[28-12-am] Inflammation and immune system

3:48 PM - 4:00 PM JST(6:48 AM - 7:00 AM UTC)

[28-12-pm05S] RK-582, a tankyrase inhibitor, enhances the antitumor effect of an immune checkpoint inhibitor by remodeling the tumor immune microenvironment

○Ayane Nakamura^1,2, Tetsuo Mashima¹, Shiho Tsuruta^1,3, Xunmei Yuan¹, Shun Morino^1,3, Fumiyuki Shirai ⁴, Hiroyuki Seimiya^1,2,3 (1. Div. Mol. Biother., Cancer Chemother. Ctr., JFCR., 2. Dept. Life. Pharm. Sci., Grad. Pharm. Sci., Univ. Meiji Pharm., 3. Dept. Comp. Biol. Med. Sci., Grad. Frontier Sci., Univ. Tokyo., 4. Drug Disc. Chem. Platf. Unit, RIKEN Center for Sustainable Res. Sci.)