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Tue. Mar 10, 2026

Wed. Mar 11, 2026

Thu. Mar 12, 2026

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KCND3 variants as a Cause of Early Repolarization and Epilepsy: Mechanistic Elucidation and Drug Repositioning

Both congenital and acquired factors are variously involved in the pathogenesis of intractable arrhythmias and cardiomyopathies. Genetic mutations in ion channels and contraction-related proteins are representative of congenital factors, while acquired factors such as therapeutic drugs and lifestyles further increase disease risk. Identification of individual molecular and electrophysiological mechanisms underlying these pathological drivers can help identify the tipping point for disease onset. This symposium will highlight studies on gene mutations linked to early repolarization syndrome, which causes fatal arrhythmias; mechanism of drug-induced arrhythmias; mathematical modeling of the pathophysiology of cardiomyocytes; and related drug discovery efforts. This approach will provide an integrated understanding of cardiac dysfunction and advance the development of personalized, clinically applicable therapies.

Towards the development of personalized therapy strategies based on the pathological analyses of intractable arrhythmias and cardiomyopathies

The 103rd Annual Meeting of The Physiological Society of Japan

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[1S03a-02]KCND3 variants as a Cause of Early Repolarization and Epilepsy: Mechanistic Elucidation and Drug Repositioning

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