[1AS-02] 【E】Transposons and Hosts: Symbiosis, Evolution, and Prospects | The 48th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Symposium

[1AS-02]【E】Transposons and Hosts: Symbiosis, Evolution, and Prospects

Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC

Room 2(Pacifico Yokohama Conference Center 3F, 301)

Organizer: Mikiko Siomi (The University of Tokyo), Yuka Iwasaki (RIKEN)

Transposons have long been thought to account for approximately 40% of the human genome. However, the Telomere-to-Telomere (T2T) Consortium recently revealed that this proportion reaches 53%. This groundbreaking discovery highlights the “peculiar" symbiotic relationship between humans (and other host organisms) and transposons spanning hundreds of millions of years, heralding a new era of transposon research. What is the true purpose of transposons co-existing in the genome? How have we, as hosts, managed to accommodate, control, and even harness their selfish nature for our benefit? Could transposons hold the potential as a novel modality for drug discovery? In this symposium, researchers exploring transposons from diverse perspectives will come together to share cutting-edge insights and engage in discussions with the audience on these fascinating questions.

9:00 AM - 9:03 AM JST(12:00 AM - 12:03 AM UTC)

Introduction

9:03 AM - 9:23 AM JST(12:03 AM - 12:23 AM UTC)

[1AS-02-01]PIWI-piRISC assembly defect underlying infertility: insights from Drosophila and mouse models

○Mikiko C Siomi¹ (1. Graduate School of Science The University of Tokyo)

Comment()

9:23 AM - 9:33 AM JST(12:23 AM - 12:33 AM UTC)

[1AS-02-02(1P-009)]Development of L1 Retrotransposon and eccDNA Reporters for Probing cGAS-STING-Mediated Innate Immune Responses

○Herve Dushimyineza^1,2, Jiawei Cai³, Tomoichiro Miyoshi⁴, Makoto T. Hayashi^2,5 (1. Graduate School of Biostudies, Kyoto University , 2. IFOM-KU Joint-Research Laboratory, Graduate School of Medicine, Kyoto University , 3. Nutrition & Biomedicine, Graduate School of Science, Technical University of Munich, 4. Laboratory for Retrotransposon Dynamics, RIKEN Center for Integrative Medical Sciences (IMS), 5. Chromosome Instabilities Unit, IFOM ETS, The AIRC Institute of Molecular Oncology)

Comment()

9:33 AM - 9:53 AM JST(12:33 AM - 12:53 AM UTC)

[1AS-02-03]Centromere-targeted integrations of an LTR retrotransposon via CENH3 chromatin in Arabidopsis

○Sayuri Tsukahara¹, Alexandros Bousios², Estela Perez-Roman², Sota Yamaguchi¹, Basile Leduque³, Aimi Nakano¹, Matthew Naish⁴, Akihisa Osakabe¹, Atsushi Toyoda⁵, Hidetaka Ito⁶, Alejandro Edera³, Sayaka Tominaga¹, Juliarni Juliarni¹, Kae Kato⁷, Shoko Oda¹, Soichi Inagaki¹, Zdravko Lorković⁸, Kiyotaka Nagaki⁹, Frédéric Berger⁸, Akira Kawabe¹⁰, Leandro Quadrana³, Ian Henderson⁴, Tetsuji Kakutani¹ (1. The University of Tokyo, 2. University of Sussex, 3. Universite Paris Saclay, 4. University of Cambridge, 5. National Institute of Genetics, Center for Genetic Resource Information, 6. Hokkaido University, 7. National Institute of Genetics, Department of Integrated Genetics, 8. Gregor Mendel Institute (GMI), 9. Okayama University, 10. Kyoto Sangyo University)

Comment()

9:53 AM - 10:13 AM JST(12:53 AM - 1:13 AM UTC)

[1AS-02-04]Understanding the disease risk of human transposons by population genetics

○Shohei Kojima^1,2 (1. Keio Univ., 2. RIKEN)

Comment()

10:13 AM - 10:33 AM JST(1:13 AM - 1:33 AM UTC)

[1AS-02-05]Exploring the evolutionary link between CRISPR-Cas and transposons

○Makoto Saito¹ (1. RIKEN Pioneering Research Institute)

Comment()

10:33 AM - 10:59 AM JST(1:33 AM - 1:59 AM UTC)

[1AS-02-06]Chasing the jumping genes

○Zhao Zhang¹ (1. Duke University)

Comment()

10:59 AM - 11:00 AM JST(1:59 AM - 2:00 AM UTC)

Conclusion

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