セッション詳細
[WS(P)26]Systemic Immune Diseases
2024年12月5日(木) 15:00 〜 15:45
Poster 4
[WS26-01-O/P]Multimodal single-cell analysis revealed B cell receptor dynamic change in systemic lupus erythematosus
○Toshiyuki Shiki Ushijima1, Hiroyuki Teruya1, Manaka Goto1, Hideyuki Takahashi1, Takahiro Itamiya1,2, Haruka Tsuchiya1, Hirofumi Shoda1, Tomohisa Okamura1,2, Keishi Fujio1 (1.Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 2.Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo)
[WS26-02-P]Efficacy evaluation of B cell targeting drugs and the involved mechanism of action study in humanized BAFF transgenic SLE mice model
○Juan Liang, Shuxin Xu, Qiuping Xu, Yuxi Zhang (GemPharmatech Co., Ltd.)
[WS26-03-O/P]The B cell inhibitory receptor CD72 is a novel C1q receptor that prevents development of SLE by inhibiting B cell response to apoptotic cells.
○Hashadi Nadeesha Walakulu Gamage1,2,3, Chizuru Akatsu2, Nobutaka Numoto1, Takahiro Tsuneshige1,2,3, Masatake Asano3, Nobutoshi Ito1, Takeshi Tsubata1,2,3 (1.Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, 2.Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 3.Department of Pathology, Nihon University School of Dentistry)
[WS26-04-O/P]New quantitative and qualitative analytical framework of scRNAseq data reveals the pathophysiology of systemic lupus erythematosus
○Masahiro Nakano1, Michihiro Kono1,2, Hiroaki Hatano1, Kenichiro Asahara1, Takahiro Nishino1, Haruka Takahashi1,2, Bunki Natsumoto1, Kazuyoshi Ishigaki1,2,3 (1.Laboratory for Human Immunogenetics, Riken Center for Integrative Medical Sciences, 2.Department of Microbiology and Immunology, Keio University School of Medicine, 3.Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q))
[WS26-05-P]Spontaneous Systemic Lupus Erythematosus Mouse Model Based on TLR7Y264H Genetic Mutation
○Ting Wang, Juan Liang (GemPharmatech Co., Ltd.)
[WS26-06-O/P]Development of the anti-human TLR7 monoclonal antibody for therapeutic intervention in systemic lupus erythematosus
○Ryutaro Fukui1, Yusuke Murakami2,1, Atsuo Kanno1, Yuji Motoi1, Atsushi Manno4, Tomohiro Honda5, Shinnosuke Yamada5, Jun Ishiguro6, Kensuke Nakamura7, Giorgio Senaldi8, Toshiyuki Shimizu3, Kensuke Miyake1 (1.The Institute of Medical Science, The University of Tokyo, 2.Department of Pharmaceutical Sciences & Research Institute of Pharmaceutical Sciences, Musashino University, 3.Graduate School of Pharmaceutical Sciences, The University of Tokyo, 4.Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., 5.Translational Science Department II, Daiichi Sankyo Co., Ltd., 6.Discovery Research Laboratories V, Daiichi Sankyo Co., Ltd., 7.Modality Research Laboratories II, Daiichi Sankyo Co., Ltd., 8.Clinical development, Daiichi Sankyo, Inc.)
[WS26-07-P]Pathogenetic role of IFNγ producing CD4+T cells in IMQ induced lupus model mice
○Reona Tanimura, Yuya Kondo, Ryota Sato, Ryohei Nishino, Hiromitsu Asashima, Haruka Miki, Hiroto Tsuboi, Takayuki Sumida, Isao Matsumoto (Department of Rheumatology, Faculty of Medicine, University of Tsukuba)
[WS26-08-P]GATA4 enhances cGAS-STING-dependent production of type I interferons in senescent lupus monocytes
○Taiga Kuga1,2, Asako Chiba1, Goh Murayama2, kosuke Hosomi1, Tomoya Nakagawa1, Yoshiyuki Yahagi1,2, Makio Kusaoi2, Ken Yamaji2, Naoto Tamura2, Sachiko Miyake1 (1.Department of Immunology, Juntendo University Faculty of Medicine, 2.Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine)
[WS26-09-P]Establishment and pathogenesis analysis of a mouse model of lupus mesenteric vasculitis.
