Session Details
[2P]Poster Presentation 2
Thu. Dec 4, 2025 5:00 PM - 7:00 PM JST
Thu. Dec 4, 2025 8:00 AM - 10:00 AM UTC
Thu. Dec 4, 2025 8:00 AM - 10:00 AM UTC
Poster & Exhibition Venue (Pacifico Yokohama Exhibition Hall)
[2P-001]Host range analysis of pBBR1 type broad host range plasmid using IncP-1α T4SS (2)
○Kazuki Moriguchi1, Kazuyuki Nakamura1, Sota Hirose2, Akina Yamamoto1, Yoshiteru Aoi1,3, Kyoko Higo-Moriguchi4 (1. Grad. Sch. of Integrated Sci. for Life, Hiroshima Univ., 2. Dept. of Biological Sci., Fac. of Sci., Hiroshima Univ., 3. Seto Inland Sea CN Res. Ctr., Hiroshima Univ., 4. Sch. of Med., Fujita Health Univ.)
[2P-002]Recovery and PCR Detection of Airborne Bacteriophage MS2 using an Inkjet Sprayer
○Takumi Inoue1, Kota Ono2, Shinji Katsura1,2,3, Masahiko Oshige1,2,3, Yinhong Tao2 (1. Dept. of Envi. Eng. Sci., Gunma Univ., 2. Grad. Sch. of Food & Pop. Health Sci., Gunma Univ., 3. GUCFW)
[2P-003]Nobel regulatory mechanism for transcription of ribosomal protein genes in budding yeast
○Shunei Tatara1, Koji Kasahara1, Naoki Shimamura1 (1. Tokyo university of agriculture)
[2P-004]Development “ExPlex CE” system for highly sensitive multiplex cancer-related SNP detection
○Yumiko Koshi1, Chihiro Manri1, Takahide Yokoi1, Hirokazu Kato2, Noriyuki Sumida2, Motohiro Yamazaki2 (1. Hitachi, Ltd., 2. Hitachi High-Tech Corporation)
[2P-005]OsGAD3-mediated GABA accumulation enhances heat stress tolerance in rice
○UMMEY KULSUM1, KAZUHITO AKAMA1 (1. Graduate School of Natural Science and Technology, Shimane University)
[2P-006]In vivo EP-based gene transfer towards mammary gland in mice.
○Kazunori Morohoshi1, Masahiro Sato2, Shingo Nakamura1 (1. National Defense Medical College, 2. Department of Genome Medicine, National Center for Child Health and Development)
[2P-007]Effects of chronic low-dose-rate irradiation on the endogenous retrotransposon LINE-1 in the mouse genome.
○KEIJI Ogura1, Murano Hayato2, Sugihara Takashi1, Fujikawa Katuyoshi1, Komura Jun-ichiro1, Kobayashi Toshiyuki1 (1. Institute for Environmental Science, 2. Tohoku Environmental Science Service Corporation)
[2P-008]Meta-analysis of Temperature Stress Responses in Human and Mouse Using Public Transcriptome Datasets
○Kotaro Uchida1, Hidemasa Bono1 (1. Hiroshima Univ.)
[2P-009]Unraveling the Role of PARK7 in Fine-Tuning Pluripotency Induction and Reprogramming
○Emmanuel Osei Mensah1, Arun Kumar Burramsetty1, Takumi Kishimoto1, Aya Fukuda1, Koji Hisatake1, Ken Nishimura1 (1. University of Tsukuba)
[2P-010]Development of a customized MassARRAY panel for detecting common mutations in alpha and beta thalassemia in Thai population
○SUKITA PUTTAMANEE1, PICHAYANOOT ROTKRUA1, KITIWAN ROJNUEANGNIT1 (1. Faculty of Medicine, Thammasat University)
[2P-011]Evolutionary optimization strategies of gene expression in plants: comparative analysis for post-transcriptional regulation between old and de novo genes in Arabidopsis thaliana
○Takuya Nakagawa1, Shun Nakano2, Sumika Yamada2, Yusei Shigematsu1, Takuto Nakatsuji2, Shoma Morita1, Soichirou Satoh1,2 (1. Grad. Sch. Life Env. Sci., Kyoto Pref. Univ., 2. Fac. Sch. Life Env. Sci., Kyoto Pref. Univ.)
[2P-012]AAV single plasmid for high-yield AAV vector production
○HIROAKI NARIKI1, YOSHINORI TANAKA1, SACHIKO OKAMOTO1 (1. TAKARA BIO INC.)
[2P-013]Complete mtDNA replacement in interspecies hybrid toward mtDNA writing
○Ken-Ichi Wada1,2,3, Kazuo Hosokawa2, Mizuo Maeda2, Yoshihiro Ito2, Yui Harada3, Yoshikazu Yonemitsu3 (1. IMCE, Kyushu University, 2. RIKEN, 3. Grad. Sch. Pharm. Sci., Kyushu Univ.)
[2P-014]Comprehensive Analysis of Hypoxia-Responsive Genes from Public Gene Expression Data by Meta-Analysis Using Machine Learning
○Motoki Uno1, Daniel Andrade2, Hidemasa Bono1 (1. Grad. Sch. Integ. Sci. Life, Hiroshima Univ., 2. Grad. Sch. Adv. Sci., Hiroshima Univ.)
[2P-015]Development of Gene Function Screening Technology Using DNA-Based Recording of Cellular Response
○Shoichi Kato1, Atsushi Ikemoto1, Jun Isayama1, Tetsuya Takimoto2, Hideyuki Saya2, Ken-ichi Hamada1 (1. JSR corporation, 2. Oncology Innovation Center, Fujita Health University)
[2P-016]One-step introduction of gene cluster into Escherichia coli genome using λ phage
○Shingo Nozaki1, Yoshihiro Miwa1 (1. RIKEN)
[2P-017]Application of CRISPR-Cas9 genome editing method for improving hydrogen gas production in Clostridium paraputrificum
○Toya Kimoto1, Emi Kunitake1, Tetsuya Kimura1 (1. Mie University)
[2P-018]Evaluation and Optimization of Genome Editing Targeting Extrachromosomal DNA
○Yohei Sugimoto1, Takeru Kachi1, Mei Kubokawa1,2, Masaki Kawamata3, Seiko Yoshino1, Hiroshi I Suzuki1 (1. Div. Molecular Oncology, Nagoya Univ. Grad. Sch. Med. , 2. Dept. Obstetrics and Gynecology, Nagoya Univ. Grad. Sch. Med., 3. Div. Organogenesis and Regeneration, MiB, Kyushu Univ.)
[2P-019]Functional analysis of a human-specific noncoding RNA, HSTR1
○Hinako Kawaguchi1, Mao Watanabe2, Masanori Imamura3, Shunsuke Suzuki1,2 (1. Shinshu Univ., 2. GS, Shinshu Univ., 3. Kanazawa Univ.)
[2P-020]Crucial roles of Grr1 in splicing and translation of HAC1 mRNA upon unfolded stress response
○Nichika Sato1, Yu Nakano2, Yasuko Matsuki2, Shota Tomomatsu1,3, Sihan Li1, Yoshitaka Matsuo1, Toshifumi Inada1 (1. The University of Tokyo, 2. Tohoku University, 3. Hoshi University)
[2P-021]Leveraging transposon traps to isolate cell cycle reporter cells exhibiting diverse time differences
○Yamato Kasahara1,2, Sakura Tamamura3, Tomo Kondo4, Miho Osugi4, Kentaro Semba1,5, Shinya Watanabe5, Kosuke Ishikawa3 (1. Waseda Univ., Grad. Sch. Adv. Sci. & Eng., Dept. Life Sci. & Med. Biosci., 2. JSPS Research Fellow (DC1), 3. Japan Biological Informatics Consortium., 4. The Univ. of Tokyo, Grad. Sch. of Sci., Dept. of Biol. Sci.Translational Research Center, Fukushima Medical Univ., 5. Translational Research Center, Fukushima Medical Univ.)
[2P-022]Expression of Redox genes from thermophiles in Escherichia coli using novel high-expression vectors
○YUQI REN1, Daisaku Tnaka2, Hayate Saitou2, Yusuke Kobayashi2, Ryota Natugami2, Masahide Ishikawa1 (1. Saitama Institute of Technology Graduate School, 2. Saitama Institute of Technology)
[2P-023]Characterization and binding mechanism analysis of a ubiquitin-binding DNA aptamer
Hajime Betto1, Tomohiro Kobashi1, Daiki Kobayashi2, Yuki Kaimoi1, Kazuyoshi Yano1,2, ○Maiko Okada1,2 (1. Grad. Sch. of Bionics, Tokyo Univ. of Tech., 2. Sch. of Biosci. and Biotechnol., Tokyo Univ. of Tech.)
[2P-024]Development of an efficient library preparation method from FFPE-derived RNA
○Taka-aki TAKEDA1 (1. TOYOBO CO., LTD.)
[2P-025]Identification and genetic analysis of a novel antibacterial Phage Tail-Like Protein produced by raw milk–derived Pseudomonas
○AKIKO KASHIWAGI1, Hiro Kasai1, Kazuto Sasaki1, Kosuke Kasai2 (1. Hirosaki Univ. Agr and Life Sci., 2. Hirosaki Univ. Health Sci.)
[2P-026]Gene expression changes in air-liquid interface cell cultures for respiratory virus isolation
○Malala Mulavu1,2, Shinji Saito2, Yukari Itakura2, Gabriel Gonzalez3, Hirofumi Sawa1,2,4 (1. Graduate School of Infectious Diseases, Hokkaido University, Japan, 2. Bioresponse Analysis Division, Institute for Vaccine Research and Development, Hokkaido University, Japan, 3. Division of Research Support, Institute of Vaccine Research and Development, Hokkaido University, Japan, 4. International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Japan)
[2P-027]Expression Analysis of Arylalkylamine N-acetyltransferase Involved in White Spot Formation in the Wings of the Two-spotted cricket, Gryllus bimaculatus
○Ayane Shimamura1, Shintaro Inoue2, Yoshiyasu Ishimaru3, Katsuyuki Miyawaki2, Akira Takahashi4, Takeshi Nikawa5, Sumihare Noji6, Takahito Watanabe2, Taro Mito2 (1. Div. of Bioresource Science, Graduate School of Sciences and Technology for Innovation, Tokushima Univ., 2. Bio-Innovation Research Center, Tokushima Univ., 3. Div. of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima Univ., 4. Dept. of Preventive Environment and Nutrition, Inst. of Biomedical Sciences, Tokushima Univ., 5. Dept. of Nutritional Physiology, Inst. of Biomedical Sciences, Tokushima Univ., 6. EvoDevo Tech Co., Ltd.)
[2P-028]Data integration of gene essentiality and expression patterns for functional annotation of uncharacterized genes
○Gina Miku Oba1, Ryuichiro Nakato1 (1. Institute for Quantitative Biosciences)
[2P-029]Towards Understanding Nse5/6’s Role in Smc5/6-Mediated Chromosome Organization
○Jumpei Fukute1,2, Kristian Jeppsson1,2, Toyonori Sakata1,2, Katsuhiko Shirahige1,2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Cell and Molecular Biology, Karolinska Institutet)
[2P-030]Detection of Novel Transposable Elements from NGS Sequences
○Akio Miyao1 (1. National Agriculture and Food Research Organization)
[2P-031]Bacterial Community Structure and Ecology in Schorl Pegmatite from the Wagu Kannon Mine
○Hidetoshi Okajima1,2, Tomoro Warashina1,3, Asako Sato1, Akihiko Nishimura4, Yohey Suzuki5, Akio Kanai1,2,3 (1. Institute for Advanced Biosciences Keio University, 2. Faculty of Environment and Information Studies, Keio University, 3. Systems Biology Program, Graduate School of Media and Governance, Keio University, 4. Japan Atomic Energy Agency, 5. School of Science, The University of Tokyo)
[2P-032]De novo genome sequencing of the endemic Japanese Kajika frog (Buergeria buergeri) using Oxford Nanopore technology
○Shun Hayashi1, Hinayo Ogino1,2, Akane Kawaguchi3, Takeshi Igawa1,2 (1. Hiroshima Univ. ARC, 2. Hiroshima Univ. Integrated Sciences for Life, 3. National Institute of Genetics)
[2P-033]Development of a Laboratory-Scale Automated RamDA-seq System to Address the Issue of Reproducibility
○Toutai Mitsuyama1,2, Haruko Shimono1 (1. National Institute of Advanced Industrial Science and Technology (AIST), 2. National Institute of Natural Sciences)
[2P-034]Detection of Small Variants (SNPs/INDELs) Using Next-Generation Sequencing
○Hiroto Kanda1 (1. Maebashi Institute of Technology)
[2P-035]Identification of Novel Transcripts in THP-1 Cells during PMA-Induced Differentiation using Nanopore Long-Read RNA Sequencing
○Xian Shi1, Mahoko Ueda2, Kensuke Yamaguchi3, Yuta Kochi2 (1. Department of Genomic Function and Diversity, Graduate School of Medical and Dental Sciences, Institute of Integrated Research, Institute of Science Tokyo, 2. Department of Genomic Function and Diversity, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 3. Biomedical Engineering Research Innovation Center, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo)
[2P-036]Whole-genome sequencing of diverse cultured prokaryotes including fastidious type strains
○Shingo Kato1, Sachiko Masuda2, Arisa Shibata2, Takashi Itoh1, Mitsuo Sakamoto1, Ken Shirasu2, Moriya Ohkuma1 (1. RIKEN BRC, 2. RIKEN CSRS)
[2P-037(2AS-09-06)]Microbiome Datahub: Integrating metagenomes and single-cell genomes of microbes
○Hiroshi Mori1, Takatomo Fujisawa1, Koichi Higashi1, Zennichi Nakagawa2, Hiroyo Nishide3, Motomu Matsui4, Takuji Yamada2, Ikuo Uchiyama3 (1. National Institute of Genetics, 2. Science Tokyo, 3. National Institute for Basic Biology, 4. Kyoto University)
[2P-038]A genome assembly and gene functional annotation of Hiroshima-derived Pacific oyster (Magallana gigas)
○Misako Imai1,2, Miyuki Kanda1,2, Moriya Mino3, Kazuhiko Koike3, Keisuke Okuhara1,2, Hidemasa Bono1,3 (1. Genome Editing Innovation Cent., Hiroshima Univ., 2. R&D Dept., PtBio Inc., 3. Grad. Sch. of Integrated Sci. for Life, Hiroshima Univ.)
[2P-039]Exploration of Tissue-Specific Gene Expression during Anhydrobiosis Induction in Polypedilum vanderplanki
○Shiho Ogami1, Yuki Yoshida2, Richard Cornette2, Takahiro Kikawada2,1 (1. The University of Tokyo, 2. NARONational Agriculture and Food Research Organization)
[2P-040]Development of a database to support the understanding and visualization of 4D genome states
○Hiroki Nakajima1 (1. RIKEN Center for Biosystems Dynamics Research)
[2P-041]Why do Two Defense Systems Coexist? Theoretical Insights into the Evolutionary Coexistence of piRNA and KZFP in TE Suppression
○Yusuke Nabeka1, Hideki Innan1 (1. Graduate Institute for Advanced Studies, SOKENDAI)
[2P-042]Sputnik virophage alters the transcriptional dynamics of its host giant virus
○Jingjie Chen1, Hiroyuki Ogata1, Hiroyuki Hikida2 (1. Kyoto University, 2. Japan Institute for Health Security)
[2P-043]Neobacillus iksanensis sp. nov. from paddy soil: A novel aerobic bacterium harboring nirB and nrfA for Dissimilatory Nitrate Reduction to Ammonium
○Seohyun Ahn1, Jeonghwan Jang1 (1. Jeonbuk National University)
[2P-044]ANKRD11: A Novel Cohesin Co-player at Enhancers and Promoters
○DENG HUIZI1, Bando Masashige1, Tei Shoin1, Sutani Takashi1, Shirahige Katsuhiko1,2 (1. The University of Tokyo·Institute for Quantitative Biosciences, 2. Karolinska Institutet·Department of Cell and Molecular Biology)
[2P-045]Population Scale 3D Genomics Reveals EBV Responsive Regulatory Rewiring in B Lymphocytes
○Saumya Agrawal1, Takeya Kasukawa1 (1. Laboratory for Large-Scale Biomedical Data Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan)
[2P-046]Proteogenomics-driven discovery of dark proteomes expanding the human protein universe and their possible relation to human disease
○Yuhta Nomura1, Naoshi Dohmae1 (1. RIKEN CSRS)
[2P-047]Haplotype-Resolved Genome Assembly and Exploration of Terpene Biosynthesis Genes in Fagaceae Species Castanopsis sieboldii
○Airi Jitsushita1, Sangwan Kim2, Naoyuki Tajima3, Sachiko Isobe4, Akiko Satake5, Hideki Hirakawa2 (1. Fac. Agr, Kyushu Univ., 2. Grad. Sch. Agr., Kyushu Univ., 3. Dept. Adv. Res. and Dev., Kazusa DNA Res. Inst., 4. Grad. Sch. Agr. and Life Sci., Univ. of Tokyo., 5. Grad. Sch. Sci., Kyushu Univ.)
[2P-048]Shape-Based Similarity for Low-Latency Decisions in Nanopore Adaptive Sampling
○Takefumi Koike1, Hiromitsu Awano1, Takashi Sato1 (1. Graduate School of Informatics, Kyoto University)
[2P-049]Mutational Signature Analysis of Isogenic Rice Koshihikari for Constructing Novel Breeding Platforms
○Motonori Tomita1,2, Hiroshi Honda3,4 (1. Dept. Human Sci., Kobe Shoin Univ., 2. New Dimension DNA Institute Co., Ltd., Kyoto Univ. Katsura VP, 3. PE Office Honda Biotech. Lab., 4. Univ. Yamanashi)
[2P-050]Development of a mapping-free genome-guided RNA-seq assembler for Eukaryotes
○Makoto Terauchi1, Noguchi Hideki1 (1. Center for genome informatics)
[2P-051]Structural diversification of the newt genome driven by transposons and gene duplications.
○Kazuto Bou1 (1. The Graduate University for Advanced Studies)
[2P-052]The dual function of PrimPol switched by ATR is responsible for replication fork stability disturbed by oncogenic KRAS
○Taichi Igarashi1, Yasuhara Takaaki1, Bunsyo Shiotani2 (1. Lab. of Genome Stress Response, Kyoto Univ., 2. Dep. of Genome Stress Signaling, Tokyo Med. Univ.)
[2P-053]The structure and function of the N-terminal self-interacting domain of Sld3 in S pombe
○Shiho Ogawa1, Asami Hishiki2, Yuto Tanii2, Sayano Hirata1, Keigo Kobara1, Katsunori Tanaka1, Hiroshi Hashimoto2, Seiji Tanaka3 (1. Kwansei Gakuin Univ., 2. Univ. of Shizuoka, 3. Kochi Univ. of Tech.)
[2P-054(2PS-08-03)]Analysis of the molecular mechanism of MCM2-7 phosphorylation by DDK using an in vitro reconstitution system
○Yugo Zaizen1, Marin Fukatsu1, Miyako Shiraishi1, Yoko Katsuki1, Yasunori Noguchi1, Masatoshi Fujita1 (1. Kyushu University)
[2P-055]Replication robustness under DNA replication stress and TRAIP-dependent PCNA unloading from chromatin
○Yasushi Shiomi1, Tomoharu Hara1, Yuki Iwai1, Masato Kanemaki2, Takekazu Kunieda1, Hideo Nishitani1,3 (1. Sch. of Sci., Univ. of Hyogo, 2. Dept. of Chromosome Sci., National Institute of Genetics, 3. Faculty of Sci. and Eng., Yamato Univ.)
[2P-056]Elucidation of the mechanism of removal of chain-terminating nucleoside analogs from newly synthesized chains by replication polymerases ε and δ
○Eri Nishizawa1, Hiromori Okubo1, Kawasumi Ryotaro1, Kouji Hirota1 (1. Tokyo Metropolitan University)
[2P-057]Functional coordination between mutagenic DNA polymerase epsilon and other error-prone polymerases
○Ratul Rahman1, Lewis Bainbridge1, Takahiro Yamaguchi1, Tamiko Minamisawa1, Mami Takahashi1, Yasukazu Daigaku1 (1. Japanese Foundation for Cancer Research)
[2P-058(2PS-08-07)]Genome-wide mapping reveals intrinsic roles of error-prone polymerases in human DNA replication.
○Lewis John Bainbridge1, Yuji Masuda2,3, Kanae Kaneko1, Tamiko Minamisawa1, Mami Takahashi1, Chikahide Masutani2,3, Yasukazu Daigaku1 (1. Japanese Foundation for Cancer Research, 2. Nagoya University, 3. Nagoya University Graduate School of Medicine)
[2P-059]Regulation of DNA replication initiation through the N-terminal intrinsically disordered region of DONSON
○Yoshitami Hashimoto1 (1. University of Tokyo Pharmacy and Life Sciences)
[2P-060(2AS-06-04)]REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
○Masaoki Kohzaki1, Katarzyna Sobkowiak2,3, Rafael Böhm4,5, Jonathan Mailler2, Florian Huber2,6, Soheila Emamzadah2, Laurence Tropia2, Sebastian Hiller4, Thanos D Halazonetis2 (1. University of Occupational and Environmental Health, Japan, 2. University of Geneva, 3. Merck Biotech Development Center, 4. University of Basel, 5. NUVISAN Innovation Campus, Berlin , 6. Ludwig Institute for Cancer Research, Lausanne)
[2P-061]Reconstruction of artificial nucleus with DNA replication ability in living mouse oocyte
○Nao Yonezawa1, Yasushi Hiraoka2, Tokuko Haraguchi2, Kazuo Yamagata1 (1. Kindai Univ., 2. FBS., Osaka Univ.)
[2P-062]Crystal structure of Vibrio vulnificus primosomal PriB protein
○Man Cheng Wang1, ChengYang Huang1 (1. Chung Shan Medical Univ)
[2P-063]Functional analysis of ATAD5/Elg1-RFC in human cells using AID method
○Yuki Iwai1, Masato Kanemaki2, Hideo Nishitani1,3, Takekazu Kunieda1, Yasushi Shiomi1 (1. Univ. of Hyogo, 2. NIG, 3. Yamato Univ.)
[2P-064(2AS-06-07)]DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
○Kaima Tsukada1, Liudmyla Lototska1, Aya Tsukada2, Ipek Ilgin Gönenç1, Charlotte Sherlaw-Sturrock3, Manil Kanade1, Antony Oliver4, Samuel Jones5, Satpal Jhujh3, Julius Bannister5, Zafar Iqbal6, Thomas Miller1, Grant Stewart3, Fena Ochs2, Andrew Blackford1,5 (1. Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2. Biotech Research & Innovation Centre, University of Copenhagen, 3. Department of Cancer and Genomic Sciences, Birmingham, University of Birmingham, 4. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, 5. Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, 6. Department of Neurology, Oslo University Hospital)
[2P-065]Analysis of RNA involvement in the intranuclear relocation of homologous donor DNA during DNA double-strand break.
○Rei Izumi1, Suzuka Hoshino2, Aoi Makita2, Masahiko Harata1,2, Chihiro Horigome1,2 (1. Tohoku Univ. , 2. Tohoku Univ.)
[2P-066]Elucidation of the role of ARID1A during SLX4-mediated DNA interstrand crosslink repair
○Masaki Shigeno1, Yoko Katsuki1, Miyako shiraishi1, Yasunori Noguchi1, Minoru Takata2, Hidetaka Kosako3, Masatoshi Fujita1 (1. Kyushu Univ., 2. Kyoto Univ., 3. Tokushima Univ.)
[2P-067]AltEx-BE: A tool to automate the selection of base editors and sgRNA design for splicing manipulation.
○Kinari Matsumoto1, Akihiro Kuno4,2,3, Seiya Mizuno4 (1. University of Tsukuba, Ph.D Program in Human Biology, 2. Department of Anatomy and Embryology, University of Tsukuba, 3. Tsukuba Institute for Advanced Research, University of Tsukuba, 4. Laboratory Animal Resource Center, University of Tsukuba)
[2P-068]Analysis of the role of strand exchange in the relocation of homologous donor DNA induced by DNA double-strand breaks.
○Suzuka Hoshino1, Rei Izumi2, Aoi Makita1, Masahiko Harata1,2, Chihiro Horigome1,2 (1. Tohoku Univ. , 2. Tohoku Univ.)
[2P-069]Verification of cell type dependence of efficiency and characteristics of in vivo base editing in mice
○Momoka Masuda1, Hayate Suzuki2, Mizuki Nisimura1, Lac Duong Hung3, Natsuki Mikami3, Sae Numata4, Seiya Mizuno2 (1. University of Tsukuba・Master’s Program in Medical Sciences, 2. University of Tsukuba・Laboratry Animal Resource Center, 3. University of Tsukuba・Doctoral Program in Human Biology, 4. University of Tsukuba・College of Medical Sciences)
[2P-070]Novel DNA damage repair mechanism by histone methyltransferase NSD2
○Yuto Hiruma1, Koh Iwasaki1, Kaho Harada1, Akira Sassa1, Kiyoe Ura1 (1. Graduate School of Science, Chiba University)
[2P-071]Multi-mutagenesis of Escherichia coli genome Using the Scarless Editing Technique HoSeI method
○Riho Hirano1, Ayane Minagawa2, Yukari Miyake1, Miho Yoshimura3, Kaneyoshi Yamamoto1,2,3 (1. Hosei Univ. Graduate School, 2. Hosei Univ. Faculty of Bioscience and Applied Chrmistry , 3. Hosei Univ. Research Center for Micro-Nano Technology)
[2P-072]Competing Related Lysogenic Phages within the Bacillus subtilis Genome
○Saya Hasegawa1, Jun Koyama1, Aoi Hirata1, Tsutomu Sato2,1 (1. Fac. Biosci. Appl. Chem., Hosei Univ., 2. Grad. Sch. of Sci. & Eng., Hosei Univ.)
[2P-073]Bacteriophage φY7 involved in the Recombination of the Bacillus subtilis spoVK Gene
○Yuna Okawaki1, Tsutomu Sato1,2 (1. Hosei Univ., Grad. Sch. of Sci. & Eng., 2. Fac. Biosci. Appl. Chem., Hosei Univ.)
[2P-074]Mechanism of defective prophage elimination at the same attB site by lysogenic phage infection
○Haon Muya1, Yuki Uchida1, Hikaru Ito1, Tsutomu Sato2,1 (1. Fac. Biosci. Appl. Chem., Hosei Univ., 2. Grad. Sch. of Sci. & Eng., Hosei Univ.)
