Session Details
[1P]F. Disorders of the Nervous System 2
Thu. Jun 30, 2022 1:00 PM - 2:00 PM JST
Thu. Jun 30, 2022 4:00 AM - 5:00 AM UTC
Thu. Jun 30, 2022 4:00 AM - 5:00 AM UTC
Poster Session Hall 2 Ginowan City Gymnasium
[1P-097]Role of glial proteasome in a Drosophila model of diabetic peripheral neuropathy
*Mari Suzuki1, Hiroshi Kuromi2, Mayumi Shindo3, Naoko Niimi1, Minoru Saitoe2, Kazunori Sango1 (1. Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 2. Learning and memory Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 3. Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
[1P-098]Does a decrease in atmospheric pressure cause Spreading Depression? - Mechanism of migraine attacks associated with low pressure
*Hitoshi Maeda1, Yuuka Akimoto1, Shunichi Kuwana1 (1. Uekusagakuen University)
[1P-099]Hypersensitivity of myelinated A fibers promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome
*Emiko Okuda-Ashitaka1, Hiroki Kamada1, Sadahito Uto1, Koichi Kawahara1, Toshiaki Minami2, Seiji Ito2, Ken-ichi Matsumoto3 (1. Dept of Biomedical Engineering, Osaka Inst of Technology, Osaka, Japan, 2. Dept of Anesthesiology, Osaka Med Pharma Univ, Takatsuki, Japan, 3. Dept of Biosign and Radioiso Exp, Interdiscip Cent for Sci Res, Org for Res Acad Info, Shimane Univ, Izumo, Japan)
[1P-100]Neural correlates of pareidolic misperceptions in Parkinson's disease patients
*Gajanan Revankar1, Yuta Kajiyama1, Noriaki Hattori1,2, Tomohito Nakano1, Tetsuya Shimokawa3, Masahito Mihara1,4, Etsuro Mori1, Hideki Mochizuki1 (1. Grad. School of Med, Osaka Uni, Osaka, Japan, 2. Faculty of Medicine, Univ of Toyama, Toyama, Japan, 3. CiNet, NICT, Osaka, Japan, 4. Kawasaki Med Sch, Kawasaki, Okayama, Japan)
[1P-101]Comparison of Cognitive Performance between Patients with Parkinson's Disease and Dystonia Using an Intraoperative Recognition Memory Test
*Lin Shi1, Guofan Qin1, Yichen Xu1 (1. Beijing Tiantan Hospital, Capital Medical University, Beijing, China)
[1P-102]Modulation of neurodegeneration by peripheral immune system in Niemann-Pick type C
*Toru Yasuda1, Toru Uchiyama1, Hideki Mochizuki2, Masafumi Onodera1 (1. National Center for Child Health and Development, Tokyo, Japan, 2. Department of Neurology, Graduate School of Medicine, Osaka University, Osaka, Japan.)
[1P-103]Generation and phenotype of ASIC2a transgenic rat with gain-of-function point mutation
*Yasuhiro Shibata1, Natsuko Kumamoto1, Eisuke Sakuma2, Yusuke Ishida3, Takashi Ueda1, Shoichi Shimada4, Sinya Ugawa1 (1. Dept ofAnatomy and Neuroscience, Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 2. Dept of Integrative Anatomy, Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 3. Div of Histology and Anatomy, Dept of Med, Tohoku Med and Pham Univ, Miyagi, Japan, 4. Dept of Neuroscience and Cell Biology, Grad sch Med, Osaka Univ, Osaka, Japan)
[1P-104]Pharmacological effect on characteristics of field potential and spike activity evoked by optogenetic callosal excitation in mouse secondary motor cortex
*Takashi Handa1, Hidenori Aizawa1 (1. Grad Sch Biomed Health Sci (Med), Hiroshima Univ)
[1P-105]Effects of Cistanche Tubulosa extract on cervical spondylotic myelopathy
*Masato Suyama1, Ximeng Yang1, Chihiro Thoda1 (1. Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama)
[1P-106]Relationships between extracellular glucose concentration and epileptic activities in an epileptic animal model using tetanus toxin.
*Mitsuyoshi Nakatani1, Antoine Ghestem2, Anton Ivanov2, Christophe Bernard2 (1. Juntendo University, 2. Aix Marseille University)
[1P-107]Molecular mechanisms of fever-associated epilepsy syndrome caused by haploinsufficiency of syntaxin 1B
*Tatsuya Mishima1, Takefumi Kofuji2, Tomonori Fujiwara1,3, Ayako Saito1, Yasuo Terao1 (1. Dept Med Physiol, Kyorin Univ Sch Med, Tokyo, Japan, 2. RI Lab, Kyorin Univ Sch Med, Tokyo, Japan, 3. Sch Medical Technology, Fac Health & Medical Care, Saitama Med Univ, Saitama, Japan)
[1P-108]Role of Increasing GLT-1 Expression in Repairing Cognitive and Neuronal Changes in a Rat Model of Epilepsy
*Ying-Jui Ho1, Yu-Shiuan Tzeng1, Wen-Yuan Liu1, Jin-Yi Yao1, Yun-Ju Hsieh1, Yong-Zhu Zhuang1 (1. Department of Psychology, Chung Shan Medical University, Taiwan)
[1P-109]Decoding and quantification of seizure susceptibility with cross-regional oscillatory brain activity patterns in a rat model of temporal lobe epilepsy
*Yuichi Takeuchi1,2, Qun Li2, Antal Berenyi2,3,4, Masabumi Minami1 (1. Dept Biopharmaceutical Sci Pharmacy, Facult Pharmaceutical Sci, Hokkaido Univ, Sapporo, Japan, 2. Dept Physiol, Facult Med, Univ Szeged, Szeged, Hungary, 3. HCEMM-SZTE Magnetotherapeutics Research Group, Univ Szeged, Szeged, Hungary, 4. Neurosci Inst, New York Univ, New York, USA)
[1P-110]Involvement of peripheral monocytes with IL-1β in the pathogenesis of West syndrome
*Tomoko Takamatsu1, Gaku Yamanaka1, Koko Ohno1, Kanako Hayashi1, Yusuke Watanabe1, Mika Takeshita1, Shinji Suzuki1, Shinichiro Morichi1, Yu Ishida1, Soken Go1, Shingo Oana1, Yasuyo Kashiwagi1, Hisashi Kawashima1 (1. Tokyo Medical University)
[1P-111]Spatiotemporal changes in excitatory and inhibitory neuronal activity during seizure progression in a pentylenetetrazol mouse model
*Matthew A Stern1,2, Ken Berglund2, Jake L Diamond2, Robert E Gross2 (1. Medical Scientist Training Program, Emory University School of Medicine, Atlanta, GA, USA, 2. Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA)
[1P-112]The involvement of oxytocin receptor activation in the change in self-grooming at the latent period in rat kainate model of epilepsy
*Hirofumi Arai1, Kiyohisa Natsume1 (1. Kyushu Institute of Technology, Fukuoka, Japan)
[1P-113]Role of hippocampal focal rhythmic discharges (FRDs) in impaired spatial working memory in epileptic mice.
*Maryam Pasdarnavab1, Laura Kück1, Fethullah Gerin1, Laura Ewell2 (1. University of Bonn, Bonn, Germany, 2. University of California - Irvine, Irvine, USA)
[1P-114]Novel inwardly rectifying potassium channel (Kir) activator NCC-1566 on the anti-epileptic effect in the seizure models.
*Yoshinobu Shimazawa1, Takeshi Nanya1, Osamu Nozawa1, Akitoshi Date1, Hiroshi Ikenaga2, Takehiro Nomura1, Daiki Takahashi1, Junji Kamon1 (1. Med Res Dept, Biol Res Labs, Nissan Chemical Corporation, 2. Pharm Res Dept, Chem Res Labs, Nissan Chemical Corporation)
[1P-115]Molecular mechanisms of epileptogenesis caused by deficiency of the cell adhesion molecule DSCAML1
*Koichi Hashizume1, Kyoka Suyama1, Shinichiro Taya1, Mikio Hoshino1 (1. National Center of Neurology and Psychiatry, Tokyo, Japan)
[1P-116]TSC inactivation increases neuronal network activity by enhancing Ca2+ influx via L-type Ca2+ channels
*Chihiro Hisatsune Hisatsune1, Tadayuki Shimada1, Akitoshi Miyamoto2, Amy Lee3, kanato Yamagata1 (1. The Tokyo Metropolitan Institute of Medical Science, 2. Laboratory of Single-Molecule Cell Biology, Kyoto University Graduate School of Biostudies, 3. Dept. of Neuroscience, University of Texas-Austin)
[1P-117]Involvement of pericytes in the pathogenesis of West syndrome
*Yusuke Watanabe1, Gaku Yamanaka1, Kanako Hayashi1, Shinji Suzuki1, Mika Takeshita1, Natsumi Morishita1, Shinichiro Morichi1, Soupei Go1, Yu Ishida1, Shingo Oana1, Fuyuko Takata2, Yasuyo Kashiwagi1, Hisashi Kawashima1 (1. Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan, 2. Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan)
[1P-118]Different rapamycin susceptibility among epileptic animal models of GATORopathy
*DI ZHAO1,2, Yuta SAWADA1, Yuichi HIRAOKA1, Tomoji MASHIMO2, Kohichi TANAKA1, Saeko ISHIDA1,2 (1. Tokyo Medical and Dental University, 2. The University of Tokyo)
[1P-119]Glial cells missing 1 induce glial cells and angiogenesis in the core region of brain injury
*Yoshitaka Hayashi1, Yasuhiro Go2, Kazuhiko Nakabayashi3, Asmaa Abdullah1, Zakiyyah Mohd1, Seiji Hitoshi1 (1. Integrative physiology, Shiga University of Medical Science, Shiga, Japan, 2. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Aichi, Japan, 3. Department of Maternal-Fetal Biology, National Center for Health and Development, Tokyo, Japan)
[1P-120]Tauopathy pathology in a novel traumatic mouse brain injury model
*Taeko Kimura1, Masami Suzukake1, Masashi Hashimoto1, Shin-ichi Hisanaga1,2, Masato Hasegawa1 (1. Tokyo Metropolitan Institute of Medical Science, 2. Department of Biological Sciences, Tokyo Metropolitan University)
[1P-121]Preconditioning exercise in rats attenuates early brain injury resulting from subarachnoid hemorrhage by reducing oxidative stress, inflammation, and neuronal apoptosis.
*Shotaro Otsuka1, Teruki Matsuoka2, Ryoma Matsuzaki2, Tomomi Nakakogawa2, Akira Tani2, Kosuke Norimatsu2, Seiya Takada2, Kazuki Nakanishi2, Ikuro Maruyama 1, Harutoshi Sakakima2, Kiyoshi Kikuchi1,3 (1. Kagoshima University Graduate School Medical and Dental Science, 2. Department of Physical Therapy, School of Health Science, Faculty of Medicine, Kagoshima University, 3. Division of Brain Science, Department of Physiology, Kurume University School of Medicine)
[1P-122]Brain injury triggers cell-type-specific endoplasmic reticulum stress responses in different time courses.
*Mika Takarada-Iemata1, Qiyan Fan1, Nahoko Okitani1, Osamu Hori1 (1. Grad Sch Med Sci, Kanazawa Univ, Ishikawa, Japan)
[1P-123]Voluntary exercise restores the ability of corticospinal tract rewiring and motor recovery loss in aged mice after brain injury
*Takashi TANAKA1,2, Hiroki URA3, Sumihito TOGI3, Yo NIIDA3, Masaki UENO4 (1. Grad Sch Health Sci, Kumamoto Health Sci Univ, Kumamoto, Japan, 2. Sch Med, Kanazawa Med Univ, Ishikawa, Japan, 3. Med Res Inst, Kanazawa Med Univ, Ishikawa, Japan, 4. Brain Res Inst, Niigata Univ, Niigata, Japan)
[1P-124]Efficacy and safety of novel thrombolysis with spot heating and ultrasound irradiation
*Ryuta Morihara1, Toru Yamashita1, Yusuke Fukui1, Yosuke Osakada1, Koh Tadokoro1, Mami Takemoto1, Tian Feng1, Xinran Hu1, Koji Abe1 (1. Okayama University)
[1P-125]Long-term neuroprotection of the progesterone receptor agonist nestorone against permanent focal cerebral ischemia in adult and old male rats.
