[27-09-am] Chemical Biology 1 | The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[27-09-am]Chemical Biology 1

Thu. Mar 27, 2025 8:30 AM - 9:54 AM JST
Thu. Mar 27, 2025 11:30 PM - 12:54 AM UTC

Room 9 (Fukuoka International Congress Center: 411 [4F])

Chair: Ohashi Nami, Daisuke Yasuda

8:30 AM - 8:42 AM JST(11:30 PM - 11:42 PM UTC)

[27-09-am01S]Discovery of covalent asparagine synthetase inhibitors produced by the fungus Stachybotrys sp.

○Zhang Lei¹, Yanjun Pan¹, Akira Hattori¹, Hidehiro Uekusa², Yoshinori Hirano³, Hideaki Kakeya¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Sch. Sci., Inst. Sci. Tokyo., 3. Facul. Sci. Technol., Keio Univ.)

8:42 AM - 8:54 AM JST(11:42 PM - 11:54 PM UTC)

[27-09-am02S]Discovery of the actinomycete metabolite inhibiting cancer stem cell sphere formation and analysis of the mechanism of action

○Miyuki Matsui¹, Hiroaki Ikeda¹, Morihiro Shibasaki¹, Kazuko Sakai², Kazuto Nishio², Masaya Imoto³, Hideaki Kakeya¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Facul. Med., Kindai Univ., 3. Grad. Sch. Med., Juntendo Univ.)

8:54 AM - 9:06 AM JST(11:54 PM - 12:06 AM UTC)

[27-09-am03]A therapeutic strategy for ischemia-related diseases via upregulation of PKCα/mTORC/HIF-1α signaling pathway

○Hiroaki Ikeda¹, Shogo Iseki¹, Nanako Fujimoto¹, Sayaka Kobayashi¹, Kazuhiro Irie², Hiroshi Harada³, Hideaki Kakeya¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Grad. Sch. Agric., Kyoto Univ., 3. Grad. Sch. Biostudies, Kyoto Univ.)

9:06 AM - 9:18 AM JST(12:06 AM - 12:18 AM UTC)

[27-09-am04]Analysis of binding proteins of a peptidic natural product yaku’amide B

○Junhao Fu¹, Koichi Kamiya¹, Kai Kitamura¹, Hiroaki Itoh¹, Kaori Sakurai², Masayuki Inoue¹ (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. Grad. Sch. Engr., Tokyo Univ. of Agriculture and Tech.)

9:18 AM - 9:30 AM JST(12:18 AM - 12:30 AM UTC)

[27-09-am05]Mechanistic investigation of antiausterity 5-arylidene rhodanine derivatives on cancer cells with tolerance to nutrient starvation focused on ER stress responses

○Kensuke Okuda¹, Akira Takagi¹, Yuuma Ito², Kentaro Oh-hashi² (1. Kobe Pharmaceutical Univ., 2. Faculty of Engineering, Gifu Univ.)

9:30 AM - 9:42 AM JST(12:30 AM - 12:42 AM UTC)

[27-09-am06S]Synthesis and analysis of the mechanisms promoting neuronal differentiation of tetracyclic furoindoline as a Notch inhibitor

○Haruki Matsuda¹, Shun Saito¹, Takeshi Yamada², Midori A. Arai¹ (1. Fac. Sci. Tec., Keio Univ., 2. Kobe Pharmaceutical Univ.)

9:42 AM - 9:54 AM JST(12:42 AM - 12:54 AM UTC)

[27-09-am07S]Discovery and mechanistic study of spiroxyindole derivatives, novel inhibitors of Notch signaling for neuroregenerative drugs

○Yuki Narushima¹, Haruki Oba¹, Shun Saito¹, Haruka Kawano², Makoto Kawatani³, Kaori Honda³, Hiroyuki Osada^3,4, Masami Ishibashi², Takayoshi Arai⁵, Makoto Inoue⁶, Midori A Arai¹ (1. Fac. Sci. and Tech., Keio Univ. , 2. Grad. Sch. Pharm. Sci., Chiba Univ., 3. RIKEN CSRS, 4. Institute of Microbial Chemistry (BIKAKEN), 5. Grad. Sch. Sci., Chiba Univ, 6. Department of Comparative Biosciences, University of Illinois at Urbana-Champaign)

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