[2P-075]Efficient Induction of Genomic Long Deletions by Multiplexed DNA Nicking
○Akiko Tomita1, Yuuya Namaki1,2, Shinichiro Nakada1 (1. Kyoto Prefectural University of Medicine, 2. Osaka University)
[2P-076]DNA Repair Signature Analysis Reveals a Polθ-Dependent Mechanism Generating Long Deletions from Trans Long-Offset Nicks
○Yuya Namaki1,2, Akiko Tomita2, Hiroyuki Sasanuma3, Shinichiro Nakada2 (1. Grad. Sch. Med., Osaka Univ., 2. Grad. Sch. Med. Sci., Kyoto Pref. Univ. Med., 3. TMIMS)
[2P-077]Isolation of non-essential 5 alternative sigma genes defective Escherichia coli strain.
○Masato Hoshino1, Genki Hirano1, Akira Katayama2, Kan Tanaka3, Kaneyoshi Yamamoto1,4,5 (1. Hosei Univ.・Grad. Sch. Sci. & Eng., 2. Nippon Med. Sch.・Grad. Sch. Med., 3. Tokyo Univ. of Sci., 4. Hosei Univ.・Nano Tech., 5. Hosei Univ.・Biosci. & Appl. Chem.)
[2P-078]Establishment of a novel method for generating multiple gene KO mouse and evaluation of its safety
○Mizuki Nishimura1, Natsuki Mikami2, Hayate Suzuki3, Akihiro Kuno4, Seiya Mizuno3 (1. Master’s Program in Medical Sciences, University of Tsukuba, 2. Ph.D Program in Human Biology, University of Tsukuba, 3. Laboratory Animal Resource Center, University of Tsukuba, 4. Department of Anatomy and Embryology, University of Tsukuba)
[2P-079]Construction of Multiple Gene Knockout Strains in Beauveria bassiana
○JILI ZHANG1, Akiko Ono2, Tomohiro Suzuki1,3 (1. C-Bio, Utsunomiya Univ., 2. FGISI, Shizuoka Univ., 3. RIMS, Shizuoka Univ.)
[2P-080]DNA-mediated interaction between UvrD helicases: Interaction between wildtype and C-terminal deletion mutants
○Hiroaki Yokota1 (1. Grad. Sch. Creation New Photon. Indust.)
[2P-081]Development of a Precise qPCR Method for Lentiviral Provirus Copy Number Quantification
○Sayuri Ueda1, Yoshinori Tanaka1, Sachiko Okamoto1 (1. TAKARA BIO INC.)
[2P-082]Regulatory mechanism of XPF-ERCC1 endonuclease activity in chromatin
○Aya Yoshida1,2, Syota Matsumoto1, Yoshimasa Takizawa1, Mitsuo Ogasawara1, Isao Kuraoka3, Hitoshi Kurumizaka1,2 (1. IQB, The Univ. of Tokyo, 2. Dept. of Biol. Sci., Grad. Sch. of Sci., The Univ. of Tokyo, 3. Dept. of Chem., Grad. Sch. of Sci., Fukuoka Univ.)
[2P-083]CLAPE: A Cre/loxP-Induced Homologous Recombination System for Scarless DNA Sequence Excision
○Toru Onishi1, Nobuhiro Ishida1, Nobuhiko Muramoto1 (1. TOYOTA CENTRAL R&D LABS., INC.)
[2P-084]Migration of DNA double-strand breaks in rRNA genes to the nucleolus-nucleoplasm-nuclear envelope interface regulates replicative lifespan in yeast
○Chihiro Horigome1,2, Yamato Okada1, Mina Iwaki1, Hagiri Kyosuke1, Rei Izumi2, Masahiko Harata1,2 (1. Tohoku Univ., Grad. Sch. of Agri. Sci, 2. Tohoku Univ., Facul. of Agri.)
[2P-085]Role and regulation of Ku70 in skeletal muscle
Manabu Koike1,2, ○Kazuhide Kitada2,3, Aki Koike1 (1. iQMS, QST, 2. Life Sci., Grad. Sch. Sci. and Eng., Saitama Univ., 3. QST hospital, QST)
[2P-086]AI Agent–driven Extension of the Soft Matter Active Vertex Model for Implementing Biological Stress-Responsive Processes
○Kensuke Otsuka1, Yuta Oriike2, Kouki Uchinomiya1, Ryota Yamada2 (1. Central Research Institute of Electric Power Industry, 2. Science AID Inc.)
[2P-087]Selective effects of oxidative stress-induced microsatellite instability in Msh2-deficient mice
○Noriko Takano1,2, Kyoko Hidaka3,2, Mizuki Ohno2 (1. Yamato University, 2. Kyushu University, 3. University of Kitakyushu)
[2P-088]Analysis of DNA double-strand breaks induced by acetaldehyde treatment
○Kenichiro Matsuzaki1, Kenji Kumatoriya1, Miki Shinohara1,2 (1. Grad. Sch. Agri., Kindai Univ., 2. ATIRI, Kindai Univ.)
[2P-089]Functional analysis of RAD52 in DNA double-strand break repair mediated by liquid–liquid phase separation
○Junhong Wu1, Chiaki Kinoshita1, Takeshi Yasuda2, Wataru Kagawa1 (1. Meisei University, 2. QST)
[2P-090]Enhancer based gene regulatory network predicts transcription factors required for maintenance of the mature pancreatic beta cell phenotype
○Ruslan Deviatiiarov1, Oleg Gusev1, Hideki Endoh1, Hiroyuki Fukuda1, Keishiro Nishimura1, Kenji Kamimoto2, Yasushi Okazaki1, Masahito Matsumoto1 (1. Juntendo University, 2. The University of Osaka)
[2P-091]Local chromatin compaction, driven by histone H1-dependent internucleosomal interactions, regulates transcriptional activity
○Satoru Ishihara1, Yoko Chikaoka2, Aya Nakayama2, Naoe Kotomura1, Kazutsune Yamagata1, Yohei Shimono1, Takeshi Kawamura2 (1. Fujita Health Univ. Sch. Med., 2. Isotope Sci. Ctr., Univ. Tokyo)
[2P-092]RLF/ZFP292 regulates pluripotency in mouse embryonic stem cells via the ZMYM–CoREST complex
○Takamasa Ito1, Masahito Yoshino1, Shin-Ya Isobe1, Chikashi Obuse1 (1. Department of Biological Sciences, Graduate School of Science, The University of Osaka)
[2P-093]Targeted Regulation of miRNA Maturation Using Synthetic PPR Proteins in Alzheimer’s Disease Models
○Samantha Sastrawidjaja Sastrawidjaja1,2, Yusuke Yagi 3, Takahiro Nakamura 4 (1. Kyushu University - Graduate Student , 2. Kyushu University - Research Assistant, 3. Edit Force - CTO , 4. Kyushu University - Professor)
[2P-094]L3MBTL2 maintains proliferation of MYCN-amplified neuroblastoma cells through repression of NRIP3 and BRME1expression
○Ryu Okada1,2,3, Hisanori Takenobu3, Shunpei Satoh3, Takehiko Kamijo3 (1. Nagoya University Graduate School of Medicine, 2. Saitama University Graduate School of Science and Engineering, 3. Saitama Cancer Center Research Institute for Clinical Oncology)
[2P-095(2PS-03-02)]Structural Robustness of Inactive X Chromosome Heterochromatin in Human Somatic Cells
○Asahi Yamaki1, Ren Matsui1, Takamasa Ito1, Shinya Isobe1, Chikashi Obuse1 (1. Osaka Univ.)
[2P-096]Lamin B receptor interacts with Dnmt1 to regulate DNA methylation
○Yuta Yanagihara1, Kohdai Yamada2, Hidetaka Kosako3, Tatsuya Sawasaki2, Yuuki Imai1,4 (1. Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, 2. Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, 3. Division of Cell Signaling, Institute of Advanced Medical Sciences, Tokushima University, 4. Department of Pathophysiology, Ehime University Graduate School of Medicine)
[2P-097]Regulation of the Stress Response by the Transcriptional Repressor HUSH Complex via Membraneless Organelles
○Chikara Iwanaga1, Shinya Isobe1, Asahi Yamaki1, Kensuke Ninomiya2, Tetsuro Hirose2, Takamasa Ito1, Chikashi Obuse1 (1. Graduate School of Science, Osaka University, 2. Graduate School of Frontier Biosciences, Osaka University)
[2P-098]Genome-wide Mapping of G-quadruplex Structures by Site-specific Cleavage with a G4-targeting Chemical Nuclease
○Satoshi Fujii1, Shinobu Sato2, Yukina Sanada2, Shigeori Takenaka2 (1. Kyushu Institute of technology, 2. Kyushu Institute of Technology)
[2P-099]Acute hypoxia increases Dnmt and DNA methylation in zebrafish development.
○GIN SODEYAMA1, Oki Hayasaka2, Makoto Kashima3, Kota Ujibe4, Mitsuru Jimbo1, Daisuke Ikeda1, Hiromi Hirata4, Sekita Yoichi5, Kamei Hiroyasu6, Fumiya Furukawa1 (1. School of Marine Biosciences, Kitasato University, 2. Faculty of Fisheries Kagoshima University, 3. Faculty of Science, Toho University, 4. College of Science and Engineering, Aoyama Gakuin University, 5. School of Sciences, Kitasato University, 6. Faculty of Biological Science and Technology, Kanazawa University)
[2P-100]Functional analysis of the histone variant macroH2A in chromatin structure
○Wenjie Xu1,2, Syota Matsumoto1, Yoshimasa Takizawa1, Mitsuo Ogasawara1, Hitoshi Kurumizaka1,2 (1. Institute for Quantitative Bioscience, The Univ. of Tokyo, 2. Dept. of Biological Sciences, Grad. Sch. of Science, The Univ. of Tokyo)
[2P-101]Dynamic changes in heterochromatin during spore formation in fission yeast
○Haruka Maki1,2, Aki Hayashi1, Jun-ichi Nakayama1,2 (1. National Institute for Basic Biology, 2. The Graduate University for Advanced Studies, SOKENDAI)
[2P-102]Functional analysis of DNA methylation at imprinted Snrpn-DMR using epigenome editing tools
○Ginji Nampo1, Mayu Fujimori1, Tohro Kimua1, Yoichi Sekita1 (1. Dept. of Biological Sciences, Grad. Sch. of Science, Kitasato Univ.)
[2P-103]Structural and biochemical analysis of nucleosome containing unnatural base pair Ds-Paʼ
○Eisho Tanida1,2, Naoki Horikoshi1, Michiko Kimoto3, Yoshimasa Takizawa1, Mitsuo Ogasawara1, Ichiro Hirao3, Hitoshi Kurumizaka1,2 (1. Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 3. Xenolis Pte. Ltd.)
[2P-104]Identify the structural alterations causing epigenetic aberrations in mesothelioma by long-read sequencing
○Yu an Chen1, Nagae Genta1, Ueda Hiroki2, Tatsuno Kenji1, Morishita Shinichi3, Sekido Yoshitaka4, Aburatani Hiroyuki1 (1. Genome Science, RCAST, Univ. of Tokyo, 2. Biological Data Science, RCAST, Univ. of Tokyo, 3. Dept. CBMS., Grad. Sch. of Frontier Sci., Univ. of Tokyo, 4. Div. Cancer Biology, Aichi Cancer Ctr. Res. Ins.)
[2P-105]Search for a synthetic lethal target in CHFR-methylated cancer cells
○Yui Ohashi1, Hideyuki Takeshima1, Yu-Yu Liu1, Teruaki Oku2, Toshikazu Ushijima1 (1. Dept. of Epigenomics, Inst. for Adv. Life Sci., Hoshi Univ., 2. Dept. of Microbiology, Hoshi Univ. Sch. of Pharm. and Pharmaceutical Sci.)
[2P-106]Genomic Hitchhiking :
Cross-kingdom chromosomal integration between mammalian and algal genomes
○Ryota Aoki1, Tomoko Matsunaga1, Hidenori Nishihara2, Tae Kuramoto2, Takuya Sakamoto3, Yuko Sato4, Hiroshi Kimura5, Sachihiro Matsunaga1 (1. Dept. of Integr. Biosci., Grad. Sch. of Front. Sci., Univ. of Tokyo., 2. Dept. Adv. Biosci., Grad. Sch. Agr., Kindai Univ., 3. Dept. of Sci., Fac. of Sci., Kanagawa Univ., 4. Med. Inst. Bioreg., Kyushu Univ., 5. Inst. of Integr. Res., Inst. of Sci. Tokyo.)
[2P-107]Long-Term Tracking of Chromosomal Dynamics in a Hybrid Cell Line Derived from Algal and Mammalian Cells
○Yuki Minoura1, Tomoko Matsunaga1, Ryota Aoki1, Yumiko Suto2, Sachihiro Matsunaga1 (1. Tokyo Univ., 2. QST)
[2P-108]Integrative omics analysis of the mechanism regulating the multipotency of mesenchymal stem-like cells by royal jelly
○Hideto Okamoto1, Yukie Nakagawa1, Nobuaki Okumura1, Shoichiro Kokabu2 (1. Institute for Bee Products and Health Science, Yamada Bee Company, Inc., 2. Division of Biochemistry, Kyushu Dental University)
[2P-109]Reconstitution and visualization of nucleosome and H3-H4 octasome in A.thaliana
○Junko Haga1, Petra Banko2, Keiichi Okimune1, Taiki Azuma1, Taichi Takasuka1,2, Ryo Morishita3, Katsumi Maenaka4, Shunsuke Kita4, Daisuke Kihara5 (1. Grad. Sch. of Global Food Resources., Hokkaido Univ., 2. Grad. Sch. of Agriculture., Hokkaido Univ., 3. CellFree Sciences Co., Ltd.,, 4. Grad. Sch. of Pharmaceutical Sciences, Hokkaido Univ., 5. Department of Biological Sciences and Department of Computer Science, Purdue Univ., West Lafayette)
[2P-110(2AS-04-05)]A pangenome approach to human LINE-1 epigenetics in polymorphic region.
○Nhi Hoang Nhi1, Guillaume Bourque1 (1. Kyoto University)
[2P-111]Analysis of the DNA replication-dependent regulation mechanism of IMD2 expression
○Takuma Yokosawa1, Takahito Ayano1,2, Masaya Oki1,3 (1. Adv. Interdiscip. Sci. and Technol., Grad. Sch. of Eng., Univ. of Fukui, 2. Japan Society for the Promotion of Science Research Fellowship for Young Scientists, 3. Life Science Innovation Center, University of Fukui)
[2P-112]Epigenetic regulation of self-incompatibility in Onoena
○Naoto Asai1, Ken-ichi Kubo2,3, Takuto Umami2, Naoki Ikeda2, Aya Imamura1,2,3, Fang-Sik Che1,2,3 (1. Grad. Sch. of Biosci., Nagahama Inst. of Bio-sci. and Tech., 2. Dept. of Bio-sci., Nagahama Inst. of Bio-sci. and Tech., 3. GERI, Nagahama Inst. of Bio-sci. and Tech.)
[2P-113]Investigating the interplay between DNA Topology and 3D genome folding
○Evanthia Iliopoulou1, Vladislav Kuzin1, Toyonori Sakata1,2, Marie-Josèphe Giraud-Panis3, Katsuhiko Shirahige1,2, Camilla Björkegren1, Laura Baranello1 (1. Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden, 2. Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan, 3. Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, University Côte d’Azur, 06107 Nice, France)
[2P-114]H2A variants contribute to chromosomal position-associated establishment of transposon-specific silent modification in Arabidopsis
○Shoko Oda1,2, Sayaka Tominaga2, Shumpei Takeuchi1, Tetsuji Kakutani1, Taiko Kim To1,2 (1. The University of Tokyo, 2. Institute of Science Tokyo)
[2P-115]Computational analysis of the molecular interactions between pioneer transcription factors and nucleosomes.
○Naoko Konami1, Koji Okuwaki1, Noboru Sato2, Kaori Fukuzawa1 (1. The Univ. of Osaka, 2. Oita Univ.)
[2P-116]Elucidation of Epigenomic Dynamics during the Transcriptional Bursting Process
○CHAEBEEN KO1, Satoshi Uchino2, Xiaohui Gao1, Hiroshi Kimura3, Hiroshi Ochiai2 (1. Graduate School of Systems Life Sciences, Kyushu university, 2. Division of Gene Expression Dynamics, Medical Institute of Bioregulation, Kyushu University, 3. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)
[2P-117]Analysis of the histone H3 variants in mouse germ cell lineage
○Takumi Ando1, Takashi Ishiuchi1 (1. University of Yamanashi)
[2P-118]Analysis of a novel protein complex regulating H3K9me2-induced anti-silencing
○Soichi Inagaki1, Mami Hirayama1, Yuriko Tanaka1 (1. Graduate School of Science, The University of Tokyo)
[2P-119]Genome sequencing and single-cell super-resolution imaging reveal early chromatin architecture remodeling induced by HRAS activation
○Takato Sasaki1, Ren Hanake1, Ryusuke Nozawa2, Toru Hirota2, Takehiko Itoh1 (1. Sch. of Life Sci. and Tech., Science Tokyo, 2. Div. Exp. Path. Cancer Inst., JFCR)
[2P-120]Phenotypic Analysis of H2A.Z-Deficient C. elegans: Visualization by Synchrotron X-ray Imaging
○Yukako Oma1,2, Natsumi Horii1, Masahiko Harata1,2,3, Yuki Takayama3,1,2 (1. Tohoku Univ., 2. A-Sync, 3. SRIS)
[2P-121]Effects of Histone Chaperones MCM2 and ASF1 on Nucleosomal DNA Uwrapping Revealed by Optical Tweezers Analysis
○Tomoko Sunami1, Kohji Hizume2, Amarjeet Kumar1, Hidetoshi Kono1,3 (1. MMS, iQLS, QST, 2. BRC, Med, Saitama Med U, 3. cQUEST, Chiba U)
[2P-122]Development of live imaging probes specific to histone modifications and analysis of H3K27ac dynamics
○Daiki Maejima1, Timothy J. Stasevich2,3, Hiroshi Kimura1,3 (1. Science Tokyo, 2. Colorado State University, 3. Cell Biology Center, Institute of Integrated Research, Science Tokyo)
[2P-123]Loss-of-function mutation of NSD2 is associated with abnormal placentation accompanied by fetal growth retardation in mice
○Eriko Ohnishi1,3, Shiori Kinoshita1, Kazuhiko Nakabayashi1, Kenichiro Hata1,2, Tomoko Kawai1 (1. Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, 2. Department of Human Molecular Genetics, Gunma University Graduate School of Medicine, 3. Department of Neurosurgery, Yamaguchi University School of Medicine)
[2P-124]Construction of artificial cell nuclei in mouse oocytes using in vitro DNA methylated T4 phage DNA
○Mitsuki Fuseya1, Nao Yonezawa1, Haruka Oda1, Kazuo Yamagata1 (1. KINDAI Univ.)
[2P-125]Polycomb Complexes Possess a Distinct Mode of Regulating Cohesin Loop Extrusion through Stalling
○Ryo Onishi1, Nayuta Yakushiji-Kaminatsui1, Shinsuke Ito1, Haruhiko Koseki1 (1. RIKEN Center for Integrative Medical Sciences)
[2P-126]Development of a Live-Cell Imaging Probe Specific for γH2AX at DNA Double-Strand Break Sites
○Fuya Endo1, Daiki Maejima1, Kimura Hiroshi2 (1. Institute of Science Tokyo, 2. Cell Biology Center, Institute of Integrated Research Institute of Science Tokyo)
[2P-127]Effects of retrotransposon activity in germ cells of middle-aged male mice on their offspring
○Kazue Kakiuchi1, Moe Shimizu1, Hiroshi Kubota1 (1. Kitasato Univ.)
[2P-128]Identification of factors controlling the maintenance and fluctuation of X chromosome inactivation
○Rena Hasegawa1, Hiroshi Kimura1,2 (1. Institute of Science Tokyo, School of Life Science and Technology, 2. Institute of Science Tokyo, Institute of Integrated Research, Cell Biology Center)
[2P-129(2PS-11-02)]Structural analysis of RNA polymerase II transcribing chromatin by ChIP-cryoEM
○Tomoya Kujirai1,2, Junko Kato1, Kyoka Yamamoto1, Seiya Hirai1, Lumi Negishi1, Mitsuo Ogasawara1, Yuki Yamaguchi3, Yoshimasa Takizawa1, Hitoshi Kurumizaka1,2 (1. Univ. Tokyo, 2. RIKEN, 3. Sci. Tokyo)
[2P-130]Mammalian Mediator subunit MED19 functionally interacts with GATA1
○Miyu Kozaki1, Fuki Kumagai1, Hikaru Tsutsumi1, Asuka Tanaka1, Ueno Ayana1, Ayano Kuga1, Yuka Ohashi1, Robert G. Roeder2, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Medical Biophysics, Kobe Univ., 2. Biochem. & Mol. Biol., the Rockefeller Univ.)
[2P-131]Identification of genes regulated by the CsoR/RcnR family transcription factor FrmR
Haruka Kajimoto1, ○mutsunari iwasa1,2, Seiya Ozawa1, Reo Shimizu1, Hazuki Kurashita1, Takashi Ano1,2, Kazuki Moriguchi3, Masahiro Okanami1,2 (1. Fac. Biol. Ortd. Sci. Technol., kindai Univ., 2. Grad. Sch. Biol. Ortd. Sci. Technol., Kindai Univ., 3. Grad. Sch. Integr. Sci. Life., Hiroshima Univ.)
[2P-132]Transcriptional regulation for gene encoding lung surfactant SFTPC
○Yuto Sakurai1, Satori Kamane1, Manaka Fujieda1, Miyu Yoshimura1, Fuki Kumagai1, Momoka Sawada1, Kyoka Imoto1, Natsuki Aoto1, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Kobe Univ., 2. Rockefeller Univ.)
[2P-133]Spatially resolved high-depth transcriptome analysis of the human late-term placenta
○Risa Shimokawa1, Zhaonan Zou1, Ryuichi Kimura1, Shinya Oki1 (1. Kumamoto University)
[2P-134]MED1’s nuclear receptor recognition motifs are necessary for sustained ERα function
○Natsuki Aoto1, Kyoka Imoto1, Yuka Ohashi1, Maho Tadokoro1, Kana Endo1, Momoka Sawada1, Koya Kawaguchi1, Robert G. Roeder2, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Medical Biophysics, Kobe Univ., 2. Biochem & Mol. Biol., the Rockefeller Univ.)
[2P-135]Cell atlas of the brain of an anhydrobiotic midge: identification of a minimal essential set of genes required tofor tolerance of nervous cells to complete desiccation.
○Oleg Gusev1, Ruslan Deviatiiarov1, Zakhar Starinnov (1. Juntendo University)
[2P-136]Analysis of formaldehyde-induced RNA polymerase II transcription elongation errors and the cellular functions of its derived long noncoding RNAs.
○Reo Shimatani1, Chihiro Nakayama1, Shoko Ito1, Koshi Imami2, Takayuki Nojima1 (1. Kyushu University, 2. RIKEN Center, Integrative Medical Sciences)
[2P-137]Elucidation of NRF3-mediated amino acid starvation response in pancreatic cancer
○soga kaito1, Hirose Shuhei1, Waku Tsuyoshi2, Kobayashi Akira1,2 (1. Grad. Sch. Life and Med. Sci., Doshisha Univ., 2. Fac. Life and Med. Sci., Doshisha Univ)
[2P-138]Elucidating the mechanism of pancreatic tumor growth via amino acid starvation response mediated by transcription factor NRF3
○Hirotomo Banno1, Kaito Soga1, Katuya Satoh1, Akira Kobayashi1,2 (1. Grad. Sch.doshisha university, 2. Doshisha Univ.)
[2P-139]Investigation of the NRF3-mediated mechanism of metastasis in pancreatic cancer
○Masako Shimono1, Taiga Asano1, Akira Kobayashi1,2 (1. Grad. Sch., Doshisha Univ., 2. Fac., Doshisha Univ.)
[2P-140]Establishment of an inducible CRISPR-Cas9-based transcription factor NRF3 knockout system to elucidate the mechanism of tumor growth in pancreatic cancer
○Aoi Tomiyama1, Kazuma Kojo1, Tsunaki Hongu3, Noriko Goto3, Akira Kobayashi1,2 (1. Grad. Sch., Doshisha Univ., 2. Fac., Doshisha Univ., 3. Kanazawa Univ.)
[2P-141]Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex
○Tatsuo Yanagisawa1, Yuko Murayama1, Haruhiko Ehara1, Mie Goto1, Mari Aoki1, Shun-ichi Sekine1 (1. RIKEN Center for Integrative Medical Sciences (IMS), Laboratory for Transcription Structural Biology)
[2P-142]Mechanism of Pol II pause-release mediated by MED26 N-terminal domain.
○Nanami Yasui1, Hidefumi Suzuki1, Ryota Abe1, Hidehisa Takahashi1 (1. Yokohama City Univ.)
[2P-143]Induction of the zinc finger transcription factor GATA2 promotes kidney inflammation-related gene expression
○Jun Takai1, Hinata Ueki1, Satoshi Uemura1 (1. Tohoku Medical and Pharmaceutical University)
[2P-144]Highly efficient selection of high-producing cells using inducible-expression technology
○Kenya Omori1, Keina Yamaguchi1, Daichi Fujikawa2, Hakuto Ietaka1, Yuto Takeda1, Yuka Toyama1, Kanako Kanai1 (1. Kyowa Kirin Co., Ltd., 2. Orchard Therapeutics Plc.)
[2P-145]Synergistic transcriptional regulation of human β4-galactosyltransferase 3 by transcription factors Sp3 and N-Myc underlying malignant phenotype acquisition in neuroblastoma
○Takeshi Sato1, Yuki Ueno1, Ryo Yamaguchi1, Taishi Kato1, Riho Tange1 (1. Lab. of Glycobiol., Nagaoka Univ. of Technol.)
