniuchi1 (1. RIKEN Center for Integrative Medical Sciences)
[3P-760]Suppressing Alzheimer's Disease by Remodeling the Intestinal Environment with L-Arginine and Limonoids.
○Ayato Hane1, Senou Ayane2, Sudo Shunsuke1, Minamisawa Mayumi1,3 (1. Department of Life Science, Chiba Institute of Technology, Graduate School of Advanced Engineering, 2. Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology , 3. Education Center, Faculty of Advanced Engineering, Chiba Institute of Technology)
[3P-761]Selection of chemically modified DNA Aptamers that bind to Dectin-1 Proteins
○Hana Tsuchitani1, Yasuhito Ebara1 (1. Kobe Univ.)
[3P-762]Mitochondrial Transfer from Skeletal Muscle to Macrophages via Extracellular Vesicles
○Mari Saida1, Norio Sato1, Yuuki Imai3,5, Noritaka Saeki2,3,4 (1. Department of Emergency and Critical Care Medicine, Ehime University Graduate School of Medicine, 2. Division of Research Coordination and Technical Development Office, Ehime University, 3. Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, 4. Department of Applied Chemistry, Ehime University Graduate School of Science and Engineering, 5. Department of Pathophysiology, Ehime University Graduate School of Medicine)
[3P-763]High-Speed AFM Visualization of ATP-Dependent Structual Dynamics and RNA Interaction of RIG-I
○Sota Kondo1, Kazuki Kato3, Mikihiro Shibata2,4 (1. Kanazawa University, 2. Kanazawa University, Nano Life, Nano-LSI, 3. Tokyo University of Science, Institute of Advanced Research, 4. Kanazawa University's New Academic Field)
[3P-764]Characterization of GPRC5C in liver macrophages
○Tomoka Muto1, Hirofumi Sato2, Shota Toyoshima2, Daisuke Hishikawa2, Mashito Sakai2 (1. Nippon Medical School, 2. Department of Biochemistry and Molecular Biology, Nippon Medical School)
[3P-765]Single-Cell RNA Sequencing of PD-1+ Tumor-Infiltrating Immune Cells in Fate-Mapping Mice: Investigation of the Combined Effects of Checkpoint Inhibition and Cytotoxic Chemotherapy
○Shunsuke Takasuga1,2, Ayuko Yamaguchi1,3, Haruka Suzuki1,3, Ebihara Takashi1,2,4 (1. Medical Biology, Akita Univ., 2. Key Research Lab, Akita Univ., 3. Thoracic Surgery, Akita Univ., 4. Ctr. for Integr. Control, Epidemiol. & Mol. Pathophysiol. of Infect. Dis., Akita Univ.)
[3P-767]Role of mesenchymal stem cells and their expressed gene NF-κB in inflammatory responses
○Hiroyuki Miwa1 (1. Saitama Medical University)
[3P-768]Investigating the Role of eEF1A1 During M1 Macrophage Polarization
○Eri SHIMURA1, Ayako Shigenaga2, Tadashi Ando3,4, Ryo Ishihara1, Takeshi Baba1, Fumiyuki Yamakura5 (1. Faculty of Medicine, Juntendo University,, 2. Institute of Health and Sports Science & Medicine, Graduate school of Health and Sports Science, Juntendo University, 3. Department of Applied Electronics, Tokyo University of Science, 4. Research Institute for Science and Technology, Tokyo University of Science, 5. Faculty of Health Science, Juntendo University)
[3P-769]Mechanisms of neutrophil regulation in the suppression of acute aortic dissection progression by molecular hydrogen
○Masumi Iketani1, Toshiyuki Aokage1,2, Mitsuhiro Kawata1,3, Ikuroh Ohsawa1 (1. Biol. Process Aging, TMIG, 2. Emerg. Med., TMIG, 3. CardioVasc. Surg., TMIG)
[3P-770]Investigation of AGEs-induced specific physiological responses in RAW264.7 cells
○Takao Toyomura1, Masahiro Watanabe1, Hidenori Wake2, Takashi Nishinaka2, Hideo Takahashi2, Masahiro Nishibori3, Shuji Mori1 (1. Sch. Pharm., Shujitsu Univ., 2. Fac. of Med., Kindai Univ., 3. Grad. Sch. of Med., Dent. and Pharm. Sci., Okayama Univ.)
[3P-771]Regulation of neutrophil extracellular traps by liver X receptors in atherosclerosis
○Kaori Endo-Umeda1, Suzuka Yamaguchi2, Kenji Yamagishi2, Yusuke Nakanishi3, Akari Suzuki4, Makoto Makishima1 (1. Nihon Univ. Sch. Med., 2. Nihon Univ. Collage of Eng., 3. Nihon Univ. Collage of Bioresour. Sci., 4. RIKEN)
[3P-772]FoxO1 suppresses Tr1 cell differentiation
○Shigenori Nagai1 (1. University of Shizuoka)
[3P-773]Analysis of determinants controlling susceptibility to dog heartworm infection in Aedes aegypti.
○Sakura Kajita1, Tatsuki Kuramoto2,3, Rika Shirafuji1, Shinya Fukumoto3 (1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2. Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 3. Department of Veterinary Medicine, Rakuno Gakuen University)
[3P-774]Abnormal Multicellular Interferon Production and Responses Underlie Adar1 Mutation-Driven Aicardi-Goutières Syndrome-like Encephalopathy
○Hyebin Yoo1, Reiichi Sugihara2, Taisuke Nakahama1,2,3,4, Yuki Kato1,2,3, Yukio Kawahara1,2,3,4,5 (1. Department of RNA Biology and Neuroscience, Graduate School of Frontier Biosciences, The University of Osaka, 2. Department of RNA Biology and Neuroscience, Graduate School of Medicine, The University of Osaka, 3. Integrated Frontier Research for Medical Science Division and RNA Frontier Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 4. Center for Infectious Disease Education and Research (CiDER), The University of Osaka, 5. Genome Editing Research and Development Center, Graduate School of Medicine, The University of Osaka)
[3P-775]Intensity of antigen-IgE interaction determines mast cell-mediated macrophage differentiation in allergic inflammation
○Yuka Nagata1, Shiori Murakami1, Atsushi Furukawa1, Ryo Suzuki1 (1. Division of Pharmaceutical Sciences Institute of Medical, Pharmaceutical, and Health Science Kanazawa University)
[3P-776]Investigation of transcription factors to induce scavenger receptor expression
○Eri Tanaka1,2, Koji Hase2, Takashi Shichita1 (1. Science Tokyo, 2. Keio Univ.)
[3P-777]Involvement of IL-17 in Food-Induced Anaphylaxis and the Mechanisms of Antigen-Specific IgE Production
○Yuya Hokama1, Takahiro Kawahara1, Zhang Man1, Nanami Soda1, Tomoharu Yasuda1 (1. Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University)
[3P-778]Immune factors produced by PBMCs upon stimulation with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1-derived exopolysaccharides inhibit HCoV-229E and SARS-CoV-2 replication
○Shuyi Tang1, Reiko Takai-Todaka2, Shoko Ishii3, Hiroki Kono3, Reiko Watanabe3, Miho Ogawa3, Hiroshi Kano3, Kazuhiko Katayama2, Toshihiro Sashihara3, Kenichi Hojo1, Kei Haga2 (1. Meiji Co., Ltd., 2. Kitasato Univ. , 3. Meiji Holdings Co., Ltd.)
[3P-779]Pluviatolide suppresses mast cell activation and IgE-mediated hypersensitivity
○Seon Young Kim1, Jeong Won Park1, Juhyun Shin1, Ji-Ae Lee1, Hyuk Soon Kim1 (1. Dong-A Univ.)
[3P-780]Screening of plant extracts for modulation of skin immunity via the skin microbiota
○Anna Kanasugi1, Masako Kaga1, Chikako Yanagi1, Masatoshi Takeiri1, Keiko Arai1, Kenji Takemoto2, Masataka Asagiri2, Yoshihide Kimura1 (1. IVY Cosmetics , 2. Department of Pharmacology, Yamaguchi University Graduate School of Medicine)
[3P-781]Role of Vitronectin (VN) in a Metabolic Dysfunction-Associated Steatohepatitis (MASH) Mouse Model
○Nana Morokawa Nana Morokawa1, Momoka Hayashida1, Kei Hashimoto2, Yasunori Miyamoto1 (1. Graduate School of Life Sciences, Course in Biological Sciences, Ochanomizu University, 2. Institute for Human Life Science, Ochanomizu University)
[3P-782]Non-tuberculous mycobacterial infection induces PD-L1 expression in macrophages
○Yukio Fujiwara1, Hiromu Yano1, Yoshihiro Komohara1 (1. Kumamoto University)
[3P-783]A SPECIAL MODEL FOR HUMAN-RAT XENOTRANSPLANTATION
○Yu Lu1,2,3, Min Ding2,4, Xiang-Long Huang1, Tong-Xv Wu1, Jian-Yun Ge3, Ludi Zhang5, Lijian Hui5, Sha Hao2, Yun-Wen Zheng1,2,3,6 (1. Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University,, 2. Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Chinese Academy of Medical Sciences, 3. Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, 4. Kumamoto University, 5. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 6. Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
[3P-784]The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow
○Shinya Abe1,2, Fumiko Toyoshima1, Koichi Ikuta2 (1. Department of Homeostatic Medicine, Medical Research Laboratory, Institute of Science Tokyo, 2. Laboratory of Immune Regulation, Institute for Life and Medical Sciences, Kyoto University)
[3P-785]Construction of Multi-subtype Beta Coronavirus Replicons and Cross-Lineage Evaluation of Antiviral Agents
○Midori TAKEDA1, Natsue MAEZONO 1, Rina UCHIKOSHI 1, Nobuyuki KATO1, Masanori IKEDA 1 (1. Joint Research Center for Human Retrovirus Infection, Kagoshima University)
[3P-786]Perturbation of the ribosome-associated quality control promotes herpes simplex virus-1 (HSV-1) mRNA translation
○Taichi Kakihana1, Hirotaka Toh2, Kanako Watanabe1, Hideaki Matsui4, Mari Mito2, Masahiko Takahashi1, Takayuki Abe1, Shintaro Iwasaki2,3, Masahiro Fujii1 (1. Niigata Univ., 2. Riken, 3. UTokyo, 4. Niigata Univ. BRI)
[3P-787]Pathological significance of apoptosis and IFNL expression in type II alveolar cells in a model of severe influenza
○Yuiko Arita1, Saya Kuribayashi2, Jun Takasaki2, Kiyoshi Takayama2, Hiroshi Kida3, Toshinori Endo4 (1. Hokkaido University Graduate School of Information Science and Technology, 2. NB Health Laboratory Co. Ltd., 3. Hokkaido University International Institute for Zoonosis Control・IVReD, 4. Hokkaido University Faculty of Information Science and Technology)
[3P-788(3AS-03-07)]Study on the Regulation of Neuronal Tropism by Non-Coding Regions of the Viral Genome RNA
○Kyousuke Kobayashi1, Tomaha Nishizawa1, Masako Ukaji1, Satoshi Koike1 (1. Tokyo Metropolitan Institute of Medical Science)
[3P-789]Analysis of the mechanism by which Ubiquitin-associated protein 2-like suppresses West Nile virus replication through binding to ubiquitinated capsid protein
○Keisuke Maezono1,2, Yuna Takahashi1, Wataru Kamitani3, Kentaro Yoshii4, Hirofumi Sawa5,6, Hiroaki Kariwa1,2, Shintaro Kobayashi1,2,5,6 (1. Lab. Public Health, Fac. Vet. Med., Hokkaido Univ., 2. IIZC, Hokkaido Univ., 3. Dept. Infect. Dis. & Host Defense, Grad. Sch. Med., Gunma Univ., 4. CCPID, Nagasaki Univ., 5. HU-IVReD, Hokkaido Univ., 6. OHRC, Hokkaido Univ.)