○Maki Fujishiro1, Kunihiro Hayakawa1, Marina Shinoura1, Yuko Kataoka2, Keigo Ikeda2, Shinji Morimoto2 (1.Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, 2.Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital)
[WS26-10-P]Contribution of phosphodiesterase 1B to neuropsychiatric manifestations in lupus-prone mice through microglial activation
○Shuhei Takeyama1, Michihito Kono1, Kohei Karino1, Yuki Kudo1, Masatoshi Kanda2, Hiroyuki Nakamura2, Maria Tada1, Ryo Hisada1, Yuichiro Fujieda1, Masaru Kato1, Olga Amengual1, Tatsuya Atsumi1 (1.Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, 2.Department of Rheumatology and Clinical Immunology, Sapporo Medical University)
[WS26-11-P]Elucidation of the impact of high-fat diet on autoimmune disease progression
○Yulu Liu1,2, Ayaka Ito1,2,3, Ibuki Shirakawa2, Azusa Kobayashi2, Michiko Kobayashi2, Takayoshi Suganami1,2 (1.Department of immonometabolism, Nagoya University Graduate School of Medicine, 2.Department of Molecular Medicine and Metabolism, Research Institue of Enviornmental Medicine, Nagoya University, 3.Institute for Advanced Research, Nagoya University)
[WS26-12-P]CD8T cells depletion promotes human Tph/Tfh and B cells proliferation without graft versus host diseases in PBMC transferred-humanized mice.
○Sota Fujimori, Piruzyan Mariam, Ryota Sato, Sayuka Kato, Yuzo Koda (Oncology & Immunology Unit, Research Division, Mitsubishi Tanabe Pharma Corporation)
[WS26-13-P]Analysis of regulatory mechanism for T cell activation via Trat1 in Sjögren's syndrome
○Ruka Nagao1, Akiko Yamamoto2, Aya Ushio4, Kunihiro Otsuka1, Shigefumi Matsuzawa1,3, Takaaki Tsunematsu1, Naozumi Ishimaru4 (1.Department of Oral Molecular Pathology, Graduate School of Biomedical Sciences, Tokushima Univ., 2.Department of Pathology, Nihon Univ. School of Dentistry, 3.Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu Univ., 4.Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental Univ.)
[WS26-14-O/P]Salivary gland fibroblasts drive autoimmune pathology via the interaction with CD4+ T cells in Sjögren’s syndrome
○Kunihiro Otsuka1,2, Hiroyuki Kondo1, Shin-Ichi Tsukumo1, Naozumi Ishimaru3, Koji Yasutomo1 (1.Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, 2.Department of Oral Molecular Pathology, Graduate School of Dentistry, Tokushima University, 3.Department of Oral Pathology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences)
[WS26-15-P]Skewed TCR usage in pathogenic T cells of SS model mouse
○Shuhei Mashimo1,2, Yuriko Tanaka1, Michitsune Arita1, Taku Naito1, Taku Kuwabara1, Marii Ise1, Akira Ishiko2, Motonari Kondo1 (1.Department of Molecular Immunology, Toho University School of Medicine, 2.Department of Dermatology, Toho University School of Medicine)
[WS26-16-P]Activation of signaling pathways via TLR4 may contribute to the elevated expression of BAFF receptor, BR3, in peripheral monocytes of patients with primary Sjögren’s syndrome.
○Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki, Hiroyuki Fukui, Kotaro Matsumoto, Masaru Takeshita, Chihiro Takahashi, Tsutomu Takeuchi, Yuko Kaneko (Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine)
[WS26-17-O/P]Anti-integrin αvβ6 antibody in Takayasu arteritis with or without ulcerative colitis
○Yuki Ishikawa1, Hiroyuki Yoshida2,3, Hajime Yoshifuji4, Koichiro Ohmura4,5, Tomoki Origuchi6, Tomonori Ishii7, Tsuneyo Mimori4,8, Akio Morinobu4, Masahiro Shiokawa2, Chikashi Terao1,9,10 (1.Laboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, 2.Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 3.Kansai Electric Power Hospital, 4.Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 5.Department of Rheumatology, Kobe City Medical Center General Hospital, 6.Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 7.Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, 8.Takeda Clinic for Rheumatic Diseases, 9.Clinical Research Center, Shizuoka General Hospital, 10.School of Pharmaceutical Sciences, University of Shizuoka, The Department of Applied Genetics)
[WS26-18-O/P]Unravelling the gene regulatory networks driving the polygenetic risk of human complex diseases
○Haruka Takahashi1,2, Hiroaki Hatano2, Masahiro Nakano2, Yumi Tsuchida3, Shuji Sumitomo3, Akari Suzuki4, Yuta Kochi5, Keishi Fujio3, Kazuhiko Yamamoto4, Kazuyoshi Ishigaki1,2,6 (1.Department of Microbiology and Immunology, Keio University School of Medicine, 2.Laboratory for Human Immunogenetics, Riken Center for Integrative Medical Sciences, 3.Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 4.Laboratory for Autoimmune Diseases, Riken Center for Integrative Medical Sciences, 5.Department of Genomic Function and Diversity, Division of Biological Data Science, Medical Research Institute, Tokyo Medical and Dental University, 6.Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q))
[WS26-19-P]Understanding the pathogenesis of Aicardi-Goutières syndrome-like encephalopathy caused by mutations in the RNA-editing enzyme ADAR1.
