The 103rd Annual Meeting of The Physiological Society of Japan

Organizers: Hiroko Izumi-Nakaseko (Toho University), Yukiko Himeno (The University of Osaka)
Chairs: Takeru Makiyama (Kyoto University), Yukiko Himeno (The University of Osaka)

Both congenital and acquired factors are variously involved in the pathogenesis of intractable arrhythmias and cardiomyopathies. Genetic mutations in ion channels and contraction-related proteins are representative of congenital factors, while acquired factors such as therapeutic drugs and lifestyles further increase disease risk. Identification of individual molecular and electrophysiological mechanisms underlying these pathological drivers can help identify the tipping point for disease onset. This symposium will highlight studies on gene mutations linked to early repolarization syndrome, which causes fatal arrhythmias; mechanism of drug-induced arrhythmias; mathematical modeling of the pathophysiology of cardiomyocytes; and related drug discovery efforts. This approach will provide an integrated understanding of cardiac dysfunction and advance the development of personalized, clinically applicable therapies.