Session Details

[1S14m]Biochemical Approaches to Deciphering DNA Methylation

Mon. Nov 3, 2025 9:00 AM - 11:00 AM JST
Mon. Nov 3, 2025 12:00 AM - 2:00 AM UTC
Room14(Room J)
Organizers:Atsuya Nishiyama(The University of Tokyo), Kyohei Arita(Yokohama City University, Graduate School of Medical Life Science)
Sponsored by:Transformative Research Areas (A) Mobile Genomics

[1S14m-00]Introduction

Atsuya Nishiyama (The University of Tokyo)
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[1S14m-01]A dual-interface mechanism for DPPA3-mediated inhibition of UHRF1 via zinc-coordinated binding to the SRA domain

Shota Tanimoto1, Christopher B. Mulholland3, Ayana Ota1, Yoshie Chiba1, Keita Sugimura1, Kyohei Arita2, Heinrich Leonhardt3, Atsuya Nishiyama1, Makoto Nakanishi1 (1.Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 2.Graduate School of Medical Life Science, Yokohama City University, 3.Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Human Biology and BioImaging, Ludwig-Maximilians-Universitat Munchen)
キーテクノロジー:ツメガエル卵抽出液
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[1S14m-02]Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Kosuke Yamaguchi1,2, Xiaoying Chen2, Fumihito Miura3,4, Masato Kanemaki1, Takashi Ito4, Pierre-Antoine Defossez2 (1.National Institute of Genetics, Molecular Cell Engineering Laboratory, 2.Universite Paris Cite, CNRS, Epigenetics and Cell Fate, 3.The University of Tokyo, Graduate School of Frontier Sciences, 4.Kyushu University Graduate School of Medical Sciences, Department of Biochemistry)
キーテクノロジー:AID法
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[1S14m-03]Dissecting the Role of Transgenerational DNA Methylation in Mouse Brains Lacking the Paternal Genome

Shinpei Yamaguchi (Toho University)
キーテクノロジー:発生工学
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[1S14m-04]Structural basis of the plant CG methyltransferase MET1: Conserved activation conformation and species-specific autoinhibition mechanism

Kyohei Arita1, Amika Kikuchi1, Atsuya Nishiyama2, Yoshie Chiba2, Taiko To Kim3 (1.Yokohama City University, Graduate School of Medical Life Science, 2.The University of Tokyo, The Institute of Medical Science, 3.Institute of Science Tokyo, Life Science and Technology)
キーテクノロジー:クライオ電子顕微鏡単粒子解析
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[1S14m-05]Chromatin remodeling-mediated transposon silencing and epigenetic maintenance via ATP-dependent and independent pathways

Akihisa Osakabe1,2, Tatsuo Kanno3, Pierre Bourguet3, Tetsuji Kakutani4, Frederic Berger3 (1.Institute for Advanced Academic Research, Chiba University, 2.Department of Biology, Chiba University, 3.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, 4.Department of Biological Sciences, The University of Tokyo)
キーテクノロジー:ゲノム生物学、生化学
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[1S14m-06]Possible new biological significance of gene body DNA methylation

Taiko K. To (Institute of Science Tokyo)
キーテクノロジー:WGBS
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[1S14m-07]Closing Remarks

Kyohei Arita (Yokohama City University, Graduate School of Medical Life Science)
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