*Motoki Tanaka1, Masahiro Sokabe2, Masato Asai1 (1. Inst for Dev Res, Aichi Dev Disabil Ctr, kasugai, Japan, 2. Nagoya Univ Grad Sch Med, Nagoya, Japan)
[1P-126]Recovery from sensory-motor dysfunctions positively correlates with a residual volume of the entopeduncular nucleus in a rat model of the intracerebral hemorrhage.
*Ryo Sakai1,2, Koshi Murata2, Kazuki Kuroda2, Takashi Ryoke2, Yugo Fukazawa2 (1. Dept Reha, Fukui Health Science Univ, Fukui, Japan, 2. Dept Med, Univ of Fukui, Fukui, Japan)
[1P-127]Transiently proliferating vessel-associated microglia harbor pro-inflammatory and precede cerebrovascular changes in a chronic hypertension rat
*Takashi Koizumi1,3, Katsutoshi Taguchi1, Ikuko Mizuta3, Hiroe Toba2, Okihiro Onishi4, Kazuya Ikoma4, Tetsuo Nakata2, Toshiki Mizuno3, Masaki Tanaka1 (1. Dept of Anatomy and Neurobiology, Grad Sch Med, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2. Dept of Clinical Pharmacology, Div of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan., 3. Dept of Neurology, Grad Sch Med, Kyoto Prefectural University of Medicine, Kyoto, Japan, 4. Dept of Orthopaedics, Grad Sch Med, Kyoto Prefectural University of Medicine, Kyoto, Japan)
[1P-128]Automatic Diagnosis, Classification and Subtyping of Ischemic Stroke based on a Deep Learning System
*Wei SHAN1,2,3, Huajun Yang1, He Fu2, Zhenzhou Wu2, Qun Wang1,2,3 (1. Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2. National Center for Clinical Medicine of Neurological Diseases, Beijing, 100070, P.R. China, 3. Beijing Institute for Brain Disorders, Beijing, 100070, P.R. China)
[1P-129]Antioxidative and neuroprotective effects of ascidiacea-derived plasmalogen in a mouse stroke model
*Yusuke Fukui1, Yumiko Nakano1, Taijun Yunoki1, Takemoto Mami1, Ryuta Morihara1, Toru Yamashita1, Koji Abe2 (1. Okayama University, 2. National Center of Neurology and Psychiatry)
[1P-130]Dynamic quantification of changes in neuronal Na+ using rapidFLIM with ION NaTRIUM Green-2
*Jan Meyer1, Niklas J. Gerkau1, Karl W. Kafitz1, Matthias Patting2, Fabian Jolmes2, Christian Henneberger3,4,5, Christine R. Rose1 (1. Institute of Neurobiology, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany, 2. Picoquant, Rudower Chaussee 29, 12489 Berlin, Germany, 3. Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany, 4. German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany, 5. Institute of Neurology, University College London, London WC1N 3BG, United Kingdom)
[1P-131]Role of Small Ubiquitin-like Modifier (SUMO)-2/3 conjugation in a mouse model of intracerebral hemorrhage
*Keita Kinoshita1, Yuki Kurauchi1, Takahiro Seki1, Hiroshi Katsuki1 (1. Dept. Chemico-Pharmacol Sci, Grad Sch Pharm, Kumamoto university, Japan)
[1P-132]Effect of Arcadlin on dendritic spine density in the hippocampal dendtate gyrus after celebral ischemia
*Nakazawa Shuma1, Yosuke Inoue1, Shota Inoue1, Natsumi Yamaguchi1, Jin Nakatani1, Toshinori Sawano1, Hidekazu Tanaka1 (1. Ritsumeikan Univ.)
[1P-133]Time-dependent neuroprotective mechanism for ischemic stroke
*Hiroo Takahashi1, Daiki Ojima1, Akio Tsuboi2, Tohru Yamamoto1 (1. Dep Mol Neurobiol, Kagawa Univ, Kagawa, Japan, 2. Grad Sch Front Biosci, Osaka Univ, Suita, Japan)
[1P-134]“Raisin bread sign” is a specific radiological feature of Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy
*Mai Kikumoto1,2, Takashi Kurashige3, Tomohiko Ohshita1,3, Kodai Kume2, Tomohisa Nezu1, Shiro Aoki1, Kazuhide Ochi4, Hiroyuki Morino5, Eiichi Nomura6, Hiroshi Yamashita7, Mayumi Kaneko8, Hirofumi Maruyama1, Hideshi Kawakami1,2 (1. Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan, 2. Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan, 3. Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan, 4. Department of Neurology, Hiroshima Prefectural Hospital, Hiroshima, Japan, 5. Department of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, 6. Department of Neurology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan, 7. Department of Neurology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan, 8. Department of Diagnostic Pathology, Hiroshima City Asa Citizens Hospital, Japan)
[1P-135]DAMPs receptor-dependent leukocyte accumulation is critical pathology of cerebral vasospasm/neuronal dysfunction after subarachnoid hemorrhage
*Hiroshi Ishii1, Yasuhiro AIDA2, Tuyoshi HATTORI1, Mika TAKARADA-IEMATA1, Mitsutoshi NAKADA2, Yasuhiko YAMAMOTO3, Osamu HORI1 (1. Dept Neuroanat, Grad Sch Med, Kanazawa Univ, Kanazawa, Japan, 2. Dept Neurosurgery, Grad Sch Med, Kanazawa Univ, Kanazawa, Japan, 3. Dept Biochem & Mol Vasc Biol, Grad Sch Med, Kanazawa Univ, Kanazawa, Japan)
[1P-136]Dynamics of plasma Serine protease inhibitor A3N (Serpina3n) level following focal cerebral ischemia in mice
*Saki Egashira1, Hiroshi Kashiwagi1, Minami Mori1, Takafumi Nakano1,3, Keiichi Irie1, Masato Hosokawa1, Fuyuki Kametani2, Yoshihiko Nakamura1, Shunya Otsubo1, Tomomitsu Satho1, Yuta Yamashita1, Kazunori Sano1, Kenichi Mishima1 (1. Fukuoka Univ., 2. Tokyo metroplitan institute of Medical Sci., 3. Dept. pharm. Fukuoka Univ. Hosp.)
[1P-137]β - Adrenergic receptor agonist reduce memory interference in APPswe/PS1dE9 mice
*Smitha Karunakaran1 (1. Centre for Brain Research)
[1P-138]Combined administration of donepezil and cilostazol ameliorates spatial memory impairment in APP knock-in mouse model for Alzheimer's disease
*Shuichi Yanai1, Tomoko Arasaki1, Takashi Saito2,3, Takaomi Saido2, Shogo Endo1 (1. Aging Neuroscience Research Team, Tokyo Metropolitan Institute of Gerontology, 2. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 3. Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University)
[1P-139]Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis
*Kun Zou1, Sadequl Islam1, Yang Sun1, Yuan Gao1, Tomohisa Nakamura1, Noriyuki Kimura2, Etsuro Matsubara2, Kensaku Kasuga3, Takeshi Ikeuchi3, Taisuke Tomita4, Makoto Michikawa1 (1. Dept Biochem, Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 2. Dept Neurol, Sch Med, Oita Univ, Oita, Japan, 3. Dept Mol Genet, Brain Res Inst, Niigata Univ, Niigata, Japan, 4. Dept Neuropathol Neurosci, Faculty Pharm Sci, Univ of Tokyo, Tokyo, Japan)
[1P-140]Stimulation of microglial cannabinoid receptor type II ameliorates cognitive decline in Alzheimer's disease mice by controlling neuroinflammation.
*Akira Sobue1,2, Okiru Komine1, Fumito Endo1, Shigeo Murayama3,4, Takashi Saito5, Takaomi Saido6, Koji Yamanaka1 (1. Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, 2. Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, 3. Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4. Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, 5. Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 6. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science.)
[1P-141]Neuronal activity-dependent alteration of tau phosphorylation
*Sosuke Yagishita1, Akiko Furuno1, Megumi Shibata1, Shoko Hashimoto2, Takashi Saito2,3, Takaomi C. Saido2, Toshiyuki Araki1 (1. National Center of Neurology and Psychiatry, Tokyo, Japan, 2. RIKEN Center for Brain Science, Saitama, Japan, 3. Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan)
[1P-142]Effects of medium flow induced by ciliated cells on neurotoxicity of Aβ containing exosome in the brain organotypic culture
*Yoshiki Yagi1, Sora Oda1, Hitoshi Tatsumi1 (1. Kanazawa Institute of Technology)
[1P-143]Presenilin 1 deficiency impairs Aβ42-to-Aβ40-converting activity of ACE
*YUAN GAO1, Yang Sun1, Sadequl Islam1, Tomohisa Nakamura1, Taisuke Tomita2, Kun Zou1, Makoto Michikawa1 (1. Grad Sch Med Sci, Nagoya City University, Nagoya, Japan, 2. Faculty of Pharmaceutical Sciences, Univ of Tokyo, Tokyo, Japna)
[1P-144]ApoE3 and ApoE4 differentially regulate γ-secretase complex formation and activity
*YANG SUN1, Yuan Gao1, Sadequl Islam1, Tomohisa Nakamura1, Kun Zou, Makoto Michikawa1 (1. Grad Sch Med Sci, Nagoya City University, Nagoya, Japan )
[1P-145]Failure of DNA Double-Strand Break Repair by Tau Mediates AD Pathology in vitro
*Megumi utsugi Asada2,1, Kengo Uemura6, Takashi Ayaki3, Maiko Uemura5, Sumio minamiyama3,7, Ryota Hikiami3,7, Toshifumi Morimura8, Akemi Shodai7, Ryosuke Takahashi3, Takatoshi Ueki4, Ayae Kinoshita2, Makoto Urushitani1,7 (1. Molec Neuro Research Center, Grad Sch Med, Univ of Shiga, Otsu, Japan, 2. Dept Human Health Sci, Grad. Sch, Grad Sch Med, Univ of Kyoto, Japan, 3. Dept Neuro, Grad Sch Med, Univ of Kyoto, Japan, 4. Dept of Integrative Anatomy, Grad Sch Med,Univ of Nagoya City, Nagoya, Japan, 5. Center Neurodegenerative Disease Research, Perelman Sch Med, Univ of Pennsylvania, Philadelphia, PA, USA, 6. Ishiki hospital, kagoshima, Japan, 7. Dept Neuro, Grad Sch Med, Univ of Shiga, Otsu, Japan, 8. Research Center for Animal Life Science, Grad Sch Med, Univ of Shiga, Otsu, Japan)
[1P-146]Insulin deficiency increases Sirt2 level in streptozotocin-treated Alzheimer's disease model mice: Sirt2 increases tau phosphorylation through ERK activation
*Chunyu Zhou1, Cha-Gyun Jung1, Mi-Jeong Kim2, Atsushi Watanabe3, Mona Abdelhamid1, Ferdous Taslima1, Makoto Michikawa1 (1. Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 2. Department of Food & Biotechnology, Korea University, 3. Laboratory of Research Advancement, Research Institute, National Center for Geriatrics and Gerontology)
[1P-147]Putative role of altered brain lipid metabolism in Alzheimer's disease pathology using postmortem human brain and mice.
*Noe Kawade1, Okiru Komine1, Akira Sobue1, Takashi Saito2, Takaomi C Saido3, Koji Yamanaka1 (1. Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Japan, 2. Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Japan, 3. RIKEN Center for Brain Science)
[1P-148]Functional relationship between the neural circuit formation factor LOTUS and Aβ- producing enzyme BACE1
*Aoi Kamiguchi1, Yuki Kawaguchi1, Junpei Matsubayashi1, Kohtaro Takei1 (1. Grad Sch Med, Univ of Yokohama city, Kanagawa, Japan)
[1P-149]Downregulation of miR-140-5p attenuates memory impairment induced by amyloid-ß oligomer in an animal model possibly through Pin1 regulation
*Pariya Khodabakhsh1, Maryam Bazrgar2, Fatemeh Mohagheghi3, Siavash Parvardeh1, Abolhassan Ahmadiani2 (1. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2. Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran, 3. Institute of Experimental Hematology, Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany)
[1P-150]Peripheral Aβ acts as a negative modulator of insulin secretion
*Takami Tomiyama1, Keiko Shigemori1, Sachiko Nomura1, Tomohiro Umeda1, Shuko Takeda2 (1. Osaka City University, 2. Osaka University)
[1P-151]Molecular mechanisms for diosgenin-elicited axonal regeneration and memory recovery
*Ximeng Yang1, Chihiro Tohda1 (1. Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama)
[1P-152]The “P1” components of evoked potentials following auditory, visual and somatosensory stimulation are enhanced in patients with myotonic dystrophy type 1
*Shugo SUWAZONO1, Hiroshi Arao2, Yukihiko Ueda3, Shino Maedou3 (1. National Hospital Organization Okinawa National Hospital, 2. Taisho University, 3. Okinawa International University)
[1P-153]White matter edematous change in the pre-treatment acute stage of leukoencephalopathy with cerebral amyloid angiopathy
*Ken Yasuda1, Takashi Ayaki1, Fangzhou Li2, Yasuhiro Kuwata1, Takakuni Maki1, Makoto Sainouchi3, Koki Moriyoshi4, Michikazu Nakamura4, Ryosuke Takahashi1 (1. Kyoto University Graduate School of Medicine, Kyoto, Japan, 2. Zhejiang University School of Medicine, Zhejiang, China, 3. Brain Research Institute, Niigata University, Niigata, Japan, 4. National Hospital Organization Kyoto Medical Center, Kyoto, Japan)
[1P-154]Time-of-day dependent impairments of memory retrieval in AD model mice micro-infused Amyloid β42 into the dorsal hippocampus.