[2P-146]Exploration of Human Epidermal Promoters with Granular Layer-Specific Activity
○Shusaku Katagiri1, Yuichi Araki, Takeshi Matsui1 (1. Tokyo University of Technology Graduate School of Bionics, Computer and Media Sciences, Bionics Program, Laboratory for Evolutionary Cell Biology of the Skin)
[2P-147]Integrative Analysis of Transcription Start Sites and Full-Length Transcripts
○Tomoe Nobusada1, Jundai Miwa1,2, Takeya Kasukawa1 (1. RIKEN IMS, 2. Grad Sch Med Life Sci, Yokohama City Univ)
[2P-148]A Key Enhancer That Coordinates the Activity of Multiple Elements in a Cardiac Super-Enhancer
○Hyejin Jo1, Ken Matsuoka1,2, Hijiri Inoue1, Osamu Tsukamoto3, Seiji Takashima1,2 (1. Dep. of Front. Bio., Osaka Univ., 2. Dep. of Med., Osaka Univ., 3. Dep. of Biochem., Hyogo Medical Univ.)
[2P-149]Structural analysis of the RNA polymerase II–DSIF–NELF complex paused at the entrance of the +1 nucleosome
○Masahiro Naganuma1, Tomoya Kujirai2,1, Haruhiko Ehara1, Tamami Uejima1, Tomoko Ito2, Mie Goto1, Mari Aoki1, Masami Henmi1, Sayako Kohno1, Mikako Shirouzu1, Hitoshi Kurumizaka2,1, Shun-ichi Sekine1 (1. RIKEN IMS, 2. UTokyo IQB)
[2P-150]The Drosophila ZAD zinc finger protein Mulberry shapes genome topology and gene activity in the early embryo
○Yusuke Umemura1,2, Takashi Fukaya1,2 (1. Laboratory of Transcription Dynamics, Research Center for Biological Visualization, Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo)
[2P-151]Live−cell single−gene imaging reveals coordinated p300&fraslHDAC dynamics that fine−tune transcriptional bursting
○Xiaohui Gao1, Hiroshi Kimura2,3, Hiroshi Ochiai1 (1. Division of Gene Expression Dynamics, Medical Institute of Bioregulation, Kyushu University, 2. School of Life Science and Technology, Institute of Science Tokyo, 3. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)
[2P-152]Effects of a solitary LTR in the KIT gene of Dominant White domestic cats on gene expression
○Reo Hayashi1, Sayumi Shimode1, Takashi Yamamoto1, Naoaki Sakamoto1, Akinori Awazu1 (1. Hiroshima University)
[2P-153]High-resolution time-series ChIP-seq analysis of RNA polymerase II elongation rates with hidden Markov models
○Junichi Sakatsume1,2, Mika Kobayashi3, Akashi Taguchi3, Youichi Nakata3, Takahide Kohro4, Youichiro Wada3, Sohei Tasaki5, Hiroshi Kimura6, Ryuichiro Nakato1,2 (1. CBMS, GSFS, The Univ. of Tokyo, 2. IQB, The Univ. of Tokyo, 3. ISC, The Univ. of Tokyo, 4. School of Medicine, Jichi Medical Univ., 5. Grad. School of Science, Hokkaido Univ., 6. Cell Biology Center, IIR, Science Tokyo)
[2P-154]The spatiotemporal dynamics of Ser2-phosphorylated RNA polymerase II in mouse tissues
○Yukino Kudo1, Mika Saotome2, Yuko Sato3, Hiroshi Kimura1,2 (1. School of Life Science and Technology, Institute of Science Tokyo., 2. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo., 3. Medical Institute of Bioregulation, Kyushu University.)
[2P-155]Heat induced expression of the EGFP gene in the cricket Gryllus bimaculatus
○Yuki Nakamura1, Sayuri Tomonari1, Kazuma Miura2, Takahito Watanabe1, Sumihare Noji3, Taro Mito1 (1. Bio-Innovation Research Center, Tokushima University, 2. Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, 3. EvoDvo Tech Inc.)
[2P-156]Development of an RNA Design Platform for Precise Control of Synthetic Gene Circuits by Manipulating RNA Half Life
○Hidekazu Hishinuma1, Hideyuki Shimizu1,2 (1. Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[2P-157]N6-methyladenosine (m6A) modification facilitates decay of NSC gene transcripts in the Drosophila larval brain
○Hideyuki Komori1, Aifu Li1, Anuradha Chimata Venkatakrishnan1, Kin Fai Au1, Cheng-Yu Lee1 (1. Univercity of Michigan)
[2P-158(2PS-07-02)]Environmental RNA as a biomonitoring tool for coral reef heat stress
○Anna Rudyk1, Hyuga Houtoku1, Mikito Murakami1, Fei Xia1, Gaurav Shimpi1, Nina Yasuda1 (1. The University of Tokyo)
[2P-159(2AS-03-05)]Investigation of the structure and interaction of an RNA aptamer targeting α-synuclein using NMR
○XIANG LI1,2, Yudai Yamaoki1,2, Takashi Nagata1,2, Kazuma Murakami3, Masato Katahira1,2 (1. Institute of Advanced Energy, Kyoto University, 2. Graduate School of Energy Science, Kyoto University, 3. Graduate School of Agriculture, Kyoto University)
[2P-160]Elucidation of the sulfur transfer mechanism of tRNA 4-thiouridine synthetase in the thermophilic eubacterium Thermus thermophilus
○Shun Inoue1, Sota Yamasaki1, Yuzuru Sugio1, Hiroyuki Hori1, Ryota Yamagami1 (1. Ehime univ.)
[2P-161]New long non coding RNA L-IST reduces cellular reducing power
○Nazuna Uchiyama1, Yuichiro Mita2, Noriko Noguchi1 (1. Doshisha University, 2. Doshisha Univ.)
[2P-162]tRNA-Mediated Suppression of Temperature-Sensitive Mutants of Mcb1 (MCM-BP) in Fission Yeast
○Novio Ananti Yusril1, Meyga Feybbi Lakukua1, Shiho Ogawa1,2, Katsunori Tanaka1,2 (1. Department of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University., Japan, 2. Department of Biosciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Japan)
[2P-163]Unraveling the epitranscriptomic codes of alternative splicing using long-read sequencing technology
○Boyi Yu1, Genta Nagae2, Keisuke Yamada2,3, Kenji Tatsuno2, Akihide Yoshimi4, Hiroyuki Aburatani2, Hiroki Ueda1 (1. Advanced Data Science Division, RCAST, UTokyo, 2. Genome Science & Medicine Division, RCAST, UTokyo, 3. Department of Neurosurgery, UTokyo, 4. Cancer RNA Research Division, National Cancer Center Research Institute)
[2P-164]Deep Learning Design of Synthetic 5′UTRs for Programmable mRNA Translation
○Michitaka Kinoshita1,2,3, Shunsuke Sumi3,4, Michiaki Hamada3,5, Hirohide Saito1,4 (1. CiRA, KU, 2. Kyoto Univ., 3. Waseda Univ., 4. IQB, UTokyo, 5. CMB, AIST)
[2P-165]CRISPRi-based Identification of Functional lncRNAs Essential for Lung Adenocarcinoma Cell Viability
○Saki Fujiwara1, Naoko Fujiwara1, Chao Zeng2, Junichi Iwakiri3, Michiaki Hamada2, Kiyoshi Asai3, Tetsuro Hirose1,4 (1. FBS, Univ. Osaka., 2. Sci. Eng, Waseda Univ., 3. GSFS, Univ. Tokyo., 4. OTRI, Univ. Osaka.)
[2P-166]Pseudouridine Modification of Transfer-Messenger RNA in Thermus thermophilus Strain HB8
○Tomohiro Nishi1, Kyosuke Fukuda1, Mone Nobeoka1, Yusuke Kuwana1, Kohsuke Kamizaki1, Shizuka Arakawa1, Ryota Yamagami1, Hiroyuki Hori1 (1. Ehime Univ.)
[2P-167]Effects of nucleolar stress on mRNA metabolism
○Fumito Hori1, Kumiko Takemori1, Seiji Masuda1 (1. Kindai Univ.)
[2P-168(2PS-04-02)]Analyzing the functional domains of MALAT1 noncoding RNA under heat shock response
○Tian Xia1,2, Rena Onoguchi-Mizutani2, Shungo Adachi3, Nobuyoshi Akimitsu1,2 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Isotope Science Center, The University of Tokyo, 3. National Cancer Center Research Institute)
[2P-169]Xrn2-dependent rapid tRNA decay pathway in animals
○Keita Miyoshi1,2, Kiito Otsubo1,2, Shunya Kaneko1, Makoto Terauchi3, Yuki Hatoyama4, Hideki Noguchi3, Masato T Kanemaki4,5, Kuniaki Saito1,2 (1. Inverte Genet Lab, Dept of Chr Sci, Natl Inst Genet, ROIS, 2. SOKENDAI, 3. RIOS-DS, 4. Mol Cell Engineering Lab, Dept of Chr Sci, Natl Inst Genet, ROIS, 5. Dept Biol Sci, Grad Sch Sci, Univ of Tokyo)
[2P-170]The tRNA pseudouridine synthase TruD from Thermus thermophilus acts not only on tRNA but also on other types of RNA.
○Kojiro Takahashi1, Ryota Yamagami1, Shogo Shingu1, Miyu Namba1, Kohsuke Kamizaki1, Hiroyuki Hori1 (1. Ehime University Graduate School)
[2P-171]The relationship between parasites and the diversification of RNA species in an experimental evolution of self-replicating RNA
○Yuki Kanai Kanai1, Norikazu Ichihashi1,2 (1. KIS, UTokyo, 2. Grad. Arts & Sci., UTokyo)
[2P-172]TRBP regulates antiviral stress granule formation and innate immune responses
○Monami Sakai1, Koji Onomoto1, Miyu Watanabe1, Akira Fukao2, Yurika Sakamura2, Mai Miyao2, Takumi Tomohiro2, Akio Yamashita3, Toshinobu Fujiwara2, Tomoko Takahashi4, Kumiko Ui-Tei5,6, Mitsutoshi Yoneyama1,7 (1. Chiba Univ., 2. Kindai Univ., 3. Ryukyus Univ., 4. Saitama Univ., 5. Institute of Science Tokyo, 6. Tokyo Univ., 7. Research Institute of Disaster Medicine, Chiba Univ.)
[2P-173]The third biosynthesis pathway of 4-thiouridine in tRNA
○Sota Yamasaki1, Yuzuru Sugio1, junya Ueda1, Ryo Isogai1, Natsumi Matsumoto1, Takuya kawamura1, Chie Tomikawa1, Minoru Hayashi1, Ryota Yamagami1, Akira Hirata2, Satoshi Ohno3, Takashi Yokogawa3,4,5, Hiroyuki Hori1 (1. Graduate School of Science and Engineering, Ehime University, 2. Graduate School of Technology, Industrial and Social Science, Tokushima University, 3. Faculty of Engineering, Gifu University, 4. Tokai National University Organization, Research and Education Center for the Development and Fostering of One Medicine Seeds, 5. The United Graduate School of Drug Discovery and Medical Informatics, Gifu University)
[2P-174]Development of a Comprehensive Analysis Method for Newly Synthesized tRNA Using MTSEA Biotinylation and Next Generation Sequencing and Application to Heat Stress Response Mechanisms
○Futa Konishi1, Yuji Furutani2, Teppei Matsuda1, Takashi Ohtsuki2, Hiroyuki Hori1, Kazunori Watanabe2, Ryota Yamagami1 (1. Graduate school of science and engineering, Ehime University, 2. Graduate School of Interdisciplinary Science and Engineering in Health Systems)
[2P-175]The study of molecular details of the interaction between alpha Synuclein and G4RNA
○YIRAN CHEN1, Yasushi Yabuki2, Norifumi Shioda2, Hidehito Tochio1 (1. Kyoto University, 2. Kumamoto University)
[2P-176]Analysis of the Interaction between the 5′-Proximal Region of SARS-CoV-2 genomic RNA and the Nucleocapsid Protein
○Shinnosuke Saito1,2, Kimura Takahiro1,2, Shion Ishikawa1,2, Takuya Katayama1,2, Yuuhei Yamano1, Kazumitsu Onizuka1,3, Fumi Nagatsugi1,3, Yuji Itoh1,2,3, Satoshi Takahashi1,2,3 (1. IMRAM, Tohoku Univ., 2. Grad. Sch.Life Sci., Tohoku Univ., 3. Grad. Sch.Sci., Tohoku Univ.)
[2P-177]Energy Parameter Estimation for RNA Secondary Structure Using SHAPE Reactivity and Loop-Context Probabilities
○Takumi Otagaki1, Goro Terai1, Junnichi Iwakiri1, Kazuteru Yamamura1, Kiyoshi Asai1 (1. University of Tokyo, Graduate School of Frontier Sciences, Computational Biology and Medical Sciences)
[2P-178]Production of high titre single-round infectious particles for detection of neutralizing antibodies against Orthoflavivirus
○Cynthia Sipho Khumalo1,2, Yukari Itakura 2, Chinatsu Nakamura 2, Kaito Maeda 1,2, Gabriel Gonzalez3, Shinji Saito2, Hirofumi Sawa1,2,4, Koshiro Tabata 2 (1. Graduate school of Infectious Diseases, Hokkaido University, 2. Department of Biological Response Analysis, Institute for Vaccine Research and Development, Hokkaido University, Japan, 3. Department of Research Support, Institute for Vaccine Research and Development, Hokkaido University, Japan, 4. One Health Research Centre, Hokkaido University, Japan)
[2P-179]Graph Contrastive Learning with Secondary Structure Information for ncRNA Representation
○HIROKO Honda1, Michiaki Hamada1 (1. Waseda University)
[2P-180]Understanding Cold and Hot Syndromes through Analysis of Herbal Medicine-Induced Transcriptomes
○Mizuki Isago1, Michiaki Hamada1,2,3 (1. Faculty of Science and Engineering, Waseda University, 2. Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology (AIST), 3. Graduate School of Medicine, Nippon Medical School)
[2P-181]NMD escape through alternative intronic polyadenylation in the VRK3 gene
○Antonina Kuznetsova1, Maria Vlasenok1, Dmitry Skvortsov1, Dmitri Pervouchine1 (1. Skolkovo Institute of Science and Technology)
[2P-182]METTL3 contributes to osimertinib resistance via stabilization of CDC25A and AURKB mRNA in EGFR-mutant NSCLC
○Ryusuke Suzuki1, Akihiko Ishimura1, Takeshi Suzuki1 (1. Div.Func.Gen., Cancer Res. Inst., Kanazawa Univ.)
[2P-183]Expression pathways of stress-response factors that suppress translational activity in Escherichia coli
○Hideji Yoshida1, Tomohiro Shimada2, Yasushi Maki1, Shou Furuike1 (1. Osaka Med. Pharm. Univ., 2. Meiji Univ.)
[2P-184]Regulation of translational speed by the non-essential ribosomal protein RPL41
○Mina Hirata1, Kazuya Ichihara1, Maho Fujino2, Takeshi Yokoyama2, Akinobu Matsumoto1 (1. Nagoya University, 2. Tohoku University)
[2P-185(2PS-02-07)]Sperm-specific regulatory mechanism of translation by TCP11
○Taichi Shiraishi1, Chisa Shiraishi1, Kazuya Ichihara1, Sakurako Goto2, Takuhiro Ito2, Koshi Imami3, Akinobu Matsumoto1 (1. Nagoya university, 2. RIKEN, 3. RIKEN.)
[2P-186]Elucidation of the physiological roles of TruA in Thermus thermophilus
○Shogo Shingu1, Rikimaru Shinkawa2, Kousuke Kamizaki1, Hiroyuki Hori1, Ryota Yamagami1 (1. Ehime Univ., 2. Ehime)
[2P-187(2MS-09-03)]Physiological Roles of ABCF Translation Factors That Alleviate Bottlenecks in Protein Synthesis
○Yuhei Chadani1, Kohei Yamasaki2, Kosei Kawamoto2, Tatsuya Nonaka3 (1. Okayama Univ. Fac. of Env. Life. Nat. Sci. and Tech, 2. Okayama Univ. Grad. Sch. of Env. Life. Nat. Sci. and Tech, 3. Okayama Univ. Fac. of Sci.)
[2P-188(2PS-02-04)]Regulation of ribosome collisions and ER-targeted translation by PELO
○Momoko Narita1, Sota Ito1, Satoshi Hashimoto1, Chisato Kikuguchi1, Toru Suzuki1, Toshifumi Inada1 (1. The Institute of Medical Science, The University of Tokyo)
[2P-189]Regulation of mRNA Fate by Developmental Stage–Dependent Changes in Transcription and Translation Start Sites in Arabidopsis thaliana.
○Hiroto Michishita1, Tomoko Kuriyama2, Masaharu Kawauchi2, Minami Matsui2,3, Yuko Makita1,2, Yukio Kurihara1,2 (1. Maebashi Tech, 2. RIKEN CSRS, 3. KIBR YCU)
[2P-190]Visualization of multiple translation frame in Repeat Associated Non-AUG (RAN) translation involved in neurodegenerative diseases at single mRNA level in living cells
○Hayato Ito1, Timothy J Stasevich2, Yoshitaka Nagai4, Hideki Taguchi1,3 (1. Science Tokyo, Sch. Life Sci. Tech., 2. Colorado State Univ, Dept. of BMB, 3. Science Tokyo, IIR, CBC, 4. Kindai Univ., Med.)
[2P-191(2PS-02-06)]Investigation of molecular mechanism of ATXN8OS CUG repeat-associated non-AUG translation
○Soyoka Sakamoto1, Hayato Ito1, Mayuka Hasumi1, Makito Hirano2, Yoshitaka Nagai2, Hideki Taguchi3 (1. Institute of Science Tokyo, 2. Kindai University, 3. Science Tokyo)
[2P-192]Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor’s loss
○Soichiro Hoshino1, Chika Tomisawa1, Hidehiko Shimizu1, Masashi Abe1, Sho Arai1, Kanako Kuwasako2, Naoki Asakawa1, Yusuke Inoue1, Takuro Horii3, Izuho Hatada3,4, Masakastsu Watanabe5,6, Nameki Nobukazu1 (1. Grad. Sch. of Sci. and Tech., Gunma Univ., 2. Fac. of Pharm., Musashino Univ., 3. IMCR, Gunma Univ., 4. GIAR, Gunma Univ., 5. CeSPI, Nagoya Univ., 6. Grad. Sch. of Pharm. Sci., Nagoya Univ.)
[2P-193]Development of a Prokaryotic–Eukaryotic Hybrid Cell-Free Translation System
○Kodai Machida1, Tomoki Muto1, Hiroaki Imataka1 (1. Dept. of Appl. Chem., Grad. Sch. of Eng., Univ. of Hyogo)
[2P-194]The spatial and sequential regulation of mRNA translation during early zebrafish development
○Keisuke Sato1, Tomoya Kotani1 (1. Hokkaido Univ.)
[2P-195]Mechanistic insights into ribosome subunit abundance regulation in response to translation failure and cellular stress
○Alexander Landis1, Chisato Kikuguchi1, Sihan Li1, Toru Suzuki1, Toshifumi Inada1 (1. Division of RNA and Gene Regulation, Institute of Medical Science, University of Tokyo)
[2P-196(2MS-09-02)]Induction mechanism of a cellular fitness determinant by a ribosomal protein
○Bungo Kakemura1, Hiroshi Kanda1, Shiori Ueda1, Ryo Matsumoto1, Satoshi Yasuhara2, Rina Nagata1, Kiichiro Taniguchi1, Shu Kondo3,4, Keita Miyoshi4, Akie Kobayashi5, Kazuhiro Takeuchi2, Kuniaki Saito4, Makoto Matsuyama5, Yasuhiro Murakawa2, Tatsushi Igaki1 (1. Lab of Genetics, Graduate School of Biostudies, Kyoto University, 2. Institute for the Advanced Study of Human Biology (ASHBi), 3. Faculty of Advanced Engineering, Tokyo University of Science, 4. Invertebrate Genetics Laboratory, National Institute of Genetics, 5. Division of Molecular Genetics, Shigei Medical Research Institute)
[2P-197]Exploration of eIF3D target genes in adult T-cell leukemia/lymphoma (ATL)
○Boyang Liu1, Rei Gibu1, Makoto Yamagishi1 (1. The University of Tokyo)
[2P-198]Analysis of the growth status of H. pylori and their ribosomes
○Yasushi Maki1, Tomohiro Miyoshi2, Tatsuya Niwa3, Shou Furuike1, Takehito Tanzawa4, Hitomi Mimuro2, Hideji Yoshida1 (1. Osaka Medical and Pharmaceutical Univ., 2. Oita Univ., 3. Institute of Science Tokyo, 4. The University of Osaka)
[2P-199]Development of capping strategies for circular mRNA
○Fumitaka Hashiya1, Kosuke Fukuchi2, Shiryu Kajihara2, Mizuki Tada2, Zheyu Meng2, Yuko Nakashima2, Tairin Kawasaki2, Seigo Kimura2, Masahito Inagaki2, Naoko Abe2, Satoshi Uchida3,4, Yasuaki Kimura2, Hiroshi Abe1,2,5 (1. Research Center for Materials Science, Nagoya University, 2. Graduate School of Science, Nagoya University, 3. Medical Research Institute, Institute of Science Tokyo, 4. Innovation Center of NanoMedicine (iCONM), 5. Institute for Glyco-core Research (iGCORE), Nagoya University)
[2P-200]Application of the split-luciferase system to detect ribosome collisions in zebrafish
○Takara Kagei1, Yuichiro Mishima1 (1. Division of Life Sciences, Graduate School of Life Science, Kyoto Sangyo University)
[2P-201]Elucidation of Yeast Growth Inhibition Mechanism through Interaction Analysis between Leucyl-tRNA Synthetase and Isobutanol
○Mano Hasegawa1, Kaho Hitomi2, Nodoka Oshimura1, Ayako Furukawa1, Kenji Sugase1, Kouichi Kuroda3 (1. Kyoto Univ., 2. Kyoto Univ., 3. Kyoto Institute of Technology Univ.)
[2P-202]Cryo-EM analysis of DOCK3 toward understanding of the activation mechanism of its activators
○Yoriko Endo1,2, Mutsko Niino2, Takamitsu Hosoya3, Mikako Shirouzu1,2 (1. Yokohama City University, 2. RIKEN-IMS, 3. LBB, IIR, Science Tokyo)
[2P-203(2AS-08-05)]Establishment of a Large-Scale Quantitative Method for Protein Folding Stability via Pulse Proteolysis
○Ko Hijikawa1,2, Kotaro Tsuboyama1,2 (1. The University of Tokyo, 2. Institute of Industrial Science)
[2P-204]Structural analysis by cryo-electron microscopy using EG-grid(R)-Functional Grid and protein stabilization reagents
○Hiroki Tanino1 (1. Osaka University)
[2P-205]Applying MagIC-cryo-EM for Native Kinetochore Structure Analysis
○Mariko Ariyoshi1, Fumiaki Makino2, Yusuke Takenoshita1, Yasuhiro Arimura3, Tatsuo Fukagawa1 (1. Grad School of Frontier Sciences, Osaka Univ., 2. JEOL Ltd, 3. Fred Hutchinson Cancer Center)
[2P-206]Measurement of Mechanical Properties of Araneidae Silk for Data-Driven Design of Artificial Spider Silk
○Yasuha Watanabe1, Hiroyuki Nakamura2,1, Masaru Mori3, Kazuharu Arakawa1,4,5 (1. Institute for Advanced Biosciences, Keio University, 2. Spiber inc., 3. Institutes of Innovation for Future Society, Nagoya University, 4. Graduate School of Media and Governance, Keio University , 5. Faculty of Environment and Information Studies, Keio University)
[2P-207]Conformational alteration of DOCK signalosome on lipid membrane
○Takehiro Shinoda1, Kazushige Katsura1, Yoshiko Ishizuka-Katsura1, Kazuharu Hanada1, Mayumi Yonemochi1, Yuki Miyamoto2, Mutsuko Kukimoto-Niino1, Junji Yamauchi3, Mikako Shirouzu1,4 (1. RIKEN IMS, 2. NCCHD, 3. Tokyo Univ. of Pharmacy and Life Sciences, 4. RIKEN BDR)
[2P-208]Engineering of the Glycan-Binding Protein Domain sPSL1a Using the Deep Learning-Based Program ProteinMPNN
○Yui Ikeo1, Shota Uchida1, Norifumi Kawakami2, Hiroaki Tateno3, Ryoichi Arai1,4 (1. Dept. of Appl. Biol., Fac. of Textile Sci. and Tech., Shinshu Univ, 2. Dept. of Biosci. Info., Fac. of Sci. and Tech., Keio Univ, 3. Cell. and Mol. Biotech. Res. Inst., AIST, 4. Inst. for Biomed. Sci., Shinshu Univ.)
[2P-209]Expression, purification and structural-functional analysis
of the Escherichia coli L-arabinose transporter AraE
○Yuta Nojiri1, Suguru Okuda1, Kenta Tsutsumi1, Ken Okamoto1, Hiroshi Kawakami1, Hideaki Itoh1, Peng Lu1, Koji Nagata1 (1. Graduate School of Agricultural and Life Sciences, The University of Tokyo)
[2P-210]Analysis of interaction characteristics of the plant receptor KAI2 using molecular docking methods.
○Keino Mizukami1, Xiaonan XIE1, Yoshinori Fukasawa1 (1. Utsunomiya University)
[2P-211]Comprehensive analysis of the site-specific effects of aspartate D-isomerization on the seeding activity of amyloid-β
○Takuya Murata1, Naoko Utsunomiya-Tate1 (1. Teikyo University)
[2P-212]Selectivity profiling of DYRK1A kinase inhibitors against DYRK2using the temperature vaulting method
○Natsumi Yamada1, Sora Suzuki2, Nanae Fukahori1, Ninako Kimura1, Yuta Komiyama3, Isao Kii1,2,3 (1. Department of Agriculture, Graduate School of Science and Technology, Shinshu University, 2. Graduate School of Medicine, Science and Technology, Shinshu University, 3. Faculty of Agriculture, Shinshu University)
[2P-213]Cross-linking mass spectrometry for structural analysis of protein complex.
○Tatsuya Niwa1 (1. CBC, IIR, Science Tokyo)
[2P-214]Single molecule observation of structural dynamics underlying tetramerization of tumor suppressor p53
○Mahiro Hiraoka1, Kotone Matsubara1, Mizuho Nakayama1,2, Ryo Takahashi3, Kohei Shiba3, Kenichi Umeda1, Hiroki Konno1, Noriyuki Kodera1, Toshio Ando1, Masanobu Ohshima1,2, Takahiro Watanabe Nakayama1 (1. WPI-Nano Life Science Institute, Kanazawa University, 2. Cancer Research Institute, Kanazawa University, 3. Refeyn Japan, K.K.)
