The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)
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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[29-13-pm]Chemical Biology 7, Drug Design 4

Sat. Mar 29, 2025 1:15 PM - 2:39 PM JST
Sat. Mar 29, 2025 4:15 AM - 5:39 AM UTC
Room 13 (Fukuoka International Congress Center: 402+403 [4F])
Chair: Takashi Osawa, Yasunobu Yamashita
1:15 PM - 1:27 PM JST(4:15 AM - 4:27 AM UTC)

[29-13-pm01]In vivo–Active Soluble Epoxide Hydrolase–targeting PROTACs with Improved Potency and Stability

○Keita Nakane1, Christophe Morisseau2, Presley D. Dowker-Key3, Gabrielle Benitez1, Jennifer T. Aguilan1, Emiko Nagai1, Simone Sidoli1, Bruce D. Hammock2, Ahmed Bettaieb3, Kosaku Shinoda1, Seiya Kitamura1 (1. Albert Einstein College of Medicine, 2. UC Davis, 3. University of Tennessee)
1:27 PM - 1:39 PM JST(4:27 AM - 4:39 AM UTC)

[29-13-pm02]Regulation of KRASG12C proteolysis by carborane-based hydrophobic tag system

○YUJIE SHAO1, Kazuki Miura1,2, Hiroyuki Nakamura1,2 (1. School of Life Science and Technology, Institute of Science Tokyo, 2. Laboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo)
1:39 PM - 1:51 PM JST(4:39 AM - 4:51 AM UTC)

[29-13-pm03S]Development of peptide bond cleavage chemistry via Cysteine acylation

○Yuya Matsumoto1, Naoki Zenmyo1, Akihiro Yasuda1, Shohei Uchinomiya1, Naoya Shindo1, Kaori Tabata1, Akio Ojida1 (1. Phamaceutical Science, Kyushu University)
1:51 PM - 2:03 PM JST(4:51 AM - 5:03 AM UTC)

[29-13-pm04S]The discovery and functional analysis of a covalent drug targeting phosphofructokinase-1

○Shunsuke Watanabe1, Kaori Tabata1, Naoya Shindo1, Akio Ojida1 (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)
2:03 PM - 2:15 PM JST(5:03 AM - 5:15 AM UTC)

[29-13-pm05S]Development of novel covalent drugs with selective inhibition on targeted cells

○Tadashi Imoto1, Kyohhei Fujita2, Yasuteru Urano1,2 (1. Grad. Sch. Pharm. Sci., The University of Tokyo, 2. Grad. Sch. Med., The University of Tokyo)
2:15 PM - 2:27 PM JST(5:15 AM - 5:27 AM UTC)

[29-13-pm06S]Optimization of the probe structure to enhance the stability and the reactivity of Retro-Cope reaction toward in situ probe synthesis strategy

○Kanta Kawai1, Mieko Tsuji1, Tasuku Hirayama1,2 (1. Gifu Pharmaceutical University, 2. JST PRESTO)
2:27 PM - 2:39 PM JST(5:27 AM - 5:39 AM UTC)

[29-13-pm07S]Design, Synthesis and Evaluation of Nrf2 Activators with Azide Groups

○Yuichiro Ueda1, Toshiki Akiyama1, Daisuke Yasuda2, Zhen Kuai1, Tomoya Hirano2, Yasunobu Yamashita1, Yuri Takada1, Yukihiro Itoh1, Takayoshi Suzuki1 (1. SANKEN, Osaka Univ., 2. Fac. Pharm., Osaka Med. Pharm. Univ.)
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