*James Martin Taihei Borg1, Satoshi Kida1 (1. University of Tokyo)
[1P-155]Targeting the promoter region of amyloid precursor protein by CRISPR/Cas 9 -Toward the therapeutic genome editing for Alzheimer's disease-
*Sonoko Tanaka1, Miki Ikeda1, Kiichiro Matsumura1, Masahiro Sonoo1, Fumiaki Saito1 (1. Sch Med, Teikyo Univ, Tokyo, Japan)
[1P-156]Evaluation of utility of Alzheimer's disease model using patient iPSC-derived neurons
*Miyaka Ogihara1, Natsuko Hemmi1, Manabu Seo2, Motoki Azuma1 (1. RICOH Company, Ltd., Kanagawa, Japan, 2. Elixirgen Scientific, Inc., Baltimore, US)
[1P-157]Beneficial effects of Dimethyl Fumarate on the cognitive impairment and neuroinflammation in Alzheimer's disease mice
*Ting Wang1, Akira Sobue1,2, Okiru Komine1, Seiji Watanabe1, Takashi Saito3, Takaomi Saido4, Koji Yamanaka1 (1. Nagoya universityDepartment of Neuroscience and Pathobiology, Research InstiDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University,Japan, 2. Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University,Japan, 3. Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences Japan, 4. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science Japan)
[1P-158]Autobiographical Episodic Memory of Chinese-Speaking Seniors with Alzheimer's Disease
*Yi-hsiu Lai1, Yu-te Lin2 (1. National University of Kaohsiung, Taiwan, 2. Kaohsiung Veterans General Hospital, Taiwan)
[1P-159]Development of next-generation tauopathy mouse model
*Naoto Watamura1, Martha Foiani2, Karen Duff2, Takaomi Saido1 (1. RIKEN, 2. University College London, DRI)
[1P-160]Sustained high body temperature exacerbates cognitive function and Alzheimer's disease-related pathologies
*Cha-Gyun Jung1, Reiko Kato2, Chuny Zhou1, Mona Abdelhamid1, Hitoshi Yamashita2, Makoto Michikawa1 (1. Nagoya City University Graduate School of Medical Sciences, 2. Chubu University)
[1P-161]D-Serine dependent pathophysiological progression of Alzheimer's disease
*Xiance Ni1,2, Ran Inoue1,3, Takashi Saito6, Takaomi Saido6, Keizo Takao2,3,4,5, Hisashi Mori1,2,3,4 (1. Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2. Graduate School of innovative Life Science, University of Toyama, 3. Research Center for Iding Brain Science (RCIBS), 4. Research center for Pre-Disease Science, University of Toyama, 5. Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, 6. Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, Wako, Saitama, Japan)
[1P-162]The effects of anserine treatment on tau-mediated neurodegeneration in a mouse model of tauopathy
*CHENXU LEI1, Tatsuhiro Hisatsune1 (1. Graduate School of Frontier Sciences, The University of Tokyo)
[1P-163]Quantitative and successive analysis of reversible memory impairment in dementia
*Katsuei Shibuki1,3,4,5, Shin Tanaka2, Masahiro Morita2, Masaharu Tanaka2, Toshiyuki Someya1, Ko Tanaka2 (1. Grad Sch Med Dent, Niigata Univ, Niigata, Japan, 2. Mishima Hospital, Niigata, Japan, 3. Kashiwazaki General Hospital and Medical Center, Niigata Japan, 4. Niigata Psychiatric Center, Niigata, Japan, 5. Brain Res Inst, Niigata Univ, Niigata, Japan)
[1P-164]A novel Rosa26-Knockin Tau expressing mouse model exhibits neuroinflammatory responses during tauopathy
*Rin Yanai1, Takeharu Minamihisamatsu1, Masafumi Shimojo1, Yuhei Takado1, Naruhiko Sahara1, Makoto Higuchi1 (1. National Institutes for Quantum Science and Technology)
[1P-165]Testosterone regulates the neuroinflammation in Alzheimer's disease mice by stimulating glial androgen receptors
*Kasumi Maekawa1, Akira Sobue1, Okiru Komine1, Takashi Saito2, Takaomi Saido3, Koji Yamanaka1 (1. Dept of Neurosci & Pathobiol, RIEM, Nagoya Univ, Aichi, Japan, 2. Dept Neurocog Sci, Inst of Brain Sci, Nagoya City Univ Grad Sch of Med Sci, Aichi, Japan, 3. Lab for Proteolytic Neurosci, RIKEN CBS, Saitama, Japan)
[1P-166]Proximity labelling proteomics identified a molecule which promotes degradation of FTLD/ALS causing C9orf72 repeat RNA.
*Ryota Uozumi1, Kohji Mori1, Shiho Gotoh1, Tesshin Miyamoto1, Shizuko Kondo1, Tomoko Yamashita1, Yuya Kawabe2, Manabu Ikeda1 (1. Grad Sch Med, Osaka University, 2. Minoh Neuropsychiatric Sanatorium)
[1P-167]Two-step dephosphorylation in the physiological axonal localization of tau
*Higashi Yuto1,2, Kakuda Satoko1,2, Miyasaka Tomohiro1,2 (1. Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan, 2. Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, Japan)
[1P-168]Soluble high-molecular-weight Aβ species inducing cerebral β-amyloidosis are abundant in Alzheimer brains with prominent cerebral amyloid angiopathy.
*Hirokazu Uchigami1,2, Mayu Kashiwagi-Hakozaki1, Tomoyasu Matsubara3, Shigeo Murayama3,4, Yuko Saito3, Tatsushi Toda2, Tadafumi Hashimoto1,5, Takeshi Iwatsubo1 (1. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 2. Department of Neurology, Graduate School of Medicine, The University of Tokyo, 3. Department of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4. Brain Bank for Neurodevelopmental, Neurology and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, 5. Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry)
[1P-169]Development of an assay for path integration performance
*Riki Koike1, Mao Yamashita1, Yuta Takaichi2, Yoshiyuki Soeda1, Akihiko Takashima1 (1. Grad Sch Sci, Gakushuin Uni, Tokyo, Japan, 2. Grad Sch Agric and Sci, Univ of Tokyo, Tokyo, Japan)
[1P-170]Effects of Down syndrome genes on amyloid-β accumulation in mice
*Keiichi Ishihara1, Eri Kawashita1, Kaneyau Nishimura2, Michiko Saito3, Haruhiko Sago4, Kazuhiro Yamakawa5, Satoshi Akiba1, Kazuyuki Takata2 (1. Dept of Pathol Biochem, Kyoto Pharm Univ, Kyoto, Japan, 2. Divi of Integ Pharm Sci, Kyoto Pharm Univ, Kyoto, Japan, 3. Bio-sci Res Centr, Kyoto Pharm Univ, Kyoto, Japan, 4. Centr for Maternal-Fetal, Neonat & Reproduct Med, Natl Centr for Child Health & Development, Tokyo, Japan, 5. Depart of Neurodevelop Dis Genet, Nagoya City Univ Grad Sch Med Sci, Aichi, Japan)
[1P-171]Identification of antisense oligonucleotides that regulate splicing of tau proteins and their potential therapeutic applications
*Kuniyuki Endo1,2, Kentaro Sahashi1, Kaori Kawai1, Yusuke Fujioka1, Masahisa Katsuno1, Gen Sobue3, Shinsuke Ishigaki1,4 (1. Dept Neurology, Nagoya Univ Grad Sch Med, Nagoya, Japan, 2. Matsukage Hospital, Nagoya, Japan, 3. Aichi Med Univ, Nagakute, Japan, 4. Brain Mind Res Cent, Nagoya University, Nagoya, Japan )
[1P-172]Stage-specific reduction of hippocampal neurogenesis in APPswe-PS1ΔE9 Alzheimer's Disease model mice
*Risako Tamura1, Daiki Hayashi1, Chenxu Lei1, Haowei Li1, Tatsuhiro Hisatsune1 (1. Graduate school of frontier sciences the university of Tokyo)
[1P-173]Impacts of Tau Accumulation and Tauopathy Pathogenesis on Microtubule Stability
*Ayaka Tatsumoto1,2, Tomohiro Miyasaka1,2 (1. Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan, 2. Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, Japan)
[1P-174]The effect of Humanin, a bioactive peptide, on cellular senescence in neurons
*Ayari Kozuka1, Dan Suzuki1, Takako Niikura1 (1. Sophia University)
[1P-175]Mitochondrial complex I abnormalities is associated with tau pathology in Alzheimer's disease
*Tatsuhiro TERADA1, Joseph Therriault2, Min Su Kang2, Takashi Matsudaira1, Tomoyasu Bunai1, Hirotsugu Takashima1, Tomokazu Obi3, Hideo Tsukada4, Pedro Rosa-Neto2, Yasuomi Ouchi1 (1. Hamamatsu University School of Medicine, 2. The McGill University Research Centre for Studies in Aging, 3. Shizuoka Institute of Epilepsy and Neurological Disorders, 4. Hamamatsu Photonics KK)
[1P-176]Pathological alterations of hippocampus in Alzheimer disease and vascular cognitive impairmet
*Shintaro Toda1, Seizi Yanagida1, Yasuhiro Kuwata1, Mayuko Baba1, Naoki Takayama1, Ken Yasuda1, Takakuni Maki1, Ryosuke Takahashi1 (1. Department of Neurology, Graduate School of Medicine, Kyoto University Hospital)
[1P-177]Brain pathologies associated with phospho-tau 181, 217 and 231, fluid biomarkers for Alzheimer's disease, in App knock-in mouse models of Aβ amyloidosis
*Yu Hirota1,2, Yasufumi Sakakibara1, Kyoko Ibaraki1, Kimi Takei1, Koichi M Iijima1,3, Michiko Sekiya1,3 (1. Dept. of Neurogenetics, National Center for Geriatrics and Gerontology, 2. JSPS Research Fellow (PD), 3. Grad Sch Pharmaceutical Sciences, Nagoya City University)
[1P-178]Identifying cellular and proteomic phenotypes across human Alzheimer's disease hippocampal tissue by multiplexed ion beam imaging
*Bryan Cannon1, Kausalia Vijayragavan1, Dmitry Tebaykin1, Dunja Mrdjen1, JP Oliveria1, Noah Greenwald1, Alex Baranski1, Mike Angelo1, Tom Montine1, Sean Bendall1 (1. Stanford University)
[1P-179]Search for methods to measure cerebral blood flow in Alzheimer's disease model mouse under stress
*Yuriko Inoue1, Hiromitsu Ezure1, Jyunji Ito2, Chika Sawa3, Masaaki Takayanagi4, Takashi Takaki 5, Yoshinobu Manome6, Akio Inoue7, Naruhito Otsuka1 (1. Dep Anat, Showa Univ Sch Med, Tokyo, Japan, 2. / School of Nurs. Reh. Sci, Showa Uni Nursing, Kanagawa, Japan, 3. Dep Anat, Showa Univ Sch Med. Tokyo, Japan, 4. Saitama Prefectural University, Saitama, Japan, 5. Div. Electron Microscopy Showa Univ, Tokyo, Japan, 6. Core Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei Uni, Tokyo, Japan, 7. Human Brain Res. Center, Kyoto Uni. Med, Kyoto, Japan)
[1P-180]N-ethylmaleimide-sensitive factor (NSF) deficient mice exhibit autism like phenotypes
*Min Jue Xie1,2,3, Keiko Iwata1,2,3, Yasuyuki Ishikawa4, Koshi Murata5, Yugo Fukazawa1,2,5, Hideo Matsuzaki (1. Div Dev Mental Func, Res Center Child Mental Dev, Univ of Fukui, 2. Life Sci lnnovation Center, Univ of Fukui, 3. United Grad Sch Child Dev, Osaka Univ, Kanazawa Univ, Hamamatsu Univ Sch Med, Chiba Univ, Univ of Fukui, 4. Dept Sys Life Engineering, Maebashi Inst Tech, Gunma, Japan, 5. Div Brain Struc Func, Dept Morphol Physiol Sci, Grad Sch Med Sci, Univ of Fukui, Fukui, Japan)
[1P-181]Generation of cortical organoids derived from Rett syndrome and MeCP2 duplication syndrome iPS cell lines
*Atsushi Shiraishi1, Yuki Hamamura1, Takahito Inoue1, Toshihide Ono1, Yuko Arioka2, Hiroki Okumura2, Takashi Futamura1, Norio Ozaki2 (1. Department of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan, 2. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan)
[1P-182]Autism spectrum disorder research focusing on the fetal period
*Erika Ida1, Yoshiyuki Kasahara1, Chihiro Yoshida1, Ryoma Ito1, Masatoshi Saito1, Yoshitaka Kimura1 (1. Grad Sch Med, Univ of Tohoku, Sendai, Japan)
[1P-183]Evaluation of Neural activity of iPSC-derived neurons from Autism Spectrum Disorder donor with Micro electrode array.
