講演情報
[18p-W2_401-8]Miniature Magnetic µCoil Fibers for Neural Stimulation and Biological Evaluation
〇(D)Etienne LEBOURDONNEC1,2, Kaoru Hiramoto2,3, Hideaki Yamamoto3,4, Ayumi Hirano-Iwata3,4, Shigehiro Ohnuma2, Hiroshi Masumoto2, Yuanyuan Guo1,2 (1.Grad. Sch. Biomed. Eng., 2.Frontier Res. Inst. for Interdisciplinary Scie., 3.Res. Inst. of Elec. Com., 4.Advanced Inst. of Mat. Res.)
キーワード：
Magnetic stimulation devices、Neuromodulation、Micro-coils
Neuromodulation has become a key approach for treating neurological and psychiatric disorders, with magnetic stimulation offering major advantages due to its non-invasive nature. However, conventional techniques such as transcranial magnetic stimulation are limited by bulky systems and low spatial precision. To overcome these constraints, we developed a minimally invasive magnetic µCoil fiber using a thermal drawing process adapted from optical fiber fabrication. The resulting fibers generate localized magnetic fields suitable for neural stimulation. Biological experiments were performed on cultured cortical neurons, with neuronal activity recorded by fluorescence microscopy. Two network pre-states were identified: synchronized networks exhibited a transient silencing during stimulation, whereas spontaneous networks showed enhanced activity following stimulation. These effects are attributed to electric fields induced by time-varying magnetic fields, which locally modulate membrane excitability in a network-state-dependent manner. Ongoing work focuses on optimizing coil geometry and testing multi-coil configurations to improve field intensity and depth, with future applications in in vivo neuromodulation.