[17a-K402-1~9] 12.6 Nanobiotechnology

11:00 AM - 11:15 AM JST(2:00 AM - 2:15 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[17a-K402-8] In vitro Evaluation of Modified Parylene C Surfaces for Anti-inflammatory Implantable Neural Electrodes

〇Mizuno Yosuke¹, Koji Sakai¹, Toichiro Goto¹, Masumi Yamaguchi¹, Aya Tanaka¹ (1.NTT BRL and BMC, NTT Corp.)

Keywords:

Anti-inflammation,Parylene C,Neural electrode

Chronic inflammation associated with long-term use of implantable neural electrodes poses a significant challenge to their functionality. While structural and flexibility improvements to electrodes have been explored to suppress inflammation, biological approaches targeting existing inflammatory responses are limited. In this study, parylene C, commonly used as an insulating material for neural electrodes, was chemically modified with anti-inflammatory molecules including docosahexaenoic acid (DHA), gallic acid (GA), and N-acetylneuraminic acid (Neu5Ac). FT-IR analysis confirmed successful modification, showing characteristic peaks such as amide bond vibrations and C=C bond absorptions. Antioxidant evaluation revealed significant radical scavenging activity for DHA and GA-modified surfaces. Furthermore, in vitro assessments using microglial cells demonstrated a significant reduction in inflammatory cytokine (TNF-α) secretion on DHA and GA-modified Parylene C surfaces without cytotoxicity. These findings suggest that chemically modifying Parylene C with anti-inflammatory molecules is a promising strategy to mitigate immune responses and improve the biocompatibility and long-term stability of implantable neural electrodes.