*Tomoaki Nakayama1, Manabu Seo2, Tomoyuki Aratani2, Azuma Motoki1 (1. RICOH COMPANY, LTD., Kanagawa, Japan, 2. Elixirgen Scientific, Inc., Baltimore, US)
[1P-184]People with autism spectrum disorder show habituation of the sympathetic response to whitenoise
*Yuuki Ooishi1, Chihiro Itoi2, Nobumasa Kato3, Makio Kashino1 (1. NTT Communication Science Laboratories, 2. Research Institute of National Rehabilitation Center for Persons with Disabilities, 3. Medical Institute of Developmental Disabilities Research, Showa University)
[1P-185]ATF5 is involved in the maintenance of interneurons in the mouse cerebral cortex.
*Riko Nakajima1, Mariko Umemura1, Ryo Kiyatake1, Shigeru Takahashi1, Yuji Takahashi1 (1. Tokyo University of Pharmacy and Life Sciences)
[1P-186]Role of autism spectrum disorder-associated gene in neocortical development
*Noriyoshi Usui1,2,3,4, Nanako Nakama1, Hana Miyauchi1, Miyuki Doi1, Koichiro Irie1, Yoshihisa Koyama1,4, Yukiko Nakamura1,4, Hideo Matsuzaki2,5, Shoichi Shimada1,2,3,4 (1. Dept Neurosci Cell Biol, Grad Sch Med, Osaka Univ, Osaka, Japan, 2. United Grad Sch Child Dev, Osaka Univ, Osaka, Japan, 3. Global Cent Med Eng Info, Osaka Univ, Osaka, Japan, 4. Addiction Res Unit, Osaka Psych Res Center, Osaka Psych Med Cent, Osaka, Japan, 5. Res Cent Child Ment Dev, Univ Fukui)
[1P-187]IL-17RA expression in the cerebral cortex during postnatal development and its alternation in the ASD model of maternal immune activation
*Tetsuya Sasaki1,2, Peiyi Bao2, Masae Ohtsuka1, Hiroko Suzaki1, Suguru Iwata1,2, Yosuke Takei1,2 (1. Dept Anat & Neurosci, Fac Med, Univ of Tsukuba, Ibaraki, Japan, 2. Doctorate Program Neurosci, Grad Sch Comp Human Sci, Univ of Tsukuba, Ibaraki, Japan)
[1P-188]Prenatal exposure to valproic acid induces proliferation of microglia in the spinal cord and mechanical allodynia in mice
*Yukio Ago1,2, Eiji Imado1,3, Sun Samnang2, Yoki Nakamura4, Kazue Nakashima4, Norimitsu Morioka4, Kazuhiro Takuma5, Norikazu Kiguchi6, Satoshi Asano1,2 (1. Dept of Cell Mol Pharmacol, Grad Sch of Biomed Health Sci, Hiroshima Univ, Hiroshima, Japan, 2. Sch of Dent, Hiroshima Univ, Hiroshima, Japan, 3. Dept of Dental Anesthesiol, Grad Sch of Biomed Health Sci, Hiroshima Univ, Hiroshima, Japan, 4. Dept of Pharmacol, Grad Sch of Biomed Health Sci, Hiroshima Univ, Hiroshima, Japan, 5. Dept of Pharmacol, Grad Sch of Dent, Osaka Univ, Osaka, Japan, 6. Dept of Physiol Sci, Sch of Pharmaceut Sci, Wakayama Med Univ, Wakayama, Japan)
[1P-189]Neural circuit organization and functions of oxytocin neurons in a mouse ASD model
*Masafumi Tsurutani1,2, Kazunari Miyamichi1 (1. RIKEN Center for Biosystems Dynamics Research, 2. Graduate School of BIOSTUDIES,Kyoto University)
[1P-190]Phenotypic characterization of a novel mouse model for Timothy syndrome by a behavioral assessment battery
*Miao Pan1,2, Yukihiro Ozawa1,2,3, Shuhei Ueda1,2, Manabu Abe4, Kenji Sakimura4, Shin-ichiro Horigane1,2, Sayaka Takemoto-Kimura1,2 (1. Dept. of Neuroscience I, Research Inst. of Environmental Med, Nagoya Univ, Nagoya, Japan, 2. Molecular/Cellular Neuroscience, Nagoya Univ. Grad. Sch. of Med., Nagoya. Japan, 3. Dept. of Pathology and Lab. Med., Nagoya Univ. Hospital, Nagoya, Japan, 4. Dept. of Comparative and Experimental Med., Brain Research Inst., Niigata Univ., Niigata, Japan)
[1P-191]Neural correlates of the impaired visual temporal order judgment by fear-relevant stimulus in individuals with autism spectrum disorders
*Takeshi Atsumi1,2, Masakazu Ide2, Mrinmoy Chakrabarty3, Yasuo Terao1 (1. Kyorin University, 2. Research Institute of National Rehabilitation Center for Persons with Disabilities, 3. Indraprastha Institute of Information Technology Delhi)
[1P-192]Prenatal chemical exposures induce the hyperplasia of lobules in developing cerebellar cortex and defection of granule cell migration
*Sachiko Yoshida1, Sharumadhi Veloo1, Yasunari Kanda2 (1. Toyohashi University of Technology, 2. National Institute of Health Sciences)
[1P-193]Transcriptomic similarity of marmoset autism model and human autism subtypes/15q duplication syndrome suggests convergent mechanisms for genetic and environmental factors
*Satoshi Watanabe1, Tomofumi Oga1, Keiko Nakagaki1, Noritaka Ichinohe1 (1. National Center of Neurology and Psychiatry)
[1P-194]Elucidating the neural circuit basis of sensory abnormalities in ASD.
*Midori Shibushita1, Ikuko Takeda1,2, Daisuke Kato1,2, Daisuke Mori3, Itaru Kushima3, Norio Ozaki3, Hiroaki Wake1,2 (1. Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate school of Medicine, 2. Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, 3. Department of Psychiatry, Nagoya University Graduate school of Medicine)
[1P-195]Hypofunction of FABP4 in mothers or pups in the pathophysiology of autism spectrum disorder
*Motoko Maekawa1, Zhengkang Sun1, Tetsuo Ohnishi2, Takeo Yoshikawa3, Yuji Owada1 (1. Tohoku University, 2. Tokyo Medical and Dental University, 3. RIKEN)
[1P-196]Dissecting neural circuits responsible for autism-like behavior in BTBR T+ltpr3tf/J mice as an idiopathic model of autism.
*Hiroyuki Arakawa1, Yuki Higuchi1, Shunichi Tachigori2, Atsuto Sanji2, Taiga Nakachi2 (1. University of the Ryukyus School of Medicine, Okinawa, Japan, 2. University of the Ryukyus Dept Medicine, Okinawa, Japan)
[1P-197]Brain-Behavior Dimensions Delineate Autism Spectrum Disorder Subgroups Linked to Distinct Molecular Pathways
*Amanda M. Buch1, Petra Vertes2, Jakob Seidlitz3,4, So Hyun Kim1, Logan Grosenick1, Conor Liston1 (1. Dept Psychiatry and Brain and Mind Res. Inst., Weill Cornell Medicine, Cornell University, NY, USA, 2. Dept Psychiatry, Univ. of Cambridge, Cambridge, United Kingdom, 3. Dept Psychiatry, Univ. of Pennsylvania, Philadelphia, PA, 4. Child and Adolescent Psychiatry and Behavioral Sci., Children’s Hosp. of Philadelphia, Philadelphia, PA)
[1P-198]Development of a nervous system-specific conditional knock-in mouse strain of a gain-of-function mutation in L-type Ca2+ channel associated with Timothy syndrome
*Yukihiro Ozawa1,2,3, Miao Pan1,2, Manabu Abe4, Kenji Sakimura4, Shin-ichiro Horigane1,2, Sayaka Takemoto-Kimura1,2 (1. Dept. of Neuroscience I, Research Inst. of Environmental Med., Nagoya Univ., Nagoya, Japan, 2. Molecular/Cellular Neuroscience, Nagoya Univ. Grad. Sch. of Med., Nagoya. Japan, 3. Dept. of Pathology and Lab. Med., Nagoya Univ. Hospital, Nagoya, Japan, 4. Dept. of Comparative and Experimental Med., Brain Research Inst., Niigata Univ., Niigata, Japan)
[1P-199]Prospective effect of nasal oxytocin administration in a marmoset model of autism
*Madoka Nakamura1, Akiko Nakagami3, Keiko Nakagaki1, Akiko Tsuchiya1, Nobuyuki Kawai2, Noritaka Ichinohe1 (1. Dept. Ultrastructural Research, NCNP, Tokyo, Japan, 2. Dept. Cognitive and Psychol Sciences, Nagoya Univ, Aichi, Japan, 3. Dept. Psychol, Japan Women's Univ, Kanagawa, Japan)
[1P-200]Aging-induced microglia-mediated neuroinflammation exacerbates α-synucleinopathy in Parkinson disease model mice
*Hiroshi Sakiyama1, Hideki Hayakawa1, Yasuyoshi Kimura1, Cesar Aguirre1, Kensuke Ikenaka1, Seiichi Nagano1, Kosuke Baba1,2, Hideki Mochizuki1 (1. Osaka University, 2. University of Toyama)
[1P-201]Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: metabolomic analysis
*Masashi Ikuno1, Hodaka Yamakado1, Ryosuke Takahashi1 (1. Department of Neurology Kyoto University Graduate School of Medicine)
[1P-202]ABNORMAL LRP AND SMAD PATHWAY INDUCED OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME (OPPG) LIKE GENETIC TYPE IN ADH- AND ALDH2-SNP*.
*Toshiaki Watanabe1, Hitoshi Takeuchi1, Wataru Sugiyama1, Kanako Sugiura1 (1. Teikyo University of Science )
[1P-203]α-Synuclein fibrils induced disruption of pacemaker firing in dopamine neurons is dependent on selective K-ATP channel activation
*Poonam Thakur1, Jochen Roeper2 (1. School of Biology, IISER Thiruvananthapuram, Kerala, India, 2. Institute for Neurophysiology, Goethe University, Frankfurt, Germany )
[1P-204]Modulation of liquid-liquid phase separation behavior of Fused in sarcoma (FUS) using antisense oligos
*Mohammad Moniruzzaman1, Yusuke Fujioka 1, Akihide Takeuchi2, Akio Masuda 3, Masahiro Neya 4, Shinsuke Ishigaki1 (1. Dept of Neurology, Nagoya Univ Grad Sch of Medicine, Aichi, Japan, 2. Dept of Developmental Biol and Functional Genomic, Ehime Univ Grad Sch of Medicine, Ehime, Japan, 3. Division of Neurogenetics, Center for Neurological Dis and Cancer, Nagoya Univ Grad Sch of Medicine, Aichi, Japan, 4. KNC Laboratories Co., Ltd., Hyogo, Japan )
[1P-205]The search for compounds to treat GBA1-related α-synucleinopathy using gba1 knock-out medaka
*Etsuro Nakanishi1, Norihito Uemura1, Masanori Sawamura1, Yosuke Taruno1, Hodaka Yamakado1, Ryosuke Takahashi1 (1. Grad Sch Med, Univ of kyoto, Kyoto, Japan)
[1P-206]Small molecule inhibitors targeting axon degeneration-inducer SARM1
*Hitoshi Murata1, Takayuki Ando2, Kazuma Oiso1, Nahoko Tomonobu1, Ken-ichi Yamamoto1, Rie Kinoshita1, Masakiyo Sakaguchi1 (1. Grad Sch Med Dent Pharma, Univ of Okayama, Okayama, Japan, 2. Dept of Drug Food Sci, SHIZUOKA INSTITUTE OF ENVIRONMENT AND HYGIENE)
[1P-207]Single intranasal administration of α-synuclein preformed fibrils induces Lewy neurites like pathology in the olfactory bulb.
