The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[3PS-05]【J】Mechanisms of Cell Fate Control in Totipotent Cells

Fri. Dec 5, 2025 2:20 PM - 4:20 PM JST
Fri. Dec 5, 2025 5:20 AM - 7:20 AM UTC
Room 5(Pacifico Yokohama Conference Center 3F, 304)
Organizer: Hirotsugu Ishizu (Keio University), Akihito Harada (Kyushu University)
Although a fertilized egg establishes totipotency through gamete fertilization and subsequently advances along diverse developmental pathways under fate regulation, many aspects of this process remain unknown. The key to understanding these processes lies in the genetic functions and epigenetic mechanisms involved in the acquisition of totipotency and pluripotency. In this symposium, we will share the latest insights into these molecular bases and introduce new developments in totipotent fate control powered by emerging technologies, including synthetic biology-based in vitro embryonic modeling.
2:20 PM - 2:23 PM JST(5:20 AM - 5:23 AM UTC)

Introduction

2:23 PM - 2:39 PM JST(5:23 AM - 5:39 AM UTC)

[3PS-05-01]Mechanism of totipotent-like state reactivation in mouse embryonic stem cells

○Hirotsugu Ishizu Ishizu1,2 (1. Keio University, 2. Chiba University)
Comment()
2:39 PM - 2:42 PM JST(5:39 AM - 5:42 AM UTC)

Q & A for Each Presentation

2:42 PM - 3:00 PM JST(5:42 AM - 6:00 AM UTC)

[3PS-05-02]Synthetic organizer cells guide in vitro mammalian development via spatial and biochemical instructions

○Toshimichi Yamada Yamada1 (1. University of California San Francisco)
Comment()
3:00 PM - 3:03 PM JST(6:00 AM - 6:03 AM UTC)

Q & A for Each Presentation

3:03 PM - 3:21 PM JST(6:03 AM - 6:21 AM UTC)

[3PS-05-03]Elucidation of the Molecular Basis of Early Human Germline Development

○Naoko Irie1 (1. Keio University)
Comment()
3:21 PM - 3:24 PM JST(6:21 AM - 6:24 AM UTC)

Q & A for Each Presentation

3:24 PM - 3:42 PM JST(6:24 AM - 6:42 AM UTC)

[3PS-05-04]Exploring multicellular patterning logic with synthetic cell-cell communication

○Satoshi Toda1 (1. The University of Osaka)
Comment()
3:42 PM - 3:45 PM JST(6:42 AM - 6:45 AM UTC)

Q & A for Each Presentation

3:45 PM - 4:03 PM JST(6:45 AM - 7:03 AM UTC)

[3PS-05-05]Technological Development of Spatial and Single-Cell Multi-Omics for Insights into Cell Fate Determination

○Akihito Harada Harada1, Takeru Fujii2, Kazumitsu Maehara1, Shinya Oki3, Yasuyuki Ohkawa2 (1. Graduate School of Medical Sciences, Kyushu University, 2. Medical Institute of Bioregulation, Kyushu University, 3. Institute of Resource Development and Analysis, Kumamoto University)
Comment()
4:03 PM - 4:06 PM JST(7:03 AM - 7:06 AM UTC)

Q & A for Each Presentation

4:06 PM - 4:18 PM JST(7:06 AM - 7:18 AM UTC)

[3PS-05-06(3P-623)]Extracellular presentation of the type IV membrane protein syntaxin4 as a potential trigger for region-specific gastrulation during early embryogenesis.

○Sae Nozaki1, Yohei Hirai1 (1. Kwansei Gakuin University)
Comment()
4:18 PM - 4:20 PM JST(7:18 AM - 7:20 AM UTC)

Q & A for Each Presentation

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