[2P-215]Development of a Crystal Contact Classification Method Using Point Cloud-Based Structural Features and Protein Language Models
○Sara Nozawa1, Kentaro Tomii2, Yoshinori Fukasawa1 (1. Utsunomiya University, 2. AIST)
[2P-216]Solution structure of the N-terminal divergent caplonin homology (NN-CH) domain of human intraflagellar transport protein 54 (IFT54) and comparison with tubulin-binding domains
○Kanako Kuwasako1,2,3,4, Dang Weirong3, He Fahu2,3, Mari Takahashi2,3,4, Kengo Tsuda2,3,4, Takashi Nageta2,5, Akiko Tanaka2, Naohiro Kobayashi2,6, Takanori Kigawa2,4, Peter Güntert7,8,9,10, Mikako Shirouzu2,3,4, Shigeyuki Yokoyama3,11,12, Yutaka Muto1,2,3,4 (1. Fac. of Pharm., Musashino Univ., 2. RIKEN CLST, 3. RIKEN SSBC, 4. RIKEN BDR, 5. Inst. Adv. Energy, Kyoto Univ., 6. RIKEN Yokohama NMR Facility, 7. Tatsuo Miyazawa Memorial Program, RIKEN GSC, 8. Inst. Biophys. Chem., Goethe Univ., 9. Lab. Phys. Chem., ETH Zurich, 10. Dept. Chem., Tokyo Metropolitan Univ., 11. RIKEN SBL, 12. Present address: Dept. of Struct. Biol. & Biochem., Science Tokyo)
[2P-217]Multifunctionalization of Protein Nanobuilding Block Complexes Using Protein Conjugation Systems
○Yu Fujisaki1, Satsuki Takahashi1, Raizo Yamamoto1, Naoya Kobayashi2, Ryutaro Asano3, Masafumi Sakono4, Hiroaki Tateno5, Masahiro Kawahara6, Ryoichi Arai1,7 (1. Dept. of Appl. Biol., Fac. of Textile Sci. and Tech., Shinshu Univ., 2. Div. of Mater. Sci., Grad. Sch. of Sci. and Tech, NAIST, 3. Dept. of Biotech. and Life Sci., Grad. Sch. of Eng., Tokyo Univ. of Agri. and Tech., 4. Dept. of Appl. Chem., Fac. of Eng., Univ. of Toyama, 5. Cell. and Mol. Biotech. Res. Inst., AIST, 6. Dept. of Chem. and Life Sci., Sch. of Adv. Eng., Kogakuin Univ., 7. Div. of Life Innov., Inst. for Biomed. Sci., Shinshu Univ.)
[2P-218]Accelerating DARUMA, a prediction model for intrinsically disordered regions
○Itsuki Shimizu1, Hiroto Anbo1, Satoshi Fukuchi1 (1. Maebashi Institute of Technology)
[2P-219]Development of Oral Subunit Vaccine Platform Using Silkworm Baculovirus Expression Vector System
○Kaori Wada1, Daiki Kaneko1, Akitsu Masuda2, Hiroaki Mon2, Ryosuke Fujita2, Fuji Tsuguru2, Hino Masato2, Kusakabe Takahiro2, Jaeman Lee2 (1. Grad. Sch. of Biores. Bioenv. Sci., Kyushu Univ., 2. Fac. Agr., Kyushu Univ.)
[2P-220]Structural analysis of substrate recognition site mutants of mitochondrial AAA-ATPase Msp1
○Sana Ogushi1, Tomoyuki Numata2, Shunsuke Matsumoto2 (1. Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 2. Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University)
[2P-221]Structure–Function Analysis of Designed Peptides Targeting the Bam Complex
○Takaaki Kato1 (1. Kobe University)
[2P-222]Analysis of Complex Formation Between the Ceramide Transport Protein CERT and the Membrane Contact Site-associated Protein VAP
○Yuki Murao1, Tatsuya Fujita1, Sayori Morita1, Ryo Watanabe1, Shuhei Sakurabayashi1, Chojiro Kojima1 (1. Yokohama National University)
[2P-223(2AS-14-07)]Structural and Functional Analysis of KnChR: A Blue-shifted Channelrhodopsin
○Wang Z. Yuzhu1, Natsume Koki2, Tanaka Tatsuki1, Akasaka Hiroaki1, Sano K. Fumiya1, Hososhima Shoko2,3, Shihoya Wataru4, Tsunoda P. Satoshi2,3, Kandori Hideki2,3, Nureki Osamu1 (1. Graduate School of Science, The University of Tokyo, 2. Graduate School of Engineering, Nagoya Institute of Technology, 3. Opto Bio Technology Research Center, Nagoya Institute of Technology, 4. Keio University School of Medicine)
[2P-224]Crystal Structures of Antigen-Binding Fragment (Fab) of Anti-Osteocalcin Antibody KTM219: Structural Basis for Quenchbody (Q-body)
Shuma Yazaki1, Misaki Komatsu1, Jinhua Dong2,3, Hiroshi Ueda2, ○Ryoichi Arai1,4 (1. Fac. of Textile Sci. and Tech., Shinshu Univ., 2. Lab. for Chem. & Life Sci., Tokyo Tech., 3. Univ. of Health & Rehabilitation Sci., 4. Inst. for Biomed. Sci., Shinshu Univ.)
[2P-225]Cryo-EM analysis of refolding hook protein upon flagellar assembly
○Yuki Hino1,2, Mao Oide2, Takayuki Kato2 (1. The University of Osaka, 2. IPR, The University of Osaka)
[2P-226]Cryo-EM Reveals the Mechanism of Activity Enhancement by Domain Rearrangement in Bispecific Antibodies
○Kyohei Sato1, Shiro Uehara1, Atsushi Tsugita1, Mayuka Ishii2, Shieru Ishiyama3, Atsushi Maejima2, Ishin Nakahara2, Misae Nazuka2, Takashi Matsui4, Christos Gatsogiannis5, Takeshi Yokoyama1, Izumi Kumagai2, Koki Makabe3, Ryutaro Asano2, Yoshikazu Tanaka1 (1. Tohoku Univ., 2. Tokyo Univ. of Agriculture and Technology, 3. Yamagata Univ., 4. Kitasato Univ., 5. Univ. of Münster)
[2P-227]Structural analysis of human aquaporin-8 using single-particle cryo-electron microscopy
○Yukihiro Tanimura1, Shota Suzuki1, Akiko Kamegawa1, Kouki Nishikawa2, Yoshinori Fujiyoshi1 (1. CeSPL, Science TOKYO, 2. JRC, TUAT)
[2P-228]Structural Insights into NlpI-Mediated Regulation of the Cell Wall Endopeptidase MepM
○SHIOU RU TZENG1, SI WEI WANG (1. National Taiwan University College of Medicine)
[2P-229]An Integrated Approach to Resolving Protein Domain Evolution Before the LUCA
○Koh Seya1, Andre Lecona Buttelli1, Tatsuya Corlett1, Hamza Giaffar2,3, Claudèle Lemay-St-Denis4, Kosuke Fujishima1,5,6, Joshua Goldford7,8,9, Shina Caroline Lynn Kamerlin10,11, Rachel Kolodny4, Eric Smith5,12,13, Liam M. Longo5,7 (1. Life Science and Technology, Institute of Science Tokyo, 2. Halicioglu Data Science Institute, 3. University of California, 4. Department of Computer Science, University of Haifa, 5. Earth-Life Science Institute (ELSI), Science Tokyo, 6. Grad.sch. of Media and Governance., Keio Univ., 7. Blue Marble Space Institute of Science, 8. Division of Geological and Planetary Sciences, California Institute of Technology, 9. Physics of Living Systems, Massachusetts Institute of Technology, 10. School of Chemistry and Biochemistry, Georgia Institute of Technology, 11. Department of Chemistry, Lund University, 12. Center for the Origin of Life, Georgia Institute of Technology, 13. Santa Fe Institute)
[2P-230]Physical Restriction on Nanoparticle Surfaces Drives Conformational Instability of Albumin
○Yuta Takahashi1, Kaumbekova Samal3, Naoya Sakaguchi1, Atsuto Onoda2, Toshiyuki Watanabe3, Masakazu Umezawa3 (1. Department of Materials Science and Technology, Graduate Scholl of Advanced Engineering, Tokyo University of Science, 2. Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 3. Department of Medical and Robotic Engineering Design, Faculty of Advanced Engineering, Tokyo University of Science)
[2P-231]Single molecule imaging of mitochondrial outer membrane fusion regulators Mfn1 and Mfn2
○Shiho Kawai1, Moe Mitamura1, Noriyuki Kodera2, Yuhei Araiso1 (1. Kanazawa university, 2. NanoLSI, Kanazawa Univ.)
[2P-232]Characterization of Ectopically Expressed Olfactory Receptors OR2A4/7 in Non-Olfactory Tissues
○Kei Yoshizawa1, Yosuke Fukutani2 (1. Dept of Advanced Interdisciplinary Science., Tokyo Univ. of Agric and Technol., 2. Dept of Biotechnol., Tokyo Univ. of Agric and Technol.)
[2P-233]Analysis of Olfactory Receptor Response Selectivity Driven by Odor Molecule Functional Groups
○Ran Asahi1, Toshiya Hayakawa2, Yosuke Fukutani1,2 (1. Dept of Advanced Interdisciplinary Science., Tokyo Univ. of Agric and Technol., 2. Dept of Biotechnol., Tokyo Univ. of Agric and Technol.)
[2P-234]Tether-dependent regulation reveals core motility mechanism of the kinesin-1 motor domain
○Rieko Sumiyoshi1, Masahiko Yamagishi1, Junichiro Yajima1 (1. Grad. Arts & Sci., Univ. Tokyo)
[2P-235]Development and ADCC activity evaluation of antigen-overexpressing cells-specific tandem multimeric VHH antibodies
○Suwandi Onggono1, Keisuke Sugimoto1, Ning Lin1, Tetsuya Kadonosono1 (1. Institute of Science Tokyo)
[2P-236]Quantitative analysis of the cleavage rate of thrombotic protein vWF by Nattokinase
○Ryuichi Hyakumoto1, Masatomo So1, Ayako Furukawa1, Kenji Sugase1 (1. Kyoto Univ.)
[2P-237]Statistical Thermodynamic Analysis for Rhodopsin Mutants Linked to Night Blindness
○Mizusa Kani1, Koki Hattori2, Satoshi Yasuda2,3, Takeshi Murata2,3, Masahiro Kinoshita2,4, Hideki Kandori1,5, Kota Katayama1,5 (1. Nagoya Institute of Technology, 2. Graduate School of Science and Engineering, Chiba University, 3. Center of Quantum Life Science for Structural Therapeutics(cQUEST), 4. Institute of Advanced Energy, Kyoto University, 5. OptoBioTechnology Research Center)
[2P-238]Generation of antimicrobial peptide sequence using deep generative models with AAindex embedded vectors
○Nobuyuki Hiraoka1, Jin Takehara2, Kodai Imaizumi2, Akira Nakayama3, Yuko Makita1,2 (1. Department of Environment and Life Engineering, Graduate School of Engineering, Maebashi Institute of Technology, 2. Department of Life Science and Informatics, Faculty of Engineering, Maebashi Institute of Technology, 3. Department of Biotechnology, Graduate School of Engineering, Maebashi Institute of Technology)
[2P-239]Cooperative roles of ERp57 and PDI family proteins in regulating protein folding
○Airu Takeuchi1,2, Motonori Matsusaki3, Tomohide Saio3, Kenji Inaba4, Shingo Kanemura1, Masaki Okumura1,2 (1. FRIS, Tohoku Univ., 2. Grad. Sch. Of Life Sci., Tohoku Univ., 3. IAMS, Tokushima Univ., 4. MIB, Kyushu Univ.)
[2P-240]Establishment of immunoassay using reconstitution of split peroxidase
○Ryosuke Noma1, Cheng Qian1, Takanobu Yasuda2, Bo Zhu2, Tetsuya Kitaguchi2 (1. LST, Science Tokyo, Kanagawa, Japan, 2. CLS, IIR, Science Tokyo, Kanagawa, Japan)
[2P-241]Alcohol and Organophosphate Metabolism in Elephants: A Transcriptomic, Kinetic, and Structural Study
○Ayuko Morita1, Kanami Watanabe1, Amnart Poapolathep2, Saranya Poapolathep2, Aksorn Saengtienchai2, Kraisiri Khidkhan2, Supaphen Sripiboon2, Kornsorn Srikulnath2, Chatchote Thitaram3, Chaleamchat Somgid3, Taweepoke Angkawanish4, Warangkhana Langkaphin4, Mitsuki Kondo5, Kazuki Takeda6, Yoshinori Ikenaka1,7,8, Shouta M.M. Nakayama1,9, Mayumi Ishizuka1 (1. Hokkaido Univ., 2. Kasetsart Univ., Thailand, 3. Chiang Mai Univ., Thailand, 4. National Elephant Institute, Thailand, 5. Kagoshima Univ., 6. Kitasato Univ., 7. One Health Research Center, Hokkaido Univ., 8. North-West Univ., South Africa, 9. Zambia Univ., Zambia)
[2P-242]Lignan metabolism in sesame seeds across germination.
○Erisa Harada1, Yukie Ohba1, Eiichiro Ono2, Jun Murata1, Akira Shiraishi1, Hiromi Toyonaga1, Toshiaki Azuma1, Toshiyuki Waki3, Masayuki P Yamamoto4, Manabu Horikawa1 (1. Suntory Foundation for Life Sciences, 2. Suntory Global Innov. Center Ltd., 3. Grad. Sch. of Eng., Tohoku Univ., 4. Grad. Sch. of Sci. and Eng., Univ. of Toyama)
[2P-243]Functional comparison between the Brevibacillus sp. DnaK chaperone system and the Escherichia coli DnaK chaperone system
○Miyako Hayashi1, Kyouhei Fukumura1, Atsushi Tabata2, Hideaki Nagamune2, Toshifumi Tomoyasu2 (1. Div. Bioresour. Sci., Grad. Sch. Sci. & Tech. for Innov., Tokushima Univ., 2. Div. Biosci. & Bioindust., Grad. Sch. Tech., Indust. & Soc. Sci., Tokushima Univ.)
[2P-244]DeepRES: Deep learning enables reaction-based comprehensive enzyme screening
○Keisuke Hirota1, Takuji Yamada1,2,3,4 (1. Institute of Science Tokyo, 2. Metagen, Inc., 3. Metagen Therapeutics, Inc., 4. digzyme, Inc.)
[2P-245]Proteomics-based determination of multiple transcriptional regulators that regulate a high cellulolytic potential of SirexAA-E
○Atsune Uesaka1, Tatsuya Nagano1, Saki Mitsumasu1 (1. Hokkaido University)
[2P-246]Identification of intramolecular regions of histone H3 involved in inducing inflammatory responses
○Kanta Kono1, Yuri Tanaka1, Ryuji Kondo1, Shawichi Iwamuro1 (1. Toho University)
[2P-247(2MS-11-03)]A Platform for the Development of E3 Ligase-Targeting Modulatory Peptides for Cancer Therapy
○Andrej Paluda1,2,3, Shun Nakamura2, Yoshinori Fujiyoshi2, Donald Cameron1, Catherine Day3 (1. University of Tokyo, Institute for Quantitative Biosciences, 2. Institute of Science Tokyo, Advanced Research Initiative, Institute of Integrated Research, 3. University of Otago, School of Biomedical Sciences, Department of Biochemistry)
[2P-248]Engineering Cytochrome P450 for Norepinephrine Biosynthesis in Escherichia coli
○Towa Takahashi1, Koko Nakata2, Toshiki Saito2, Shunsuke Takahashi1 (1. Div. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ., 2. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ.)
[2P-249]Dual-enzyme immobilization via a silica-binding protein "Si-tag" toward industrial applications
○Shun-ichi Matsuura1, Takeshi Ikeda2,3, Takako Nagase1, Osamu Satou1, Naoki Mimura1, Manami Chiba1, Shiori Abe1, Nozomi Natsui1, Aritomo Yamaguchi1 (1. Res. Inst. Chem. Proc. Technol., AIST, 2. Grad. Sch. Integr. Sci. Life, Hiroshima Univ., 3. PRESTO, JST)
[2P-250]Role of CRMP4 in cuprizone-induced demyelination mouse model
○Yunming Cao1, Ryo Ashihina1, Toshio Ohshima1 (1. Waseda university)
[2P-251]Activation Mechanism of Extracellularly Flipped Syntaxin4 as a Novel Factor in Local Signal Propagation
○Yume Inoue1, Yohei Hirai1 (1. KwanseiGakuin Univercity)
[2P-252]Development of an optogenetics tool using anion channel rhodopsin in response to red light
○Keito Minamisawa1, Shoko Hososhima1,2, Satoshi Tsunoda1,2, Hideki Kandori1,2 (1. Graduate school of engineering, Nagoya institute of technology, 2. Opto Bio Technology Research Center, Nagoya Institute of Technology)
[2P-253]Monitoring Heatstroke: A Proteomics-Based Multibiomarker Approach to Assess Potential Post-Heatstroke Complications
○Jiayi Jin1, Sing Ying Wong1, Kenta Kondo2, Toshiaki Iba2, Nobuhiro Hayashi1 (1. Institue of Science Tokyo, 2. Juntendo University Graduate School of Medicine)
[2P-254]Detection of numerous adaptive amino-acid changes
○Ichizo Kobayashi1,2,3 (1. National Institute for Basic Biology, 2. Hosei Univ. , 3. Univ. Tokyo)
[2P-255]Predicting the localization of CaMKIIα/β heterododecamers to F-actin via HS-AFM and mathematical modeling of subunit organization
○Keisuke Matsushima1, Takashi Sumikama2,3, Hideji Murakoshi4, Mikihiro Shibata2,5 (1. Grad. Sch. Math. & Phys., Kanazawa Univ., 2. WPI-NanoLSI, Kanazawa Univ., 3. Grad. Sch. Biostudies., Kyoto Univ., 4. upportive Center for Brain Research, National Institute for Physiological Sciences, 5. InFiniti, Kanazawa Univ.)
[2P-256]SERTAD1 is a novel PP2A adapter that induces site-specific dephosphorylation of HSF1 distinct from IER5
○Haruka Sugiyama1, Taisei Nakada1, Koyo Yano1, Hiroshi Sakurai1 (1. Kanazawa University)
[2P-257]SERTAD proteins are novel PP2A adapters that regulate dephosphorylation of CDC25A
○Koyo Yano1, Taisei Nakada1, Haruka Sugiyama1, Yuto Yoshii1, Satsuki Kimura1, Hiroshi Sakurai1 (1. Kanazawa University)
[2P-258]Elucidation of the Aggregation Mechanism of Pbp1 Regulated by Metal Ions
○Ayano Yamada1, Kosuke Shiraishi1, Masatomo So1, Ayako Furukawa1, Hiroya Yurimoto1, Kenji Sugase1 (1. Kyoto Univ.)
[2P-259]Roles of Hsf1 splice variants in Polypedilum vanderplanki under different stress conditions
○Shoko Tokumoto1, Yugo Miyata2, Ruslan Deviatiiarov1, Richard Cornette3, Oleg Gusev1, Takahiro Kikawada3 (1. Juntendo University, 2. Institute of Science Tokyo, 3. National Agriculture and Food Research Organization)
[2P-260]Potential for intercellular mRNA transfer via virus like particles engineered from endogenous molecules
○Daiki Katano1,2, Ayaka Nakamura3, Aki Kurosaki1, Hiromi Miura1, Natsuko Kawano2, Masato Ohtsuka1 (1. Tokai Univ., 2. Meiji Univ., 3. Department of Life Science Support, Research Innovation Center, University Hospitals Sector, Tokai Univ.)
[2P-261]An archaeal protein that induces ribosomal large subunit dimerization
○Koharu Sasaki1, Chiaki Yaeshima1, Sonoko Ishino2, Ahmed H Hassan3, Gabriel Demo3, Toshio Uchiumi1, Kosuke Ito1 (1. Grad. Sch. of Sci. and Tech., Niigata Univ, 2. Dept. of Biosci. and Biotech., Faculty of Agriculture, Kyushu Univ., 3. Central European Institute of Tech., Masaryk Univ.)
[2P-262]Its own architect: Flipping cardiolipin synthase and its physiological meaning
○Katsuhiro Sawasato1, Bogdanov Mikhail2 (1. Iwate University, 2. University of Texas)
[2P-263]Development of Automated Cell-Free-Based Enzyme Evaluation Technique for High-throughput Screening of AI-designed Sequences
○Mari Ohta1, Maiko Tanabe1, Akira Kimura2, Takahiro Mimori2, Kazuhide Aikoh1, Michiaki Hamada2, Daisuke Kiga2, Kiyoto Ito1, Akihiko Kandori1 (1. Hitachi, Ltd. Research & development Group, 2. Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda university)
[2P-264]Protein fusion to the N-terminus of MotB, the stator of the E. coli flagellar motor, affects the rotor and inhibits counterclockwise rotation
○yumiko uchida1, Akihiko Ishijima1, Hajime Fukuoka1 (1. Grad. Sch. Front. Biosci., Univ. Osaka)
[2P-265]Peptide Turnover Prediction Model Using Large-Scale Time-Series Proteomics Data
○Koki Ishino1, Yuting Liu1, Akiyasu C Yoshizawa1, Shujiro Okuda1 (1. Medical AI Center, Niigata University School of Medicine)
[2P-266]Analysis of Hsp104-driven disaggregation activity for TDP-43 amyloid fibrils
○Natsumi Hirota1, kentarou Noi2, Masafumi Yohda1, Kyosuke Shinohara1 (1. Tokyo University of Agriculture and Technology, 2. Kobe University)
[2P-267]Establishment of a method for identifying novel substrates of cancer stem cell-related kinase using in vitro kinase assay
○Nagisa Furuno1, Hisakazu Kato2, Ryuta Ueda2,3, Hidekazu Takahashi3, Seiji Takashima1,2 (1. Dept. of Med. Biochem., Grad. Sch. of Front. Biosci., Osaka Univ., 2. Dept. of Med. Biochem., Grad. Sch. of Med., Osaka Univ., 3. Dept. of Gastroenterological Surg., Grad. Sch. of Med., Osaka Univ.)
[2P-268]Functional analysis of RNA-binding proteins in the cyanobacterium Synechocystis sp. PCC 6803
○Kenta Kakazu1, Sotaro Machida1, Satoru Watanabe1 (1. Tokyo university of Agriculture)
[2P-269]Elucidation of the regulatory mechanism of macropinocytosis by Plekhs1-PI(3,4)P2.
○Shunsuke Kimura1,2, Keisuke Tanaka2, Nobuhide Kobayashi2, Shunsuke Takano2, Taichi Masuyama2, Koji Hase2 (1. Hokkaido Univ., 2. Keio Univ.)
[2P-270]Role of PDIA1 in the Formation of the ER Mannosidase EDEM2 Complex and Regulation of TXNDC11 Translation.
○Yusuke Tanigawa1, Shuichiro Osita1, Moe Yamashiro1, Watanabe Momoka1, Noritaka Hashii2, Chia-Yen Liew3, Chi-Kung Ni3, Yuta Amagai4, Kenji Inaba4, Hirokazu Yagi5,6, Koichi Kato5,6,7, Satoshi Ninagawa1,8 (1. Dept. of Bioresour. Sci., Grad. Sch of Agr., Kobe Univ., 2. NIHS Division of Biological Chemistry and Biologicals, 3. Carbohydrate Mass Spectrometry Lab., Inst. of At & Mol Sci, Acad. Sin., 4. Medical Institute of Bioregulation, Kyushu University, 5. NINS, 6. Dept. of Struct. Bio & Biomol. Eng., Grad. of. Phar., Nagoya City Univ., 7. IMS, 8. Biosig. Res. Ctr., Kobe Univ.)
[2P-271]Thermostabilization of a PET-degrading enzyme via consensus design and introduction of a disulfide bond
○Tetsundo Ogi1, Riri Fukunaga1, Housei Zhao1, Satoshi Akanuma1 (1. Waseda University)
[2P-272]Preparation and characterization of a human ferritin-anti-HER3 single-chain antibody fusion protein
○Shota Mizuno1, Tamotsu Kanai1, Yoshihide Makino1 (1. Toyama Prefectural University)
[2P-273]Possible molecular mechanism for acute encephalopathy by angel-wing mushroom ingestion
○Koki Sekimata1, Takumi Sato1, Tomohiro Asakawa2, Fumihiko Maekawa3, Eiki Kimura3, Shoko Takada1, Masakazu Suzuki4, Hideo Dohra4,5,6, Yoshinori Fukazawa1, Hirokazu Kawagishi7, Tomohiro Suzuki1,5 (1. C-Bio, Utsunomiya Univ., 2. Inst. Innov. Sci. and Technol., Tokai Univ , 3. Environ. Risk and Health Div., Natl. Inst. Environ.Stud. , 4. Grad. Sch. of Sci. and Technol., Shizuoka Univ., 5. RIMS, Shizuoka Univ., 6. RIGST, Shizuoka Univ., 7. Grad. Sch. of Agric., Shizuoka Univ.)
[2P-274]The gating of the mechanosensitive TRAAK channel is regulated by tension in the inner leaflet of lipid bilayer
○Takahisa Maki1, Yuka Matsuki2, Masayuki Iwamoto1, Shigetoshi Oiki3 (1. Dept. Mol. Neurosci., Facul. Med. Sci., Univ. Fukui, 2. Dept. Anesth. Reanimatol., Facul. Med. Sci., Univ. Fukui, 3. Biomed. Imaging Res. Cent., Univ. Fukui)
[2P-275]Development of a cell-free olfactory sensor using odorant receptors nanodisc
○Yutaka Kuwamura1, Hibiki Watanabe2, Masahiko Hasumi2, Hiromasa Shimizu2, Yosuke Fukutani1 (1. Dept. of AIS, Tokyo Univ of Agric and Technol, 2. Dept. of Applied Physics and Chemical Engineering, Tokyo Univ of Agric and Technol)
[2P-276]Engineering a Thermostable DNA Polymerase via Fusion with Sul7d Family Protein for Enhanced PCR Performance
○Ikumi Oshio1, Toshiki Saitou1, Koko Nakata1, Shunsuke Takahashi2 (1. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ., 2. Div. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ.)
[2P-277(2AS-10-04)]Development of a designer cell elimination system using plant hormone.