*Masanori Sawamura1, Rie Hikawa1, Junichiro Ohira1, Hodaka Yamakado1, Ryosuke Takahashi1 (1. Kyoto University Hospital)
[1P-208]Functional segregation of neuronal ELAVL protein splicing isoforms in human cells and their involvement in ALS pathophysiology.
*Minami Hasegawa-Ogawa1, Asako Onda-Ohto1,2, Hirotaka James Okano1 (1. Division of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, 2. Department of Neurology, The Jikei University School of Medicine)
[1P-209]Phosphorylation of CRMP1 modulates motor function of amyotrophic lateral sclerosis model mice
*Tetsuya Asano1, Haruko Nakamura1, Yuko Kawamoto1, Mikiko Tada1, Yayoi Kimura2, Hiroshi Takano3, Ryoji Yao3, Shunta Hashiguchi1, Keita Takahashi1, Misako Kunii1, Kenichi Tanaka1, Yoshio Goshima4, Fumio Nakamura5, Hideyuki Takeuchi1, Hiroshi Doi1, Fumiaki Tanaka1 (1. Dept Neurol & Stroke Med, Yokohama City Univ, Kanagawa, Japan, 2. Adv Med Res Ctr, Yokohama City Univ, Kanagawa, Japan, 3. Dept Cell Biol, Cancer Inst, Japanese Foundation for Cancer Res, Tokyo, Japan, 4. Dept Mol Pharmacol & Neurobiol, Yokohama City Univ, Kanagawa, Japan, 5. Dept Biochem, Tokyo Women's Med Univ, Tokyo, Japan)
[1P-210]A therapeutic approach to reduce the hyperactivity of striatal neurons for controlling dyskinesias
*Goichi Beck1, Stella M Papa2, Hideki Mochizuki1 (1. Dept Neurol, Osaka Univ Grad Sch Med, Suita, Japan, 2. YNPRC, Emory Univ, Atlanta, USA)
[1P-211]A novel evaluating method with the internal capsule demyelination mouse model for drugs promoting remyelination
*Reiji Yamazaki1, Yasuyuki Osanai1, Tom Kouki1, Yoshiaki Shinohara1, Nobuhiko Ohno1 (1. Jichi Medical University)
[1P-212]The novel mice model to investigate the mechanisms of Glial cytoplasmic inclusions (GCIs) formation in multiple system atrophy (MSA)
*Tomoyuki Ishimoto1, Hodaka Yamakado1, Miki Oono1, Seiji Kaji1, Takashi Ayaki1, Takakuni Maki1, Shu-ichi Matsuzawa1, Ryosuke Takahashi1 (1. Department of Neurology Kyoto University Graduate School of Medicine)
[1P-213]Autonomic dysfunction and anemia in a mouse model of prodromal Parkinson's disease
*Tomoyuki Taguchi1, Masashi Ikuno1, Hodaka Yamakado1, Ryosuke Takahashi1 (1. Department of Neurology Kyoto University Graduate School of Medicine)
[1P-214]Optineurin/TIA1 pathway reduces ubiquitinated TDP-43 aggregation by promoting stress granule clearance
*Taichi Kakihana1, Masahiko Takahashi1, Yoshinori Katsuragi1, Shun-Ichi Yamashita1, Tomotake Kanki1, Osamu Onodera2, Masahiro Fujii1 (1. Niigata University, Graduate School of Medical and Dental Sciences, 2. Niigata University, Brain Research Institute)
[1P-215]Neural correlates of impulsive compulsive behaviours in Parkinson's Disease - Japanese retrospective study
*Ikko Kimura1,2, Yuta Kajiyama1,3,4, Gajanan Subhash Revankar3, Kotarou Ogawa1,3, Kaoru Amano2,5, Hideki Mochizuki1,3 (1. Department of Neurology, Osaka University Hospital, Suita, Japan, 2. Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology, Suita, Japan, 3. Graduate School of Medicine, Osaka University, Suita, Japan, 4. Department of Neurology, Sakai City Medical Centre, 5. Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan)
[1P-216]Pathophysiological study of amyotrophic lateral sclerosis using gene edit human iPS cells
*Asako Onda-Ohto1,2, Minami Hasegawa-Ogawa1, Hiromasa Matsuno1,2, Keiko Bono1,2, Hiromi Hiraki1,2, Yumi Kanegae3, Yasuyuki Iguchi2, Hirotaka James Okano1 (1. 1.Division of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan, 2. 2.Division of Neurology, The Jikei University School of Medicine, Tokyo, Japan, 3. 3.Core Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan)
[1P-217]Motor neuron TDP-43 pathology links pathomechanisms of ALS, PSP, and CBD
*Yuichi Riku1,2, Shinsuke Ishigaki2, Yusuke Fujioka2, Masato Hasegawa3, Akio Akagi1, Yasushi Iwasaki1, Mari Yoshida1, Masahisa Katsuno2, Gen Sobue1 (1. Aichi Med. Univ., 2. Dept. Neurol, Nagoya Univ., 3. Tokyo Metropolitan Institute of Medical Science)
[1P-218]Drug screening for the treatment of mitochondrial dysfunction by using mitochondria disease patient-derived induced pluripotent stem cells
*Kohei Homma1, Kazuo Tsubota1, Hideyuki Okano2, Yoko Ozawa1,3 (1. Dept of Ophthal., Keio Univ Sch of Med, 2. Dept of Physiol., Keio Univ Sch of Med,, 3. Dept of Ophthal., St. Luke's Intl Univ)
[1P-219]Attractin deficiency promotes microglial activation resulting in dopaminergic neurodegeneration.
*Ayuka Ehara1, Shuichi Ueda1, Nobuko Tokuda1 (1. Dept Anat, Dokkyo Med Univ, Tochigi, Japan)
[1P-220]Zinc-binding metallothionein inhibits the SOD1 aggregation via binding of core regions for aggregate growth
*Eiichi Tokuda1, Maiko Keima1, Chiako Ikeda1, Yasuhiro Kosuge1, Shin-ichi Ono2 (1. Sch Pharm, Nihon Univ, Chiba, Japan, 2. Dep. Neurol., Akiru Med. Center)
[1P-221]Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation
*Junyi Liu1, Tsuyoshi Inoshita1, Kahori Shiba1, Nobutaka Hattori1, Yuzuru Imai1 (1. Graduate School of Medicine, Juntendo University, Tokyo, Japan)
[1P-222]Comparative analysis of differential expression of α-synuclein in the cerebral cortex between mouse and human brain
*Katsutoshi Taguchi1, Yoshihisa Watanabe2, Atsushi Tsujimura2, Masaki Tanaka1 (1. Dept. of Anatomy and Neurobiology, Kyoto Prefectual University of Medicine, 2. Dept. of Basic Geriatrics, Kyoto Prefectual University of Medicine)
[1P-223]Phenotypic heterogeneity in the cerebellum in two lines of Inpp4a mutant mice
*Dang Minh Tran1, Nozomu Yoshioka1, Junko Sasaki 2, Takehiko Sasaki 2, Hirohide Takebayashi 1 (1. Grad Sch Med & Den, Univ of Niigata, Japan, 2. Med Research Institute, Tokyo Med & Den Univ, Japan)
[1P-224]Brain-gut interaction originate from intestinal lipid sensor suppresses the PGD2-microglia-neuroinflammation cycle
*Keisuke Yoshikawa1, Kensuke Iwasa1, Shinji Yamamoto1, Chikara Haruta1, Kei Maruyama1 (1. Department of Pharmacology, Faculty of Medicine, Saitama Medical University)
[1P-225]To clarify the function of phospholipid flippase in the brain
*Yuta Umemura1, Tomoha Ohshima1, Tsuzumi Nakajima1, Takuto Matsuda1, Muneyuki Kawase1, Shu Tokunaga1, Hisashi Oishi2, Hitomi Tsuiji1, Takao Kohno1, Mitsuharu Hattori1 (1. Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan, 2. Department of Comparative and Experimental Medicine, Graduate School of Medical Sciences, Nagoya City University, Aichi, Japan)
[1P-226]Temporal changes of subcellular locations of alpha-synuclein aggregates in mice
*Hiroshi Kameda1, Shinichiro Okamoto1, Masato Koike1 (1. Grad Sch Med, Juntendo University, Tokyo, Japan)
[1P-227]Expression patterns of immune exhaustion molecules in the mouse model of amyotrophic lateral sclerosis
*Yuta Morisaki1, Ran Aono1, Motoki Ohshima1, Ami Okabe1, Mayo Teragawa1, Koji Yamanaka2, Hidemi Misawa1 (1. Div. Pharmacol., Fac. Pharmacy, Keio Univ., 2. Dept. Neurosci. & Pathobiol., Res. Inst. Environ. Med., Nagoya Univ.)
[1P-228]Pathological analysis of DEAD-box RNA helicases, DDX5 and DDX17 in amyotrophic lateral sclerosis.
*Shingo Ikeda1, Hiroshi Doi1, Mikiko Tada1, Shunta Hashiguchi1, Keita Tkahashi1, Misako Kunii1, Kenichi Tanaka1, Shigeru Koyano2, Hideyuki Takeuchi1, Fumiaki Tanaka1 (1. Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 2. Department of Neurology, Yokohama Minami Kyousai Hospital)
[1P-229]Novel PRKCG mutations in Japanese autosomal dominant spinocerebellar ataxia
*Yui Tada Tada1, Kodai Kume1, Soma Noguchi2, Ryosuke Ohsawa1, Norio Sakai2, Hideshi Kawakami1 (1. RIRBM, Hiroshima Univ, Hiroshimaa, Japan, 2. Grad Sch Biomed & Health Sci, Hiroshima Univ, Hiroshimaa, Japan)
[1P-230]Microtubule affinity-regulating kinases contribute differently to tau-induced neurodegeneration
*Grigorii Sultanakhmetov1, Akiko Asada1, Kanae Ando1 (1. Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan)
[1P-231]Investigation of drug effects on optic nerve growth in a mouse model of normal tension glaucoma
*Shogo Shibue1, Chihiro Tohda1 (1. Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama)
[1P-232]Serum neurofilament light chain associated with outcome in Guillain-Barré syndrome across regions and disease spectrum
*Benjamin Hoehn1, Zhahirul Islam2, Kazim A. Sheikh3, Thomas Harbo4, Israt Jahan2, Shoma Hayat2, Henk-André Kroon1, Ellen Cahir-McFarland1, Ted Yednock1, Sanjay Keswani1, Quazi Deen Mohammad5 (1. Annexon Biosciences, Inc., Brisbane, CA, USA, 2. Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh, 3. Department of Neurology, McGovern Medical School, Houston, TX, USA, 4. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark, 5. National Institute of Neurosciences and Hospital, Dhaka, Bangladesh)
[1P-234]Emodin alleviates SBMA phenotype via down regulation of androgen receptor
*Hiroaki Adachi1, Qiang Qiang1, Tomoko Toyota1, Masahisa Katsuno2, Gen Sobue2 (1. Sch Med, Univ of Occupational and Environmental Health, Kitakyushu, Japan, 2. Nagoya University Graduate School of Medicine)
[1P-235]Establishment of GFP tagged Tau based high throughput screening for the Tau modifiers discovery
*Maika Itsuno1, Sumihiro Maeda1, Hideyuki Okano1 (1. Grad Sch Med, Keio Univ, Tokyo, Japan)
[1P-236]TBK1 selectively eliminates abnormal monomeric TDP-43 via humoral factors.
