Session Details
[28P-pm]Evaluation of drug efficacy and safety, Chemotherapeutic agents, Kampo medicines, Others
Fri. Mar 28, 2025 1:30 PM - 5:00 PM JST
Fri. Mar 28, 2025 4:30 AM - 8:00 AM UTC
Fri. Mar 28, 2025 4:30 AM - 8:00 AM UTC
Poster (MARINE MESSE FUKUOKA Hall B: Exhibition Room [1F])
[28P-pm155]Discovery of a novel gamma-glutamylcyclotransferase inhibitor plumbagin by cell-based screening using luminescence probe LISA-103
○Keiko Taniguchi1, Yukie Nohara2, Mano Horinaka1, Hiromi Ii3, Susumu Nakata3, Taku Yoshiya2, Toshiyuki Sakai1 (1. Dept. Drug Discov. Med., Kyoto Pref. Univ. Med., 2. Peptide Inst., Inc., 3. Dept. Clin. Oncol., Kyoto Pharm. Univ.)
[28P-pm156]Smoking-induced suppression of β-casein
in milk is associated with an increase in miR-210-5p expression in mammary epithelia
○Takeshi Chiba1,2, Akira Takaguri3,4, Toshiyasu Mikuma5, Toshimi Kimura1,2, Tomoji Maeda5 (1. Dep. Pharm., Juntendo Univ., 2. Fac. Pharm., Jutendo Univ., 3. Fac. Pharm. Sci., Hokkaido Univ. Sci., 4. Creation Research Institute of Life Science in KITA-no-DAICHI, Hokkaido Univ., Sci., 5. Nihon Pharm. Univ.)
[28P-pm157]Improvement of ocular surface dysfunctions by a novel TRPV1 antagonist SJP-0132 in scopolamine-induced dry eye rat model
○Atsuhiro Kanda1, Tomoka Uemura1, Shinya Kobayashi1, Yuya Atsumi1, Chika Higashi2, Ken-ichi Amano2, Tomoyuki Wada1 (1. Senju Pharmaceutical Co., Ltd., 2. Mochida Pharmaceutical Co., Ltd.)
[28P-pm158S]Possible Involvement of β1- but not β3- and β2 -Adrenoceptors in the Positive Chronotropic Effects of Mirabegron, a Drug for Overactive Bladder Treatment
○Aino Nagai1, Nana Kashimoto1, Kazuha Okawa1, Rina Inoue1, Mina Shinkuma1, Midori Matsushita1, Kazuo Noguchi1 (1. Sch.Pharm.Sci.,Mukogawa Women’s Univ.)
[28P-pm159S]Effects of polymethoxyflavones from citrus peel on an in vitro coronary artery spasm model
○Saki Umeda1, Anzu Akiba1, Aoi Takeuchi1, Asaka Sato1, Yuma Kato1, Midori Matsushita1, Kazuo Noguchi1 (1. Sch.Pharm.Sci.,Mukogawa Women's Univ.)
[28P-pm160]Nrf2 activation and HO-1 induction effect by indobufen
○Naoki Yamakawa1, Ai Kameyama1, Yuichi Tasaka1, Izushi Yasuhisa1, Yoshihisa Kitamura1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[28P-pm161S]Study on structure-activity relationship of indobufen for Nrf2 activation effect
○Eriko Okamoto1, Ai Kameyama1, Yuichi Tasaka1, Izushi Yasuhisa1, Yoshihisa Kitamura1, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[28P-pm162S]Search for nonsteroidal anti-inflammatory drugs that activate Nrf2
○Mio Makino1, Ai Kameyama1, Yuichi Tasaka1, Izushi Yasuhisa1, Yoshihisa Kitamura1, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[28P-pm163S]Inhibitory effects of flurbiprofen isomers on gastric ulcer formation and their impact on prostaglandin metabolism
○Yusei Yamashiro1, Risako Takeuchi1, Yuichi Tasaka1, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[28P-pm164]Protein-Protein Interaction Blocker from Herbal Medicines- Polysaccharides from Ligustrum lucidum with Selectively Inhibitory Effect on Podoplanin-induced Platelet Aggregation
Yu-Ling Huang1, ○Pei-Wen Hsieh1,2,3 (1. Graduate Institute of Natural Products, Chang Gung University, 2. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 3. Department of General Surgery, Chang Gung Memorial Hospital)
[28P-pm165]Effect of p53 in the G2/M arrest of human lung adenocarcinoma A549 cells induced by 7-Isopropyloxy-Eupafolin
○Masaaki Nomura1, Eiko Sato1, Sae Yamaguchi1, Moe Yamanishi1, Yume Honda1, Tatsuo Takahashi1, Yuri Ikeda-Matsuo1 (1. Hokuriku University)
[28P-pm166S]Changes in expression of gastrointestinal-derived appetite-regulating hormones during various anticancer drug-induced reductions in food intake in mice.