○Satoshi Yoshimoto1, Zhuohao Yang2, Yoshitaka Shirasaki2, Satoshi Yotsumoto3, Kosuke Dodo1 (1. RIKEN, 2. University of Tokyo, 3. Tokyo University of Pharmacy and Life Sciences)
[2P-278]Functional Analysis of the Circadian Clock KaiBC Homologs in the Cyanobacterium Synechocystis sp. PCC 6803
○Riri Yoshimatsu1, Takahiro Iida2, Takahisa Ikegami3, Risa Mutoh2 (1. Grad.Sch.Sci, Toho Univ., 2. Fac.Sci,Toho Univ., 3. Yokohama-cu Univ.)
[2P-279]Search for novel protein functional sites based on spatial distribution of disease associated missense variants
○Chie Motono1,2, Kagiwada Harumi1, Koseki Jun1, Hijikata Atsushi3, Kenichiro Imai1,2 (1. CMB, AIST, 2. IRC-SCT, AIST, 3. Sch.Life Sci., Tokyo Univ. Pharm. Life Sci.)
[2P-280]Development of a FLISA platform using fluorescent antibody fragments for cancer diagnosis
○Sung-Ho Kim1, Il-hyeok Jung1, Hanool Yun1, Sun-Hee Kim1, Hee-Jin Jeong1 (1. Hongik Univ.)
[2P-281]Acquisition of oligomycin-resistant strains of yeast FoF1-ATP synthase
○Yuma Tojo1,2, Kazuto Takegawa1,2, Takeshi Ito3, Yasuo Shinohara1,2 (1. Graduate School of Pharmaceutical Sciences, Tokushima University, 2. Institute of Advanced Medical Sciences, Tokushima University, 3. Graduate School of Agriculture, Ehime University)
[2P-282]Functional analysis of the major chitinase for chitin degradation in chitinolytic Clostridium paraputrificum
○KONATSU URABE1, NODOKA KUWAHARA1, ITSUKI SEKO1, GUNZI NAKANO1, EMI KUNITAKE1, TETUYA KIMURA1 (1. Mie University)
[2P-283]Cell-selective delivery of siRNA by combining membrane penetration-enhancing peptides and receptor ligands
○Rurino Murata1, Tadashi Hamano1, Kei Fujiwara1, Nobuhide Doi1 (1. Graduate School of Science and Technology, Keio University)
[2P-284(2MS-05-01)]Functional characterization of tubulin carboxypeptidases in endothelial and non-endothelial cells
○Yuji Tsuyama1,2, Miho Kobayashi1, Tetsuro Watabe1 (1. Dept.of Biochemi., SCIENCE TOKYO, 2. Dept. of Oral and Maxillofacial Surgical Oncology., SCIENCE TOKYO)
[2P-285(2AS-09-03)]Robustness Evaluation of Ultrahigh-speed Bottom-up Proteomics and its Application to Human Plasma Proteome Analysis
○Ayana Tomioka1, Ryota Tomioka1, Eisuke Kanao1,2, Kosuke Ogata1, Koshi Imami1,3, Naoyuki Sugiyama1,4, Yasushi Ishihama1 (1. Grad. Sch. of Pharm. Sci., Kyoto Univ., 2. NIBN, 3. RIKEN IMS, 4. NCVC)
[2P-286]Exploration of Candidate Macrophage-Activating Constituents in Velvet Antler of Cervus nippon
○Hanchen Liang1, Yuji Takeda2, Shinichi Saitoh2, Hironobu Asao2, Hidetoshi Nara1 (1. Ishinomaki Senshu Univ., 2. Yamagata Univ.)
[2P-287]Amyloid polymorphisms of SARS-CoV-2 spike peptides and their effects on red blood cell agglutination
○Manami Yamaguchi1, Emi Hibino1, Akihiro Narita2, Kouta Mayanagi3, Natsuko Goda1, Takeshi Tenno1,4, Hidekazu Hiroaki1,4,5 (1. Grad. Sch. Pharm. Sci., Nagoya Univ. , 2. Grad. Sch. Sci., Nagoya Univ. , 3. Grad. Sch. Pharm. Sci., Kyushu Univ. , 4. BeCellBar, LLC., 5. COMIT)
[2P-288]MORC2 is a phosphorylation-dependent DNA compaction machine
○Jeongveen Park1, Kyoung-wook Moon1, Winnie Tan2, Shabih Shakeel2, Je-Kyung Ryu1 (1. Seoul National University, 2. Walter and Eliza Hall Institute of Medical Research)
[2P-289]Investigating the self-assembly of TIA1 and the roles of its RRM domains
○ANUPAP CHAUYJAROENSUK1, Naotaka Sekiyama1, Aya Ogino2, Hiroki Konno3, Hidehito Tochio1 (1. Grad. Sch. Sci., Kyoto Univ., 2. Grad. Sch. of Nat. Sci. & Technol., Kanazawa Univ., 3. WPI Nano Life Sci. Inst. (WPI-Nano LSI), Kanazawa Univ.)
[2P-291]Analysis of Mechanical Responses in Bone of Sox9K396R Mice
○Nozomi Okubo1, Tadayoshi Hayata2, Masafumi Inui1 (1. Meiji University , 2. Tokyo University of Science)
[2P-292]High-Salt Tolerant Endonuclease: Application of NucleoGoneTM Endonuclease, Cold- and Salt-Active, in AAV Manufacturing.
Sayuri Ueda1, Satoshi Imai1, Rei Kojima1, Yoshinori Tanaka1, Hiroyuki Matsumoto1, ○Sachiko Okamoto1 (1. Takara Bio Inc.)
[2P-293]Analysis of changes in the localization of chloroplast proteins to the cytoplasm under stress condition
○Hiroki Yamaguchi1 (1. Rikkyo University)
[2P-294]Elucidation of the Regulatory Mechanism Governing PPM1K Function via Ser248 Phosphorylation
○Nodoka Nakamura1, Goda Yuka1, Osawa Jin2, Sueyoshi Noriyuki1 (1. Fac. Agr., Kagawa Univ., 2. The Unit. Grad. Sch. of Agr. Sci., Ehime Univ.)
[2P-295]Expression analysis of VMO1 in the chicken ovary and oviduct, and molecular characterization of VMO1 protein
○Haruna Imai1, Kyoko Kojima-Aikawa2, Clara Imura2 (1. Div. of Advanced Sciences, Grad. Sch. of Humanities and Sciences, Ochanomizu Univ., 2. Fac. Of Core Res., Ochanomizu Univ.)
[2P-296]The acquisition of tau degradation by neofunctionalization of E3 ubiquitin ligase Praja1 may be supported by loss of function in the inhibitory domain.
○Shiho Aoki1, Wataru Onodera1, Akihiko Takashima2, Toru Asahi1, Yoshiyuki Soeda3 (1. Waseda University, 2. Gakusyuin Univiersity, 3. Nihon University)
[2P-297]Identification and Characterization of a Short Chain Isoform of Coagulation Factor XII Expressed in HepG2 Cells
○Sayaka Okino1, Maho Saita1, Sumika Nakamura1, Kyoko Aikawa2 (1. Division of Advanced Sciences, Graduate School of Humanities and Sciences, Ochanomizu Univ., 2. Division of Natural Sciences, Faculty of Core Research, Ochanomizu Univ.)
[2P-298]The Potential of PSRP1-Induced Liquid-Liquid Phase Separation to Suppress Chloroplast Ribosome Degradation
○Saori Morinaka1, Kenta Tanaka1, Yusuke Yoshizawa1, Yasuhiko Sekine1 (1. RIKKYO UNIVERSITY)
[2P-299]Evaluation of β-oxidation activation mechanism in skeletal muscle cells using FAO Blue
○Jun-ichiro Takahashi1, Ko Suzuki1, Yoshiko Kubota1, Kiriko Kaneko1, Kazumichi Furuyama1 (1. Iwate Medical University)
[2P-300]Examining the assembly mechanism of tardigrade-unique cytoskeleton CAHS
○Akihiro Tanaka1, Yuta Shimamoto1 (1. National Institute of Genetics)
[2P-301]Sulfur Transferases Related to Catabolism of Sulfur Oxidizer
○Nozomi Yamauchi1,2, Ryota Sugihara1,2, Manabu Fukui1,2, Tomohiro Watanabe1,2 (1. Hokkaido Univ. ILTS, 2. Hokkaido Univ. Env. Science)
[2P-302]Identification of Ferritin Molecules Contributing to Iron Accumulation in the Radula Tissue of Chitons
○Rui Onishi1, Kouki Okada1, Nicole Angeline VIZCONDE1, Tadayoshi Kanao1, Takashi Tamura1, Kenji Okoshi2, Michiko Nemoto1 (1. Okayama Univ., 2. Toho Univ.)
[2P-303]DNA under attack: HS-AFM captures dynamic defense by protamine condensation against nuclease cleavage
○JINGGE YANG1, Yujia Qiu1, Keesiang Lim2, Richard W Wong2,3 (1. Division of Nano Life Science in the Graduate School of Frontier Science Initiative, Kanazawa University, 2. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, 3. Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University)
[2P-304(2PS-09-06)]Interaction Analysis of Designable LNP with Membrane-mimetic SUVs to Elucidate the Mechanism of Cell Tropism (Second report)
○Kozue Furuya1, Shu Okumura1, Masaaki Takada1, Mitsuko Sugano1 (1. Toshiba Corporation)
[2P-305]Steroid Metabolism Evaluation Method by Multidimensional Omics Analyses
○Kohta Nakatani1, Takeshi Bamba2, Masaki Matsumoto1 (1. Niigata University, 2. Kyushu University)
[2P-306]Influence of minerals on the glycation of amino acids under in vitro condition
○Mai Tsukada1, Ryosuke Makino2, Kazumi Kita2 (1. Iwate Univ. Graduate School of Arts and Sciences, 2. Iwate Univ. Faculty of Agriculture)
[2P-307(2PS-18-06)]Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes
○Akieda Sayaka1, Yukako Nishizaki1, Fumitake Yamaguchi1, Yukari Date1 (1. University of Miyazaki)
[2P-308]Alcohols act on various membrane targets according to the lipid theory and inhibit glucose transporter noncompetitively
○Yukifumi Uesono1 (1. The University of Tokyo)
[2P-309]Glycocalyx injuring model using human immortalized brain microvascular endothelial cells by acrolein exposure
○Shizuno Matsuda1, Masahiro Komeno1, Akari Shino1, Machi Morishita1, Momo Shimekake1, Kaho Kurano1, Tomomi Furihata2, Nobuaki Higashi3, Itsuko Ishii4, Kazuei Igarashi4,5, Toshihiko Toida4, Kyohei Higashi1 (1. Fac. Pharm. Sci., Tokyo Univ. Sci., 2. Sch. Pharm. Tokyo Univ. Pharm Life Sci, 3. Sch. Pharm. Pharm. Hoshi Univ., 4. Grad. Sch. Pharm. Sci., Chiba Univ., 5. Amine Pharma Research Institute)
[2P-310]Precision Norlaudanosoline Biosynthesis using Landing Pad Platform in E. coli Engineering
○Koko Nakata1, Toshiki Saito1, Shunsuke Takahashi1 (1. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki University.)
[2P-311]Investigation of the autophagy-promoting effects of trehalose analogs and their derivatives
○Ayano Kitada1, Miyagi Ami1, Wada Shunichi2, Kobayashi Masaki1,3 (1. Ochanomizu Univ., 2. IMC, 3. HLS)
[2P-312]Comprehensive analysis of glycosaminoglycans produced by pancreatic cancer cell lines
○Reo Watanabe1, Kazuto Tuji1, Shoo Katsumoto1, Kazuki Sato1, Akira Sato1, Masahiro Komeno1, Takeshi Wada1, Toshihiko Toida2, Kyohei Higashi1 (1. Tokyo University of Science, 2. Chiba University)
[2P-313]Development of a glycopeptide similarity calculation method
○Yushi Takahashi1 (1. Medical AI Center, School of Medicine, Niigata University)
[2P-314]The roles of creatine phosphate shuttle molecules in larvae of the marine invertebrate chordate Ciona
○Yasunori Sasakura Sasakura1, Akiko Hozumi1, Yanbin Wang1, Junko Nishino2, Akira Shiraishi3, Takehiro Watanabe3, Satake Honoo3, Atsuo S Nishino2 (1. Univ. Tsukuba, 2. Hirosaki Univ., 3. SUNBOR)
[2P-315]Cross-Study Integration and Re-analysis Platform for Metabolomics Data
○Eisuke HAYAKAWA1,2, Kozo NISHIDA2, Mikiko TAKAHASHI2, Rira MATSUTA3,5, Shiho FUJIMURA1, Takaki OKA4, Hiroyuki YAMAMOTO5, Hiroshi TSUGAWA4, Shin KAWANO6 (1. Kyushu Institute of Technology, 2. RIKEN, 3. Keio University, 4. Tokyo University of Agriculture and Technology, 5. Human Metabolome Technologies., 6. Kitasato University)
[2P-316]Physiological Functions of NAXD in Obesity
○Haruka Suzuki1, Kodai Takahashi1, Nobuhito Goda1 (1. Waseda Univ.)
[2P-317]Analysis of the Insertion Timing and Evolutionary Dynamics of Nuclear Mitochondrial DNA (NUMTs) in the Genus Panthera
○Yuzuki Inaba1, Takashi Kitano1 (1. Graduate School of Science and Engineering, Ibaraki University)
[2P-318]Mitochondrial genome sequencing and phylogenetic analysis of the freshwater snail Fukuia kurodai ooyagii (Pomatiopsidae)
○Yuki Ebata1, Akira Ooyagi2, Kazuo Umetsu3, Takashi Kitano1 (1. Graduate School of Science and Engineering, Ibaraki University, 2. Shimokita Field Science Nest, 3. Department of Forensic Medicine, Faculty of Medicine, Yamagata University)
[2P-319]A comprehensive genome-wide identification of the SLC26 family across the Insecta and Malacostraca
○Shinichiro Hidaka1, Michael F. Romero2, Akira Kato1 (1. Institute of Science Tokyo, 2. Mayo Clinic)
[2P-320]Identification and Classification of Zinc Finger Proteins Encoded in the Genome of an Ascidian
○Natsuko Tamura1, Yutaka Satou1 (1. Kyoto Univ.)
[2P-321]Giant genes in extremely reduced genome microorganisms
○Yu Nakajima1, Takao Segawa2, Masaki Mizutani3, Yu Sato4, Masaru K Nobu5 (1. MRU, JAMSTEC, 2. Nihon Univ., 3. Gakushuin Univ., 4. Yamaguchi Univ., 5. X-STAR, JAMSTEC)
[2P-322]Human population in Yayoi period Doigahama site from ancient mtDNA
○Jun Gojobori1, Fuzuki Mizuno2, Masami Matsushita3, Takayuki Matsushita3, Kunihiko Kurosaki2, Shintaroh Ueda4 (1. SOKENDAI, 2. Toho Univ., 3. Doigahama Site Anthropelogical Museum, 4. Univ. of Tokyo)
[2P-323]Endogenous retroviruses modulate host antiviral responses by fusing with human immune genes
○Hitoshi Ohtani1 (1. Nagoya University)
[2P-324]ATG gene duplication in vertebrates: evolutionary divergence and the functional implications
○Sidi Zhang1, Ikuko Koyama-Honda1, Noboru Mizushima1 (1. Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo)
[2P-325]Orthogonal Modes of Gene Expression Evolution Shape Human Neocortical Development and Disease Vulnerability
○Xuanhao D. ZHOU1, Yuki Yamauchi1, Ikuo K. Suzuki1 (1. Department of biological science, University of Tokyo)
[2P-326]IKZF2 expression is upregulated by haplotype where detected natural selection signature in ancient Jomon population
○Tsubasa Suzuki1,2,3, Yusuke Watanabe3, Yoshiki Wakiyama3, Akiho Kuga3, Koji Ishiya4,5, Kae Koganebuchi3, Takafumi Katsumura6,7, Hajime Ishida8,9, Takafumi Ishida3, Hiroshi Kawasaki4,10, Takashi Gakuhari4,5, Fumitaka Inoue11, Masanori Imamura4,10, Hiroki Oota3 (1. Graduate School of Science, Kyoto University, 2. Center for the Evolutionary Origins of Human Behavior, Kyoto University, 3. Graduate School of Science, The University of Tokyo, 4. apiens Life Sciences, Evolution and Medicine Research Center, Kanazawa University, 5. Institute for the Study of Ancient Civilizations and Cultural Resources, Kanazawa University, 6. Graduate School of Design, Faculty of Design, Kyushu University, 7. Kitasato University School of Medicine, 8. Graduate School of Medicine, University of the Ryukyus, 9. Social Medical Corporation Ashinokai Mt.Olive Hospital, 10. Graduate School of Medical Sciences, Kanazawa University, 11. Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University)
[2P-327]Relationship between the number of OTUs used for phylogenetic inference and long-branch bias
○Kazuki Takeuchi1, Tokumasa Horiike1 (1. graduate school of Shizuoka University)
[2P-328]What Filters Do We Need? Using Full-UDG Siblings to Validate Non-UDG Ancient DNA Processing
○Odongoo Ravdandorj1,4, Chuluun Sampildondov3, Khulan Janchiv2, Takashi Gakuhari4 (1. Sapiens Life Sciences, Evolution and Medicine Research Center, Kanazawa University, 2. Department of Biology, School of Arts and Sciences, National University of Mongolia, 3. Chinggis Khaan National Museum, 4. Institute for the Study of Ancient Civilizations and Cultural Resources, Kanazawa University)
[2P-329]Phenotypic analysis of the East Asian-specific ALDH2 allele using single-nucleotide edited iPS cell-derived hepatocyte-like cells
○Yuka Nakamura1, Tomoko Matsumoto2, Asei Hirai3, Yusuke Hamazaki4, Hideyuki Tanabe5, Atsushi Toyoda6, Taeko Ohtomo1, Yusuke Watanabe1, Kae Koganebuchi1, Jun Ohashi1, Takafumi Ishida1, Knut Woltjen2, Takanori Takebe3,7, Hiroki Oota1 (1. The University of Tokyo, 2. Center for iPS Cell Research and Application, Kyoto University, 3. Science Tokyo, 4. Center for the Evolutionary Origins of Human Behavior, Kyoto University, 5. The Graduate University for Advanced Studies, 6. National Institute of Genetics, 7. The University of Osaka)
[2P-330]Coding sequence inhomogeneity predicts compartmentalization across the tree of life
○Rory Thomas Cerbus1,2, Kyogo Kawaguchi2,3, Ichiro Hiratani1 (1. RIKEN Center for Biosystems Dynamics Research (BDR), 2. RIKEN Pioneering Research Institute (PRI), 3. University of Tokyo, Institute for Physics of Intelligence)
[2P-331]Analysis of Host Adaptation-Related Genomic Changes in SARS-CoV-2 during the Pandemic
○Yuki Iwasaki1, Masahito Yamamoto1, Mariko Uemura1, Masafumi Shionyu1 (1. Nagahama Institute of Bio-Science and Technology)
[2P-332]Phylogenetic relationships and migration route to the Japanese archipelago of Rattus rattus species complex using whole-genome sequencing data
○Asato Makita1, Hitoshi Suzuki2, Toshinori Endo3, Naoki Osada3 (1. Info. BioI. Lab., Grad. Sch. of IST, Hokkaido Univ., 2. Hokkaido Univ., 3. Info. BioI. Lab., Faculty of IST, Hokkaido Univ.)
[2P-333]Exploring Sequence Space with Generative AI
○Hafumi Nishi1,2 (1. Tohoku Univ., 2. Ochanomizu Univ.)
[2P-334]Antibacterial effect of a novel guanidopolyamine produced by an extreme thermophile, Thermus thermophilus
○Sorachi Kosaka1, Teruyuki Kobayashi2, Noriyuki Kogure1, Koichi Takao3, Takeshi Uemura3, Yusuke Terui1 (1. School of Pharmacy, International University of Health and Welfare, 2. Faculty of Pharmacy, Chiba Institute of Science, 3. Department of Pharmaceutical Sciences, Josai University)
[2P-335]Tissue-specific transgene expression by engineered non-toxic herpes simplex virus-based vectors
○Yoshitaka Miyagawa1, Motoyo Maruyama2,3, Atsushi Sakai2, Yuriko Sato1, Seiji Kuroda1, Hiromi Kinoh4, Motoko Yamamoto1, Ryotaro Hashizume5, Hidenori Suzuki2, Justus B Cohen6, Joseph C Glorioso6, Takashi Okada4 (1. Dept. of Biochem. Mole. Biol., NIPPON MED SCH, 2. Dept. of Pham., NIPPON MED SCH, 3. Dept. of Lab. Anim. Sci., NIPPON MED SCH, 4. Div. of Mole. Medi. Genet., Univ. of TOKYO, 5. Dept. of Path. Matrix, Biol., Univ. of Mie, 6. Dept. of MicroBiol. Mole. Genet., Univ. of Pit)
[2P-337(2PS-07-03)]Assessment of the Effects of ZnO on Reef-Building Corals
○Mikito Murakami1, Hyuga Hotoku1, Hirokazu Takahashi2, Nina Yasuda1 (1. The University of Tokyo, 2. Shiseido Co., Ltd.)
[2P-338]Identification of Iron-Modulating Drugs Using a Fluorescence-Based Iron Reporter
○Joan Komen Komen1,2, Ayato Maeda1,2, Akihiro Nita2, Moroishi Toshiro2 (1. Kumamoto University, 2. Institute of Science Tokyo)
[2P-339]Mass++ ver.4 Official Release: The indispensable companion for mass spectrometry data analysis
Satoshi Tanaka1,2, Masaki Murase1, Masaki Kato1,3,4, Hiroyuki Yamamoto1,5, Masaaki Matsubara1,6, Yushi Takahashi1,7, Tsuyoshi Tabata1,8, Maiko Kusano1,9, Shin Kawano1,10, Shujiro Okuda7, ○Akiyasu C. Yoshizawa1,7 (1. Mass++ Users Group, 2. Trans-IT Co., Ltd., 3. RIKEN Information R&D and Strategy Headquarters, RIKEN, 4. Medical Research Inst., Kanazawa Medical University, 5. Human Metabolome Technologies, Inc., 6. The Noguchi Inst., 7. Medical AI Center, Niigata University, 8. Mass Soft, 9. School of Medicine, Showa Medical University, 10. School of Frontier Engineering, Kitasato University)
[2P-340]Aquaporins and Transient Receptor Potential Channels as Potential Sensors in Tardigrade Anhydrobiosis
○Saori Motomura Harada1,2, Sae Tanaka1,2, Kazuharu Arakawa1,2,3 (1. IAB, Keio Univ., 2. Graduate School of Media and Governance, Keio Univ., 3. ExCELLS, NINS)
[2P-341]Metaproteomics Analysis of the Human Gut Microbiome Based on Public Metadata
○Futao Sun1 (1. Niigata University Graduate School of Medical and Dental Sciences)
[2P-342]Investigation of novel oxidized derivatives of 2-oxo-imidazole dipeptides
○Masaki Okamoto1, Somei Komae1, Takahiro Katsuki1,2, Singo Kasamatsu1, Hideshi Ihara1 (1. Dept. of Biol. Sci., Grad. Sch. of Sci., Osaka Metro. Univ., 2. Toyo Inst. of Food Tech.)
[2P-343]Development of a simple method for detecting biomolecules by hot-melt mass spectrometry utilizing ionization interference of polymer films
○Hiromi Suzuki1, Makoto Sawada1 (1. Research Institute of Environmental Medicine, Nagoya University)
[2P-344]Performance evaluation of miRNA Enhance Buffer in next-generation sequencing analysis: Comparison with commercially available extraction kits
○Azumi Naruse1, Arizumi Kikuchi1, Sizuku Ueno1, Kimiaki Takagi2, Kenichi Nonaka1,3, Yoshifumi Yutoh4 (1. Daiyukai Research Institute for Medical Science, 2. Daiyukai General Hospital, Urology, 3. Daiyukai General Hospital, Surgery, 4. KANTO CHEMICAL CO.,INC.)
[2P-345]SYTL2 enhances cell proliferation and metastasis through regulation of RAB27A and is highly expressed in gastric signet ring cell carcinoma
○Yu-Seon Lee1,2, Woong Kim2, Seok-Jun Kim1,2,3 (1. Department of Integrative Biological Sciences & BK 21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, Republic of Korea , 2. Institute of Well-Aging Medicare & Chosun University G-LAMP Project group, Chosun University, Gwangju, Republic of Korea, 3. Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea)
[2P-346]Investigation of normalization methods for comparing proteome data obtained under different experimental conditions
○Manaka Nishizaki1, Norie Araki2, Shin Kawano1 (1. Kitasato Univ., 2. Kumamoto Univ.)
[2P-347]Screening of Plant Extracts Identifies Litsea japonica and Hedera rhombea as Potential Suppressors of Microglia-Mediated Neuroinflammation
○AREUM CHOI1, Woong Kim2, Seok-Jun Kim1,2,3 (1. Department of Integrative Biological Science, BK 21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, Republic of Korea, 2. Institute of Well-Aging Medicare & CSU G-LAMP Project group, Chosun University, Gwangju, Republic of Korea, 3. Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea)
[2P-348]Evaluation of a Meta-Proteome Data Analysis Method for Multiple Software Using Mock Communities and Its Application to the Japanese Gut Microbiome
○Ryota Fukumoto1, Yoshio Kodera2, Shin Kawano1 (1. KitasatoUniv, 2. Kitasato Univ)
[2P-349]Detection of Chromosome Sets and Classification of Individual Chromosomes from Large-Scale Concatenated Images Using Deep Learning
○Kosuke Oshima1, Kiyoshi Nisshikawa1, Kan Okubo1, Takuya Abe2 (1. Tokyo Metropolitan Univ., 2. Tohoku Medical and Pharmaceutical Univ.)
[2P-350]Functional analyses of the CENP-T complex in Mucor lusitanicus
○Yaoyi Zhou1, Haruhiko Asakawa 1, Shreyas Sridhar1, Mariko Ariyoshi1, Tatsuo Fukagawa1 (1. Osaka University)
[2P-351]DeepSAHF: Fast Deep Learning-Based Detection of Senescence-Associated Chromatin Features
○Yik-Lok Claire Chung1, Shinya Ohta1, Hideki Tanizawa1, Ken-ichi Noma1,2 (1. IGM, Hokkaido Univ., 2. IMB, Oregon Univ.)