○Hyebin Yoo1, Reiichi Sugihara2, Taisuke Nakahama1,2,3,4, Yuki Kato1,2,3, Yukio Kawahara1,2,3,4,5 (1.Department of RNA Biology and Neuroscience, Graduate School of Frontier Biosciences, Osaka University, 2.Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, 3.Integrated Frontier Research for Medical Science Division and RNA Frontier Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 4.Center for Infectious Disease Education and Research (CiDER), Osaka University, 5.Genome Editing Research and Development Center, Graduate School of Medicine, Osaka University)
[WS26-20-P]An Enterococcus phage-derived enzyme suppresses graft-versus-host disease
○Kosuke Fujimoto1,2, Satoshi Uematsu1,2 (1.Department of Immunology and Genomics Graduate School of Medicine, Osaka Metropolitan University, 2.Division of Metagenome Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo)
[WS26-21-P]Lysosomal dysfunction in dendritic cells causes autoimmune diseases
Yoshiko Mori Saitoh1,2, Kenichi Harada3, Yoh Wada4,5, Ge-Hong Sun Wada6, Tamami Denda7, Yasunori Ota7, Hiroshi Sagara8, Yuji Watanabe8, Sadahiro Iwabuchi9, Shinichi Hashimoto9, Kensuke Miyake2,10, ○Shin-Ichiroh Saitoh1,2 (1.Department of Intractable Disorders, Institute of Advanced Medicine, Wakayama Medical University., 2.Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo., 3.Department of Human Pathology, Kanazawa University School of Medicine., 4.Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University., 5.Center for Infectious Disease Education and Research (CiDER), Osaka University., 6.Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women’s College., 7.Department of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo., 8.Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo., 9.Department of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University., 10.Laboratory of Innate Immunity, The Institute of Medical Science, The University of Tokyo)
[WS26-22-P]Point mutation at the ligand binding domain disrupts RORgt function in Th17 lineage differentiation and restricts autoimmune diseases
○Keisuke Miyako1,2, Toshio Kanno1, Yusuke Endo1 (1.1.Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, 2.2.Department of Applied Genomics, Kazusa DNA Research Institute)
[WS26-23-P]Neuropilin-1 (NRP1) as a potential marker of self-reactive Th cells in autoimmune disease
○Ben JE RAVENEY1, Atsuko Kimura1, Youwei Lin2, Tomoko Okomoto2, Atsuko Katsumoto2, Reiko Saika2, Wakiro Sato1, Shinji Oki1, Takashi Yamamura1 (1.Department of Immunology, National Institute of Neuroscience; National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan, 2.Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan)
[WS26-24-P]TFAM deficient mice spontanously develop inflammation and autoantibodies.
○Taku Kuwabara, Yuriko Tanaka, Marii Ise, Taku Naito, Shuhei Mashi, Motonari Kondo (Toho University)
[WS26-25-O/P]Novel transcriptomic evidence for a shared immunological signature-based treatment of Adult-onset Still's disease and other autoinflammatory diseases
○Ikuo Takazawa1, Haruka Tsuchiya1, Takahiro Itamiya1,2, Harumi Shirai1, Yumi Tsuchida1, Yasuo Nagafuchi1,2, Hirofumi Shoda1, Tomohisa Okamura1,2, Keishi Fujio1 (1.Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 2.Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo)
[WS26-26-O/P]Isoliquiritigenin inhibits activation of NLRP3 inflammasome with CAPS mutations by suppressing caspase-1 activation and mutant NLRP3 aggregation
○Koudai Kani1, Hiroe Honda2, Kiyoshi Takatsu2, Yoshinori Nagai1 (1.Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, 2.Toyama Prefectural Institute for Pharmaceutical Research)
[WS26-27-P]Proteasome dysfunction in adipocytes induces lipodystrophy and autoinflammation
○Rinna Koga, Junko Morimoto, Kunihiro Otsuka, Koji Yasutomo (Department of Immunology and Parasitology, Tokushima University Graduate School of Medicine)
[WS26-28-P]Phenotypic and Therapeutic Evaluation of Humanized C3 Transgenic Mice as a Model for C3 glomerulopathy-Like Autoimmune Disease
○Shuxin Xu, Juan Liang, Qiuping Xu, Kaiyuan Zi (GemPharmatech Co., Ltd.)
[WS26-29-P]Inborn errors of immunity with a missense mutation of COMMD8
○Mizuki Kishi1,2, Taiichiro Shirai1,3, Kazuhiro Suzuki1,2,3,4 (1.Laboratory of Immune Response Dynamics, Immunology Frontier Research Center, Osaka University, Japan, 2.Graduate School of Medicine, Osaka University, Japan, 3.Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Japan, 4.Center for Infectious Disease Education and Research, Osaka University, Japan)