Presentation Information
[PPS04-P21]Biophysical Determinants of Cellular Viability under Martian Geophysical Forcing: Comparative Study of Extremophile Mechanics
*Yuliia Biliak1, Mikołaj Zawadzki1, Natalia Godlewska1 (1.University of Warsaw)
Keywords:
Martian Surface Forcing,Space Medicine,Extremophiles,Biophysics,Habitability,Interplanetary Sustainability
As humanity looks toward long-term interplanetary presence, a critical challenge arises: enhancing the intrinsic resilience of terrestrial biological systems against Martian geophysical forcing. While habitat engineering is essential, understanding the fundamental biophysical limits of cellular systems is the first step toward enabling Earth-based life to endure extreme extraterrestrial stressors. This study establishes a theoretical framework for evaluating the mechanical and thermodynamic stability of cells exposed to low atmospheric pressure, extreme desiccation, perchlorate-induced osmotic stress etc.
By synthesizing the survival strategies of diverse Earth-based extremophiles, we investigate a spectrum of structural adaptations—ranging from the modulation of lipid bilayer phase behavior and cytoskeletal reinforcement to the role of specialized protective proteins that prevent molecular aggregation. We model how these synergistic mechanisms preserve cellular integrity and prevent mechanical failure under Martian-like constraints. Rather than focusing on a single pathway, this work identifies the multi-scale "mechanical tipping points" that must be addressed to stabilize Earth-derived organisms in analog and future Mars environments. This research provides a foundational biophysical roadmap for future bioengineering, synthetic biology, and life-support strategies, bridging the gap between terrestrial biology and interplanetary sustainability.
By synthesizing the survival strategies of diverse Earth-based extremophiles, we investigate a spectrum of structural adaptations—ranging from the modulation of lipid bilayer phase behavior and cytoskeletal reinforcement to the role of specialized protective proteins that prevent molecular aggregation. We model how these synergistic mechanisms preserve cellular integrity and prevent mechanical failure under Martian-like constraints. Rather than focusing on a single pathway, this work identifies the multi-scale "mechanical tipping points" that must be addressed to stabilize Earth-derived organisms in analog and future Mars environments. This research provides a foundational biophysical roadmap for future bioengineering, synthetic biology, and life-support strategies, bridging the gap between terrestrial biology and interplanetary sustainability.