[2P-352]TRF1 Promotes Mitotic Telomere Deprotection by Transporting AURKB Activity
○Shunya Kosaka1, Diana Romero Zamora1, Makoto Hayashi1 (1. Kyoto University)
[2P-353]Improving Accuracy of Sister Chromatid Shape Classification Using Deep Learning with Spatial Information Emphasis
○Toshiharu Akama1, Kiyoshi Nishikawa1, Kan Okubo1, Takuya Abe2 (1. Tokyo Metropolitan Univ., 2. Tohoku Medical and Pharmaceutical Univ.)
[2P-354]Loss of PIGB exhibits laminopathy-like phenotypes in Drosophila.
○Eisuke Sawada1, Miki Yamamoto-hino1, Satoshi Goto1 (1. Rikkyo Univ.)
[2P-355]Automated Detection Method for Chromosome Breakage Based on the YOLO Object Detection Model
○Miura Ko1, Kiyoshi Nishikawa1, Kan Okubo1, Takuya Abe2 (1. Tokyo Metropolitan University, 2. Tohoku Medical and Pharmaceutical University)
[2P-356]SUMO post-translational modification is involved in the survival mechanism of fission yeast cells with circular chromosomes
○Katsunori Tanaka1,2, Ying Huang1, Hujiarui Gu2, Harumu Ishikawa2, Sae Fujita1, Tetsushi Iida3, Shiho Ogawa1,2 (1. Dept. of Bioscience., Kwansei Gakuin Univ., 2. Dept. of Biosciences., Kwansei Gakuin Univ., 3. BRC, RIKEN)
[2P-357]Analysis of the recognitionof chromosome bridge by cGAS
○Karen Sugimoto1, Kenichiro Matsuzaki1, Miki Shinohara1,2 (1. Advanced Bioscience, Graduate School of Agriculture, Kindai University, 2. Agricultural Technology and Innovation Research Institute, Kindai University)
[2P-358]Development of a Method for Visualization and Quantitative Analysis of the Dynamics of the Nuclear Membrane Protein Mps3
○TIANYI QIAN1, Hironori Shigeta1, Masaru Ito2, Akira Shinohara2, Shigeto Seno1 (1. Graduate School of Information Science and Technology, The University of Osaka, 2. Institute for Protein Research, The University of Osaka)
[2P-359]The HP1-binding protein PRR14 interacts with condensin and contributes to mitotic progression
Aoi Takami1, Suzuha Gose1, Sota Nomura1, Madison Wong1, Hiroto Imai1, Ryota Mochizuki1, Takamasa Ito1, Shin-ya Isobe1, ○Chikashi Obuse1 (1. The Univ. of Osaka)
[2P-360]Structure and transmission to progenies of the B chromosome in medicinal plant Atractylodes lancea
○Kazuya Hara1, Shinji Kikuchi1, Yasuhiro Tsusaka2, Kenta Shirasawa3 (1. Graduate School of Horticulture, Chiba University, 2. Tsumura, 3. kazusa DNA research)
[2P-361]Kinetochore Assembly Independent of CENP-A and CENP-C in Mucor lusitanicus
○Haruhiko Asakawa1, Yaoyi Zhou1, Shreyas Sridhar1, Tatsuo Fukagawa1 (1. The University of Osaka)
[2P-362]Dynamics of single nucleosome during the cell cycle in living human cells
○Yu Nagata1,2, Shiori Iida1,2, Yuki Hatoyama1,3, Masato Kanemaki1,3, Kazuhiro Maeshima1,2 (1. Department of Genetics, School of Life Science, The Graduate University for Advanced Studies, SOKENDAI, 2. Genome Dynamics laboratory, National Institute of Genetics, 3. Molecular Cell Engineering Laboratory, National Institute of Genetics)
[2P-363]Toward the creation of parthenogenetic medaka: Insights from meiosis in Amazon molly
○Yu Ikeda1, Shuji Shigenobu2, Manfred Schartl3, Minoru Tanaka4, Mariko Kikuchi4 (1. Department of Biological Science・School of Science・Nagoya University, 2. Trans-Omics Facility・Trans-Scale Biology Center・National Institute of Basic Biology, 3. Department of Developmental Biochemistry・Biocenter・University of Würzburg, 4. Department of Biological Science・Graduate School of Science・Nagoya University)
[2P-364]The C-terminal domain of SSX2 enhances nuclear translocation and condensate formation
○Kazashi Kato1, Eika Kan2, Hiroaki Daitoku1, Akiyoshi Fukamizu1, Kenji Iwasaki1,3 (1. Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), 2. Grad. Sch. Sci. Tech., Univ. of Tsukuba, 3. QiLS, Univ. of Tsukuba)
[2P-365]Quadruplex nucleic acid recognition mechanism of a novel quadruplex nucleic acid-binding protein RBM22 prepared by Cytiva Protein Select tag
○Kai Ohmori1, Kei Matsuo1, Yoshitaka Sugisawa1, Hidetaka Torigoe1 (1. Dept. of Chem., Grad. Sch. of Sci., Tokyo Univ. of Sci.)
[2P-366]Acquisition and repeated alteration of (TTGGG)n telomeric repeats in Odonata (dragonflies and damselflies)
Tatsuhiro Gotoh1, Haruka Suzuki1, Ryo Futahashi2, ○Mizuko Osanai-Futahashi1 (1. Ibaraki Univ., 2. AIST)
[2P-367]Development of nucleolus-targeted DDS using nuclear-migratablenanoparticles
○Haruka Taniguchi1, Mitsuki Tsuruta1, Soma Kawashima1, Keiko Kawauchi2, Daisuke Miyoshi2, Koji Nagahama2 (1. Graduate School of FIRST, Konan University, 2. Department of Nanobiochemistry, FIRST, Konan University)
[2P-368]Basic research to elucidate the mechanism of formation of G-body, an assembly of glycolytic enzymes and other proteins, using a jar fermenter
○Honoka Morikawa1, Natsuko Miura1, Michihiko Kataoka1 (1. Dept. Appl. Biol. Chem., Grad. Sch. Agric., Osaka Metropolitan Univ.)
[2P-369]Protein-protein interaction analysis of Morc1, a testis-specific transposon repressor
○Kiichirou Sakata1, Hiroya Yamazaki1, Yosuke Isota1, Hidetaka Kosako2, Siomi Mikiko1 (1. School of Science, The University of Tokyo, 2. Institute of Advanced Medical Sciences, Tokushima University)
[2P-370]Phosphorylation dependent mechanism of NPM1 IDR in nucleolar structure
○Taiyo Kikuchi1, Mitsuru Okuwaki1 (1. Graduate School of Pharmaceutical Science, Kitasato University)
[2P-371]Mechanisms and functions of phase separated nuclear droplets in cardiomyocytes
○Tai Sada1, Wataru Kimura1 (1. RIKEN BDR)
[2P-372]Formation of yeast proteasome storage granules under organic acid stress
○Shoei Tanaka1, Mitsuki Imajo2, Shingo Izawa2 (1. Kyoto Inst. Technol., 2. Dept. Appl. Biol., Kyoto Inst. Technol.)
[2P-373]Molecular Basis of SP7-Mediated Osteoblast Differentiation: Super-Enhancer Regulation and Liquid–Liquid Phase Separation
○Priscillia Christiany1, Shinse Fujita1, Hiroyuki Okada1, Yasuhide Iwanaga1, Ung-il Chung1, Hironori Hojo1 (1. University of Tokyo)
[2P-374]Identification of heat-responsive granules by CRISPR knock-in screening
○Yuriko Shiraishi1, Yuma Hanai1, Patrick Louis Lagman Hilario1, Nobuyasu Yoshida1, Masayoshi Shiina1, Sojiro Ukeda1, Katsutomo Okamura1 (1. Nara Institute of Science and Technology)
[2P-375]A Synthetic Cell-Penetrating Peptide with Nucleolar Targeting Capable of Delivering Plasmid DNA, Proteins, and Doxorubicin
○Khai Quang Nguyen1, Ryo Yonezawa1,2, Nahoko Kobayashi3, Tetsuhiko Yoshida3, Shuichi Asakawa1,2 (1. University of Tokyo, Graduate School of Agricultural and Life Sciences, Aquatic Molecular Biology and Biotechnology, 2. University of Tokyo, Graduate School of Agricultural and Life Sciences, Signal Peptidome Laboratory, 3. Toagosei Co., LTD, Institute For Advanced Science)
[2P-376]Is the extracellular secretion of the ALS-associated protein SOD1 facilitated by genetic mutations?
○Yudai Fujiwara1, Chinatsu Okachi2, Rinon Asada2, Akira Hosomi1,2 (1. Shinshu Univ, Graduate School of Science and Technology , 2. Shinshu Univ, Faculty of Agriculture)
[2P-377]Establishment of reporter cells aimed at conferring hypoxia defense mechanisms through the regulation of PHD localization
○Yudai Suetsugu1,2, Kiko Yoshitake1,2, Kento Sonoda1,3, Shinichi Kawaguchi1,2,3, Tadayuki Tsujita1,2,3 (1. Department of Advanced Health Sciences, Graduate School of Advanced Health Science, Saga University, 2. Department of Biological Resource Science, Faculty of Agriculture, Saga University, 3. The United Graduate School of Agricultural Sciences, Kagoshima University)
[2P-378]Investigation of Endoplasmic Reticulum Quality Control in Regulating Protein C Secretion under Conditions of Excessive N-Linked Glycosylation
○Yamato Kuwajima1, Maya Muroda2, Satomi Nagaya1, Ibuki Yasuda1, Reina Tsukida1, Momoka Hayase1, Rikuto Yui1, Makiko Meguro-Horike3, Shin-Ichi Horike3, Kengo Saito4, Hiroshi Kawasaki4, Eriko Morishita1,5 (1. Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 2. School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 3. Division of Animal Disease Model, Department of Advanced Sciences, Research Center for Experimental Modeling of Human Disease, Kanazawa University, 4. Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, 5. Department of Hematology, Kanazawa University Hospital)
[2P-379]CRISPR screening identifies suppressors and regulatory pathways of polyglutamine aggregation
○Oishi Shuka1, Ogasawara Takanori1, Muramoto Tetsuya1 (1. Toho University)
[2P-380]Cytoskeleton as a track for the cytoplasmic delivery of the tight junction scaffold protein ZO-1 in HaCaT keratinocytes
○Reika Saito1, Junya Abe1, Yohei Hirai1 (1. Department of Biomedical Science, School of Biological and Environmental Science, Kwnsei Gakuin University)
[2P-381]Cell permeable biotin derivate (biotin-methyl ester) enhances synchronized cargo release in RUSH system and accelerates TurboID-based proximity labeling in vivo.
○Taisei Uehara1, Arata Takiguchi1, Takuro Tojima2, Akihiko Nakano2,3, Kagawa Shion1, Tatsuo Nehira1, Takunori Satoh1, Akiko K. Satoh1 (1. Graduate School of Integrated Sciences for Life, Hiroshima University, 2. RIKEN Center for Advanced Photonics, 3. Institute of Science Tokyo)
[2P-382]Exploration and functional characterization of a novel PIP2-binding site in β-arrestin
○Ritsuki Kuramoto1, Tatsuya Ikuta1, Masataka Yangawa2, Asuka Inoue1,2 (1. Tohoku Univ., 2. Kyoto Univ.)
[2P-383]A Novel Protein Quality Control Mechanism for Tyrosinase, the Rate-Limiting Enzyme Essential for Melanin Production
○Miku Komai1, Shota Wada1, Ami Sugisawa1, Ryo Ushioda1,2 (1. Kyoto- Sangyo Univ., 2. Institute for Protein Dynamics, Kyoto- Sangyo Univ.)
[2P-384]Analysis of subcellular distribution mechanism of Prox1, a regulator of granule cell differentiation in the hippocampus.
○Taichi Kashiwagi1, Sae Kaneko1, Tokiharu Takahashi1 (1. Department. of Histology and Neuroanatomy, Tokyo Medical University)
[2P-385]Structure-activity relationship analysis of 7'-hydroxytanzawaic acid-type M-COPA analogs
○Ryosuke Koyama1, Haruka Hirai1, Daiki Usukura1, Ryunosuke Shiogama1, Yamato Kanai1, Motoyuki Shimonaka1, Takatsugu Murata1, Isamu Shiina1 (1. Tokyo University of Science)
[2P-386]Down-regulation of c-Myc expression accumulates cell-surface proteins including VIMENTIN via suppression of endocytosis pathway.
○Kazuki OMOTEYAMA1, Toshiyuki SATO1, Masaaki SATO1, Atsuhiro TSUTIYA1, Mitsumi ARITO1, Tomohiro KATO1, Manae S KUROKAWA1 (1. St. Marianna University School of Medicine)
[2P-388]Transcytosis of cell-penetrating peptide-tagged antibodies into intestinal epithelial cells
○Nanami Soda1, Hitoshi Azuma1, Akifumi Higashiura2, Keita Yamane1, Yusei Ota1, Yuya Hokama1, Norihisa Nishimichi1, Tomoharu Yasuda1 (1. Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University., 2. Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University.)
[2P-389]Analysis of the Mechanism of Clathrin Coating Formation Using a Rapamycin-Induced Heterodimerization Method
○Yuka Tsuji1, Keiko Mi1, Risa Kokubo1, Makoto Nagano2,1, Junko Toshima3,1, Jiro Toshima1 (1. Tokyo University of Science, 2. National Institute of Infectious Diseases, 3. Tokyo University of Technology)
[2P-390(2PS-13-09)]Impaired ciliary cholesterol trafficking causes polycystic kidney disease in a peroxisome biogenesis disorder, Zellweger syndrome
○Takeshi Itabashi1,2, Tomoka Morita1,2, Moe Hirosawa1,2, Tatsuo Miyamoto1,2 (1. Dept. Mol. Cell Phys., Grad. Sch. Med., Yamaguchi Univ., 2. RICeD, Yamaguchi Univ.)
[2P-391]Biochemical Analysis of Multiple Inhibitory Mechanisms of DS16570511 on Mitochondrial Calcium Uptake
○Akiko Yamamoto1, Masatake Asano1 (1. Nihon University School of Dentistry)
[2P-392]A novel assay system to dissect protein import across peroxisome membrane
○Keisuke Nakayama1, Yukio Fujiki2,3,4, Kanji Okumoto1 (1. Grad. Sch. of Sys. Life Sci., Kyushu Univ., 2. Inst. for Adv. Study, Kyushu Univ., 3. Fac. of Arts and Sci., Kyushu Univ., 4. Sch. of Sci., Univ. of Hyogo)
[2P-393]LAMP homologue LMP-1 is involved in the morphology and function of HEBE granules, a novel lysosome-associated peptide storage organelle in C. elegans.
○Kenji Nishikori1, Hirohisa Shiraishi1, Takahiro Tanji2, Ayako Ohashi-Kobayashi1 (1. Iwate Med. Univ., 2. Iryo Sosei Univ.)
[2P-394]Efficient production of osmotically-induced migrasomes utilizing thermosensitive cell culture substrates
○Koki Yoshikawa1, Shogo Saito1, Mina Okochi1 (1. Institute of Science Tokyo)
[2P-395]Activation of the cGAS-STING pathway in microglia causes LRRK2 recruitment to organelles at the centrosomal area
○Shoichi Suenaga1, Maria Sakurai1, Takeshi Iwatsubo2, Tomoki Kuwahara1 (1. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 2. National Center of Neurology and Psychiatry)
[2P-396]Components of Sebosomes, the secretory membrane vesicles of sebocytes
○Ayako Nagai1,2 (1. Department of Clinical Research, NHO Ehime Medical Center, 2. Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine)
[2P-397(2PS-13-02)]Functional Analysis of Novel Membrane Lipid Transport Factor in Peroxisome Biogenesis
○Akane Kamigaki1, Mikio Nishimura2, Shoji Mano1,3 (1. Natl. Inst. Basic. Biol., 2. Konan Univ., 3. Graduate Univ. Advanced Studies)
[2P-398(2PS-13-04)]Conserved targeting mechanism of C-tail-anchored proteins across species
○Chenxing Jiang1, Rechal Kumar1, Maki Kamoshita1, Marco Anteghini3, Ruth E. Carmichael1, Lucy Brunt4, Doug McNeall6, Joseph L. Costello1, Harley Worthy1, Lakhan Ekal2, Markus Islinger5, Steffen Scholpp4, Michael Schrader1 (1. University of Exeter, Biosciences, UK, 2. EMBL, Hamburg, Germany, 3. Wageningen University, NL, 4. Living Systems Institute, University of Exeter, UK, 5. University of Heidelberg, Germany, 6. UK Met Office)
[2P-399]Preparation of giant liposomes using inkjet device and construction of semi-artificial secretory cells
○Naohide Hirashima1, Souto Iida1, Masahiko Tanaka1 (1. Grad. Sch. Pharmceut. Sci., Naogya City Univ.)
[2P-400]A zebrafish mutant screen reveals Nrf2 activation induced by lysosomal dysfunction via identification of a responsible gene
○Toshiki Obokata Obokata1,2, Bian Lixuan1, Makoto Kobayashi1 (1. Institute of medicine, University of Tsukuba, 2. Ph.D. program in human biology, University of Tsukuba)
[2P-401]Molecular mechanisms of cell death induced by PI4P accumulation in the trans-Golgi region
○Marika Toide1, Yasuka Kawamoto1, Sadao Wakabayashi1, Hajime Tajima Sakurai1, Kanae Sasaki1, Hiderou Yoshida1 (1. Dept. of Life Sci., Grad. Sch., Univ. of Hyogo)
[2P-402]Functional analysis of the transcription factor FOXL2 regulating the Golgi stress response
○Daiki Maeda1 (1. University of Hyogo)
[2P-403]Analysis of transcriptional and morphological regulation mechanisms during Golgi perturbation
○Hajime Tajima Sakurai1, Marika Toide1, Misako Kimura1, Rei Tanaka1, Tamaki Hanada1, Ayane Kawasaki1, Sadao Wakabayashi1, Kanae Sasaki1, Shigeomi Shimizu2, Kazufumi Hosoda3, Hiderou Yoshida1 (1. Univ of Hyogo, 2. Science Tokyo, 3. NICT)
[2P-404]Classification and sorting of ER-stressed cells based on the morphological information using Ghost Cytometry
○Mika Uematsu1, Kaori Matsuyama1, Keisuke Wagatsuma1, Sadao Ota1,2 (1. ThinkCyte, KK, 2. RCAST, The University of Tokyo)
[2P-405]Functional analysis of the mitochondria-localized unstructured protein MAHS & LEAM of an anhydrobiotic tardigrade, Ramazzottius varieornatus
○Sae Tanaka1, Kazuharu Arakawa1,2 (1. IAB, Keio Univ., 2. ExCELLS, NINS)
[2P-406]Identification of a novel nuclear–vacuolar junction factor critical for lipid droplet biogenesis under glucose starvation
○Yusuke Mito1, Shintaro Fujimoto1, Yasushi Tamura1 (1. Yamagata University)
[2P-407]Molecular Analysis of Intracellular pH-dependent Reversible Directional Switching in neural migration
○Katsutoshi Mizuno1,4, Wakana Terao2, Ryota Kato3, Satoshi Fujita3,4, Takafumi Itoh2, Masami Yamada1,4 (1. University of Fukui, Facul. of Med, 2. Fukui Prefectural Univer, 3. University of Fukui, Facul. of Engineering, 4. Life Science Innovation Center, University of Fukui)
[2P-408]Identification of the Syntaxin3 Core Site for Tight Junction Assembly in a human Keratinocyte cell line
○Akari Kitadai1, Junya Abe1, Yohei Hirai1 (1. Kwansei Gakuin University)
[2P-409]Conserved and Divergent Mechanisms of Membrane Bleb–Driven Extravasation
○Mizuki Morita1, Junichi Ikenouchi1, Daisuke Saito1 (1. Kyushu Univ.)
[2P-410]Regulation of Cancer Cell Motility via Twist Stabilization by Deubiquitinating Enzyme USP7
○Chiharu Miyajima1, Haruna Nakagaki1, Shin Watanabe1, Hidetoshi Hayashi1, Yasumichi Inoue1 (1. Nagoya City Univ.)
[2P-411]Analysis of Curvature-Dependent Remodeling of Cell–Cell Junctions Regulating Collective Cell Fluidity
○Arata Nagai1, Sayuki Hirano1, Hirohumi Shintaku2, Kazuhiro Aoki1 (1. Graduate School of Biostudies, Kyoto University, 2. Graduate School of Biosystems Science, Kyoto University)
[2P-412]Development of photo-activatable E-cadherin
○Yukina Asakura1, Tetsuhisa Otani1 (1. Tokyo Metropolitan Univ. Graduate school of Sciences, Department of Biological Sciences)
[2P-413]Reconstructing Epithelial Microenvironments Through ECM Stiffness-Modulated Patterning
○Yen Xuan Ngo1,2, Kasinan Suthiwanich1,3, Masaya Hagiwara1,2 (1. RIKEN, Clustering of Pioneering Research, 2. RIKEN, Center for Biosystems Dynamics Research, 3. University Health Network, Toronto General Hospital Research Institute)
[2P-414]Analysis of Integrin Localization with a Focus on the Morphology of Retraction Fibers Formed during Cell Migration
○Rin Nagaoka1, Koki Yoshikawa1, Eisuke Muraoka1, Shogo Saito1, Mina Okochi1 (1. Institute of Science Tokyo)
[2P-415]Analysis of the execution mechanism of cell extrusion during tissue development using Drosophila epithelial tissue
○Marina Awai1, Haruna Kajita1, Atsuto Nakagawa1, Akihito Kira1, Kohki Kawane1 (1. Kyoto Sangyo Univ.)
[2P-416]Analysis of tight junction dynamics and epithelial barrier maintenance mechanisms in cell extrusion
○Shion Matsuda1, Haruna Kajita1, Sayaka Nakai1, Kohki Kawane1 (1. Kyoto Sangyo University)
[2P-417]Analysis of the dynamics of adhesion between cells and extracellular matrix during cell extrusion
○Rukiya Shimoyama1, Ruka Kamikawa1, Kohki Kawane1 (1. Kyotosangyo university)
[2P-418]Involvement of macrophages in cell extrusion
○Atsuto Nakagawa1, Kohki Kawane1 (1. KYOTO SANGYO Univ.)
[2P-419]Competitive cellular interaction via autophagy during tissue development
○Sakura Toyooka1, Syogo Harada1, Eiji Inoue1, Kohki Kawane1 (1. Kyoto Sangyo Univ.)
[2P-420]Role of caspases during cell turnover of intestinal epithelium in Drosophila melanogaster
○Yoshiki Miyaura1, Akihito Kira1, Seisuke Kimura1, Kohki Kawane1 (1. Kyoto Sangyo University)
[2P-421]Development of AI-Based Tracking of Densely Packed Cells
○Kenshiro Taguchi1, Yifei Li2, Ankyu Tomohiro3, Daisuke Nanba3, Jun'ichi Kotoku1,2 (1. Graduate Degree Program of Health Data Science,Teikyo Univ., 2. Medical Care and Technology, Teikyo Univ. , 3. Division of Regenerative Medicine and Therapeutics, Faculty of Medicine, Tottori Univ.)
[2P-422]Mimicking human gastrulation: Microprint culture of human iPS cells
○Ryo Kojima1, Miyu Mori1, Shota Tsuji1, Hazuki Tsuboi1, Yohei Hayashi3, Kiyoshi Ohnuma2 (1. Graduate School of Department of Materials Science and Bioengineering, Nagaoka University of Technology, 2. Department of Science and Technology Innovation, Nagaoka University of Technology, 3. RIKEN)
[2P-423]Identification of a novel molecular mechanism of cytokinesis in Tetrahymena
Kanako Yamaki1, Shinya Matsuda1, Wolfgang Maier3, Jacek Gaertig2, ○Kentaro Nakano1 (1. University of Tsukuba, 2. University of Georgia, 3. University of Freiburg)
[2P-424]Roles of Src family tyrosine kinase activities in brain development.
○Shiho Ito1, Yoshiaki V Nishimura2, Takeshi Kawauchi1,3 (1. Dept. Adaptive & Maladaptive Responses in Health & Dis., Grad. Sch. of Med., Kyoto Univ., 2. Div. Neurosci., Tohoku Med. and Pharm., Univ., 3. Dept. Physiol., Keio Univ. Sch. of Med.)
[2P-425]How Do Cells Regulate the Switch Between Stable and Dynamic Regimes of Cell–Matrix Adhesion? Insights from a Unified Mechanochemical Model
○Eiji Matsumoto1, Shinji Deguchi1 (1. The University of Osaka)
[2P-426]Functional role of THBS3 in Cell Competition
○Kengo Matsuba1, Olivia Marchia Kusuma1, Eilma Akter2, Shunsuke Kon1 (1. Division of Cell Biology, Research Institute for Biomedical Sciences, Tokyo University of Science Div. of Cell. Biol., Res.Inst. for Biomed. Sci.,Tokyo Univ. of Sci, 2. Department of Oncogenesis Growth Regulation, Research Institute, Osaka International Cancer Institute)
[2P-427]Elucidation of the invasion mechanism of human-derived glioma cells via mechanosensitive ion channels
○Maoka Koike1, Takunori Minegishi1, Naoyuki Inagaki1 (1. Nara Institute of Science and Technology)
[2P-428]Shootin1b-mediated mechanical regulation of phagocytosis
○Nana Kashimoto1, Takuto Watanabe1, Kentaro Baba1, Naoyuki Inagaki1 (1. Nara Institute of Science and Technology)
[2P-429]Analysis of Entosis in Breast Cancer Cell Lines
○Yuki Takei1,2, Yusuke Hayashi1,2, Kazushi Azuma1, Kentaro Semba1,3, Yusuke Yamamoto2 (1. Dept. of Life Sci. & Med.Biosci., Waseda Univ., 2. Lab. of Integ. Onco., Natl. Cancer Ctr. Res. Inst., 3. TR Ctr., Fukushima Med. Univ.)