[3P-790]Development of a Biolayer Interferometry-based assay for measuring the physical titer of lentiviral vectors
○Yukage Kobari1, Yuko Kasahara1, Yukihiko Hirai1, Yasushi Soda1, Takashi Okada1 (1. The Institute of Medical School, The University of Tokyo, Division of Molecular and Medical Genetics, Center for Gene & Cell Therapy kyo)
[3P-791]Live imaging of intestinal colonization by O157 in a mouse infection model
○Yuna Oshima1, Daiki Yamaguchi2, Maki Kabumoto1, Mami Kobayashi1, Miho Ishikawa1, Miyabi Sakamoto1, Takumi Terashima1, Kinnosuke Yahiro1 (1. Kyoto Pharmaceutical University, 2. Meiji Pharmaceutical University)
[3P-792]Establishment of reverse genetics system for an emerging human pathogenic orthonairovirus
○Yume Mimura1, Asako Shigeno1, Keita Mizuma1, Keita Matsuno1,2,3,4 (1. Hokkaido Univ. IIZC DRAM, 2. Hokkaido Univ. OHRC, 3. Hokkaido Univ. IVReD, 4. Hokkaido Univ. IIZC International Collaboration Unit)
[3P-793(3AS-03-03)]Quantifying Host Immune Responses to Viruses Using Large-Scale Animal RNA-Seq Data for Detection of Viral Infection
○Luca Nishimura1, Hiroaki Unno1, Junna Kawasaki2,3, Jumpei Ito1, Kei Sato1 (1. IMSUT, 2. Chiba Univ., 3. NIID)
[3P-794]Fatty Acid Desaturase Inhibitor–Mediated Cell Death in Naegleria Amoeba
○Yoshi Odaka1, Keen Wilson1, Alex Wilson1 (1. University of Cincinnati)
[3P-795]Reconstruction of a Three-Layered Urothelium and Establishment of a Novel In Vitro Model for Urinary Tract Infection (UTI)
○Mizuki Fukuda1,2, Kazuhiro Ofuji1,2, Yukari Usuda1,2, Maiko Takahashi1, Hidetada Hirakawa4, Minoru Takasato1,2,3 (1. RIKEN BDR, 2. Kyoto Univ., 3. Osaka Univ., 4. Gunma Univ.)
[3P-796]Characterization of PDZ domains interacted with viral proteins
○Takeshi Tenno1, Haruka Takagi1, Uiko Tomiyasu1, Hidekazu Hiroaki1 (1. Grad. Sch. Pharm. Sci., Nagoya Univ.)
[3P-797]Immune cell interaction network analysis and dynamics analysis after COVID-19 infection and vaccination by scRNA-seq
○Setsu Kunieda1, Risa Yokokawa1, Shinji Nakaoka1 (1. Hokkaido University)
[3P-798]The antiviral immune response to tick-borne encephalitis virus in the absence of STING
○Moe Ikegawa1, Kentaro Yoshii1, Takumi Kawasaki1 (1. Nagasaki University)
[3P-799]Establishment of Highly Permissive Vero Cells Lacking IRF1-Mediated Constitutive Antiviral Defense
○Tomoko Honda1, Kotomi Shinozaki1,2, Daisuke Yamane1,2 (1. Tokyo Metropolitan Institute of Medical Science, 2. Ochanomizu University, Humanities and Sciences)
[3P-800]Search for human norovirus receptor candidate molecules using human intestinal organoids
○Kazuyuki Yamasaki1, Kei Haga1, Reiko Todaka1, Kazuhiko Katayama1 (1. Graduate School of Infection Control Science, Kitasato University.)
[3P-801]A Rapid, Culture-Independent Workflow for Identifying Drug-Resistant Bacteria Using PMA, Real-Time PCR, and Nanopore Sequencing
○Rajalakshmi Balasubramanian1, Yu Suzuki1, Satomi Asai1,2, Eisaku Yoshihara1, Miki Miyazawa2, Tadashi Imanishi1 (1. Tokai University School of Medicine, 2. Tokai University Hospital)
[3P-802]Cholesterol restriction primes antiviral innate immunity via SREBP1 transcription factor-driven noncanonical type I IFNs
○Tasuku Nishimura1, Takahisa Kouwaki1,2, Ken Takashima1,2, Hiroyuki Oshiumi1,2 (1. Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 2. Department of Immunology, Faculty of Life Sciences, Kumamoto University)
[3P-803]Comprehensive Analysis to Reveal Confinement of RNA Virus Genome Secondary Structure
○Shohei Ogino1, Junna Kawasaki2, Michiaki Hamada1,3,4 (1. Waseda University, 2. Chiba University, 3. National Institute of Advanced Industrial Science and Technology, 4. Nippon Medical School)
[3P-804]Establishment of a lethal mouse model and analysis of its pathogenicity
○Rio Harada1,2, Cassia Sousa Moraes1,2, Atsuko Inoue1,3, Chilekwa Kabamba1,2, Joshua Kranrod1,4, Shuichi Osawa5, Motohito Goto6, Riichi Takahashi6, Koshiro Tabata1, Shinji Saito1, Gabriel Gonzalez1, Noriko Nagata5, Ito Mamoru6, Makoto Suematsu6, Hirofumi Sawa1,7,8, Yukari Itakura1 (1. Institute for Vaccine Research and Development, Hokkaido University, 2. Graduate School of Infectious Diseases, Hokkaido University, 3. Faculty of Pharmaceutical Science, Graduate School of Life Science, Hokkaido University, 4. Graduate School of Medicine, Hokkaido University, 5. Ibaraki Prefectural Institute of Public Health, 6. Central Institute for Experimental Medicine and Life Science, 7. International Institute for Zoonosis Control, Hokkaido University, 8. One Health Research Center, Hokkaido University)
[3P-805]Disruption of lipid metabolic pathways by a zoonotic Orthonairovirus leads to lethal disease in a mouse model
○Kittiya Intaruck1, Marumi Ohno2,3,4, Katendi Changula5, Naganori Nao4,1,6, Siddabasave B Gowda7, Kosuke Okuya8, Yasuko Orba3,9, Joseph Ndebe1, Hayato Harima10, Qiu Yongjin11, Akina Mori Kajihara12, Hirofumi Sawa3,4,6, Ayato Takada6,12, Masahiro Kajihara1,6 (1. Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, 2. Division of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, 3. Institute for Vaccine Research and Development, Hokkaido University, 4. One Health Research Center, Hokkaido University, 5. Department of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, 6. Hokudai Center for Zoonosis Control in Zambia, School of Veterinary Medicine, University of Zambia, 7. Faculty of Health Sciences, Hokkaido University, 8. Joint Faculty of Veterinary Medicine, Kagoshima University, 9. Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, 10. Laboratory of Veterinary Public Health, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 11. Laboratory of Parasitology, School of Veterinary Medicine, Hokkaido University, 12. Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University)
[3P-806]Novel Cell Penetrant Antibodies for Rabies Prophylaxis
○Joshua Walter Kranrod1,2, Shinji Saito1, Cassia Sousa1,3, Koshiro Tabata1, Michihito Sasaki1,4, Naoto Ito5,6,7, Gabriel Gonzalez8, Masaaki Murakami1,2,9,10, Hirofumi Sawa1, Yukari Itakura1 (1. Division of Biological Response Analysis, Institute for Vaccine Research and Development, Hokkaido University, 2. Division of Molecular Psychoimmunology, Institute for Genetic Medicine, and Graduate School of Medicine, Hokkaido University, 3. Graduate School of Infectious Diseases, Hokkaido University, 4. Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, 5. Joint Graduate School of Veterinary Sciences, Gifu University, 6. Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, 7. Center for One Medicine Innovative Translational Research (COMIT), Institute for Advanced Study, Gifu University, 8. Division of Research Support, Institute for Vaccine Research and Development, Hokkaido University, 9. Division of Molecular Neuroimmunology, National Institute for Physiological Sciences, 10. Group of Quantum Immunology, Institute for Quantum Life Sciences, National Institute for Quantum and Radiological Science and Technology)
[3P-807]Characterization and Functional Insights into the Deamidase Family in Legionella
Anna Makovska1, Erik Walinda1, Daichi Morimoto2, Hideki Yashiroda3, Tsunehiro Mizushima4, Minsoo Kim1, ○Tohru Tezuka1 (1. Graduate School of Medicine, Kyoto University, 2. Graduate School of Engineering, Kyoto University, 3. Faculty of Pharmaceutical Sciences, Teikyo Heisei University, 4. Graduate School of Science, University of Hyogo)
[3P-808]Real-time Bioluminescence Monitoring of Virus–Host Dynamics during Flaviviridae Infection
○Masahiko Ito1, Xiaoyu Li1, Jie Liu1, Mami Matsuda2, Kwang Su Kim3, Toru Takada4, Haruyo Aoyagi2, Takayuki Hishiki5, Fumihiro Kato6, Shigeru Tajima7, Koichi Watashi8, Hideki Aizaki2, Masayoshi Fukasawa9, Takanobu Kato2, Takaji Wakita2, Shingo Iwami3, Ryosuke Suzuki2, Tetsuro Suzuki1 (1. Dept. of Microbiol. & Immunol., Hamamatsu Univ. Sch. Med., 2. Dept. of Virol. II, NIID., 3. iBLab, Grad. Sch. Sci., Nagoya Univ., 4. Math. Biol. Lab., Grad. Sch. Syst. Life Sci., Kyushu Univ., 5. Dept. of Drug Dev., NIID., 6. Ctr. for Quality Mgmt. Systems, NIID., 7. Dept. of Virol. I, NIID., 8. Res. Ctr. for Drug & Vaccine Dev., NIID., 9. Dept. of Biochem. & Cell Biol., NIID.)
[3P-809]Association analysis of fever and human leukocyte antigen genes by mRNA-Based SARS-CoV-2 Vaccination
○Hiroki Narashima1, Koichiro Tateishi2, Shingo Suzuki1, Atsuko Shigenari1, Sayaka Ito1, Norio Yamamoto2, Takashi Shiina1, The Tokai University COVID-19 Working Group (1. Department of Molecular Life Science, Tokai University School of Medicine, 2. Department of Microbiology, Tokai University)
[3P-810]Construction of human disease network based on comprehensive analysis of electric medical records
○Tadashi Imanishi1,2, Hiroto Kubomatsu1,3, Yoshiro Yamamoto3,4 (1. Mol Life Sci, Tokai Univ Sch Med, 2. Inst Med Sci, Tokai Univ, 3. Dept Math, Grad Sch Sci, Tokai Univ, 4. Dept Math, Tokai Univ)
[3P-811(3AS-05-05)]Development of a mitochondria-activating ATP prodrug for regulation of aging
○Takahisa Anada1, Michiharu Kawahara1, Masaru Tanaka1 (1. Kyushu University)
[3P-812]Loss of Akr1b7 impairs oocyte maturation, leading to a reduction in littermate
○Keishiro Isayama1, Kenji Watanabe1, Takayuki Ohnishi1, Yoichi Mizukami1 (1. Yamaguchi Univ., Org. for Res. Initiatives, Ctr. for Gene Res.)