*Shohei Sakai1, Kotaro Oiwa2,1, Seiji Watanabe1, Okiru Komine1, Koji Yamanaka1 (1. Dept Neurosci Pathobiol, RIEM, Nagoya Univ, Nagoya, Japan, 2. Dept Neurol, Grad Sch Med, Nagoya Univ, Nagoya, Japan)
[1P-237]Drosophila VPS13 regulates neuronal synaptic activity and mitochondrial homeostasis
*Kahori Fukushima1, Tsuyoshi Inoshita1, Jun Ogata1, Nobutaka Hattori1 (1. Juntendo University Graduate School of Medicine)
[1P-238]Analysis of gene expression profiles in the dorsal root ganglion of microgravity exposed mice and ALS model mice
*Masaaki Yoshikawa1, Mutsumi Matsukawa1, Hideki Oshima2, Shin Aizawa1, Takashi Shiga3 (1. Div of Anat Sci, Dept of Funct Morphol, Nihon Univ Sch of Med, Tokyo, Japan, 2. Div of Neurosurg, Dept of Neurol Surg, Nihon Univ Sch of Med, Tokyo, Japan, 3. Fac of Med, Univ of Tsukuba, Tsukuba, Japan)
[1P-239]Coordination of RAN translation in FTLD/ALS causing C9orf72-GGGGCC repeat.
*Shiho GOTOH1, Kohji Mori1, Tomoko Yamashita1, Ryota Uozumi1, Tesshin Miyamoto1, Shizuko Kondo1, Tsubasa Omi1, Yuya Kawabe1, Yoshitaka Nagai2, Manabu Ikeda1 (1. Osaka University, 2. Kindai University)
[1P-240]Role of dystrophin Dp427 in neurobehavior of canines with Duchenne Muscular Dystrophy
*Eri Takeuchi1, Yasumasa Hashimoto1, Michihiro Imamura1, Takefumi Kikusui2, Masayuki Sekiguchi1,3, Yoshitsugu Aoki1 (1. Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. School of Veterinary Medicine, Azabu University, 3. Faculty of Pharmaceutical Science, Tokyo University of Science)
[1P-241]Neuroinflammation potentiates α-synuclein pathology in a mouse model of Parkinson's disease.
*Hideki Hayakawa1, Kousuke Baba1,2, Hiroshi Sakiyama1, Chi-Jing Choong1, Yasuyoshi Kimura1, Kensuke Ikenaka 1, Cesar Aguirre1, Tatsusada Okuno1, Seiichi Nagano1,3, Yoshitaka Nagai4, Hideki Mochizuki1 (1. Department of Neurology, Osaka University Graduate School of Medicine, 2. Department of Neurology, Faculty of Medicine, University of Toyama, 3. Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 4. Department of Neurology, Faculty of Medicine, Kindai University)
[1P-242]Establishment of cognitive function assessment and eating behavior assessment using FTLD model marmosets
*Yuri Kim1, Kuniyuki Iwata(Endo)1,2, Junichi Hata3, Mitsuki Rikitake3, Masahisa Katsuno1, Gen Sobue4, Katsuki Nakamura5, Shinsuke Ishigaki1,6 (1. Department of Neurology, Nagoya University Graduate School of Medicine., 2. Department of Psychiatry, Nagoya University Graduate School of Medicine., 3. Tokyo Metropolitan University, 4. Aichi Medical University, 5. Primate Research Institute, Kyoto University, 6. Brain and Mind Research Center, Nagoya University )
[1P-243]Involvement of oxidative stress in methylmercury-induced toxicity in cultured normal rat cerebellar astrocytes
*Shoto Sasaki1, Takayuki Negishi 1,2, Takamasa Tsuzuki2, Kazunori Yukawa1,2 (1. Graduate school of Pharmacy, Meijo University, 2. Faculty of Pharmacy, Meijo University)
[1P-244]Neuroprotection against Parkinson's disease through the attenuation of mitochondrial dysfunction and neuroinflammation mediated apoptosis by Chlorogenic acid
*Saumitra Singh1, Surya Singh1 (1. Banaras Hindu University)
[1P-245]Longitudinal analysis of primate progressive synucleinopathies model revealed slowing in saccade reaction time.
*Wajd Amly1, Chih-Yang Chen1,2, Tadashi Isa1,2,3 (1. Department of Neuroscience, Graduate school of Medicine, Kyoto University, 2. Institute for the Advanced Study of Human Biology (WPI-ASHBI), Kyoto University, 3. Human Brain Research Center, Graduate School of Medicine, Kyoto University)
[1P-246]Prenatal exposure of the PGD2 receptor agonist effects on social communication and neuronal morphology in male offspring.
*Atsuko Hayata-Takano1,2, Taiga Kikuchi2, Hiroki Toyoda3, Ikuko Mohri4, Masaya Tachibana1,4, Takafumi Kato1,3, Masako Taniike4, Hitoshi Hashimoto1,2,5,6,7 (1. Mol Res Center for Child Mental Develop, United Grad Sch Child Development, Osaka Univ, Osaka, Japan, 2. Grad Sch Pharmaceutical Sci, Osaka Univ, Osaka, Japan, 3. Grad Sch Dent, Osaka Univ, Osaka, Japan, 4. United Grad Sch Child Development, Osaka Univ, Osaka, Japan, 5. Grad Sch Med, Osaka Univ, Osaka, Japan, 6. Inst Datability Sci, Osaka Univ, Osaka, Japan, 7. Inst Open Transdiscip Res Initiatives, Osaka Univ, Osaka, Japan)
[1P-247]Targeting neurons with functional oxytocin receptors: A novel set of simple knock-in mouse lines for oxytocin receptor visualization and manipulation
*Yukiko U. Inoue1, Hideki Miwa2, Kei Hori3, Ryosuke Kaneko4, Yuki Morimoto1, Eriko Koike1, Junko Asami1, Satoshi Kamijo2, Mitsuhiko Yamada2, Mikio Hoshino3, Takayoshi Inoue1 (1. Dep of Biochem and Cellular Biol, National Institute of Neurosci, Tokyo, Japan, 2. Dep of Neuropsychopharmacology, National Institute of Mental Health, Tokyo, Japan, 3. Dep of Biochem and Cellular Biol, National Institute of Neurosci, Tokyo, Japan, 4. KOKORO-Biol, Lab for Integrated Biol, Grad Sch of Frontier Biosci, Osaka Univ, Osaka, Japan)
[1P-248]Impaired function of PLEKHG2, a Rho-guanine nucleotide-exchange factor, disrupts corticogenesis in neurodevelopmental phenotypes
*Masashi Nishikawa1, Hidenori Ito1, Hidenori Tabata1, Koh-ichi Ngata1 (1. Institute for Developmental Research, Aichi Developmental Disability Center)
[1P-249]Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes
*Koh-ichi Nagata1, Masashi Nishikawa1, Hidenori Ito1 (1. Institute for Developmental Research, Aichi Developmental Disability Center)
[1P-250]Electrophysiological analysis of ASD model mice with impaired autophagy
*Moeka Ohno1,2, Shuji Wakatsuki1, Toshiyuki Araki1,2 (1. Natl Inst Neurosci, NCNP, Tokyo, Japan, 2. Grad Sch Eng, TUAT, Tokyo, Japan)
[1P-251]Reactive astrocyte-mediated mechanisms of memory disorder in tubular sclerosis complex model mouse
*Tadayuki Shimada1, Hiroko Sugiura1, Kanato Yamagata1,2 (1. Child Brain Project, Tokyo Metropolitan Institute of Medical Science, 2. Takada Nishishiro Hospital)
[1P-252]Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder
*Xiaoye Tian2, Noriyoshi Usui1,2,3, Wakana Harigai2, Ko Miyoshi2, Koh Shinoda4, Junya Tanaka5, Shoichi Shimada1,2,3, Taiichi Katayama2, Takeshi Yoshimura2 (1. Grad Sch Med, Osaka Univ, Suita, Japan, 2. United Grad Sch Child Development, Osaka Univ, Suita, Japan, 3. Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Hirakata, Japan, 4. Grad Sch Med, Yamaguchi Univ, Ube, Japan, 5. Grad Sch Med, Ehime Univ, Toon, Japan )
[1P-253]Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment and behavioral phenotypes.
*Tianying Wang1,2, Adya Saran Sinha1, Hiroki Mutoh1, Yuchio Yanagawa3, Tomoko Kawai4, Kenichiro Hata4, Atsuo Fukuda1 (1. Dept Neurophysiol., Hamamatsu Univ. Sch. Med., Hamamatsu, Japan, 2. Dept Biofunc imaging.,Hamamatsu Univ. Sch. Med., Hamamatsu, Japan, 3. Dept. Genet Behav Neurosci., Gunma Univ. Grad. Sch. Med., Maebashi, Japan, 4. Dept. Maternal-Fetal Biol., Natl Res Inst Child Health Dev., Tokyo, Japan)
[1P-254]miR-219 restored oligodendrocyte development impaired in a mouse model of Krabbe disease.
*Naoko Inamura1, Shinji Go2, Takashi Watanabe2, Hiroshi Takase3, Atsuo Nakayama1,4, Hirohide Takebayashi5, Junko Matsuda2, Yasushi Enokido1 (1. Institute for Developmental Research, Aichi Developmental Disability Center, 2. Dept. of Pathophysiology and Metabolism, Kawasaki Med. Sch., 3. Grad. Sch. of Med. Sci., Nagoya City Univ., 4. Grad. Sch. of Med., Nagoya Univ., 5. Grad. Sch. of Med. and Dent. Sci., Niigata Univ.)
[1P-255]Analysis of cerebellar organoids derived from patients carrying TSC2 mutation.
*Hiroki Okumura1,2, Yuko Arioka1,3, Yu Hayashi1, Itaru Kushima1, Daisuke Mori1, Norio Ozaki1 (1. Dept of Psychiatry, Grad Sch Med, Nagoya Univ, 2. Dept of Hospital Pharmacy, Nagoya Univ Hospital, 3. CAMCR, Nagoya Univ Hospital)
[1P-256]Whole brain neural connectivity in the Rett syndrome model marmoset with MECP2 gene deletion
*Daisuke Yoshimaru1,2,3,4, Noriyuki Kishi2,4, Junichi Hata2,1,5, Tomokazu Tsurugizawa3,2, Yawara Haga5,2, Hirotaka James Okano1, Hideyuki Okano2,4 (1. The Jikei University School of Medicine, 2. RIKEN, 3. National Institute of Advanced Industrial Science and Technology (AIST), 4. Keio University, 5. Tokyo Metropolitan University)
[1P-257]Therapeutic effects of bumetanide on neurological dysfunction in a mouse model of Angelman syndrome
*Kiyoshi Egawa1, Miho Watanabe2, Fukuda Atsuo2 (1. Pediatric dept, Hokkaido Univ. Grad. Med., 2. Dept. of Neurophysiology, Hamamatsu Univ. Sch. of Med.)
[1P-258]Role of GAP43 in the development of mouse cerebral cortex
*Mariko Noda1, Ayumi Matsumoto2, Hidenori Ito1, Takanori Yamagata2, Koh-ichi Nagata1 (1. Inst Dev Res, Aichi Dev Disability Cntr, Aichi, Japan, 2. Dept Pediatrics, Jichi medical university)
[1P-259]In vivo wide-field Ca2+ imaging of the cortical spontaneous activity in the Cdkl5 kinase-dead knock-in mice reveals altered functional connectivity in large-scale cortical networks upon the loss-of-function of CDKL5
*Toshiki Nomura1, Tomonari Murakami2, Kumiko Saitou2,4, Kenichi Ohki2,3, Teruyuki Tanaka1 (1. Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, 2. Department of Physiology, Graduate School of Medicine, The University of Tokyo, 3. International Research Center for Neurointelligence (IRCN), The University of Tokyo, 4. Neural Circuit Unit, Okinawa Institute of Science and Technology Graduate University (OIST))
[1P-260]Mechanisms of eye movement abnormalities in mouse models of neurodevelopmental disorders
*Koichiro Irie1,2, Noriyoshi Usui1,3,4, Shotaro Harada5, Takao Imai5, Shoichi Shimada1,3,4 (1. Dept. Neurosci. Cell Biol., Grad. Sch. Med., Osaka Univ., Osaka, Japan., 2. CentMeRE., Grad. Sch. Med., Osaka Univ., Osaka, Japan., 3. UGSCD., Osaka Univ., Osaka, Japan., 4. Addiction., OPRC., OPMC., Osaka, Japan., 5. Dept. Otolaryngol. Head Neck Surg., Grad. Sch. Med., Osaka Univ., Osaka, Japan.)