[2P-430]Evaluation of Desiccation Stress in Caenorhabditis elegans Expressing an Ice-Binding Protein
○Daiki Shimose1, Ryouhei Kuriyama1, Yuka Ikemoto2, Yoichi Shinkai3, Masahiro Kuramochi1 (1. ibaraki Univ., 2. JASRI, 3. AIST)
[2P-431]Synergistic activation of TRPA1 in intestinal enterochromaffin cell
○Koji Shibasaki1, Kokono Kusu1, Yurina Hada1 (1. Lab of Neurochem., Univ. Nagasaki)
[2P-432]Deformation control of multiple-protrusion liposomes via microtubule polymerization toward bio-actuator design
○Takuma Nishimura1, Hiroto Ishii1, Yusei Sato1, Satoshi Nanjo2, Naoya Morikawa2, Masahiko yamagishi1, Hiroaki Suzuki3, Junichiro Yajima1 (1. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 2. Graduate School of Science and Engineering, Chuo University, 3. Faculty of Science and Engineering, Chuo University)
[2P-433]Functional analysis of Dpcd on actin fiber structure of tracheal ciliated cells
○Mayu Nakayama1, Ayano Koike1, Hiroshi Hamada2, Yukiko U. Inoue3, Takayoshi Inoue3, Kyosuke Shinohara1 (1. Tokyo University of Agriculture and Technology, 2. Institute of Physical and Chemical Research, 3. National Center of Neurology and Psychiatry)
[2P-434]Roles of Syntaxin 3 and 4 in Regulating the Behavior of Mouse B16 Melanoma Cells
○Ayaka Furuie1, Junya Abe1, Yohei Hirai1 (1. kwanseiGakuinUniversity)
[2P-435]Structural and Functional Diversity of Actin Filaments Regulated by JRAB
○Chie Sakamoto1,2, Hiroshi Yamada3, Natsuki Matsushita4, Kohji Takei3, Takuya Sasaki2,5, Ayuko Sakane2,5 (1. Faculty of Medicine, Tokushima Univ., 2. Mol. Cell. Func. Unit, IPHF, Tokushima Univ., 3. Dept. of Neurosci., Grad. Sch. of Med., Dent. and Pharm. Sci., Okayama Univ., 4. Div. of Lab. Animal Res., Aichi Med. Univ. Sch. of Med., 5. pLED, Tokushima Univ.)
[2P-436]Barrier Protection in DSS-Induced Intestinal Organoids through ROCK Inhibition
○Jung-ha Park1,2, Somin Jin2, Soojung Jin2, Hyun Ju Kwon1,2,3 (1. Department of Biopharmaceutics, College of Engineering, Dong-eui University, Busan 47340, Korea, 2. Core-Facility Center for Tissue Regeneration, Dong-eui University, Busan 47340, Korea, 3. Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea)
[2P-437]Comparison of gene transfer efficiency between different typesof droplet electroporation
○Maya Yoshida1, Ryuto Shinozaki3, Hirofumi Kurita1, Takayuki Shibata4, Kohjiro Matsumoto5, Rika Numano1,2 (1. Toyohashi Univ. of Tech., Dept. of Appli. Chem. and Life Sci., 2. Toyohashi Univ. of Tech., Inst. for Research on next-generation Semiconductor and Sensing, 3. Okinawa Inst. of Sci. and Tech., Membrane Cooperativity Unit,, 4. Toyohashi Univ. of Tech., Dept. of Mech. Engineering., 5. Nepa Gene Co., Ltd.)
[2P-438]Operando X-ray dynamics reveals the membrane-protective mechanism of ice-binding proteins
○Shinnosuke Harada1, Masahiro Kuramochi1,2 (1. Ibaraki Univ., 2. Univ. of Tokyo)
[2P-439]Efficient Sample Preparation Workflow Using Cryo-FIB-SEM and Its Application to Cryo-ET Analysis
○Rintaro Kawano1, Naoki Hosogi1, Hideki Matsushima1, Chikako Nakayama1, Noriaki Mizuno1 (1. JEOL Ltd.)
[2P-440]Growth initiation of the starved Escherichia coli
○hayato fujita1, Genki Hirano1, Miho Yoshimura2, Kaneyoshi Yamamoto1,2,3 (1. Hosei University Graduate School, 2. Research Center fir Micro-Nano Technology, 3. Hosei Univ.)
[2P-441]LLife cycle of snow algae isolated from the Hakuba Daisekkei in Nagano Prefecture
○Masaki Ihara1, Michiko Kobayashi1, Koji Imamura2, Mitsuyoshi Miyata 2, Tomoya Takeda2 (1. Shinshu University, 2. EPSON)
[2P-442]Molecular basis of HP1-denpendent activation of the chromosomal passenger complex
○ISHIN TO1,2, Ryu-Suke Nozawa1, Yasuhiro Hirano1,3, Toru Hirota1,2 (1. Cancer Institute, Japanese Foundation for Cancer Research, 2. Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 3. Graduate School of Frontier Biosciences, Osaka University)
[2P-443]Structural and biochemical characterization of the CCAN cluster assembled through oligomerization of CENP-C
○Yutaka Mahana1, tatsuo Fukagawa1 (1. The University of Osaka)
[2P-444]Nucleolar-localized glycosidase Neu4 inhibits c-Myc stabilization through interacting with RPL5 and RPL11.
○Toshiki Hyodo1, Yuki Gono2, Yuko Futagami2, Masaharu Komatsu1,2, Kazuhiro Shiozaki1,2 (1. Unit. Grad. Sch. of Agricult. Sci., Kagoshima Univ., 2. Food Life Sci, Fac.Fish., Kagoshima Univ.)
[2P-445]Towards Elucidating Cell Cycle–Dependent Intracellular Temperature Changes Using Fluorescent Nanodiamonds
○Kiichi Kaminaga1,4, Risa Ujiie1, Chihiro Suzuki1,2, Keiji Suzuki3, Hiroshi Abe4, Takeshi Ohshima4, Onoda Shinobu4, Ryuji Igarashi1,2,5 (1. IQLS, QST, 2. Graduate School of Science and Engineering, Chiba Univ., 3. Atomic Bomb Disease Institute, Nagasaki Univ., 4. Takasaki Institute for Advanced Quantum Science, QST, 5. Dept. of Life Science and Technology, Institute of Science Tokyo)
[2P-446]Intracellular temperature dynamics after X-ray irradiation monitored by fluorescent nanodiamonds and their Cell cycle dependence
○Risa Ujiie1, Kiichi Kaminaga1, Chihiro Suzuki1, Satomi Yanagihara1, Keiji Suzuki2, Hiroyuki Abe1, Takeshi Oshima1, Ryuji Igarashi1 (1. QST, 2. Nagasaki University)
[2P-447]Development of a Novel Nano-Quantum Sensor Fabrication Method for Sensitive Intracellular Temperature Measurement
○Chihiro Suzuki1,2, RISA Ujiie1, So Tze Kit1, Tamami Yanagi1,3, Kiichi Kaminaga1, Hiroshi Abe1, Shinobu Onoda1, Takeshi Oshima1, Ryuji Igarashi1,2,3 (1. National Institutes for Quantum Science and Technology, 2. Chiba Univ. Graduate School of Science and Engineering, 3. Institute of Science Tokyo School of Life Science and Technology)
[2P-448]Molecular mechanisms of microtubule inhibitor resistance in lung cancer cells
○Keisuke Ikeda1, Moe Sugasaki2, Urara Kasuga3, Michiko Hirata3, Masaki Inada2,3 (1. Dept. of Ind. and Tech. and Innov., Tokyo Univ. of Agri. and Tech., 2. Dept. of Collab. and Edu. Curr., Tokyo Univ. of Agri. and Tech., 3. Dept. of Biotech. and Life Sci., Tokyo Univ. of Agri. and Tech.)
[2P-449]Cellular response to low-temperature atmospheric pressure plasma stress
○Katsuki Johzuka1,3, Shinji Yoshimura2,3 (1. Astrobiology center, Ntional Institute of Natural Sciences, 2. National Institute for Fusion Science, 3. SOKENDAI)
[2P-450]Effects of various organic acids on the dynamic behavior of intracellular pH in E. coli
○Mihiro Kobayashi1, Masahiro Mizuno1, Masakazu Kataoka1 (1. Shinshu univ.)
[2P-451]Roles of the BMP signaling pathway in cardiomyocyte proliferation and sarcomere disassembly
○Mingxuan Ju1, Wataru Kimura1 (1. RIKEN BDR)
[2P-452]Analysis of the mechanisms of bacterial growth promotion by addition of fluorinated solvents with a focus on oxidative stress
○Keita Saito1, Ryosuke Hosoki1, Koji Kawada1, Katsuaki Izawa1, Yoshihisa yamashige2, Shojiro Kikuchi3, Yuichi Ogawa1, Masahiko Harata1 (1. Tohoku University Graduate School of Agriculture, 2. Kyoto University Graduate School of Agriculture, 3. Hyogo Medical University Institute of Advanced Medical Sciences)
[2P-453]Functional analysis of cell proliferation by the centrosome protein CEP169
○Shunsuke Imai1, Kanako Terada1, Kousei Yamamoto1, Hayata Kurihara1, Yasuhiko Terada1 (1. Dept. of Chem. and Biochem., Grad. Sch. of Adv. Sci. and Eng., Univ. of Waseda)
[2P-454]Regulation Mitotic Chromosome by the nucleolar protein MYBBP1A
○Shunsuke Aoki1, Kazashi Kato1,2, Haruka Shimamoto1, Yuichiro Kogure1, Masato Kanemaki3, Keiji Kimura1,2 (1. Grad. Sch. of Life and Env. Sci., Univ. of Tsukuba, 2. TARA, Univ. of Tsukuba, 3. Dep. of Chr. Sci., NIG)
[2P-455]Analysis of a novel cell proliferation control mechanism mediated by reciprocal regulation of UBE3B ubiquitin ligase isoforms
○Kaito Iwashita1, Kazuyoshi Yano1, Maiko Okada1 (1. Grad. Sch. of Bionics, Tokyo Univ. of Tech.)
[2P-456]The role of inositol in lifespan of fission yeast cells in stationary phase
○Ema Inaba1, Ryu Sawai1, Shunsuke Shimazaki1, Kohhei Yamada1, Ayumu Yamamoto1 (1. Grad. Sch. Int. Sci. Tech., Shizuoka Univ.)
[2P-457(2PS-18-07)]Does reduction of upstream molecules in the insulin signaling pathway explain obesity-induced insulin resistance?
○So Morishita1, Shinsuke Uda2, Hiroyuki Kubota1 (1. Kyushu University, 2. Yamaguchi University)
[2P-458]Regulation of autophagic response by CNOT11 via IL-6/JAK/STAT signaling
○Saori Nishijima1, Toru Suzuki2, Tadashi Yamamoto1 (1. Okinawa Institute of Science and Technology, 2. Tokyo Univ)
[2P-459]Identification and mechanistic analysis of intracellular modulators regulating PROTAC-induced targeted protein degradation
○Yuki Mori1,2, Yoshino Akizuki1,2, Rikuto Honda1,2, Fumiaki Ohtake1,2 (1. Institute for Advanced Life Sciences, Hoshi University, 2. Graduate school of Pharmaceutical Sciences, Hoshi University)
[2P-460]Identification of regulators of mutant Huntingtin degradation
○Nobuhide Ichigozaki1, Shota Tomomatsu2, Fumiaki Ohtake1,2 (1. School of Pharmaceutical Science, Hoshi University, 2. Institute for Advanced Life Science, Hoshi University)
[2P-461]A novel role of Sec16A in the regulation of the mTORC1 pathway
○Yuichiro IOI1, Misaki Kobayashi1, Chiaki Ishii1, Hideki Shibata1, Terunao Takahara1 (1. Graduate School of Bioagricultural Sciences, Nagoya University)
[2P-462]Role of cytohesin-2, an Arf6 guanine-nucleotide exchange factor, in neurite outgrowth
○Shiori Tada1, Hideji Yako1, Junji Yamauchi1 (1. Tokyo University of Pharmacy and Life Sciences)
[2P-463]Phosphorylation analysis of a novel ERK substrate identified by yeast three-hybrid screening
○Yuto Ishii1,2, Yuji Kubota1, Mutsuhiro Takekawa1 (1. Div. of Cell Signaling & Mol. Med., IMSUT, 2. Dept. of Comput. Biol. and Med. Sci., Grad. Sch. of Front. Sci., Univ. of Tokyo)
[2P-464]Functional analysis of the proteins Pkd1 and Pkd2, which are related to autosomal dominant polycystic kidney disease.
○Takayuki Koyano1, Kaori Onishi1 (1. Shigei Medical Research Institute)
[2P-465]Functional regulation of T-type calcium channels by the cell cycle-regulating kinase, the NIMA-related kinase 4
○ANKUSH SHARMA1,2, Naresh Dakshinamoorthy2, Andres Maturana1, Anamika Bhargava2 (1. Nagoya University, 2. Indian Institute of Technology Hyderabad)
[2P-466]Plasmodium NIMA-related kinease 3 mediates phosphorylation signaling that regulates male gametogenesis.
Mark Tetteh-Tsifoanya1, Takashi Sekine1, Hidetaka Kosako2, Tomoko Ishino1, ○Naoaki Shinzawa1 (1. Dept. Parasitol. Trop. Med., Grad. Sch. Med. Dent., Ins. Sci. Tokyo, 2. Inst. Adv. Med. Sci., Tokushima Univ.)
[2P-467]Role of Nrf2 in the SUMOylation-dependent regulation of insulin secretion from pancreatic β-cells
○Yuta Kato1,2, Eri Mukai1 (1. Ritsumeikan Univ., 2. Ritsumeikan Advanced Research Academy (Student Fellowship))
[2P-468]Quantitative imaging of GPCRs downstream signalings
○Reiko Inouye1,2, Koichi Inoue3, Ryosuke Tanii4, Yuhei Goto1,2, Kazuhiro Aoki1,2,3 (1. Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University, 2. Faculty of Science, Kyoto University, 3. Exploratory Research Center on Life and Living Systems, 4. Sanford Research)
[2P-469]Development of a microfluidic device for measuring the stimulus area dependence of drug response
○Kohei Niiya1, Ryuta Nakamura1, Katsuya Hirano1, Hidekuni Takao1, Kyohei Terao1 (1. Kagawa University)
[2P-470]Analysis of doxorubicin-induced cardiomyocyte damage and NF-kB signaling in H9c2 cardiomyocyte cells treated with retinoic acid
○Mawo Shimizu1, Teppei Nakamura1, Masami Morimatu1 (1. Laboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Medicine, Hokkaido University)
[2P-471]Investigation of the anti-inflammatory mechanisms of plant-derived lactic acid bacteria
○Satomi Uesugi1, Hiroshi Takemori1 (1. Gifu Univ.)
[2P-472]Development of Milk-Derived Extracellular Vesicles as Peptide Carriers
○Aina Niimi1, Takemori Hiroshi1 (1. Gifu University)
[2P-473]Elaborating cortical pyramidal dendrites require dephosphorylation of Signal Regulatory Protein α by Protein Tyrosine Phosphatase δ
○Miyu Wakatsuki1,2, Kohtaro Takizawa1, Fumio Nakamura1 (1. Department of Biochemistry, Tokyo Women’s Medical University, 2. Division of Rheumatic Diseases, National Center for Global Health and Medicine)
[2P-474]Three NFAT isoforms are involved in cyclosporin A–induced anagen prolongation
○Kenta Hagiwara1, Hiroaki Kitamura1, Yuka Tsuchiya1, Tokuro Iwabuchi1 (1. Tokyo university of technology)
[2P-475]Inhibition of PTEN Restores Akt Signaling and Reduces MDMA-Induced Apoptosis and Autophagy
○YU Xiu-Xin1, Yeh Ting-Yin1, Huang Yuahn-Sieh1 (1. Department and Graduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan)
[2P-476]Exploration of KISS1R agonist peptides through cell phenotypic screening
○Kosato Hamaoka1, Hiro Ishi1, Ning Lin1, Tetsuya Kadonosono1 (1. Institute of Science Tokyo)
[2P-477]Design of Recombinase Based Genome Integrated Switchable Generic Circuits
○Toshiki Saito1, Tomohiro Nawata1, Koko Nakata1, Shunsuke Takahashi2 (1. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ., 2. Div. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ.)
[2P-478]Involvement of three types of laminin in the anagen transition of the human hair cycle via suppression of BMP4 expression
○Hinano Kinjo1, Yume Hiraga1, Kenta Hagiwara1, Haruyo Yamanishi1, Tokuro Iwabuchi1 (1. Faculty of Bioscience and Biotechnology, Tokyo University of Technology)
[2P-479]Intracellular dynamics of response regulator CheY and chemotaxis behavior in a single Vibrio alginolyticus cell
Eito Kawamura1, Ryoya Takase1, Ren Shibata2, Yumiko Uchida1, Akihiko Ishijima1, ○Hajime Fukuoka1 (1. Grad. Sch. Front Biosci., Univ. of Osaka, 2. Sch. Eng. Sci., Univ. of Osaka)
[2P-480]Peptide derived from waterfowl feather keratin contributes to the protection of the epidermis and wound healing
○Hideki Inoue1, Koyo Amano1, Saki Ohta1, Yuri Hosaka2 (1. Kanagawa Institute of Technology, 2. Toyo Feather Industry Co. Ltd.)
[2P-481]Characterization of Novel Ligands Targeting the Brain-Enriched Orphan Receptor GPR88
○Karina Rodriguez1 (1. Gunma University Graduate School of Science and Technology)
[2P-482]Involvement of Primary Cilia in Insulin Secretion and Intercellular Coordination in Pancreatic Beta Cells
○Ryosuke Yamamoto1, Yuta Kato1, Eri Mukai1 (1. Ritsumeikan Univ.)
[2P-483]SMAD5 phosphorylation by ALK1 is modulated by the interaction of the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2
○Yoichi Teratake1, Yukihito Ishizaka1 (1. Japan Institute for Health Security)
[2P-484]Enhancing beige adipogenesis and lipid metabolism in human adipocytes through vitamin E homologue and myokines
○Yume Suzuki1, Ayaka Tsubota1, Haruka Takeuchi2, Miho Hanai2, Chikako Kiyose2, Hideki Inoue1 (1. Dept. of Applied Bioscience, Kanagawa Institute of Technology, 2. Dept. of Nutrient and Lifescience, Kanagawa Institute of Technology)
[2P-485]Potentials of BMP8 in preventing glucocorticoid–induced osteoporosis
○YENCHUN HSU1, YINGWEN WANG1, CHINGWEI LUO1 (1. National Yang Ming Chiao Tung University)
[2P-486]Exploration of Extract Combinations Exhibiting Both Hydroxyl Radical Scavenging and NRF2 Activation
○Tomomi Degawa1, Chiaki Homma2, Kazuya Yamada2, Masahiro Kurono2, Hirotaka Miyazaki1 (1. POLA Innovation Center, POLA Inc., 2. Sunsho Pharmaceutical Co., Ltd.)
[2P-487]Investigation of cell senescence associated gene by CAGE method in human normal fibroblast TIG-1.
○Marino Chinen1, Kaho Irei1, Marina Fujiyoshi1, Kosuke Tashiro2, Yoshinori Katakura2, Kenji Kishihara3, Tsukasa Fujiki3 (1. Fac. of pharm, Nagasaki International Univ., 2. Fac. of Agr, Kyushu Univ., 3. Grad. Sch. of Pharm, Nagasaki International Univ.)
[2P-488]Establishment of a Ferroptosis Evaluation System Using HeLa Cells for the Discovery of GPx4 Inhibitors
○Yuki Yoshiizumi1, Kosuke Nakada1, Takashi Kodama2, Kyoko Furuita2, Yohei Miyanoiri2, Minhee Kang3, Ju Yeon Lee4, Jin Young Kim4, Young Ho Jeon3, Chojiro Kojima1,2 (1. Graduate School of Engineering Science, Yokohama National University, 2. Institute for Protein Research, The University of Osaka, 3. College of Pharmacy, Korea University, 4. Research Center for Bioconvergence Analysis, Korea Basic Science Institute)
[2P-489]Elucidation of the mitochondria-dependent cell death mechanism induced by Ridaifen-B in breast cancer cells
○Mihiro Suzuki1, Yuta Semba1, Amane Yoneoka2, Kyoka Komukai2, Takatsugu Murata2, Isamu Shiina2, Yukitoshi Nagahara1 (1. Graduate School of Tokyo Denki University, 2. Tokyo University of Science)
[2P-490]Attempt to detect cancer cells utilizing E2F activity out of control by RB
○Hitomi Ogata1, Kiyoshi Ohtani1 (1. Department of Biomedical Chemistry, Graduate School of Science and Technology, Kwansei Gakuin University)
[2P-491]The transcription factor NF-kB suppresses the tumor suppressive E2F1 activity
○Ayane Murakami1, Kiyoshi Ohtani1 (1. Department of Biomedical Chemistry, Graduate School of Science and Technology, Kwansei Gakuin University)
[2P-492]Demonstration of phagocyte-mediated clearance of ferroptotic cells before plasma membrane rupture
○Keita Taniguchi1, Mori Yasushi2, Akari Shimizu3, Satsuki Ito3, Kyoko Chiba4, Hideyo Sato5, Sho Kobayashi1,2,3, Naomi Abe-Kanoh1,2,3 (1. Grad. Sch. Agr. Sci., Yamagata Univ., 2. United Grad. Sch. Agr. Sci., Iwate Univ., 3. Dept. Food Life Environ. Sci., Fac. Agr., Yamagata Univ., 4. Frontier Res. Inst. Interdisc. Sci., Tohoku Univ., 5. Dept. Med. Tech., Fac. Med., Niigata Univ.)
[2P-493]Antitumor effect of extracellular vesicles secreted by epigenetically modified senescent cancer cells
○Naoya Hasegawa1, Hikaru Hatano1, Hiyori Iitsuka1, Sogo Aoki1, Kiyoshi Sato1, Hiroyoshi Kawakami1 (1. Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University)
[2P-494]Role of Annexin IX in programmed cell death during the pupal metamorphosis of the silkworm, Bombyx mori
○Saki Tanaka1, Eiji Kotani1, Keiko Takaki1 (1. Kyoto Institute of Technology)
[2P-495]Targeting Oncogenic Stress Limits: Discovery of ACA-28 as a Selective ERK Pathway Agonist for Cancer Therapy
○Reiko Sugiura1 (1. Kindai University, Faculty of Pharmacy)
[2P-496]Structure–activity relationship and mechanisms of induction of p53-independent G2/M arrest and cell death by 3-styrylchromone derivatives
○Kazushi Sonoda1, Yuta Semba1, Koichi Takao2, Yoshiaki Sugita2, Hiroshi Sakagami3, Seiichi Tamura3, Yukitoshi Nagahara3,1 (1. Sch. Sci. and Eng., Tokyo Denki Univ., 2. Facu. Pharm., Josai Univ., 3. Sch. Dent., Meikai Univ.)
[2P-497]Mechanisms of ferroptosis induction through GPX4 degradation triggered by conjugated fatty acids
○Soma Taguchi1, Yusuke Hirata1, Ryota Kojima1, Shinnosuke Kimura1, Takuya Niijima1, Takuya Noguchi1,2, Atsushi Matsuzawa1 (1. Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2. Dep. of Med. Biochem., Sch. of Pharm., Iwate Med. Univ.)
[2P-498]Tolerance to extracellular acidic pH facilitates tumor plasticity through Immune Modulation
○Manami Hasegawa1,2, Bo Xu1, Keisuke Maeda1, FeiFei Cai1, Runmei Cui3, Ritsuko Ando1, Miyuki Nishida1, Ken Matsumoto1, Chisato Iwabuchi-Yoshida1, Kazuyuki Yamagata1, Rika Tsuchida1, Tsuyoshi Osawa1,2,3 (1. Div. of Integrative Nutriomics & Oncology, RCAST, U Tokyo, 2. Dept. of Chemistry & Biotechnology, Eng., U Tokyo, 3. Dept. of Biological Sciences, Sci., U Tokyo)
[2P-499]Analysis of the mechanism for regulation of cellular senescence by lamin B receptor
○Mami Sugimoto1, Keisuke Tanabe1, Rena Okazaki1, Yoshimi Yamakami1, Yuki Takauji1, Michihiko Fuji1 (1. Yokohama City University・Nanobioscience)
[2P-500]Proteostatic defect induces alterations of cellular physical properties thereby triggering cell competition
○Wonjae Song1, Kei Kozawa1, Yasuyuki Fujita1 (1. Kyoto Eniversity Medical School)
[2P-501]Cell competition eliminates disease-linked de novo mutant cells to ensure robust development but is vulnerable to environmental pH stress
○Yuki Akieda1, Hikari Ukawa1, Tohru Ishitani1 (1. Dept. of Homeostatic Regulation, RIMD, Univ. of Osaka)
[2P-502]Radiation-mitigating and longevity-promoting activity of spermidine involves mitochondria-rejuvenating function
○Rajkumar S. Kalra1, Kayo Sugiyama1, Mika Yamaoka1, Yoichiro Kusunoki1, Kengo Yoshida1 (1. Department of Molecular Biosciences, Radiation Effects Research Foundation (RERF), Hiroshima)
[2P-503]Search for natural compounds that ameliorate age-related impairment of proteostasis
○Yuki Konishi1, Mariko Kitajima1, Hayato Ishikawa1, Motoyuki Itoh1, Ayako Tonoki1 (1. Graduate School of Pharmaceutical Sciences,Chiba University)
[2P-504]Esophageal cancer-related gene-4 induces lysosome-dependent cell death mediated by cathepsins in astrocytes
○Naoto Oikawa1, Lifu Zhang1, Toru Kondo1 (1. Hokkaido University)
[2P-505(2AS-04-06)]RUNX1 transcriptionally suppresses LINE1 in hematopoietic stem cells.
○Motomi Osato1,5, Bibek Dutta2, Arusyak Ivanyan1, Michelle Meng Huang Mok2, Haruhito Totani2, Yong Tham Chen 2, Akiko Niibori-Nambu2, Chu Guo 3, Yutaka Nakachi3, Miki Bundo3, Toshio Suda2, Wee-Joo Chng 2, Kimi Araki4, Kazuya Iwamoto3, Goro Sashida1 (1. Kumamoto Univ. IRCMS, 2. Natl. Univ. Singapore, CSI, 3. Grad. Sch.Med. Sci., Kumamoto Univ., 4. Kumamoto Univ. IRDA, 5. Kumamoto Kenhoku Hosp.)
[2P-506]Crossing Species Boundaries with DNA Repair Factors: Can Longevity-Associated Proteins Advance the Mouse Aging Model?
○Ruifeng SHEN1, Yutaro HORI2, Takehiko KOBAYASHI2 (1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2. Institute for Quantitative Biosciences)
[2P-507]Effects of Rapamycin on RTEL1 gene expression and telomerase activity
○Takahiro Oda1, Shigeru Hanamata1, Fumiaki Uchiumi1 (1. Department of Gene Regulation, Graduate School of Pharmaceutical Science, Tokyo University of Science)
[2P-508]Coordination of chromatin determinants (CODE) tensors quantified epigenetic aging with single-cell accuracy.