[3P-813]Mechanisms of age-related morphological and functional changes in neuronal nuclei
○Rinka Obata1,2, Hiroki Kawai, Arthur Stefano Moscheni2, Yu Nagata2, Koichiro Maki3, Taiji Adachi3, Yusuke Kishi1,2 (1. Graduate School of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences University of Tokyo , 2. Institute for quantitative bioscience University of Tokyo, 3. Institute for Life and Medical Sciences Kyoto University)
[3P-814]Gut Microbiome Profiles in Ecuadorian Centenarians
○Yui Ikeyama1, Paúl León2, Martina Armas4, Yoko Iwauchi1, Kazuyoshi Hosomichi1, Vanessa I Romero2,3 (1. Graduate School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 2. Escuela de Biotecnología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Ecuador, 3. Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Ecuador, 4. Escuela de Medicina, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito – Quito, Ecuador)
[3P-815]Histopathological analysis of age-related changes using organoids derived from aged mouse organs toward elucidation of carcinogenesis mechanisms
○Nanaho Hidaka1, Kayoko Yamada1, Haru Yamamoto1, Tatsuya Usui1, Kazuaki Sasaki1 (1. Tokyo University of Agriculture and Technology)
[3P-816]Soluble guanylate cyclase subunit GUCY1A2 is associated with inflammatory phenotype in senescent cells
○Ryota Kobori1,2, Soichiro Kumamoto1, Tomohisa Baba1, Yasuhiro Nakano1,3, Yoshikazu Johmura1,3 (1. Div. Cancer Senescence Biol., Cancer Res. Inst., Kanazawa Univ., 2. Div. of Biol. Sci. & Tech., Grad. Sch. of Natural Sci. & Tech., Kanazawa Univ., 3. Integrated Systems of Aging Res., Inst. Frontier Sci. Initiative, Kanazawa Univ.)
[3P-817]Nuclear deformation caused by mitochondria stress response induced SOST upregulation resulted in age-related bone loss
○Kenji Watanabe1, Shuichi Shibuya2, Hidetoshi Nojiri3, Takahiko Shimizu4 (1. Juntendo Univ. Intractable disease research center, 2. Sanyo-Onoda City Univ. Faculty of Pharmacy, 3. Juntendo Univ. Dept. of Med. for ortho. and motor organ, 4. Juntendo University Graduate School of Medicine)
[3P-818]Anti-aging effects of Jason Winters Tea via muscle cells
○Takeru Murakami1, Rana Yamamoto2, Yoshinori Katakura3 (1. Kyushu University, Graduate School of Systems Life Sciences, 2. Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, 3. Kyushu University, Faculty of Agriculture)
[3P-819]Machine Learning based Non-Invasive Aging Prediction for Personalized Anti-Aging Therapies
○Yoshihiro Ando1, Yuichiro Yada2, Yasumasa Bessho1, Naoki Honda2, Takaaki Matsui1 (1. Nara Institute of Science and Technology, 2. Nagoya University)
[3P-820]Skin improvement effects of elastin-derived peptides
○ZHANG YUXUAN1, Tsubaki Taiki1, Katakura Yoshinori1 (1. Kyushu University)
[3P-821]Investigating the Role of ZNF598-Dependent Translational Quality Control in Neural Stem Cell Aging
○Ziqing Yang1, Quan Wu1, Fumio Matsuzaki1 (1. Kyoto University)
[3P-822]Effects of gut microbiota metabolite tryptamine and its analog 7-fluoro-tryptamine on osteoblast and osteoclast function
○Chisato Sampei1, Ren Sato1, Tadayoshi Hayata1 (1. Tokyo University of Science)
[3P-823]Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans
○Rika Inomata1, Ryuichi Saito1, Diansheng Wang1, Satoshi Shimazaki1 (1. TOA Biophama CO., LTD.)
[3P-824]Proteome Analysis of Age-Related Changes in Mouse Testicular Cells at Differentiation Stage
○MASARU MORI1, Maezawa So2, Otsuka Kai2, Nakamura Tatsuya2, Hayashi Yohei3 (1. Nagoya University, 2. Tokyo University of Science, 3. Institute of Science Tokyo)
[3P-825]Effect of aging on the miRNA expression profile of exosomes secreted by CD45-positive cells localized in skeletal muscle
○Noriaki Kawanishi1, Katsuhiko Suzuki2 (1. Chiba Institute of Technology, 2. Waseda Univ.)
[3P-826]Loss of intracellular iron homeostasis induces leukemia cell death
○Saho Yoshikawa1, Yoshiki Yamamoto2, Ayuna Hattori3, Takahiro Ito3, Rikuto Toda4, Takamasa Ishii5, Masaki Miyazawa6 (1. Graduate School of Engineering, Tokai Univ., 2. Graduate School and Faculty of Pharmaceutical Sciences, Kyoto Univ., 3. Institute for Life and Medical Sciences, Kyoto Univ., 4. Graduate School of Science and Technology, Tokai Univ. , 5. School of Medicine, Tokai Univ., 6. School of Health Studies, Tokai Univ.)
[3P-827]Mechanistic Insight into Mutant p53-Driven Breast Cancer Malignancy via Mevalonate Pathway Activation and Morphological Changes
○Akitoshi Nakayama1, Masataka Yokoyama1, Tomoaki Tanaka1,2 (1. Dept. of Mol. Diag., Chiba Univ. Grad. Sch. of Med., 2. Chiba Univ. Res. Inst. of Disaster Med.)
[3P-828]Distinct regulation of tumor suppressor genes by E2F enables discrimination of cancer cells from normal growing cells
○Yaxuan Zhou1, Kiyoshi Ohtani1 (1. Dept. of Biomed. Chem., Grad. Sch. of Sci. and Tech., Kwansei Gakuin Univ.)
[3P-829]Development of a 3D Organoid Culture Method for Canine Oral Melanoma
○Hana Suzuki1, Honoka Hashizume1, Tatsuya Usui1, Kazuaki Sasaki1 (1. Tokyo University of Agriculture and Technology)
[3P-830]Epithelial cells induce cell death in precancerous cells via the MHC-I interaction
○Shiyu Ayukawa1, Nagisa Kamoshita1, Yu Chen1, Mei Okumura1, Mao Fukami1, Takeshi Maruyama1 (1. Tokyo University of Pharmacy and Life Science)
[3P-831]Elucidation of Signaling Molecule via GAG Chains Using Cochlin as a Probe
○Marin Fujita1, Kyoko Aikawa2, Kazuo Yamamoto3 (1. Div.of Advanced Sciences, Grad. Sch. of Humanities and Sciences, Ochanomizu Univ., 2. Fac.Of Core Res., Ochanomizu Univ, 3. Inst. For HLS., Ochanomizu Univ)
[3P-832]Evaluation of TGF-β responsiveness of pancreatic cancer cells with epithelial or mesenchymal traits
○KAZUKI KURITA1, MICHIYO HONDA1 (1. Meiji university)
[3P-833]Inhibition of VGCC and BKCa Channels by Trimebutine Maleate Suppresses Stemness and Drug Resistance in Ovarian Cancer Stem Cells
○Somin Woo1, JiHye Seo3, Heejin Lee4, Young-Kyu Kim4, Sang-Hyun Min2 (1. Kyungpook Natl. Univ., Dept. of Pharmacy, 2. Kyungpook Natl. Univ., Dept. of Innovative Pharm. Sci., 3. Kyungpook Natl. Univ., Dept. of Life Sci., 4. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDIhub))
[3P-834]Elucidation of the role of interactions between cancer stem cells and cancer-associated fibroblasts in breast cancer development
○Risako Okada1, Naoomi Tominaga1, Kana Tominaga1 (1. Yamaguchi University Graduate School)
[3P-835(3PS-07-07)]Alternative splicing drives neighboring cell-mediated defective cell elimination
○Mai Miyake1, Yuki Akieda1, Akihito Harada2, Yasuyuki Ohkawa3, Tohru Ishitani1 (1. RIMD, UOsaka, 2. Fac. of Med. Sci., Kyushu Univ., 3. MiB, Kyushu Univ.)
[3P-836]Mitochondrial gene mutation detected in a breast cancer patient activates interferon-stimulated gene expression
○Kenji Watanabe1, Shigeru Yamamoto2, Noriko Maeda2, Naruyo Nishimura1, Keishiro Isayama1, Mikako Yagi4, Dongchon Kang3, Masaaki Oka2, Hiroaki Nagano2, Yoichi Mizukami1 (1. Institute of Gene Research, Science Research Center, Univ. of Yamaguchi., 2. Dept. of Digestive Surgery and Surgical Oncology, Grad. Sch. of Med., Univ. of Yamaguchi, 3. Dept. of Clinical Chemistry and Laboratory Medicine, Grad. Sch. of Med. Sci., Univ. of Kyushu, 4. Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University)
[3P-837(3AS-14-06)]Multi-omics Analysis of Extracellular Vesicles Derived from epithelial-mesenchymal transition induced Pancreatic Cancer Cells
○Haruna Aiba1,3, Hayasaka Ryosuke1, Masako Hasebe1, Momo Sato1,3, Yukako Suzuki1,3, Tomoyoshi Soga1, Harunori Yoshikawa1, Akiyoshi Hirayama1,2,3 (1. Inst. Adv. Bio. sci., Keio Univ., 2. Dept. Environ. Info. Stud., Keio Univ. , 3. Syst. Biol. Program, Grad. Sch. Media Gov., Keio Univ.)
[3P-838]Establishment of a mouse model of lung metastasis using patient-derived feline mammary tumor cells and its usefulness
○Haru Yamamoto1, Tatsuya Usui1, Kazuaki Sasaki1 (1. Tokyo Universtiy of Agriculture and Technology, Cooperative Division of Veterinary Sciences, Laboratory of Veterinary Pharmacology)
[3P-839]Pathology × Morphological Simulation × Bioinformatics: Morphological Basis of Lung Adenocarcinoma
○Toru Matsu-ura1, Linjun Zha1, James P Sluka2, Tomohiro Murakawa3, Koji Tsuta1 (1. Dept. of Pathology, Kansai Medical University, 2. Biocomplexity Institute, Indiana University, Bloomington, 3. Dept. of Thoracic Surgery, Kansai Medical University)
[3P-840]Inhibition of cholesterol biosynthesis suppresses proliferation of whole genome doubling cancer cells
○Junna Tanaka1, Hiroki Kuwajima1, Ryuzaburo Yuki1, Yuji Nakayama1 (1. Kyoto Pharmaceutical University)
[3P-841]Inhibition of endoplasmic reticulum-associated degradation in cancer leads to cell proliferation suppression
○Ryoya Sugimoto1, Yuto tsukioka2, Syuma Kitamura2, Hikari Kitano1, Hidetoshi Fujita2 (1. Osaka Institute of Technology Graduate School of Engineering, 2. Osaka Institute of Technology)
[3P-842]RhoA activation induces epidermal differentiation in cutaneous squamous cell carcinoma cells
○Yamato Shinta1, Amanda R. J. G. Anribali2, Maho Ishino2, Souta Takeuchi1, Hiroaki Hirata2 (1. Dept. Biotech., Grad Sch. of Eng., Kanazawa Inst. Tech., 2. Dept. of Life Sci. & Biotech., Kanazawa Inst. Tech.)
