[14a-K507-1~9] CS.5 Code-sharing Session of 6.5 & 7.5

9:30 AM - 9:45 AM JST(12:30 AM - 12:45 AM UTC)

[14a-K507-3] Structure Analysis of Amyloid β Oligomers Linked at Two Positions

〇Chikara Harada¹, Atsuya Matsui^1,2, Yumi Irie³, Ayumi Uchino³, Ayaka Chikugo³, Kotaro Fujii¹, Katsuma Hosoi¹, Akio Nakanishi¹, Yusuke Kageyama¹, Nobuyasu Naruse¹, Chihiro Tsukano³, Kazuhiro Irie^3,4, Yutaka Mera¹ (1.Shiga Univ. of Med. Sci., 2.General Care & Education Tennri Hosp., 3.Kyoto Univ., 4.Doshisya Univ.)

Keywords:

amyloid β,atomic force microscopy

In pathological research on Alzheimer’s disease, amyloid β (Aβ) oligomers are considered to play a crucial role, but their diverse forms and types have made detailed analysis challenging. In this study, a method was established to precisely analyze height information using atomic force microscopy (AFM) by artificially synthesizing Aβ dimers and trimers to control their morphology. Aβ dimers were observed as spherical particles, and histogram analysis of their height distribution revealed peaks suggesting the presence of intermolecular parallel β-sheet structures.