[17a-K503-1~6] 6.6 Probe Microscopy

11:15 AM - 11:30 AM JST(2:15 AM - 2:30 AM UTC)

[17a-K503-6] Mass Spectrometry Imaging of Drug Distribution in Mouse Brain by Tapping-Mode Scanning Probe Electrospray Ionization

〇(B)Yang Zhou¹, Yoichi Otsuka¹, Mengze Sun¹, Hiroko Koyama², Shota Hatano², Ryo Honda³, Teiko Nomura³, Satoshi Oyama⁴, Michisato Toyoda¹ (1.School of Science, Osaka Univ., 2.Graduate School of Engineering, Gifu Univ., 3.United Graduate School of Drug Discovery and Medical Information Sciences, Gifu Univ., 4.School of Data Science, Nagoya City Univ.)

Keywords:

Scanning Probe Microscope,Mass Spectrometry Imaging

Mass spectrometry imaging (MSI) is an analytical technique that visualizes the distribution of multiple compounds in a sample. We have developed a tapping-mode scanning probe electrospray ionization (t-SPESI) technique. In this study, we used t-SPESI to perform MSI of mouse brain sections treated with a drug containing ACR and PEG, with the aim of visualizing its distribution in the brain. In this presentation, we will discuss the brain distribution of ACR and PEG in detail.