[3P-843]A possible link between high-risk HPV-E6 mediated destabilization of CENP-E with chromosomal instability
○Kanako Hori1,2, Nanami Seshimo, Ryusuke Nozawa1, Toru Hirota1 (1. Japanese Foundation for Cancer Research , 2. Tokyo University of science)
[3P-844]The role of INHBA in the EMT Induction of Oral squamous cell carcinoma
○Yuriko Yawata1, Kiyotake Yamamoto1, Motoharu Sarubo1, Yasuhiro Mouri1, Kudo Yasusei1 (1. Tokushima University)
[3P-845]The phosphatase CTDNEP1 functions as a tumor suppressor gene in pancreatic cancer
○Mayuka Nii1, Uchita Yuna1, Hayata Tadayoshi1 (1. Tokyo University of Science)
[3P-846]Development of a new treatment for sorafenib-resistant hepatocellular carcinoma
○Noriyoshi Tanaka1, Kouta Tonegawa1, Ichiro Yajima1,2 (1. Department of Bioscience and Engineering, College of Systems Engineering and Sciences, Shibaura institute of Technology Graduate School of Engineering and Science, 2. Department o Bioscience an Engineering, Shibaura Institute of Technology of System Engineering and Science)
[3P-847]Analysis of migration and invasion inhibition in triple-negative breast cancer cells by CD9-binding peptides
○MAHIRO HIRATA1, Kotomi Kuroha, Shogo Saito1, Mina Okochi1 (1. Institute of Science Tokyo)
[3P-848]Fermented tree bark extract from Alnus japonica to ameliorate the liver cancer stem cells derived tumorigenesis
○Kenly Wuputra1,2,3,6, Yoshimasa Matsusura4, Satoshi Gushiken5, Hirosuke Fukuda5, Chia-Chen Ku1,2,3, Wu Chun-Chieh9, Yi-Chun Tsai6,7, Toshihiko Nozaki8, Yoshiharu Tanaka4, Kazunari K. Yokoyama1,2,3 (1. Cell Therapy Research Center, Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan., 2. Gradute Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., 3. Regenerative Medicine and Cell Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., 4. Radiation Biology and Molecular Genetics, Division of Quantum Radiation, Faculty of Technology, Osaka Metropolitan University, Osaka 599-8531, Japan., 5. Okinawa Eco-Science Co., Ltd., Okinawa 905-2261, Japan., 6. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan., 7. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University CiJin Hospital, Kaohsiung 805, Taiwan., 8. Ryukyu Fertilizer Co., Ltd., Okinawa 904-2162, Japan., 9. Department of Pathology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung 820, Taiwan.)
[3P-849]Establishment of a Canine Bladder Cancer Organoid Model Induced by Chemical Exposure
○Yuko Nagashima1, Haru Yamamoto1, Yoshiko Naito1, Tatsuya Usui1, Kazuaki Sasaki1 (1. Tokyo University of Agriculture and Technology)
[3P-850]SARS-CoV-2 nucleocapsid protein induced Non-Small Cell Lung Cancer Malignancy via TLR4/HIF-1α signaling pathway
○Markus Yovian Widjaja Lomanto1,3, Cat-Khanh Vuong3, Adeline Castro Ramos2,3, Toshiharu Yamashita3, Mizuho Fukushige3, Osamu Ohneda3 (1. Human Biology Program, School of Integrative and Global Majors, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2. Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 3. Laboratory of Regenerative Medicine and Stem Cell Biology, Faculty of Medicine, University of Tsukuba)
[3P-851]Exploration of up-regulation signaling of NF90, Domain associated with zinc fingers (DZF) protein, in tumor by comprehensive inhibitor screening method.
○Rena Kishiue1, Takuma Higuchi1, Keiko Morisawa1, Shuji Sakamoto1 (1. Lab. of Mol. Biol., Sci. Res. Ctr., Kochi Medical school, Kochi Univ.)
[3P-852]Immunocellular analysis of the PDAC tumour environment by scRNA-seq.
○Misaki Sugihara1, Endo Toshinori1 (1. Hokkaido University)
[3P-853]Organelle dynamics and a novel nutrient sensing mechanism in cancer cells
○Tomoya Matsushita1, Mayu Asao2, Sho Aki4, Tuyoshi Osawa1,3,2 (1. Department of Chemistry & Biotechnology School of Engineering, The University of Tokyo, Nutriomics, 2. Department of Department of Advanced Interdisciplinary Studies, The University of Tokyo, 3. RCAST The University of Tokyo, 4. The University of Osaka Premium Research Institute for Human Metaverse Medicine)
[3P-854]Deamidation of NF-κB p65 at N139 promotes aggressiveness and bone destruction in oral squamous cell carcinoma cells in a mouse xenograft model
○yiran tu1, Jing Gao1, Eijiro Jimi1,2, Takenobu Katagiri3 (1. Lab of Mol Cell Biochem, Fac Dent Sci, Kyushu Univ , 2. OBT Res Cent, Fac Dent Sci, Kyushu Univ , 3. Div Biomed Sci, RCGM, Saitama Med Univ)
[3P-855]Analysis of metastasis suppressing miRNAs in extracellular vesicles derived from an Nanog overexpressing melanoma
Sora Yorikawa1, ○Hideaki Matsuoka1, Mikako Saito1 (1. Tokyo University of Agriculture and Technology)
[3P-856]Analysis of the suppression mechanism of melanoma metastasis by iPS cell-specific miRNAs
Asuka Tamura1, Noa Katayama1, Misato Nakano1, ○Mikako Saito1 (1. Tokyo University of Agriculture and Technology)
[3P-857]Molecular analysis of anoikis resistance mediated by TAZ-TEAD in metastatic breast cancer
○Hidetsugu Nakagawa1, Kazunori Mori1, Masato Higurashi1, Momoko Uchida1, Fumihiro Ishikawa2, Motoko Shibanuma1 (1. Div. CancerCellBiol., Dept. Pharm. Sci., Showa Med. Univ. Grad. Sch. Pharm., 2. Ctr. for Biotechnol., Showa Med. Univ.)
[3P-858]The Role of Carbonic Anhydrase IV (Car4) in Mouse Testicular Teratoma Pathogenesis
○Suzuka Saeki1, Atsushi Suzuki1 (1. Grad.Sch.Sci Eng,Yokohama Natl. Univ.)
[3P-859]Ribosome Stalling-Mediated Cell Death under Glutamine Starvation
○Riko Harada1, Akinobu Matsumoto2, Tsuyoshi Osawa1 (1. Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 2. Group of Gene Expression and Regulation, Nagoya University)
[3P-860]LGALS3BP Drives Tumorigenesis via sPLA2-Ⅹ-Mediated EV Hydrolysis and TAM Uptake via Galectin-3
○Akane Kanamori1,2, Ai Kotani1,3 (1. RIMD, Univ. Osaka, 2. Dept. Mol. Life Sci., Tokai Univ. Sch. Med., 3. Dept. Immunol. Tokai Univ. Sch. Med.)
[3P-861]Mechanical Interaction between Epidermal Cancer Cell Aggregates and the Extracellular Matrix in 3D Culture
○Ryu Moriguchi1, Satuki simada2, Hiroaki Hirata2 (1. Graduate Program in Bioscience and Chemistry, 2. Department of Life Science and Biotechnology)
[3P-862]the role of m5U modification in glioblastomas
○Tetsuya Hayashi1,2, Daisuke Ando2, Yoshiteru Shimoda1, Masayuki Kanamori1, Hidenori Endo1, Sherif Rashad2,3, Niizuma Kuniyasu1,2,3 (1. Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 2. Department of Translational Neuroscience, Graduate School of Medicine, Tohoku University, 3. Department of Neurosurgical Engineering, Graduate School of Biomedical Engineering, Tohoku University)
[3P-863]Anticancer Activity of Fucoidan in Leukemia Cells
○Reo Ishii1 (1. CHIBA INSTITUTE OF TECHNOLOGY)
[3P-864]MYC protein degradation as a synergistic role of RUNX1 and RUNX3 in breast cancer
○Nawaphat Jangphattananont1, Junichi Matsuo1, Yong Wei Peng2, Linda Shyue Huey Chuang1, Yoshiaki Ito1 (1. Cancer Science Institute of Singapore, National University of Singapore, Singapore, 2. Department of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore.)
[3P-865]Exercise-induced AMPK activation in cancer cells suppresses skeletal muscle atrophy via small extracellular vesicles
○Takuya Fukunaga1, Tatsuya Hayashi1, Tatsuro Egawa1 (1. Graduate School of Human and Environmental Studies, Kyoto University)
[3P-867]Analysis of Synthetic Lethal Candidate Gene PDIA6 Associated with SETDB1 Mutations
○Jiang Xinyi1, Suzuki Koya2, Qiu Mengshi1, Murakami-Tonami Yuko1 (1. Tokyo University of Technology, Graduate School of Bionics, Computer and Media Sciences, Department of Bionics, Laboratory of Tumor Molecular Genetics, 2. Teikyo University, Institute of Advanced Medical Research)
[3P-868]Effects of Aminobutyric Acid Derivatives on the Cell Death of Human Breast Cancer and Human Lung Cancer
○Yuka Shimura1 (1. Kyoritsu Woman University)
[3P-869]Catechol-O-methyltransferase attenuates invasion potential by upregulation of desmogleins and is associated with better prognosis in ovarian cancer
○Yuki Nishida1, Tomo Soga2, Shojiro Kitajima1 (1. Keio University, IAB, 2. Keio University, Bio2Q)
[3P-870]Multi-agent simulation of the fibroblast–macrophage cellular circuit and AI-based analysis of cell cluster dynamics
○Yusei Ishii1, Masanori Hariyama1, Ken-ichi Inoue2 (1. Tohoku Univ., 2. Dokkyo Medical Univ.)
