Session Details
[2PS-10]【J】Aberrant metabolic resilience as aging mechanisms
Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 10(Pacifico Yokohama Conference Center 4F, 413)
Organizer: Hiroshi Kondoh (Kyoto university), Keiyo Takubo (Tohoku University)
In old age and frailty, impaired "resilience" causes a gradual decline of daily activity and the incidence of multiple diseases. SASP derived from senescent cells that accumulate in old individuals induces a decrease in resilience. Senothrerapy is advocated for repairing resilience. Metabolic resilience is one of them, whose latest findings will be presented and discussed.
[2PS-10-01]SARS-CoV-2-Induced Inflammation Triggers Cellular Senescence
○Shunya Tsuji1, Eiji Hara2 (1. Laboratory of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 2. Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka)
[2PS-10-02(2P-806)]Mechanisms of aging caused by glucocorticoids
○Noriyuki Okudaira1, Misato Terahara1, Masaki Kobayashi1, Masataka Murakawa1, Takao Susa1, Miho Akimoto1, Masayoshi Iizuka2,1, Mimi Adachi1 (1. Teikyo Univ. of Med. Dep Biochem, 2. Teikyo Univ. of Med. Dep Int Med)
[2PS-10-03]SDHAF1 Driven Complex II Activation Confers Metabolic Resilience in Aged Hematopoietic Stem Cells
○Shintaro Watanuki1,2, Hiroshi Kobayashi1,2, Keiyo Takubo1,2 (1. Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, 2. Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security)
[2PS-10-04]Novel senolytic mechanism targeting metabolic changes associated with cellular senescence
○Takumi Mikawa1, Hiroshi Kondoh1,2 (1. Kyoto University Hospital, 2. Graduate School of Medicine, Kyoto University)
[2PS-10-05]Age-related changes in the mode of inheritance of mutant mitochondrial DNA during oogenesis.
○Kaori Ishikawa1, Haruma Sasaki2, Chika Higuchi3, Katsuhiko Hayashi3, Kazuto Nakada1 (1. Institute of Life and Environmental Sciences, University of Tsukuba, 2. Master's Program in Biology, Graduate School of Science and Technology, University of Tsukuba, 3. Graduate School of Medicine, Osaka University)
[2PS-10-06(2P-808)]Dnmt3a overexpression disrupts skeletal muscle homeostasis, promotes an aging-like phenotype
○Yasutomi Kamei1, Mamoru Oyabu1, Yuto Ohira1, Kiyoshi Yoshioka2, Runa Kawaguchi1, Atsushi Kubo3, Yukino Hatazawa1, Hinako Yukitoshi1, Huascar Pedro Ortuste Quiroga4, Naoki Horii4, Fumihito Miura5, Hiromitsu Araki5, Masaki Okano4, Izuho Hatada6, Hitoshi Gotoh7, Tatsuya Yoshizawa7, So-ichiro Fukada3, Yoshihiro Ogawa5, Takashi Ito5, Kengo Ishihara8, Yusuke Ono4 (1. Kyoto Prefectural University, 2. Institute for Research on Productive Aging, 3. Osaka University, 4. Kumamoto University, 5. Kyushu University , 6. Gunma University, 7. Kyoto Prefectural University of Medicine, 8. Ryukoku University)