[16a-K303-1~10] 8.4 Plasma life sciences

9:30 AM - 9:45 AM JST(12:30 AM - 12:45 AM UTC)

[16a-K303-3] Incubation time dependence of the selective inactivation effect of plasma-activated lactated Ringer's solution on skin and lung cancer cells

〇Ryogo Nonaka¹, Kei Sasaki², Zhenfei Dong², Kenji Motohashi³ (1.Grad. Sch. Sci. Eng., Toyo Univ., 2.Fac. Sci. Eng., Toyo Univ., 3.Fac. Life Sci., Toyo Univ.)

Keywords:

plasma

In this study, we aimed to quantitatively investigate the selective inactivation of skin and lung cancer cells by irradiating lactated Ringer's solution with He plasma mixed with oxygen to increase the amount of reactive oxygen species produced. In this study, we defined the average inactivation time τ by utilizing the fact that the survival rate decreases exponentially with the plasma exposure time, and used the ratio of normal cells to cancer cells as an index of the selective inactivation effect of cancer cells (hereinafter referred to as the cancer cell inactivation enhancement ratio). We then investigated the effect of the incubation time after adding plasma-activated lactated Ringer's solution on the cancer cell inactivation enhancement ratio.