[3P-871]Proximity labelling with near-infrared fluorescent protein and phycocyanobilin interrogates tumor microenvironment
○Ryo Ida1,2, Kazuhiro Aoki2,3,4,5,6, Michiyuki Matsuda1,7, Kenta Terai8 (1. Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, 2. Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University, 3. Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, 4. Division of Quantitative Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5. Basic Biology Program, The Graduate University for Advanced Studies, SOKENDAI, 6. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 7. Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 8. Department of Anatomy and Cell Biology, Graduate School of Biomedical Sciences, Tokushima University)
[3P-872]Unsupervised annotation of spatial transcriptomes based on vectorial information
○Ryosuke Nomura1,2, Shunsuke A Sakai1,3, Shun-ichiro Kageyama1, Riu Yamashita1,2 (1. National Cancer Center, 2. Dept. of Computational Biology and Medical Sciences, GSFS, UTokyo, 3. Dept. of Integrated Biosciences, GSFS, UTokyo)
[3P-873]Mechanisms of Therapeutic Resistance and Cell Death in MSI-High Solid Tumors
○Katsuya Iuchi1,2, Gou Yamamoto2 (1. Tohoku University, 2. Saitama Cancer Center)
[3P-874(3AS-17-03)]Reduction of cell proliferative capacity of leukemic ATL cells by the removal of HTLV-1 provirus
○Ayano Kawahara1, Ayane Katayama1, Azuki Yasuoka1, Mayuko Yagi1, Satoshi Takeda2, Jun Komano1 (1. Osaka Medical and Pharmaceutical University , 2. Japan Institute for Health Security)
[3P-875]Site-specific miRNA alternation in fimbriae/fallopian tube/tumor of BRCA1 mutated high grade serous ovarian carcinoma and extracellular vesicle analyses
○Yurika Yamada1, Akira Yokoi1, Yukari Nagao1, Suzuki Kazuhiro1, Hiroaki Yamada1, Eri Inami1, Masami Kitagawa1, Kosuke Yoshida1, Takao Yasui2, Hiroaki Kajiyama1 (1. Dept. of Obst. & Gyne., Nagoya Univ. Grad. Sch. of Med., 2. Dept. of Life Sci. & Tech., Tokyo Inst. of Tech)
[3P-876]Elucidating cancer cell-adipocyte interactions in pancreatic ductal adenocarcinoma with extrapancreatic fat invasion
○Takuya Otsuka1,2,3, Takako Ooshio1, Ryodai Yamamura1, Soichiro Hata1, Taiga Hirata1, Reo Sato1, Teppei Shimamura4, Yoshihiro Matsuno3,5, Utano Tomaru2,3, Shinya Tanaka2,3,6,7, Masahiro Sonoshita1 (1. Division of Biomedical Oncology, Institute for Genetic Medicine, Hokkaido University, 2. Department of Surgical Pathology, Hokkaido University Hospital, 3. Department of Molecular Diagnostic Pathology, Graduate school of Medicine, Hokkaido University, 4. Department of Computational and Systems Biology, Medical Research Laboratory, Institute of Science Tokyo, 5. Pathology Center, National Hospital Organization Hokkaido Cancer Center, 6. Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, 7. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University)
[3P-877]Regulation of intracellular cholesterol dynamics alters statin sensitivity in cancer cells
○Jiro Tashiro1, Akihiro Sugiura1, Takuro Ishikawa1, Tomoko Warita2, Katsuhiko Warita1 (1. Department of Veterinary Anatomy, School of Veterinary Medicine, Tottori University, 2. Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University)
[3P-878]Functional characterization of Th7R cells, a Th1-like CD4 T cell subset prognostically relevant in immune checkpoint inhibitor therapy
○Satoshi Yamasaki1, Katsuhisa Horimoto2, Ou Yamaguchi2, Atsuto Mouri2, Ayako Shiono2, Yu Miura2, Kosuke Hashimoto2, Hisao Imai2, Kyoichi Kaira2, Hiroshi Kagamu2 (1. Department of Clinical Cancer Genomics, Saitama Medical University International Medical Center, 2. Department of Respiratory Medicine, Saitama Medical University International Medical Center)
[3P-879(3MS-15-08)]Elucidation of IL-7R–Mediated Central Nervous System Infiltration in Acute Lymphoblastic Leukemia and the Development of a Targeted Therapeutic Strategy
○Motochika Hamada1,2, Hiroki Takashima1, Masahiro Yasunaga1,2 (1. Center for Advanced Medical Development, National Cancer Center, 2. Department of Advanced Life Sciences, Graduate School of Frontier Sciences, The University of Tokyo)
[3P-880(3MS-15-06)]Identification of pancreatic cancer stem cells by single cell analysis and development of therapeutic methods
○Osamu Sugahara1, Tsunaki Higa1, Keiichi I. Nakayama1 (1. Institute of Science Tokyo)
[3P-881]Clonal diversity shapes the tumour microenvironment leading to distinct immunotherapy responses in metastatic urothelial carcinoma
○Takashi Kamatani1, Kota Umeda2, Fuyuki Miya3, Yutaka Suzuki4, Jo Nishino5, Mamoru Kato5, Kazuhiro Kakimi6, Nobuyuki Tanaka2, Mototsugu Oya2, Tatsuhiko Tsunoda7 (1. Institute of Science Tokyo, 2. Keio Univ.Urology, 3. Keio Univ.Center for Medical Genetics, 4. Tokyo Univ.Comp.Biology, 5. Natinal Cancer Cent., 6. Kinki Univ., 7. Tokyo Univ.Biological Sciences)
[3P-882]Regulation of cell competition and early tumor suppression by the cytoskeleton-modulating peptide JIP
○Kosei Shimada1, Amane Nishiyama1, Keigo Ogawa1, Shiyu Ayukawa2, Takeshi Maruyama2, Yukako Oda1 (1. Kyoto University, Graduate School of Biostudies, Laboratory of Functional Biology, 2. Tokyo University of Pharmacy and Life Sciences, Department of Medical Science, Laboratory of Cellular Defense Medical Science)
[3P-883]Anti-tumor effects of eosinophil granule MBP
○Shun Tamaki1,2,3,4, Rei Kawashima1,2,3, Yuki I Kawamura4, Tatsunori Maekawa1,2,3, Sakura Arikawa2,4, Takafumi Ichikawa1,2,3 (1. Dept. Biochem., Sch. Allied Health Sci., Kitasato Univ., 2. Dept. Regulation Biochem., Grad. Sch. Med. Sci., Kitasato Univ., 3. Dept. Med. & Cell Design, Sch. Allied Health Sci., Kitasato Univ., 4. Res. Inst. NCGM., JIHS.)
[3P-884]Gunma University Organoid Biobank for Personalized Therapy Development in Colorectal Cancer
○Moe Kondo1,2, Shintaro Uchida2,3, Takuya Shiraishi3, Tsukasa Oda2, Eiji Miyauchi2, Hiroshi Saeki3, Nobuo Sasaki2 (1. Department of Biomedical Sciences, Graduate School of Medicine, Gunma University, 2. Laboratory for Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, 3. Department of General Surgical Science, Graduate School of Medicine, Gunma University)
[3P-885]Synthetic lethality using DNA methylation silencing
○Ryoma Mashiko1 (1. Hoshi University)
[3P-886]Multimodal Deep Generative Modeling of Spatial Transcriptomics for Subcellular Cell Interaction Analysis in the Tumor Microenvironment
○Bairui Du1, Renzhi Yang1, Hisanori Kiryu1 (1. The University of Tokyo)
[3P-887]A Machine Learning Model for Pathogenic Variant Prediction Integrating Variant- and Patient-Specific Contexts
○Haruko Nakagawa1,2,5, Takashi Kamatani2,3, Naoya Ishibashi2, Satoru Aoyama2, Fuyuki Miya4,2, Sadakatsu Ikeda2 (1. Department of Functional Genome Informatics, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 2. Department of Precision Cancer Medicine, Institute of Science Tokyo Hospital, 3. Department of AI Technology Development, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 4. Center for Medical Genetics, Keio University School of Medicine, 5. Omics AI Research Team, Advanced General Intelligence in Science Program (AGIS), TRIP Headquarters, RIKEN)
[3P-888]Roles of Trp53 and Cdkn2a in Early Stages of Oral Carcinogenesis
○Zichao Lu1, Yasuhiro Mouri1, yasusei Kudo1 (1. Tokushima university)
[3P-889]Spatial and temporal analysis of mechanical and biological characteristics in mouse ulcerative colitis
○Kazuki Shimada1, Hiroshi Y. Yoshikawa1, Hirotaka Tao2, Takahisa Matsuzaki1 (1. Graduate School of Engineering, The University of Osaka, 2. Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan)
[3P-890]Development of a Conditional NCYM Knock-in Mouse and Its Application to Pancreatic Organoids
○Shofa Khamdanatuz Zufairo’1,2, Akiko Endo1, Ummi Maryam Zulfin1,2, Daisuke Muto1,2, Harumi Saida1, Kimi Araki3, Yoshitaka Hippo1, Yusuke Suenaga1 (1. Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute, 2. Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 3. Institute of Resource Development and Analysis, Kumamoto University)
[3P-891]Comparison of ADCC activity between daratumumab and isatuximab in multiple myeloma with varying CD38 expression levels
○Yuto Takahashi1, akihiro Kitadate2, Sayaka Iwama1, Wataru Kuroki2, Sho Ikeda2, Naoto Takahashi2 (1. Dept. of Life Sci., Grad. Sch. of Eng. Sci., Univ. of Akita, 2. Dept. of Hematology, Nephrology, and Rheumatology, Grad. Sch. of Med., Univ. of Akita)
[3P-892]Gene expression changes in Head and Neck Squamous Cell Carcinoma promoting tumor cell elimination by natural killer cells
○Shoko Miyoshi1, Yuki Hosokawa2, Kodai Nagashio1, Yuji Hayashi2, Hajime Yano1, Junya Tanaka1, Naohito Hato2 (1. Dept. Mol. Cell. Physiol. Ehime Univ., 2. Dept. of Otorhinolaryngology, Head and Neck Surgery)
[3P-893]Development of gold nanorods for thermotherapy
○Junya Hirata1, Yumi Yoshida2, Koji Maeda2, Shingo Sotoma2 (1. Graduate School of Science and Technology, Kyoto Institute of Technology, 2. Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology)
[3P-894]geneSCOPE: gene spatial co-occurrence of pairwise expression
○Shicheng Zhang1, Koichi Saeki1, Hiroshi Haeno1 (1. Tokyo University of Science)
[3P-895]Mechanism of stress granule-dependent translational inhibition by anticancer G-quadruplex ligands
○Arata Hayashi1,2, Sachiko Okabe1, Takeru Shiino1,2, Risa Ito1,2, Yuna Mogi1,2, Kazuo Nagasawa3 (1. Div. Mol. Biother., JFCR Cancer Chemother. Ctr.,, 2. Dept. Comput. Sci. Med. Sci., Grad. Sch. Frontier Sci., Univ. Tokyo,, 3. Biomed. Fac. Technol., Tokyo Univ. Agric. Technol.)
[3P-896]Topographical Features of Nanostructures Regulate Tumoroid Formation and Maintain the Biological Characteristics of Tumor Tissue
○Wooyoung Shim1, Ji-Yoon Lee1, Han-Sin Lee1 (1. CellStormer Co., Ltd.)
[3P-897]Influence of structural changes induced by TY amino acid deletion on Newt p53 protein function
○RYUSHIN TAKATA1,2, TOMOYA NAKAYOSHI1,2, KAZUKO OKAMOTO1,2, MIEI NAKAJIMA3, HONOKA UMEYAMA3, TAMAYO OKAMURA4, TAKESHI IGAWA1,2, TAKASHI TAKEUCHI3, TOSHINORI HAYASHI1,2 (1. Hiroshima University Amphibian Research Center, 2. Hiroshima University Graduate School of Integrated Sciences for Life, 3. Tottori University Graduate School of Medical Sciences, 4. Hiroshima University School of Science Biological Science)
[3P-898]Development of siRNA for KRAS and BRAF mutations using a cell-derived Xenograft
○Yoshimasa Asano1,2, Yoshiaki Kobayashi2, Atsushi Sato2, Hiroaki Taniguchi3, Kumiko Ui-Tei2,4 (1. Nihon Univ., 2. The Univ. of Tokyo, 3. Keio Univ., 4. Science Univ.)