[1P-261]Imaging of 5-HT2A receptors in rats with semi-chronic administration of phencyclidine
*Eiichi Jodo1, Tomoaki Nakazono1, Kazumi Takahashi1, Songji Zhao 2, Naoyuki Ukon2, Yoshiaki Suzuki1, Kenyo Hoshino3, Satoshi Eifuku1 (1. Fukushima Medical University School of Medicine, Fukushima, Japan, 2. Advanced clinical research center, Fukushima Medical University, Fukushima, Japan, 3. Ichiyokai Hospital, Fukushima, Japan)
[1P-262]Spine morphological changes in Reln-del mice
*YOUYUN ZHU1, Yumi Tsuneura2, Hiroyuki Mizoguchi1, Masahito Sawahata1, Daisuke Mori1, Takao Kohno3, Mitsuharu Hattori3, Toshitaka Nabeshima4, Norio Ozaki1, Kiyofumi Yamada1 (1. Nagoya University, 2. Aichi Developmental Disability Center, 3. Nagoya City University, 4. Fujita Health University)
[1P-263]Reduced operant task engagement and altered neural oscillations in a triple-hit rat model of schizophrenia.
*Michele Chan1, Qun Li2, Gyongyi Horvath2, Antal Berenyi2,3,4, Masabumi Minami1, Yuichi Takeuchi1,2 (1. Dept Biopharmaceutical Sci Pharmacy, Facult Pharmaceutical Sci, Hokkaido Univ, Sapporo, Japan, 2. Dept Physiol, Facult Med, Univ Szeged, Szeged, Hungary, 3. HCEMM-SZTE Magnetotherapeutics Research Group, Univ Szeged, Szeged, Hungary, 4. Neurosci Inst, New York Univ, New York, USA)
[1P-264]Randomization of semantic network in the brain of schizophrenia revealed by fMRI
*Yukiko Matsumoto1, Satoshi Nishida3, Hayashi Ryusuke5, Shuraku Son2, Akio Murakami2, Naganobu Yoshikawa4, Hiroyoshi Ito6, Naoya Oishi2, Naoki Masuda7, Toshiya Murai2, Karl Friston8, Shinji Nishimoto4, Hidehiko Takahashi1 (1. Tokyo Medical and Dental University, Tokyo, Japan, 2. Kyoto University, Kyoto, Japan, 3. National Institute of Information and Communications Technology (NICT), Osaka, Japan, 4. Osaka University, Osaka, Japan, 5. National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan, 6. University of Tsukuba, Ibaraki, Japan, 7. University at Buffalo, State University of New York, USA, 8. UCL Queen Square Institute of Neurology, London, UK)
[1P-265]Effect of duration of inter-stimulus-interval on phase-locking value of auditory steady-state responses
*Naho Konoike1, Haruhiko Iwaoki1, Miki Miwa1, Kosuke Itoh2, Katsuki Nakamura1 (1. Primate Research Institute, Kyoto University, 2. Brain Research Institute, University of Niigata)
[1P-266]Dendritic compartment-specific accumulation of dendritic spines is a hallmark of cortical circuit maturation during adolescence
*Ryo Egashira1, Meng-Tsen Ke2, Tsuyoshi Takagi3,4, Shunsuke Isii4, Tsuyoshi Miyakawa5, Takeshi Imai1 (1. Kyushu University Graduate School of Medical Sciences, 2. RIKEN Center for Developmental Biology, Kobe, Japan, 3. Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan, 4. RIKEN Tsukuba Institute, Tsukuba, Japan, 5. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan)
[1P-267]Distorted neurocomputation by heavily-weighted synapses in mental disorders
*Kisho Obi-Nagata1, Norimitsu Suzuki1, Matthew L. MacDonald4, Kenneth N. Fish4, Fukutoshi Shirai1, Tsukasa Okimura2, Kenichiro Nagahama5,6, Shoji Tanaka3, Masanobu Kano5,6, Robert A. Sweet4, Akiko Hayashi-Takagi1 (1. RIKEN Center for Brain Science, 2. Keio University, Tokyo, Japan, 3. Sophia University, Tokyo, Japan, 4. University of Pittsburgh, Pennsylvania, US, 5. Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 6. International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan)
[1P-268]A novel therapeutic strategy for cognitive dysfunctions under clinically relevant antipsychotic treatment in a mouse model of schizophrenia
*Yosefu Arime1, Yoshito Saitoh1, Yasuo Uchida2, Mikiko Ishikawa1, Chikako Kamiyoshihara1, Kazuki Fujii3,4, Keizo Takao3,4, Noriaki Ohkawa1 (1. Res Cen Adv Med Sci, Dokkyo Med Univ, Mibu, Japan, 2. Grad Sch Pharm Sci, Univ of Tohoku, Sendai, Japan, 3. Fac Med, Univ of Toyama, Toyama, Japan, 4. Life Sci Res Cen, Univ of Toyama, Toyama, Japan)
[1P-269]Analysis of the mechanism of pathological neural circuit formation in schizophrenia mouse model
*MAYU FUKUDA1, JUN MUKAI1 (1. PMC, Univ of Tsukuba, Tokyo, Japan)
[1P-270]Investigation of the molecular background behind the behavioral deficits seen in Importin α4/KPNA4 Knockout Mice
*Koki Sakurai1, Yoichi Miyamoto2, Makiko Morita1, Tom Macpherson1, Takaaki Ozawa1, Masahiro Oka2, Takatoshi Hikida1 (1. Institute for Protein Research, Osaka Univ., 2. Laboratory of Nuclear Transport Dynamics, National Institute for Biomedical Innovation)
[1P-271]Meta-analysis of transcriptional regulatory networks for lipid metabolism in neural cells from schizophrenia patients based on an open-source intelligence approach
*Katsuyuki Yugi1,2,3, Lisa Okamoto1,2, Soyoka Watanabe1,2, Senka Deno1,2, Xiang Nie1, Junichi Maruyama1, Masaru Tomita2, Atsushi Hatano1,4 (1. RIKEN IMS, Yokohama, Japan, 2. Inst Adv Biosci, Keio Univ, Fujisawa, Japan, 3. Grad Sch Sci, Univ of Tokyo, Tokyo, Japan, 4. Grad Sch Med Dent Sci, Niigata Univ, Niigata, Japan)
[1P-272]Roles of Lim-domain binding 2 as a functional modulator of EGR transcription factors and its implication in the pathogenesis of mental disorders
*Tetsuo ohnishi1,2, Masahiro Mitsumasu1, Yuji Kiyama5,7, Fumiko Arima-Yoshida9,7, Mistutaka Kadota12, Yoshimi Tanaka10, Tomoe Ichikawa11,3, Kazuyuki Yamada4, Akihiro Nakaya13, Makoto Arai3, Yasue Horiuchi3, Chie Shimamoto-Mitsuyama2, Motoko Maekawa2,8, Masanari Itokawa3, Haruhiko Bito6, Shigehiro Kuraku12, Toshiya Manabe7, Hiroyuki Okuno5, Takeo Yoshikawa2, Kohichi Tanaka1 (1. Inst of Med Res, Tokyo Med Dent Univ, Tokyo, Japan, 2. RIKEN CBS, Wako, Japan, 3. Tokyo Metropl Inst of Med Sci, Tokyo, Japan, 4. Shizuoka Sangyo Univ, Iwata, Japan, 5. Grad Sch of Med Dent Sci, Kagoshima Univ, Kagoshima, Japan, 6. Grad Sch of Med, the Univ of Tokyo, Tokyo, Japan, 7. IMS, the Univ of Tokyo, Tokyo, Japan, 8. Tohoku Univ Sch of Med, Sendai, Japan, 9. Inst of Clin Med Res, Jikei Univ, Tokyo, Japan, 10. RIKEN, Wako, Japan, 11. Meiji Pharmaceut Univ, Kiyose, Japan, 12. RIKEN BDR, Kobe, Japan, 13. Grad Sch of Front Sci, the Univ of Tokyo, Tokyo, Japan)
[1P-273]Cross-sectional AMPA Receptor Distribution in Psychiatric Disorders
*Mai Hatano1, Tomoyuki Miyazaki1, Waki Nakajima1, Tsuyoshi Eiro1, Kotaro Nakano1, Yuichi Kimura2, Hiroyuki Uchida3, Takuya Takahashi1 (1. Department of Physiology Yokohama City University graduate school of medicine, 2. Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan, 3. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan)
[1P-274]Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study
*Kazutaka Ohi1, Ryo Ochi2, Yoshihiro Noda2, Masataka Wada2, Shunsuke Sugiyama1, Akira Nishi2, Toshiki Shioiri1, Masaru Mimura2, Shinichiro Nakajima2 (1. Department of Psychiatry, Gifu University Graduate School of Medicine, 2. Department of Neuropsychiatry, Keio University School of Medicine)
[1P-275]The dorsal striatum-dorsal raphe nucleus circuit regulated by N-acetyltransferase, Shati/Nat8l, determine the sensitivity to stress through striatal 5-HT control
*Hajime Miyanishi1, Shin-ichi Muramatsu2,3, Michihiro Mieda4, Atsumi Nitta1 (1. Dept Pharm Therap and Neuropharmacol, Grad Sch Med and Pharm, Univ of Toyama, 2. Div Neuro Gene Therap, Open Innov Ctr, Univ of Jichi Med, 3. Ctr Gene and Cell Therap, Ins Med Sci, Univ of Tokyo, 4. Dept Integr Neurophysiol, Grad Sch Med Sci, Univ of Kanazawa)
[1P-276]Dextran sulfate sodium-induced colitis in C57BL/6J mice increases their susceptibility to chronic unpredictable mild stress that induces depressive-like behavior
*Kazuki Nagasawa1, Miki Komoto1, Ayumi Asada1, Yasuyuki Ohshima1, Kayo Miyanaga1, Hirotoshi Morimoto2, Takeshi Yasukawa2, Katsuya Morito1, Yoshinobu Uozumi2, Kentaro Takayama1 (1. Kyoto Pharmaceutical University, 2. Ako Kasei, Co., Ltd)
[1P-277]Development and behavioral characterization of micro social defeat-models using male BALB/c mice.