○Shiori Yonamine1, Haruka Kitamura1, Hayato Nanri1, Shinki Soga1, Miho Kiyama1, Takayuki Ogiwara1, Risako Kon1, Nobutomo Ikarashi1, Yoshihiko Chiba1, Tomoo Hosoe1, Hiroyasu Sakai1 (1. Hoshi Univ.)
[28P-pm167S]Vincristine administration-induced downregulation of collagen and elastin gene expression in the skin of mouse
○Haruka Kitamura1, Yuan Someya1, Miho Kiyama1, Mao Ueda1, Yui Urase1, Hayato Nanri1, Shinki Soga1, Risako Kon1, Nobutomo Ikarashi1, Yoshihiko Chiba1, Tomoo Hosoe1, Hiroyasu Sakai1 (1. Hoshi Univ.)
[28P-pm168S]Upregulation of p21 and p53 genes during cisplatin administration-induced thinning of the dermal layer of murine skin.
○Mao Ueda1, Yui Urase1, Miho Kiyama1, Haruka Kitamura1, Yuan Someya1, Hayato Nanri1, Shinki Soga1, Risako Kon1, Nobutomo Ikarashi1, Yoshihiko Chiba1, Tomoo Hosoe1, Hiroyasu Sakai1 (1. Hoshi Univ.)
[28P-pm169S]Effect of metformin on cisplatin-induced upregulation of MuRF1 and atrogin-1 and downregulation of PGC-1alpha gene in C2C12 myotubes.
○Kento Kojima1, Ryunosuke Ichikawa1, Sinki Soga1, Hayato Nanri1, Miho Kiyama1, Takayuki Ogiwara1, RIsako Kon1, Tomonobu Ikarashi1, Yoshihiko Chiba1, 智夫 Hosoe1, Yasuhiro Saka1 (1. Hoshi Univ.)
[28P-pm170]Animal biles enhance wound healing response of intestinal epithelial cells
○Shiro Watanabe1, Taku Komura1, Yoshiaki Tabuchi2 (1. Institute of Natural Medicine, University of Toyama, 2. Life Science Research Center, University of Toyama)
[28P-pm171]Linker and conjugation site synergy in Antibody-drug conjugates: Impacts on biological activity
○michihiko aoyama1, minoru tada1, hidetomo yokoo1, takahito ito1, takashi misawa1, yosuke demizu1, akiko ishii-watabe1 (1. NIHS)
[28P-pm172]Mechanistic Investigation of a 2-Aminophenyl Chromone Derivative as a Selective Anti-Neoplastic Agent Targeting Multidrug-Resistant Cancer Cells
○Yi-Han Chang1,2, Hsin-Yi Hung1, Ching-Hui Su2, Po-Yu Chien2,3, Chin-Chuan Hung2,3 (1. School of Pharmacy, College of Medicine, National Cheng Kung University, 2. Department of Pharmacy, College of Pharmacy, China Medical University, 3. Department of Pharmacy, China Medical University Hospital)
[28P-pm173]Investigation of pathophysiological improvement by LXR agonists in evaporative dry eye
○Munenori Inayama1, Kana Ikemoto1, Toshio Hani1, Atsuhiro Kanda1 (1. Senju pharm. Co., Ltd.)