[3P-899]Electrical signal propagation in E. coli biofilms associated with growth arrest
○Mitsuki Suzuki1, Martin Robert1, Ryunosuke Sakai1 (1. Kyoto University)
[3P-900(3PS-15-04)]Taurine-Induced tRNA Stabilization Restores Mitochondrial Function in KARS1-Mutant iPS Cells
○Takeshi Tokuyama1, Haruna Tani2, Taisei Wakigawa3, Kumiko Iwabuchi4, Fuad Gandhi Torizal1, Razan E Ahmed1, Pamorn Chittavanich1, Kouki Mii1, Eri Kitaguti1, Wei Fan-Yan2,1, Iwasaki Shintaro 3, Hideki Uosaki1 (1. Div. Funct. Biochem., Dept. Biochem., Jichi Med. Univ., Sch. Med., 2. Dept. of Modomics Biol. & Med., IDAC, Tohoku Univ., 3. RNA Sys. Biochem. Lab., RIKEN CPR, 4. Div. of Regen. Med., Ctr. for Mol. Med., Jichi Med. Univ.)
[3P-901]Elucidation of the SFPQ-mediated regulatory mechanism of long gene expression and its role in muscle mass maintenance through skeletal muscle mitochondrial control.
○Motoyasu Hosokawa1, Kei Iida2, Jun Tanihata3, Ryosuke Kawakami1, Takeshi Imamura1, Shin'ichi Takeda4, Masatoshi Hagiwara5, Akihide Takeuchi1 (1. Ehime University Graduate School of Medicine, 2. Fac. of Sci. and Eng., Kindai Univ., 3. Jikei Univ. Sch. Med., 4. Nat. Inst. Neurosci., Nat. Cent. Neuro. and Psyc., 5. Grad. Sch. Med., Kyoto Univ.)
[3P-902]Secretion of specific metabolites and changes in miRNA expression in murine osteoblastic cells exposed to α-particles
○Satoru Monzen1,2, Yota Tatara3, Mitsuru Chiba2,4, Yasushi Mariya5, Andrzej Wojcik6 (1. Hirosaki Univ. Dep. Rad., 2. Hirosaki Univ. RCBS, 3. Hirosaki Univ. Dep. Stress Resp., 4. Hirosaki Univ. Dep.Biomed., 5. Aomori Rosai Hosp. Cancer center, 6. Stockholm Univ. CRPR)
[3P-903]DHLA-capped gold nanoclusters ameliorated inflammatory response during high glucose condition and lipid accumulation
○Kai-Chieh Chou1, Chun-Ting Chen1, Kuang-Ling Ou1, Juin-Hong herng1, Yi-Wen Wang1 (1. National Defense Medical University)
[3P-904]Molecular mechanisms of time-restricted feeding (TRF) on the proliferation, differentiation, and maturation of endocrine cells in the pancreatic islet periphery.
○Keiko Nakao1, Akemi Hara1, Megumi Kumagai3, Yu Inoue2,1, Shoka Yokoyama1, Keita Oyanagi1, Ryoko Tuge1, Yoshio Fujitani2 (1. Saitama Medical University, Depat of Physiology, 2. Institute for Molecular & Cellular Regulation Gunma University, 3. Saitama Medical University, Dept of Pharmacology)
[3P-905]Insulin secretion stress causes pancreatic β-cell dysfunction through TFE3 activation
○Yuki Aida1, Nozomu Kadota1, Yuichi Koshiishi2, Koji Kasahara3, Kohsuke Kataoka1 (1. Grad. Sch. of Med. Life Sci, Yokohama City Univ., 2. NODAI Genome Research Center, Tokyo University of Agriculture, 3. Department of Molecular Microbiology, Tokyo University of Agriculture)
[3P-906]Activation mechanism of transcription factor TFE3 by excess insulin secretion in pancreatic β-cells
○YUKA ASHINA1, Kohsuke Kataoka1 (1. Grad. Sch. of Med. Life Sci, Yokohama City Univ.)
[3P-907]The importance of methylation at the 2-position of the naphthoquinone ring in vitamin K derivatives found in plants
○Kurumi Nakagawa1, Shunta Sudo1, Mei Koyanagi2, Yoshitomo Suhara1,2, Liqing Zang3, Yasuhito Shiamada4, Miki Senda5, Toshiya Senda5, Yoshihisa Hirota1,2 (1. Grad. Sch. Eng. and Sci., Shibaura Inst. of Tech., 2. Dept. Life Sci., Shibaura Inst. of Tech., 3. Mie Univ., Grad. Sch. Reg. Innov., 4. Mie Univ., Fac. Med., 5. KEK, Inst. Mater. Struct. Sci.)
[3P-908]Role of Nrf2 in skeletal muscle in response to high-fat diet
○Miu Yasutake1, Mami Yamada1, Mitsuharu Okutsu1 (1. Nagoya City University)
[3P-909(3PS-09-04)]Growth phase diets, rich in long- and short-chain fatty acids and a branched-chain amino acid, diminish histone acetyltransferase Gcn5 function and shorten adult lifespan
Shoko Mizutani1, Yukako Hattori2, ○Tadashi Uemura3 (1. Kyoto Univ. GSB, 2. Kyoto Univ. GSB, Hakubi, 3. Kyoto Univ. GSB, LiMe)
[3P-910]Juvenility analysis reveals mitochondrial segmental heterogeneity
○Masaki Mori1 (1. National Center for Child Health and Development)
[3P-911]Identification of components in haskap berries that inhibit degranulation of mast cells.
○Sena Izuka1, Naoko HORI-TAMURA1 (1. Kobe Women's University)
[3P-912]xCT in macrophage aggravates the pathology of obesity model mouse
○Tsumugi Takemoto1, Yugo Kato1, Yosuke Horikoshi1, Kazuhiro Nakaso1 (1. Devision of Biochemistry, Faculty of Medicine, Tottori University)
[3P-913(3AS-05-07)]Identification of muscle atrophy-related metabolites (atrometabolites) by integrated metabolomic analysis and regulation of muscle mass by polyamine metabolic enzyme Amd1,2
○Mamoru Oyabu2,1, Tomoki Sato3, Runa Kawaguchi1, Kiyoshi Yoshioka4,1, Naoki Ito2, Takahiro Eguchi2, Hitoshi Gotoh5, Tatsuya Yoshizawa5, Yoshihiro Ogawa6, Yusuke Ono7,8, Shinji Miura3, Yasutomi Kamei1 (1. Kyoto Prefectural University, 2. National Center for Geriatrics and Gerontology, 3. University of Shizuoka, 4. Institute for Research on Productive Aging, 5. Kyoto Prefectural University of Medicine, 6. Kyushu University, 7. Kumamoto University, 8. Tokyo Metropolitan Geriatric Medical Center)
[3P-914]Effects of vitamin K intake on novel object recognition in mice by suppressing ferrotosis
○Ayaka Kato1, Rina Watanabe1, Haruka Kawamura2, Chikara Kato3, Susumu Takekoshi4, Motoki Takagi1,2, Yoshitomo Suhara1,2, Yoshihisa Hirota1,2, Kazuki Takeda5 (1. Department of System Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, 2. Department of Life Science, Shibaura Institute of Technology, 3. College of Agriculture, Academic Institute, Shizuoka University, 4. Department of Cell Biology, Tokai University, 5. Department of Veterinary Medicine, Kitasato University)
[3P-915]Investigation of Gut Microbiome-Associated Obesity Regulation and Reactive Oxygen Species Homeostasis via a Gastrointestinal 3D Organoid Model
○CHIA-CHEN KU1, Kenly Wuputra1, Ya-Han Yang1, Yi-Chang Liu2, Deng-Chyang Wu1,2, Chao-Hung Kuo1,2, Chih-Yen Chen3, Kazunari K. Yokoyama2,1 (1. Kaohsiung Medical University, 2. Kaohsiung Medical University Hospital, 3. National Yang Ming Chiao Tung University)
[3P-916]Evaluation of the enzymatic conversion mechanism in the side chain cleavage of vitamin K derivatives depending on the presence of double bonds
○Shunta Sudo1, Kurumi Nakagawa1, Koyanagi Mei2, Suhara Yoshitomo1, Hirota Yoshihisa1 (1. Grad. Sch. Eng. and Sci., Shibaura Inst. of Tech, 2. Dep. Life. Sci., Shibaura Inst of Tech)
[3P-917]Establishment of a comprehensive quantification method for the metabolic intermediate menadione and its conjugates aimed at application as non-invasive biomarkers.
○Tomu Takano1, Shintaro Tagami1, Satoshi Asano1, Miyuu Nishikawa2, Shinichi Ikushiro2, Yoshihisa Hirota1 (1. Grad. Sch. Eng. and Sci., Shibaura Inst. of Tech., 2. Dept. of Biotech, Fac., of Eng., Toyama Pref., Univ.)
[3P-918]Functional Characterization of East Asian NCOA4 Single Nucleotide Polymorphisms
○Ju Won Eom1, Moon-Suhn Ryu1 (1. Yonsei Univ.)
[3P-919]Inhibitory Effects of Vegetable Extracts on LPS-Induced Muscle Inflammation
○Takahiro Inoue1, So Wakasa1, Shinsuke Mohri1, Eri Mukai1 (1. Ritsumeikan Univ.)
[3P-920]Maternal high-fat diet alters fetal autonomic activity independently of leptin receptor genotype in high-risk mouse models of type 2 diabetes mellitus
○Yoshiyuki Kasahara1, Chihiro Yoshida1, Yoshitaka Kimura1, Masatoshi Saito1 (1. Tohoku Univ. Grad. Sch. of Med.)
[3P-921]mRNA turnover mediated by YTHDF2 and the CCR4-NOT complex regulates pancreatic β-cell homeostasis
○Yuki Tara1, Hirotatsu Imai2, Akio Yamashita3, Tadashi Yamamoto1 (1. Okinawa Institute of Science and Technology Graduate University, 2. University of the Ryukyus, 3. Kindai University)
[3P-922]Functional Analysis of NRG1–ERBB3 Signaling in MASLD Progression Using Hepatocyte-Specific Erbb3 Knockout Mice
○Minami Yoshikai1, Nobuhito Goda1 (1. Waseda University)
[3P-923]The effect of Serine (D-Ser/L-Ser) on inhibiting blood glucose elevation in lean mice
○Akira Toda1, Kisara Ueda1, Koki Daido1, Daichi Fuchisawa1, Futoshi Furuya1, Shinsuke Mohri1, Eri Mukai1 (1. Ritsumeikan University Graduate School)
[3P-924]Novel Functions of the Transcriptional Repressor PARIS in Lipid Metabolism and Their Relevance to Metabolic Diseases
○Kazuki Hachiya1, Hiroto Fukai1, Yuka Nozaki1, Yuhei Mizunoe1, Yoshikazu Higami1 (1. Tokyo University of Science)
[3P-925]The Mechanism of Elevated Blood Glucose in Mice under Long-Term Social Isolation
○Hiromu Uchikawa1, Tomohiro Izumi, Futoshi Furuya1, Eri Mukai1 (1. Ritsumeikan Univ.)