*Hideaki Nishizawa1, Yuhei Yajima1, Atsushi Toyoda1,2 (1. College of Agriculture, Ibaraki University, 2. United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology)
[1P-278]IDO1 in the prefrontal cortex regulates depression-like behavior following chronic social defeat stress
*Kazuo Kunisawa1, Aika Kosuge1, Tsubasa Iida1, Tomoki Kawai1, Moeka Tanabe1, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,4, Akihiro Mouri1,4 (1. Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., Aichi, Japan, 2. Dept. Adv Diagnostic Syst Dev., Grad. Sch. Health Sci., Fujita Health Univ., Aichi, Japan, 3. Adv Diagnostic Syst Res Lab., Grad. Sch. Health Sci., Fujita Health Univ., Aichi, Japan, 4. NPO. J-DO., Aichi, Japan)
[1P-279]Transcriptomic evidence of hyper-maturation in the mouse hippocampus induced by genetic and other factors
*Hideo Hagihara1, Hisatsugu Koshimizu1, Satoko Hattori1, Miho Tanaka2, Kazutaka Ikeda2, Tsuyoshi Miyakawa1 (1. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan, 2. Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
[1P-280]Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamine
*Ryota Shinohara1,2, Brendan D Hare2, Rong-Jian Liu2, Jin Hua Li2, Xiao-Yuan Li2, Catharine H Duman2, Ralph J DiLeone2, Ronald S Duman2 (1. Div Pharmacol, Grad Sch Med, Kobe Univ, Kobe, Japan, 2. Dept Psychiatry, Yale Sch Med, New Haven, USA)
[1P-281]Identification of stress biomarkers in feces and blood plasma of the social defeat model of mouse
*Yuhei Yajima1, Isamu Nakamura2, Takahiro Kawase3, Takamitsu Tsukahara3, Atsushi Toyoda1,4 (1. Col of Agr Ibaraki Univ, Ibaraki, Japan, 2. Ctr for Med Sci, Ibaraki Pref Univ of Health Sci, Ibaraki, Japan, 3. Kyoto Inst of Nutr & Pathol Inc, Kyoto, Japan, 4. United Grad Sch of Agr Sci, Tokyo Univ of Agri and Tech, Tokyo, Japan)
[1P-282]Interoceptive awareness in Depression during emotional experiences: An examination using heartbeat evoked potentials
*HIROYOSHI OGISHIMA1, Hironori Shimada2 (1. Research Institute of Future Design, Kochi University of Technology, Kochi, Japan, 2. 2)Faculty of Human Sciences, Waseda University, Saitama, Japan)
[1P-283]Detection of depressive mood states based on EEG data during news listening
*Hiroki Watanabe1, Kohei Fuseda1, Jyunpei Saito1, Yasushi Naruse1, Aya S Ihara1 (1. National Institute of Information and Communications Technology)
[1P-284]Application of a deep learning-based animal-pose analysis software for tail-suspension test
*Tamio FURUSE Furuse1, Tomoko Kushida1, Shizuka Nishimura1, Ikuko Yamada1, Masaru Tamura1 (1. RIKEN BioResource Research Center)
[1P-285]Brain-Metabolic axis: Molecular mechanism of exacerbated depression-like behaviors in a diabetes mellitus model
*Yusuke Temma1, Ryuhei Miyake1, Kisho Obi-Nagata1, Yuta Katayama2, Hideo Hagihara3, Tsuyoshi Miyakawa3, Keiichi I Nakayama2, Akiko Hayashi-Takagi1 (1. Lab for Multi-scale Biological Psychiatry, RIKEN CBS, Saitama, Japan, 2. Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 3. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan)
[1P-286]Effects of ketamine on chronic social defeat stress-induced depressive-like behaviors and Arc-positive cell activity of the cingulate cortex in mice
*Yoshikazu Nikaido1,2, Yoko Midorikawa2, Tetsuya Kushikata2, Kazuyoshi Hirota2 (1. Dept Frail Res Prevent, Hirosaki Univ, Hirosaki, Japan, 2. Dept Anesth, Hirosaki Univ, Hirosaki, Japan)
[1P-287]Ultrasound exposure improves depressive-like behavior in olfactory bulbectomized rats
*Tsugumi Yamauchi1,2, Toshinori Yoshioka1, Daisuke Yamada1, Takumi Hamano1, Hiroko Ichikawa2, Maika Ikeda6, Masato Kamei6, Takaya Otsuki6, Yasuo Sato6, Kyoko Nii6, Masashi Suzuki6, Satoshi Iriyama4, Kazumi Yoshizawa5, Syoichi Nishino6, Satoru Miyazaki3, Akiyoshi Saitoh1 (1. Lab Pharmacol, Fac Pharm Sci, Tokyo Univ of Science, 2. Lab Psychol., Inst of Arts and Sci, Tokyo Univ of Science, 3. Lab Bioinfo, Fac Pharm Sci, Tokyo Univ of Science, 4. Lab Quant info dynamics., Fac Sci and Tech, Tokyo Univ of Science, 5. Lab Disease Pharmcol., Fac Pharm Sci, Tokyo Univ of Science, 6. FUJIMIC, inc. Tokyo)
[1P-288]Subcortical morphometry and magnetic susceptibility analysis in major depression disorder
*Shuhei Shibukawa1,3,4, Kan Hirohito2, Norihide Maikusa1, Koike Shinsuke1 (1. The University of Tokyo, 2. Nagoya University, 3. Juntendo University, 4. Tokyo Medical University)
[1P-289]A novel animal model of bipolar disorder using a reverse translational approach
*Wataru Ota1, Susumu Jitsuki2, Tomomi Yamanoue1, Tomoyuki Miyazaki1, Waki Nakajima1, Mai Hatano1, Akane Sano1, Hideaki Tani3, Nobuhiro Nagai3, Teruki Koizumi3, Shinichiro Nakajima3, Masaru Mimura3, Hiroyuki Uchida3, Takuya Takahashi1 (1. Dept. Physiol., Yokohama City Univ. Sch. of Med., Kanagawa, Japan, 2. Dept. Biochem., Mie Univ. Fac. of Med., Mie, Japan, 3. Dept. Neuropsychiat., Keio Univ. Sch. of Med., Tokyo, Japan)
[1P-290]Comparison of the activity profiles of transcription factors in the brains of mice experienced different stressors
*Hajime Yamamoto1, Ryoichiro Hara1, Kentaro Abe1 (1. Tohoku University, Graduate School of Life Science)
[1P-291]Social defeat-induced cognitive impairment : The effect of dietary restriction
*HSIAO JOU TUNG1, PEI YU WANG1 (1. Grad Inst of Brain and Mind Sci, Natl Taiwan Univ, Coll of Med, Taipei, Taiwan)
[1P-292]Cellular phenotypes and causal candidate genes in iPSC-derived neurons of a bipolar disorder family
*Gakuya Takamatsu1,2, Yoko Manome4, Kae Koganebuchi7,6, Dimitar Dimitrov8, Kanako Toyama1, Jun-Seok Lee1,7, Kumiko Yanagi5, Minami Hasegawa4, Tomoko Hayakawa9,1, Tsuyoshi Kondo2, Takahashi Tomoyuki8, Tadashi Kaname5, Hirotaka James Okano4, Ryosuke Kimura3, Masayuki Matsushita1 (1. Dept of Mol Cell Physiol, Grad Sch Med, Univ of the Ryukyus, 2. Dept of Neuropsy, Grad Sch Med, Univ of the Ryukyus, Okinawa, Japan, 3. Dept of Hum Biol Anat, Grad Sch Med, Univ of the Ryukyus, Okinawa, Japan, 4. Div of Regen Med, Jikei Univ Sch of Med, Tokyo, Japan, 5. Dept of Gen Med, Natl Ctr for Chd Hlth Dev, Tokyo, Japan, 6. Dept of Biol Sci, Grad Sch of Sci, Univ of Tokyo, Tokyo, Japan, 7. Adv Med Res Ctr, Fac of Med, Univ of the Ryukyus, Okinawa, Japan, 8. Cel and Mol Syn Func Unit, Okinawa Inst of Sci Tech Grad Univ, Okinawa, Japan, 9. Dept of Phamc, Jichi Med Univ, Tochigi, Japan)
[1P-293]Development of a gene therapy using adeno-associated virus to rescue cerebellar ataxia in Cbln1-defficient mice
*Tokiwa Yamasaki1, Wataru Kakegawa1, Michisuke Yuzaki1 (1. Keio University)
[1P-294]in vitro cytotoxicity assay of antisense oligonucleotides to predict CNS-toxicity in vivo.
*Maho Katsuyama1, Kotaro Yoshioka1, Chunyan Jia1, Su Su Lei Mon1, Taiki Matsubayashi1, Kie Tanaka1, Tetsuya Nagata1, Takanori Yokota1 (1. Tokyo Medical and Dental University)
[1P-295]JigSAP (jigsaw-shaped self-assembling peptide) for regenerative medicine of the subacute phase of ischemic stroke
*Itsuki Ajioka1,2, Takahiro Muraoka2,3, Go Watanabe2,4 (1. Tokyo Medical and Dental U (TMDU), Tokyo, Japan, 2. KISTEC, Kanagawa, Japan, 3. Tokyo University of Agriculture and Technology, Tokyo, Japan, 4. Kitasato University, Kanagawa, Japan)
[1P-296]Development of 3D culture scaffolds for directional neuronal growth
*Marco Terenzio1, Lokesh Agrawal1, Laurent Guillaud1, Menouer Saidani1 (1. Okinawa Institute of Science and Technology Graduate University)
[1P-297]Metformin enhances the efficacy of epidermal neural crest stem cells in neuropathic pain
*Afsaneh Asgari Taei1, Pariya Khodabakhsh2, Hamed Shafaroodi3, Leila Dargahi4 (1. Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 4. Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran)
[1P-298]Anti-inflammatory effects of siponimod on astrocyte
*Akihiro Ogasawara1, Hideyuki Takeuchi1, Hiroyasu Komiya1, Yuki Ogawa1, Keita Takahashi1, Hiroshi Doi1, Fumiaki Tanaka1 (1. Department of Neurology and Stroke Medicine, Yokohama City University)
[1P-299]Targeted orexin 1 receptors within the vlPAG for modulation migraine-induced trigeminal nociception, and migraine-related cognitive deficiency in rats
*Razieh Kooshki1, Mehdi Abbasnejad2 (1. Department of Biology, Faculty of Sciences, Lorestan University, Khorramabad, Iran, 2. Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran)
[1P-300]A low amyloidogenic E61K transthyretin mutation causes familial amyloid polyneuropathy: the mechanism of neurodegeneration
*Tatsufumi Murakami1, Mineykuki Mizuguchi2, Kazunori Sango3, Shigenobu Tone4, Yoshihide Sunada1 (1. Kawasaki Medical School, 2. Toyama Medical and Pharmaceutical University, 3. Tokyo Metropolitan Institute of Medical Science, 4. Tokyo Denki University)
[1P-301]The associations between affects and eating behavior in young Korean adults
*Jae-Won Jung1, Kyung-A Lee1, Na-Hyun Kim1, Yukiori Goto2, Young-A Lee1 (1. Dept Food Sci & Nutr, Daegu Catholic Univ, Gyeongsan, South Korea, 2. Primate Res Inst, Kyoto Univ, Aichi, Japan)
[1P-302]Microglia – pyramidal tract interaction in spinal cord injury and their contribution on neural activity and motor function recovery
*Ryotaro Oishi1, Ippei Yamauchi1, Hiroaki Nakashima1, Daisuke Kato1, Shiro Imagama1, Hiroaki Wake1 (1. Grad Sch Med, Univ of Nagoya, Nagoya, Japan)
[1P-303]Reduction of Spasticity and Plastic Changes in Spinal Neural Circuits by Inhibition of Ia Fiber activity in C6 Hemi-section Mice
*Takuto Hanasaki1, Sachiko Lee1 (1. Grad Sch Med, Univ of Nagoya, Aichi, Japan)
[1P-304]Potentiation of anti-glioblastoma effect with combined interferon-gamma and temozolomide: Role of inflammatory and redox system
*Hamideh Bashiri1, Amirhossein Moslemizadeh2, Reza Kheirandish2, Mohammad Hadi Mohammad Hadi Nematollahi1 (1. Kerman University of Medical Sciences, 2. Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran)
[1P-305]Analysis of LINE-1 retrotransposition in the brain with newly created retrotransposition-monitor mice
*Shinya Fujii1, Miki Bundo1, Yutaka Nakachi1, Kimi Araki2, Kazuya Iwamoto1 (1. Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, 2. Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University)
[1P-306]Introduction of comprehensive phenotyping analysis at Japan Mouse Clinic
*Ikuko Yamada1, Ikuo Miura1, Hirotoshi Shibuya1, Tamio Furuse1, Masaru Tamura1 (1. RIKEN BioResource Research Center)
[1P-307]Perturbation of gut microbiota and brain tissue damages caused by neonatal nasal inflammation
*Sanae Hasegawa-Ishii1, Hinami Asano2, Yuko Mishima1, Takako Osaki3 (1. Fac Health Sci, Kyorin Univ, 2. Grad Sch Health Sci, Kyorin Univ, 3. Dept Infect Dis, Sch Med, Kyorin Univ)
[1P-308]Diphenylarsinic acid-induced activation of NF-κB signaling pathways in cultured rat cerebellar astrocytes
*Takayuki Negishi1,2, Naohiro Kajita1, Shoto Sasaki2, Takamasa Tsuzuki1, Kazunori Yukawa1,2 (1. Faculty of Pharmacy, Meijo University, 2. Graduate School of Pharmacy, Meijo University)
[1P-309]Resting-state functional connectivity MRI classification of eating disorder in multi-site data
*Tsunehiko Takamura1, Sato Yasuhiro2, Yoshiyuki Hirano3, Masanori Isobe4, Keima Tose4, Tomomi Noda4, Naoki Kodama5, Kazufumi Yoshihara6, Yoshiya Moriguchi1, Astushi Sekiguchi1 (1. Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan, 2. Department of Psychosomatic Medicine, Tohoku University Hospital, Miyagi, Japan, 3. Research Center for Child Mental Development, Chiba University, Chiba, Japan, 4. Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5. Division of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan., 6. Department of Psychosomatic Medicine, Kyushu University, Fukuoka, Japan)