[28P-pm174]Comparison of CaV1.2 assay results: Best practices-implemented protocol vs. conventional protocol
Koji Nakano1, Mao Yamaguchi1, Satomi Tomizawa1, Rie Ura1, Nao Sakamoto1, Yuji Suzuki1, ○Masaru Tsuboi1 (1. Drug Safety Testing Center Co., Ltd. (DSTC))
[28P-pm175S]Therapeutic sensitivity to pediatric tumor via the regulatory mechanism on tumor suppressor p53
○Keita Yamashita1 (1. Kagoshima University)
[28P-pm176]Exploration of amodiaquine-induced liver injury biomarkers in co-cultured peripheral blood mononuclear cells and cultured hepatic carcinoma cells
○Ryosuke Nakamura1,2, Yuchen Sun2, Toshiko Momiyama2, Ruri Hanajiri-Kikura2 (1. Teikyo University, 2. Natl Inst Health Sci)
[28P-pm177S]Effects of the Antipsychotic Drug Olanzapine on Mitochondrial Membrane Potential
○Fumika Yamamoto1, Haruhi Yoshida1, Tsuyoshi Inoue1, Kazuo Harada1 (1. Sch. Pharm. Sci., Osaka Univ.)
[28P-pm178]Comparative the efficacy of retinol palmitate (VA pal) and other ingredient on corneal epithelial wound healing and evaluation of the efficacy of emulsified VA pal.
○Haruki Horiuchi1, Keisuke Watanabe1, Hiroshi Iijima1 (1. Lion Corporation)
[28P-pm179S]Tomatidine prevents LPS-induced activation of BV2 microglia
○Rei Ikeda1, Yuka Kawade1, Haruyoshi Murakami1, Ayami Kita1, Ryota Araki1, Takeshi Yabe1 (1. Pharm.Sci.,Setsunan Univ.)
[28P-pm180]Study of the efficacy and mechanism of action of Kampo medicine “Meiroin” for allergic conjunctivitis
○Tomoko Yamaguchi1, Takanori Ikawa1, Masahiko Komorisono1, Daisuke Izawa1 (1. Kobayashi Pharmaceutical Co., Ltd.)
[28P-pm181]Licorice leaf extract inhibits the production of fibroblast growth factor 5 induced by prostaglandin D2, related to hair loss.
○Mizuho Tanabe1, Masamichi Sasaki1, Hiroyasu Iwahashi1, Nobuaki Ohto1, Yoko Hashii1, Akinori Kiso1, Yoshihito Kawashima1 (1. Maruzen Pharm.)
[28P-pm182S]Effects on muscarinic receptors of mice intestine smooth muscle by resin glycoside fraction (pharbitin) from Pharbitidis Semen
○Saori Hideta1, Yuki Matsuo1, Jianrong Zhou1, Jun Fang1, Kazumi Yokomizo1, Naofumi Tokutomi1, Masateru Ono2 (1. Fac. Pharm. Sci., Sojo Univ., 2. Sch. Agri., Tokai Univ.)
[28P-pm183S]Study on the Effects of Phellamurin on the stomach
○Miku Goto1, Ryuitiro Suzuki2, Toru Kimura2, Toru Tanaka2 (1. Grad. Sch. Pharm. Sci., Josai Univ., 2. Pharm. Sci., Josai Univ.)
[28P-pm184S]Investigation of the effect of PGC-1α activator ZLN005 in a mouse model of myocardial infarction
○Taiga Okumura1, Takahiro Sasaki1, Yoshiki Kuse1, Shinsuke Nakamura1, Masamitsu Shimazawa1 (1. Gifu Pharm Univ.)
[28P-pm185]Influence of Sorafenib on Gd-EOB-DTPA Uptake: An experimental study using DCE-MRI
○Dong-Cheol Woo1,2, Yeon Ji Chae1,2, Do-Wan Lee3, Chul-Woong Woo2, Yu Sub Sung1,2, Eunyoung Tak1, Chang Hoon Ha1, Jin Kyung Roh1, In-jeong Baek1,2, Chan-Gi Pack1,2, Hwon Heo2, Kyung Won Kim3, Jeong Kon Kim3, Yoonseok Choi4 (1. Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 2. Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, 3. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 4. Medical Research Institute, Gangneung Asan Hospital)
[28P-pm186S]The properties of laxative action of Kampo medicines containing rhubarb.
○Shota Nishimoto1, Risako Kon1, Yusuke Iwasaki1, Nobutomo Ikarashi1, Hiroyasu Sakai1, Tomoo Hosoe1 (1. Hoshi Univ.)