[3P-926]Mechanisms of Branched-Chain Keto Acid-Induced Glucose Metabolism Impairment
○Enomoto Hikaru1 (1. ritumeikan university)
[3P-927]Elucidating the Nitrogen Source Uptake Mechanisms in Microalgae
○Iori Inagaki1 (1. Nagahama Institute of Bio-Science and Technology)
[3P-928]Exploring the link between ribosome dysfunction and tumorigenesis using zebrafish models.
○Ryota Odahara1, Takumi Ishizuka1, Mariko Nagatomo1, Naoya Kenmochi1, Tamayo Uechi1 (1. University of Miyazaki)
[3P-929]Cardio-regional pathway analysis of knock-in mice with hereditary cardiomyopathy by RNA-Seq
○Atsushi Uchimura1,2,3, Kenji Watanabe1, Keishiro Isayama1, Seiji Machida2, Takashi Kitahara3, Yoichi Mizukami1 (1. Institute of Gene Research, Science Research Center, Univ. of Yamaguchi, 2. Department of Pharmacy, Kokura Memorial Hospital, 3. Dept. of Clinical Pharmacology, Grad. Sch. of Med., Univ. of Yamaguchi)
[3P-930]Targeting the heart in DMD: DG9 peptide boosts PMO delivery and exon skipping to preserve cardiac function
○Rika Maruyama1, Md Nur Ahad Shah1, Harry Wilton-Clark1, Courtney S. Young2, Melissa J. Spencer2, Hong M. Moulton3, Gavin Y. Oudit4, Toshifumi Yokota1 (1. Dept. of Medical Genetics, University of Alberta, 2. Dept. of Neurology, University of California, Los Angeles, 3. Dept. of Biomedical Sciences, Oregon State University, 4. Mazankowski Alberta Heart Institute, University of Alberta)
[3P-931(3PS-07-06)]Molecular Pathogenesis of Mitochondrial Diseases Elucidated by Multi-Omics Analysis Focusing on Dark Regions of the Genome
○Kohta Nakamura1, Yoshihito Kishita1,2, Atsuko Okazaki1, Ayumu Sugiura1, Yukiko Yatsuka1, Kokoro Ozaki1,3, Naoyuki Matsumoto1, Taku Omata4, Maki Nodera5,6, Holger Prokisch7,8, Yuichi Shiraishi9, Hiroshi Matsumoto10, Akira Ohtake10,11, Kei Murayama1, Yasushi Okazaki1 (1. Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University,, 2. Department of Life Science, Faculty of Science and Engineering, Kindai University, 3. Department of Neuroimmunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4. Department of Pediatrics, Tokyo Women’s Medical University, Yachiyo Medical Center, 5. Fukushima Medical University Pediatric, 6. SUYAMA KIDS CLINIC, 7. Institute of Neurogenomics, Computational Health Center, Helmholtz Zentrum München, 8. School of Medicine, Institute of Human Genetics, Technical University of Munich, 9. Division of Genome Analysis Platform Development, National Cancer Center Research Institute, 10. Department of Pediatrics, Saitama Medical University, 11. Department of Clinical Genomics, Saitama Medical University)
[3P-932]In vivo and in vitro analysis of mice carrying the missense mutation in the guanosine diphosphate mannose 4,6-dehydratase (Gmds) gene: morphological, behavioral, and cellular studies
○Abdullah Syafiq Edyanto1,2, Yuji Imai1, Akiteru Maeno3, Yasuhiro Utsuno4, Satoko Miyatake4,5, Kohei Hamanaka4, Naomichi Matsumoto4,5,6, Tsuyoshi Koide1,2 (1. Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan, 2. Graduate Institute for Advanced Studies, SOKENDAI, Mishima, Shizuoka, Japan, 3. Cell Architecture Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan, 4. Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan, 5. Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan, 6. Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan)
[3P-933]A safe and highly accurate gene knock-in method using genome-editing adenovirus vectors without double-strand break
○Megumi Yamaji1, Mariko Nakamura1, Izumu Saito2, Shigeto Sato1, Tomoko Nakanishi1 (1. Center for Biomedical Reseach Resources, Juntendo University Graduate School of Medicine, 2. Department of Physiology, Juntendo University Graduate School of Medicine)
[3P-934]Compound heterozygous variants in the PTF1A gene and its distal enhancer cause pancreatic hypoplasia/agenesis
○Michihiko ARAMAKI1, Hibiki DOI1, Yuko FUKUI1, Kenichi KASHIMADA2, Maki FUKAMI1 (1. National Research Institute of Child Health and Development, 2. National Center for Child Health and Development)
[3P-935(3MS-15-07)]Single-cell and spatial transcriptomics to identify Mitochondrial Disease progression and treatment targets.
○Tasneem Qaqorh1, Yusuke Takahashi1, Kohei Sameshima1, Kentaro Otani1, Issei Yazawa1, Yuya Nishida1, Kohei Otani1, Yoshitaka Fujihara1, Mizuki Honda2, Shinya Oki2, Yasuyuki Ohkawa3, David R. Thorburn4, Ann E. Frazier4, Atsuhito Takeda5, Yoshihiko Ikeda1, Heima Sakaguchi1, Takuya Watanabe1, Norihide Fukushima1, Yasumasa Tsukamoto1, Naomasa Makita1, Osamu Yamaguchi1, Kei Murayama6, Akira Ohtake7, Yasushi Okazaki8, Takanari Kimura9, Hisakazu Kato9, Hijiri Inoue9, Ken Matsuoka9, Seiji Takashima9, Yasunori Shintani1 (1. National Cerebral and Cardiovascular Center, 2. Kyoto University, 3. Kyushu University, 4. Murdoch Children’s Research Institute, Royal Children’s Hospital, and University of Melbourne, 5. Hokkaido University, 6. Chiba Children’s Hospital, 7. Saitama Medical University, 8. Juntendo University, 9. Osaka University)
[3P-936]Generation and characterization of cells with knockout SPOUT1
○Yuto Tanabe1, Ryotaro Kawasumi1, Koji Hirota1, Nobe Yuuko1, Taoka Masato1 (1. Tokyo Metropolitan University)
[3P-937]Establishment of the animal disease model of craniofacial fibrous dysplasia
○Sayuri Tatsuta1, Rinna Kanai1, Asami Tsuji1, Satoru Toyosawa2, Sinsuke Ohba1, Makoto Abe1 (1. The University of Osaka Graduate School of Dentistry, Dept of Tissue and Developmental Biology , 2. The University of Osaka Graduate School of Dentistry,Dept of Oral and Maxillofacial Pathology)
[3P-938]Elucidation of the mechanism for aberrant splicing of the INPP5E gene in canine ciliopathies
○Ayano Kurogi1, So Masaki1, Satoshi Tanaka1, Naoyuki Kataoka1 (1. The University of Tokyo)
[3P-939]Functional analysis of sox9 in lung development using Xenopus crispants
○Nusrat Hossain1,2, Takeshi Igawa1, Makoto Suzuki1, Nanoka Suzuki1, Hajime Ogino1 (1. Amphibian Research Center, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagami-yama, Higashi-hiroshima, Hiroshima, 739-8526, Japan, 2. Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh)
[3P-940]Introduction of comprehensive phenotyping analysis at Japan Mouse Clinic
○Masaru Tamura1 (1. RIKEN BioResource Research Center)
[3P-941]Calcium imaging reveals underlying molecular mechanisms and orchestrated cell-cell communication of pollen tube reception
○Chiharu Kato1, Teruaki Goromaru2, Takuya Nagae2, Yoko Mizuta3, Akane Mizukami1, Satohiro Okuda1, Tetsuya Higashiyama1 (1. The University of Tokyo, 2. Nagoya University, 3. Nagoya Unibersity)
[3P-942]Functional Evaluation of Calendula as a Medicinal Plant in Biodiversity
○Hana Kuramochi1, Mayumi Minamisawa1,2 (1. Department of Life Science, Chiba Institute of Technology, Graduate School of Advanced Engineering, 2. Education Center, Faculty of Advanced Engineering, Chiba Institute of Technology)
[3P-943]Identification of pollen factor associated with the pistil pre-zygotic reproductive barrier peptide in Arabidopsis via GWAS
○Kazuki Hirano1, Takuya Nagae2, Hiroki Miura1, Seiji Takayama1, Sota Fujii1 (1. The University of Tokyo, 2. RIKEN, Center for Sustainable Resource Science)
[3P-944(3AS-18-08)]Membrane remodeling and calcium signal transduction via cyclic nucleotide-gated channels induced by the local anesthetic lidocaine in Arabidopsis roots
○Noriyasu Magari1,2, Ken Yokawa2 (1. Keio University School of Medicine, 2. Kitami Institute of Technology)
[3P-945]Elucidating the cause of reduced flower-bud formation in the Arabidopsis deficients in Cngc2
○Mina Sato1, Kazuma Katano1 (1. Ritsimeikan University)
[3P-946]Resistance to broad spectrum of viruses in tomato receptor-like kinase BAM1 and BAM2 mutants
○HOKUN YUM1, Kami Murakami1, Ito Kotaro 3, Chiaki Konishi3, Hiroki Atarashi2, Kenji Nakahara1 (1. HOKKAIDO UNIVERSITY, 2. Nihon Del Monte Corporation, 3. Kikkoman Corporation)
[3P-947]Exploring the role of autophagy in plant defense responses against aphids
○Asuka Seino1, Hangil Kim3, Miyuki Suto2, Kenji Nakahara2 (1. Graduate School of Agriculture, Hokkaido University, 2. Research Faculty of Agriculture, Hokkaido Unoversity, 3. Department of Forest Environment Protection, Kangwon National University)
[3P-948]Cucumber mosaic virus 2b disrupts jasmonic acid-mediated antiviral defense in tobacco plants
○Kenzie Sachisiva Anindita1, Eun Ji Jeon1, Masanao Sato1, Kenji Nakahara1 (1. Hokkaido University)
[3P-949]Identification and functional analysis of novel factors involved in interspecies reproductive barriers in the natural strain of Arabidopsis thaliana
○Tsukasa Matsuura1, Yoshinobu Kato1,2, Kenta Shirasawa3, Seiji Takayama1, Sota Fujii1,4 (1. Grad. Sch. Agric. Lif. Sci, Univ. Tokyo, 2. Precursory Research for Embryonic Science and Technology, 3. Kazusa DNA. Res. Inst., 4. Suntory Rising Stars Encouragement Program in Life Sciences)
[3P-950]Analysis of the relationship between the BdP23k protein and silicon absorption /silica synthesis in Brachypodium distachyon.
○Shu Watanabe1, Taode Bilige1, Shin-ichiro Kidou1,2 (1. Grad. Sch. of Sci., Nagoya City Univ., 2. Research Center for Biological Diversity)
[3P-951]Comprehensive analysis of genes targeted by the transcriptional regulator PFP in the roots of Arabidopsis thaliana
○Yurina Sugimoto1, Yuri Yokoyama2, Shin-ichiro kidou1,2 (1. Grad. Sch. of Sci., Nagoya City Univ., 2. Research Center for Biological Diversity, Nagoya City Univ.)
