Session Details
[3MS-02]【E】Transcriptional Research from Chromatin Dynamics to Translational Insights
Fri. Dec 5, 2025 11:15 AM - 12:35 PM JST
Fri. Dec 5, 2025 2:15 AM - 3:35 AM UTC
Fri. Dec 5, 2025 2:15 AM - 3:35 AM UTC
Room 2(Pacifico Yokohama Conference Center 3F, 301)
Organizer: Takashi Ito (Nagasaki University), Satoshi Inoue (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
This session will explore the complexities of transcriptional regulation, integrating foundational chromatin studies with advanced in vivo approaches. Key topics include chromatin dynamics, the roles of transcription factors, and the functions of RNA polymerase II, presented by a leading expert in the field. Furthermore, the discussion will examine how aberrant hormone receptor activity and chromatin architecture drive prostate and breast cancer progression. The mechanisms of gene transcription in aging, cancer, and therapeutic contexts will be analyzed, with an emphasis on translating molecular insights into clinical applications.
Introduction
[3MS-02-01]Modulation of Prostate Cancer Progression by the AR-Coregulator Transcriptional Network
○Edwin Cheung1 (1. University of Macau)
[3MS-02-02]Decoding the Hox Code: Integrated Analysis of Transcriptional Networks in Development and Adult Homeostasis
○Hiroshi Asahara1,2, Masayasu Sega1, Kohei Kita1 (1. Institute of Science Tokyo, 2. Scripps Research)
[3MS-02-03]Surfactin uncovers RRM2 as a downstream oncogenic effector of altered BAF/PBAF complexes
○Naoko Hattori1 (1. Nagasaki Univ.)
[3MS-02-04]Roles and Regulation of Mitochondrial Respiratory Chain Supercomplex Formation
○Satoshi Inoue1,2 (1. Systems Aging Sci and Med, TMIG, 2. Systems Med, Saitama Med Univ)
[3MS-02-05]The HMGN Nucleosome-binding Proteins Have Strong and Specific Effects upon Gene Expression in Humans
Grisel Cruz-Becerra1, Jonathan Zau1, Ann Dao1, Risa Purow-Ruderman1, ○James Takuro Kadonaga1 (1. Dept. Molecular Biology, UC San Diego, La Jolla, CA USA)