[3P-952]Proteome-wide identification of a tobacco remorin NtREM1.2-interacting proteins dependent on the gene expression of a potato virus X movement protein
○Yuki Inoue1, Mengyue Chen2,3, Yoshiyuki Itoh4, Miki Hisada4, Ken Komatsu1,2, Yasuhiko Matsushita1,2,5, Nobumitsu Sasaki1,2 (1. Grad. Sch. of Agr., Tokyo Univ. of Agr. and Tech., 2. Unit. Grad. Sch. of Agr. Sci., Tokyo Univ. of Agr. and Tech., 3. Iwate Biotech. Res. Cent., 4. SCOP, Tokyo Univ. of Agr. and Tech., 5. Gene Res. Cent., Tokyo Univ. of Agr. and Tech.)
[3P-953]ATTED-II Version 12: Plant Gene Coexpression Database with Expanded Species Coverage and Enhanced Cross-Species Comparison
Daffa Akbar APRILIO1, Dalia KHATUN1, ○Takeshi Obayashi1,2 (1. Grad. Sch. Info. Sci., Tohoku Univ., 2. WPI-AIMEC, Tohoku Univ.)
[3P-954]The host factor that guides viral proteins involved in cell-to-cell movement to plasmodesmata in plants
○Ema Iwashita1, Akiho Kobayashi1, Yuuki Yoshida1, Chika Watanabe1, Souto Noda1, Taketo Yamashita1, Yoshiyuki Imura1 (1. College of Bioresource Sciences, Nihon University)
[3P-955]Suppression of early infection of tobamovirus via N gene-mediated resistance and the role of movement protein
○Hiroki Takei1, Munehisa Yoshikawa2,3, Yasuhiko Matsushita1,4, Nobumitsu Sasaki1,4 (1. Grad. Sch. of Agr. Sci., Tokyo Univ. of Agr. & Tech., 2. Unit. Grad. Sch. of Agr. Sci., Tokyo Univ. of Agr. & Tech., 3. Iwate Biotech. Res. Cent., 4. Gene Res. Cent., Tokyo Univ. of Agr. & Tech.)
[3P-956]Integrated Analysis of Pigments and Metagenomes Reveals Functional Dynamics of Marine Plankton
○Shoma Hemmi2, Toyonobu Fujii3,1, Akane Kitamura1, Gaku Kumano4,1, Minoru Ikeda3,1, Takeshi Obayashi2,1 (1. WPI-AIMEC, Tohoku Univ., 2. Grad. Sch. Info. Sci., Tohoku Univ., 3. Grad. Sch. Agr., Sci., Tohoku Univ., 4. Grad. Sch. Life, Sci., Tohoku Univ.)
[3P-957]Probiotic-derived extracellular vesicles as modulators of gut microbiota to reduce trimethylamine oxide generation
Bao-Hong Lee2, Cheng-Hao Huang1, Yi-Wen Wang1, ○Wei-Hsuan Hsu1 (1. National Cheng Kung University, 2. National Chiayi University)
[3P-958]Numerical Fluid Simulation of the Effect of Axolotl Tail Morphology on Swimming Efficiency
○Yoshichika Yokoe1,2,3, Haruka Sugiyama2 (1. University of Tokyo, 2. Haru labo, 3. SciMoun Technology)
[3P-959]Identification of Cataract-Associated Genes Using Machine Learning
○Hayato Ohno1, Yoshihiro Takamura2,3, Masaru Inatani 2, Masaya Oki1,3 (1. Graduate School of Engineering, Department of Materials Science and Biotechnology, University of Fukui, 2. Graduate School of Medical Sciences, Department of Ophthalmology, University of Fukui, 3. Life Science Innovation Center, University of Fukui)
[3P-960(3PS-06-02)]The Pathophysiological Role of Skin Tissue Renin-Angiotensin System in Hypertension
○Shinya Taguchi1 (1. Yokohama City University)
[3P-961]Single cell multiomics sequencing reveals features of circulating immune populations in IgA nephropathy patients undergoing tonsillectomy
○Diego Diez1, Takashi Sato2, Masayuki Mizui3, Shuhei Sakakibara4, Daisuke Okuzaki5 (1. The University of Osaka, Immunology Frontier Research Center, Quantitative Immunology Research Unit, 2. The University of Osaka, Graduate School of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, 3. The University of Osaka, Graduate School of Medicine, Department of Nephrology, 4. The University of Osaka, Immunology Frontier Research Center, Systems Immunology, 5. The University of Osaka, Immunology Frontier Research Center, Human Immunology Single Cell Genomics)
[3P-962]Recent progress in the generation and distribution of genetically modified rat model from AdAMS and NBRP-Rat
○Yoshihito HAYASHI1, Saeko ISHIDA1, Hiroaki TAKETSURU1, Kosuke HATTORI1, Yuko YAMAUCHI1, Ryuya IIDA1, Kazuto YOSHIMI2,1, Tomoji MASHIMO2,1 (1. Division of Animal Genetics, Institute of medical science, The University of Tokyo, 2. Division of Genome Engineering, Institute of medical science, The University of Tokyo)
[3P-963]The effect of adaptation to one antibiotic on resistance to other antibiotics
○Kozumi Imamura1, Saburo Tsuru2, Chikara Furusawa2,3,4 (1. Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2. Universal Biol. Inst., Grad. Sch. of Sci., Univ. of Tokyo, 3. Dept. of Phys., Grad. Sch. of Sci., Univ. of Tokyo, 4. BDR, RIKEN)
[3P-964]Mechanistic analysis of skeletal muscle atrophy in a bleomycin-induced pulmonary fibrosis model
○Atsushi Koike1, Ko Fujimori1 (1. Osaka Medical & Pharmaceutical University)
[3P-965(3PS-01-06)]Chromosome-level Genome Assembly of the Novel Model Fish Garra rufa: A Genomic Foundation for Human Disease Research at 37°C
○Yasuhito Shimada1,2,3, Koto Nanjo Kon4, Kiki Syaputri Handayani5, Liqing Zang1,6, Victor David Gultom5, Fahurozzi Fahurozzi5, Oleg Simakov4, Tetsuo Kon4 (1. Mie Zebra Res Cen., 2. Mie Univ Grad Sch Med., 3. Zebra-Innov., 4. Vienna Univ., 5. BRIN, 6. Mie Univ Grad Sch Regional)
[3P-966]Elucidation of the mechanism of pathological angiogenesis mediated by AP-1
○Yusei Nakano1, Kazuya kobayashi1, Masaru inatani2, Yoshihiro Takamura2, Masaya Oki1,3 (1. Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, 2. Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 3. Life Science Innovation Center, University of Fukui)
[3P-967]High-Sensitivity In Vivo Bioluminescence Imaging Enabled by the Near-Infrared Substrate AkaSuke
○Ryohei Saito-Moriya1,2, Satoshi Iwano3,4, Nobuo Kitada5, Rika Obata6, Kenji Sueyoshi1, Takashi Hirano5, Hiroshi Aoyama2, Shojiro Maki5, Takahiro Kuchimaru7 (1. Kitasato University, 2. Tokyo University of Pharmacy & Life Sciences, 3. RIKEN, 4. University of Miyazaki, 5. The University of Electro-Communications, 6. Keio University, 7. Jichi Medical University)
[3P-968]Radiation tolerance of the Japanese seacucumber, Apostichopus japonicus
○Toru Koike1, Katsuya Nozaki2, Atena Endo4, Fuka Takahashi2, Moeka Miyata2, Masahiro Asakawa3, Hideo Dohra2 (1. Faculty of Global Interdisciplinary Science and Innovation, Shizuoka University, 2. Faculty of Science, Shizuoka University, 3. Graduate School of Integrated Science and Technology, Shizuoka University, 4. Faculty of Science, Shizuoka University (Institute of Science Tokyo, Grad. School))
[3P-969]Mutant allele-specific reframed genome editing gene therapy for retinitis pigmentosa mouse model
○Kosuke Fujita1, Kazuhisa Yamada1, Koji N Nishiguchi1 (1. Nagoya Univ.)
[3P-970]Role of tfcp2l1 in hypoxia/reoxygenation-induced catch-up growth in zebrafish embryo
○Saki Miyama1, Sogo Ube2, Yuto Nakagawa1, Taiki Nagaya1, Oki Hayasaka3, Makoto Kashima2, Hiroyasu Kamei4 (1. Graduate School of Natural Science and Technology, Kanazawa University, 2. Faculty of Science Department of Biomolecular Science, Toho University, 3. Faculty of Fisheries, Kagoshima University, 4. Faculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University)
[3P-971]The development of efficient system in regeneration and gene therapy
○Kenji Ohba1, Yuri Ofusa1, Ryuzo Yamazaki1, Hiroaki Mizukami1 (1. Jichi Medical University)
[3P-972]Evolutionary conservation of hibernation-related genes in hibernating squirrels and their impact on daily torpor in mice
○Kisae Obo1, Moeko Ishigaki2, Nene Sakabe1, Sara Hirota2, Gakuto Onuma2, Kei Tamura1,2, Michihiko Ito1,2, Takuya Matsuo1,2, Daisuke Tsukamoto1,2 (1. Dept. of Biol. Sci., Grad. Sch. of Sci., Kitasato Univ., 2. Dept. of Biol. Sci., Sch. of Sci., Kitasato Univ.)
[3P-973]Expanding Data Integration through NANDO (Nanbyo Disease Ontology)
○Terue Takatsuki1, Atsuo Kikuchi2, Jae-Moon Shin1, Masae Hosoda1, Tatsuya Kushida3, Toyofumi Fujiwara1 (1. ROIS-DS・DBCLS, 2. Tohoku Univ. Med., 3. RIKEN・BRC)
[3P-974]Large-scale in vitro screening of BioBank Japan human sera on cellular phenotypes by staining multiple organelles (Cell Painting).
○Yoji Sagiya1, Chizu Tanikawa1, Yuka Okamoto2, Hiromi Tsuru2, Koichi Matsuda1,2 (1. Grad. Sch. of Frontier Sci., Univ. of Tokyo, 2. Inst. of Medical Sci., Univ. of Tokyo)
[3P-975]Development of an Automated Pipeline for Drug Repositioning Using Disease-Specific Gene Expression Data
○Yi Cong1, Naoki Osada2, Toshinori Endo2 (1. Info. Biol. Lab., Grad. Sch. of IST, Hokkaido Univ., 2. Info. Biol. Lab., Faculty of IST, Hokkaido Univ.)
[3P-976]Enhanced drug screening efficacy in zebrafish using a high oxygen-permeable culture plate
○Liqing Zang1, Shota Kondo 1, Yukiya Komada2, Norihiro Nishimura1 (1. Mie University, 2. Mitsui Chemicals, Inc)
[3P-977]DDrare ~ Database of Drug Development for Rare and Intractable Diseases ~
○Ryuichi Sakate1 (1. National Institutes of Biomedical Innovation, Health and Nutrition)
[3P-978]High-fat diet and/or exercise-induced regulation of GLUT4 levels in white adipose tissue.
○Yume Kato1, Hirokaze Yagi1, Mami Yamada1, Mitsuharu Okutsu1 (1. Nagoya City Univ.)
[3P-979]Development of Versatile Bioluminescent Probes for In Vivo Imaging
○Nobuo Kitada1, Genta Kamiya1, Jumpei Hatakeyama1, Ryohei Moriya2, Masahiro Kiyama3, Satoshi Iwano3, Sung-Bae Kim4, Takashi Hirano1, Shojiro Maki1 (1. The University of Electro-Communications, 2. Kitasato University, 3. Miyazaki University, 4. National Institute of Advanced Industrial Science and Technology)