○Kenta Ninomiya1, Elena Chrysostomou2,3, Joseph A Rhodenhiser4, Cayla Miller3, Lauren Sullivan3, Uri Manor2,3, Alexey V Terskikh1,5 (1. The University of Western Australia , 2. Salk Institute for Biological Studies, 3. The University California San Diego, 4. Sanford Burnham Prebys Medical Discovery Institute, 5. Scintillon Institute)
[2P-509]Proteomic alterations of extracellular vesicles associated with cellular senescence and their functional analysis
○Kyojiro Kawakami1, Ryutaro Sato1,2, Keitaro Umezawa1, Hiroki Tsumoto1, Koji Fukui2, Yuri Miura1 (1. Tokyo Metropolitan Institute for Geriatrics and Gerontology, 2. Shibaura Institute of Technology)
[2P-510]Identification and functional analysis of ATP-dependent RNA helicase DDX5 in senescence-associated aggregate
○Yasuhiro Takenaka1, Masataka Hirasaki2, Yoshihiko Kakinuma1 (1. Nippon Medical School, 2. Saitama Medical University)
[2P-511]Timing of Sepsis Onset in a Mouse Model of Acute Radiation-Induced Gastrointestinal Syndrome
○Kanako Yamanouchi1, Karin Kakihara2, Takamasa Nagai1, Masaru Yamaguchi3, Takakiyo Tsujiguchi4, Mitsuru Chiba1 (1. Dept. of Medical Technology, Grad. School of Health Sciences, Hirosaki Univ., 2. School of Health Sciences, Hirosaki Univ., 3. Dept. of Radiation Science, Grad. School of Health Sciences, Hirosaki Univ., 4. Disaster & Radiation Emergency Med. Center, Hirosaki Univ.)
[2P-512]Genetic Analysis of the Mechanism Initiating Cell Competition
○Hitomi Nakamura1, Bo Zhang1, Ryo Matsumoto1, Mai Sakaguchi1, Tomoe Kobayashi2, Makoto Matsuyama2, Keita Miyoshi3, Shu Kondo3,4, Kuniaki Saito3, Hiroshi Kanda1, Tatsushi Igaki1 (1. Kyoto University , Graduate School of Biostudies, Department of Genetics, 2. Shigei Medical Research Institute, Division of Molecular Genetics, 3. National Institute of Genetics, Department of Chromosome Science, Invertebrate Genetics Laboratory, 4. Tokyo University of Science, Department of Biological Science and Technology)
[2P-513]SMG1/DNA-PK–NRF2 axis in regulating the cellular homeostatic response to ROS
○Yumiko Fujikawa1, Hirotatsu Imai2, Kae Suzuki3, Hidehito Kuroyanagi2, Daisuke Utsumi7, Kenzo Takahashi4, Shigeo Ohno5, Akio Yamashita6 (1. Dept. of Investigative Med., Grad. Sch. Med., Univ. of the Ryukyus, 2. Dept. of Biochem., Grad. Sch. Med., Univ. of the Ryukyus, 3. Protein Sci. Lab., Grad. Sch. Sci. & Eng., Saitama Univ., 4. Dept. of Dermatol., Grad. Sch. Med., Univ. of the Ryukyus, 5. Res. Inst. for Dis. of Old Age, Juntendo Univ. Sch. Med., 6. Kindai Univ., Grad. Sch. Pharm., 7. Adv. Med. Res. Ctr., Univ. of the Ryukyus)
[2P-514]The involvement of causative proteins for amyotrophic lateral sclerosis in the induction of spoptosis, a novel type of cell death
○Rikako Yamamoto1, Ko Eto2 (1. Dept. Biol. Grad. Sch. Sci. & Tech., Kumamoto Univ., 2. Dept. Biol. Sci., Fac. Adv. Sci. & Tech., Kumamoto Univ.)
[2P-515]Motor neurons could die of spoptosis, a novel cell death mechanism, in amyotrophic lateral sclerosis
○Riko Oyama1, Taichi Kurogi2, Ko Eto3 (1. Dept. Biol., Fac. Sci., Kumamoto Univ., 2. Dept. Biol., Grad. Sch. Sci. & Tech., Kumamoto Univ., 3. Dept. Biol. Sci., Fac. Adv. Sci. & Tech., Kumamoto Univ.)
[2P-516]Changes in ERK dynamics associated with cellular senescence
○Shunsuke Muraki1,2, Yuhei Goto1,3, Tatsuki Tsuruoka1, Sachiya Nakashima1, Kazuhiro Aoki1,3 (1. Graduate School of Biostudies, Kyoto University, 2. Faculty of Science, Kyoto University, 3. CeLiSIS, Kyoto University)
[2P-517]Investigation of the effects of the cell volume-sensitive chloride channel inhibitor NPPB on apoptosis and cell morphology in Xenopus oocytes.
○Yamato Miyamoto1, Hina Okuno1, Kanami Doi1, Himena Hagino1, Kenichi Sato1 (1. Kyoto Sangyo University)
[2P-518]Genetic screening for factors controlling high-temperature growth in Saccharomyces cerevisiae
○Chiho Iida1, Yukiko Nakase2, Yuichi Morozumi3, Daisuke Watanabe1 (1. NAIST, 2. Yamato Univ., 3. Yamanashi Univ.)
[2P-519]Development of Alginate Gel Beads for Spheroid Cultures using Centrifugal Extrusion
○Hiroyoshi Aoki1, Kota Imai2, Aya Nozaki2, Yutaka Yamagata1 (1. RIKEN, 2. TOYO Corporation)
[2P-520]Development of a method for inducing stable tau aggregation by blue light irradiation in Neuro2a cells introduced with the optogenetic tool OptoTau.
○Hisanao Matsui1, Tomoya Uchida1, Toshiki Takahashi1, Shigeo Sakuragi1, Yoshiyuki Soeda2, Akihiko Takashima3, Hideaki Yoshimura4, Hiroko Bannai1 (1. Waseda Univ., 2. Nihon Univ., 3. Gakushuin Univ., 4. The University of Tokyo)
[2P-521]Development and Application of Novel Fluorescent Probes for the Simple Detection of Extracellular Vesicles (EVs)
○Kotaro Terada1, Hiroshi Takemori1, Kyouji Furuta1 (1. Gifu University)
[2P-522]Transcriptional coactivator DDX5 gene is a target of E2F1 and DDX5 augments E2F1-induced tumor suppressor gene expression and apoptosis, thereby forming a feed forward loop between DDX5 and E2F1
○Rinka Nakajima1, Kiyoshi Ohtani1 (1. Kwansei Gakuin Univ.)
[2P-523]WDR1 functions as a coactivator of E2F1 in the nucleus and forms positive feedback loop in E2F1-mediated tumor suppressive mechanism
○Mashiro Shirasawa1, Kiyoshi Ohtani1 (1. Dept. of Biomed. Chem. Grad. Sch. of Sci. andTech. Kwansei Gakuin Univ.)
[2P-524]Development of an Optically Controlled Nanoneedle Method for Intracellular Molecular Delivery and Retrieval
○Akihiro Matsushita1, Keisuke Tano1, Hidekuni Takao1, Kyohei Terao1 (1. Kagawa University)
[2P-525]Isolation and identification of marine microorganisms that degrade Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] from Osaka Bay
○Takumi Iida1, Mana Ninomiya1, Sung Yi Shiuan1, Ami Kakinuma1, Keita Kobayashi2, Natsuko Miura1,2, Michihiko Kataoka1,2 (1. Dept. Appl. Biol. Chem., Grad. Sch. of Agric., Osaka Metropolitan Univ., 2. Appl. Life Sci., Grad. Sch. of Life and Environ. Sci., Osaka Prefecture Univ.)
[2P-526]Expanding the genetic toolkit for the anhydrobiotic cell line Pv11
○Yuki Yoshida1, Gregorius Altius Pratama1, Masahiko Hotta2, Takahiro Kikawada1,2 (1. NIAS, NARO, 2. Grad. Sch. Frontier Sci., Univ. Tokyo)
[2P-527]Quality control of isolated islets for islet transplantation: Assessment of dynamic change of isolated islets using holotomographic microscopy
○Naoaki Sakata1,2, Gumpei Yoshimatsu1,2, Ryo Kawakami1,2, Shohta Kodama1,2 (1. Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, 2. Center for Regenerative Medicine, Fukuoka University Hospital)
[2P-528]Correlation analysis between antigen affinity and trogocytosis levels of HER2-targeting CAR-T cells
○Taiki Abe1, Mahiro Matsumoto1, Takumi Abe1, Ning Lin1, Tetsuya Kadonosono1 (1. Institute of Science Tokyo)
[2P-529]The effects of P-cadherin in epidermal keratinocytes
○Sakura Ikeda1, Yohei Hirai1 (1. Kwansei Gakuin University)
[2P-530]Development of a standardized experimental platform for cell biology and biomedical research in the “KIBO” module of the International Space Station
○Toko Hashizume1, Kazumi Koga1, Kirima Junya1, Tomoko Ishige1, Tomokazu Yamazaki1, Akira Higashibata1 (1. Japan Aerospace Exploration Agency)
[2P-531]Plasmid injection into plant cells using electrically induced bubbles
○Yuudai Aokusa1, Kei Tateishi1, Nobutoshi Ota1, Yasuhiro Moriizumi2, So Makabe2, Yibo Ma1, Yoko Yamanishi1 (1. Kyushu University, 2. BEX CO., LTD.)
[2P-532]Development of an Atopic Dermatitis Model: Hyperactivation of JAK/STAT Pathways in HaCaT Keratinocytes
○Mika Sato1, Junya Abe1, Yohei Hirai1 (1. Kwansei Gakuin University)
[2P-533]Development of a high-activity mitochondria isolation method from tissue
○Naoko Yamamoto1, Yuya Ouchi1, Munetaka Ishiyama1, Satoru Torii2, Shigeomi Shimizu2 (1. Dojindo Laboratories, 2. Institute of Science Tokyo, Institute of Integrated Research Advanced Research Initiative, Pathological Cell Biology)
[2P-534]Functional analysis of Rab7 in regulation of autophagy by the deacetylase SIRT1
○Yukika Saga1, Ryusuke Hosoda1, Atsushi Kuno1 (1. Dept. of Pharmacology, Sapporo Medical Univ. School of Medicine)
[2P-535]Isolation and Gene Expression Analysis of iPS Cell-derived Cardiac Pacemaker Cells Based on Spontaneous Beating
○Lanyu Huang1,2, Kazuki Hattori4, Saburo Ito5, Hiromi Kirisako4, Sadao Ota 4, Yuichiro Miyaoka1,2,3 (1. Grad. Sch. Med and Dent Sci., Inst of Science Tokyo, 2. Regenerative Medicine Project, TMIMS, 3. Grad. Sch. Hum Sci., Ochanomizu Univ., 4. RCAST, The University of Tokyo., 5. Yamaha Motor Co.)
[2P-536]Additive melanogenesis inhibitory effect of tranexamic acid and niacinamide
○Junya Akaishi1, Nanako Maekubo1, Ishu Ismayil1 (1. Chifure Holdings Corporation)
[2P-537]Plug-and-play genomic integration via a landing pad system for E.coli Engineering
○Tomohiro Nawata1, Koko Nakata1, Toshiki Saito1, Shunsuke Takahashi2 (1. Dept. Life Sci. Eng., Grad. Sch. Sci. Eng., Tokyo Denki Univ., 2. Div. Life Sci. Eng., Sch. Sci. Eng., Tokyo Denki Univ.)
[2P-538]Photodynamically activated ROS induction via nanoparticles triggers apoptosis in hepatocellular carcinoma cells
○Won-Jin Kim1,2, Seok-Jun Kim1,2,3 (1. Department of Integrative Biological Sciences & BK 21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, Republic of Korea, 2. Institute of Well-Aging Medicare & Chosun University G-LAMP Project group, Chosun University, Gwangju, Republic of Korea, 3. Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea)
[2P-539]Tandemly Connected NMR for Real-Time Analysis of Lactate Metabolic Dynamics Induced by the MCT1 Inhibitor AZD3965
○Naoya Tochio1, Takanori KIgawa1 (1. RIKEN)
[2P-540]Physicochemical Field Mediates Cell–Cell Interactions and Multicellular Structure Formation
Tadashi Nakano1, Tokuko Haraguchi2, ○Yasushi Hiraoka2 (1. Osaka Metropolitan University, 2. Osaka University)
[2P-541]Reversion of Properties in Transformed Cells Induced by Pprotein Phosphatase Inhibitor Microystin-LR
○Yasunari Yunoki1, Risa Eto2, Shota seto2, Kazuhiro Shiozaki1,2, Shota Takumi1,2, Masaharu Komatu1,2 (1. The united Graduate school of Arricultural Sciences, 2. Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University)
[2P-542]Investigation of an Efficient Primary Cell Culture Method for Peritoneal-Derived Cells in Pleurodeles waltl
○Sana Kobayashi1,2, Mai Takehara1,2, Yuta Nakao1,2, He ran1,2, Toshinori Hayashi1,2 (1. Hiroshima University Graduate School of Integrated Sciences for Life, 2. Hiroshima University Amphibian Research Center)
[2P-543]Metabolic regulation underlying cold-induced embryonic diapause in vertebrates
○Tatsuhiro Nagata1, Yumi Yoshida2, Sayaka Tojima1, Tadashi Nomura1,3 (1. Applied Biology, Kyoto Institute of Technology, 2. Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, 3. Center for Social and BioMedical Engineering, Kyoto Institute of Technology)
[2P-544]Generation of transgenic zebrafish expressing human gap junction proteins for xenotransplantation of human cardiomyocytes.
○Issa Watanabe1, Chinmoy Patra2, Kiyoshi Ohnuma3 (1. Nagaoka University of Technology Graduate School of Department of Materials Science and Bioengineering, 2. Agharkar Research Institute of Department of Developmental Biology, 3. Nagaoka University of Technology of Department of Science of Technology Innovation)
[2P-545]New insights into muscle regeneration controlled by the cholesterol transporter ABCA1
○Hayataka Takase1, Sumiko Dohmae2, Yoshio Yamauchi1, Ryuichiro Sato1, Takashi Sasaki1 (1. The University of Tokyo, 2. Chubu University)
[2P-546]Genetic evidence: zebrafish hoxba and hoxbb clusters are essential for the anterior-posterior positioning of pectoral fins
○Renka Fujii1, Morimichi Kikuchi1, Kobayashi Daiki1, Yuki Kawabe1, Haruna Kanno1, Sohju Toyama1, Farah Tawakkal1, Kazuya Yamada1, Akinori Kawamura1 (1. Division of Life Science, Grad. Sch. Sci. Eng., Saitama Univ.)
[2P-547]Role of CXCR4/SDF1 signaling in the initial migration of cardiac neural crest cells.
○Yumi Unozu1, Kunio Inoue1, Saori Tani-Matsuhana1 (1. Kobe University)
[2P-548]Regenerative evaluation of tracheal defect reconstruction using human iPS cell-derived Scaffold-free cartilage in a large animal model.
○Masaya Matsubara1, Shojiro Hanaki1,2, Tomoka Takao1, Yuki Fujisawa1, Tatsunori Osone1, Shigeo Otake1, Ryousuke Iwai3, Kazuhiro Yamamoto4, Takeshi Takarada1 (1. Okayama University Graduate School , 2. Kurashiki Central Hospital, 3. Okayama Science University, 4. Okayama University)
[2P-549]Mathematical analysis of fluctuation of developmental patterns
○Koichiro Uriu1 (1. Institute of Science Tokyo)
[2P-550]Annexin A5 controls mineralization through WNT signaling
○Hisashi Ideno1, Koichiro Komatsu1, Kazuhisa Nakashima1, Toshihiko Amemiya2, Yoshinori Arai2, Akira Nifuji1 (1. Tsurumi University, 2. Nihon University)
[2P-551]Molecular chaperone GRP94 is crucial for craniofacial development
○Rinna Kanai1, Naoya Saeki1, Sayuri Tatsuta1, Yukako Akamatsu3, Tomoko Sumitomo2, Sinsuke Ohba1, Makoto Abe1 (1. The University of Osaka Graduate School of Dentistry,Dept of Tissue and Developmental Biology, 2. Tokushima University Graduate School of Oral Science, Dept of Oral Microbiology, 3. The University of Osaka Graduate School of Dentistry,Dept of Microbiology)
[2P-552(2AS-14-06)]A blue light receptor CRY1 regulates de novo shoot regeneration
○Min Li1, Hikaru Sato1, Takuya Sakamoto2, Yayoi Inui1, Kazunari Yamamoto1, Tomonao Matsushita3, Sachihiro Matsunaga1 (1. Dept. Integrated Biosci., Grad. Sch. Frontier Sci., Univ. Tokyo, 2. Dept. Sci., Fac. Sci., Kanagawa Univ., 3. Dept. Biological Sci., Grad. Sch. Sci., Kyoto Univ.)
[2P-553]The role of microtubules in the epithelial monolayer during focal deformation
○Koshi Tasaki1, Minami Aoyama2, Komaki Ninomiya1, Erina Kuranaga1,2 (1. Kyoto Univ., 2. Tohoku Univ.)
[2P-554]Live imaging of collagen structures in developing fish fin ray bones using a novel in vivo visualizing technique
○Hiromu Hino1,2, Shigeru Kondo2, Junpei Kuroda1,2 (1. JT Biohistory Research Hall, 2. University of Osaka, Frontier of Bio Sciences)
[2P-555]The role of Cadherin-11 in morphogenesis of organs formed by epithelial-mesenchymal interaction
○Shuai Shao1, Kosei Oishi1, Tian Tian1, Kanji Mizuta1, Ichiro Takahashi1, Keigo Yoshizaki1 (1. Kyushu University)
[2P-556]Analysis of epigenetic regulation for induction of cell dedifferentiation in plants
○Hayato Kikuchi1, Hikaru Sato1, Takuya Sakamoto2, Kana Yoshida1, Ayaka Horie1, Hinaho Uesugi1, Yayoi Inui1, Sachihiro Matsunaga1 (1. Dept.Integr.Biosci.,Grad.Sch.Front.Sci.,Univ.Tokyo, 2. Dept.Sci.,Fac.Sci.,Kanagawa Univ.)
[2P-557]Exploring interacting factors and functional analysis of the histone demethylase LDL3 during shoot regeneration in Arabidopsis thaliana
○Tasuku Nakahashi1, Hikaru Sato1, Nodoka Handa1, Yuki Sakamoto2, Takuya Sakamoto3, Sachihiro Matsunaga1 (1. Dept. Integr. Biosci., Grad. Sch. Front. Sci., Univ. Tokyo, 2. Fac. Sci., Univ. Shinshu, 3. Fac. Sci., Univ. Kanagawa)
[2P-558]AI-Driven Workflow for Automated Histomorphometric and Mineralization Analysis in Bone Regeneration
○XIN LIN LAI1, Tzu-Hui Chu2,1, Yu-Chi Lo3, Hsin-Yu Shu1, Chen-Yong Huang1, Min-Hung Liaong1, Jia-Fwu Shyu2,1 (1. National Defense Medical University, 2. National Defense MedicalUniversity, 3. National DefenseMedical University)
[2P-559]Heterocercal to Homocercal Transition of Teleost caudal fin by posterior hoxc genes
○Taisei Tani1, Sae Oikawa1, Rina Koita1,2, Akiteru Maeno3, Ikuko Watakabe4, Shinichi Higashijima4, Masaru Matsuda2, Akinori Kawamura1 (1. Saitama Univ., 2. Utsunomiya Univ., 3. National Institute of Genetics, 4. National Institute for Basic Biology)
[2P-560]Transplantation Site-Driven Maturation of iPSC-Derived Cartilage: Method Development and Optimization
○Yuki Fujisawa1, Tomoka Takao1, Tatsunori Osone1, Shigeo Otake1, Takeshi Takarada1 (1. Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
[2P-561]Myotendinous junction development driven by transient embryonic gene expression program
○Coalesco Smith1, Tao Ye1, Minchul Kim1 (1. Institute of Genetics and of Molecular and Cellular Biology (IGBMC))
[2P-562]Reproducing organogenesis ex utero using whole mouse embryo culture
○Akihiro Nita1, Toshiro Moroishi1 (1. Institute of Science Tokyo)
[2P-563]Hypoxia/reoxygenation evokes higher fin regeneration capability via bud23 in zebrafish larvae
○Shunta Yamagishi1, Makoto Kashima2, Hiroyasu Kamei3 (1. Kanazawa University, 2. Toho University, 3. Kanazawa University)
[2P-564]Functional analysis of the retinoic acid response elements in the Foxp1 promotor
○Katsuki Mukaigasa1, Chie Sakuma1, Hiroyuki Yaginuma1 (1. Fukushima Medical University)
[2P-565]Roles of bZIP transcription factor Nrl in the retina and lens of the medaka Oryzias latipes
○Takahiro Abue1, Shogo Iijima2, Erika Kobayashi1, Yutaka Daido1, Takehiro G Kusakabe1,2 (1. Department of Biology, Graduate School of Natural Science, Konan University, Kobe, Japan , 2. Department of Biology, Faculty of Science and Engineering, Konan University, Kobe, Japan)
[2P-566]Roles for FGFR2b Ligands during Lacrimal Gland Development
○Hideyo Ohuchi1, Shiori Ikeda1, Keita Sato1, Hirofumi Fujita1, Tetsuya Bando1, Tsutomu Nohno1 (1. Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University)
[2P-567]Generation of rat-derived kidney through interspecies blastocyst complementation
○Shunsuke YURI1, Ayako Isotani2 (1. NCGG, 2. NAIST)
[2P-568]Temporal observation of chitin structures ectopically induced in the Drosophila wing disc implicates that chitin synthesis and fiber formation are temporally separated
○Kaori Ebina1, Shuhei Horie2, Reiko Tajiri3 (1. Laboratory for extracellular morphogenesis, Department of biology, faculty of science, Chiba university, 2. Course of biology, Graduate School of Science and Engineering, 3. Graduate School of Science)
[2P-569]Screening for Genes Associated with the Regenerative Polarity of Zebrafish Caudal Fin Rays
○Riku Yamada1, Ryoko Yamazaki1, Toshiaki Uemoto1, Makoto Kashima2, Yuta Suzuki2, Misaki Sakashita1, Naoyuki Wada1 (1. Tokyo University of Science, 2. Toho University)
[2P-570]Whole-Neuromast Regeneration Using a Zebrafish Caudal Fin Amputation Model
○Tomoki Sano1, Ayaka Sato1, Yasumasa Bessho1, Takaaki Matsui1 (1. Nara Institute of Science and Technology)
[2P-571]Forward Genetic Screening for Light-Dependent Developmental Plasticity Factors in the Nematode Pristionchus pacificus
○Ryo Watanabe1, Ageha Onodera1, Takahiro Chihara1, Misako Okumura1 (1. Graduate School of Integrated Sciences for Life, Hiroshima University)
[2P-572]Mechanism of cuticle unfolding associated with body shape change during Drosophila metamorphosis
○Toi Chikazawa2, Yufuko Ando3, Reiko Tajiri1 (1. Graduate School of Science, Chiba University, 2. Faculty of Science, Chiba University, 3. Graduate School of Science and Engineering, Chiba University)
[2P-573]Discovery of a molecule that inhibits plant hormone, brassinosteroid
○Ayami Nakagawa1, Keiko Kuwata1, Shuya Yamada1, Yumiko Takebayashi2, Tsuyoshi Hirota1, Ayato Sato1, Naoyuki Uchida3, Hitoshi Sakakibara2,4, Akie Shimotohno1, Kenichiro Itami1,5, Kei Murakami6, Keiko U Torii1,7,8 (1. ITbM, Nagoya Univ., 2. RIKEN CSRS, 3. Center for Gene Res., Nagoya Univ., 4. Grad. Sch. Agr. Nagoya Univ., 5. RIKEN PRI, 6. Sch. Sci., Kwansei Gakuin Univ., 7. Dep. of Mol. Biosci., Univ. Texas at Austin, 8. Howard Hughes Medical Institute)
[2P-574]Stalk elongation in Dictyostelium discoideum is driven by cell intercalation mediated by Ig-like repeat adhesion receptors.
○Satoshi Kuwana1, Hidenori Hashimura1, Tomoko Adachi1, Takahiro Kanazawa2, Shoko Fujishiro1, Toyoko Sugita1, Tetsutaro Hayashi3, Mika Yoshimura3, Mariko Kuse3, Itoshi Nikaido3,4, Satoshi Sawai1 (1. Grad. Sch. Arts Sci., Univ. Tokyo, 2. Dept. Phys., Univ. Chicago, 3. Omics AI Res. Team, AGIS, TRIP HQ, RIKEN, 4. Dept. Funct. Genome Inform., Div. Biol. Data Sci., Med. Res. Lab., IIR, Inst. Sci. Tokyo)
[2P-575]Abcg2a regulates hemato-vascular development through PI3K/Akt/mTOR signaling in the zebrafish
○Kotaro Ichikawa1, Ryohei Fujita2, Hana Yamamoto3, Madoka Ouchi4, Jingjing Kobayashi3, Hiroyasu Kamei3, Masato Honda5, Takumi Nishiuchi6, Isao Kobayashi3 (1. Div. of Biol. Sci. & Tech., Grad. Sch. of Nat. Sci., Kanazawa Univ., 2. Div. of Nat. Sys., Grad. Sch. of Nat. Sci., Kanazawa Univ., 3. Fac. of Biol. Sci. & Tech., Inst. of Sci. Eng., Kanazawa Univ., 4. Fac. of Nat. Sys., Inst. of Sci. Eng., Kanazawa Univ., 5. Inst. of Nat. & Env. Tech., Kanazawa Univ., 6. Res. Cent. for Exp. Model. of Human Dis., Biosci. Core Faci.)
[2P-576(2PS-05-03)]Adaptive system for lifelong maintenance of intestinal stem cells
○May Nakajima-Koyama1, Eisuke Nishida2, Takuya Yamamoto1,3,4 (1. Kyoto Univ., CiRA, 2. RIKEN, 3. Kyoto Univ., ASHBi, 4. RIKEN, AIP)
[2P-577(2PS-01-03)]A Generalizable Method to Discover Purification Markers of Organoid-Forming Cells in Diverse Tissues
○LINGNA YU1,2, Nozomi Hojo1, Katsuyuki Shiroguchi1 (1. RIKEN Center for Biosystems Dynamics Research (BDR), 2. The University of Osaka)
[2P-578]SFRP1/2 acts on WNT and BMP pathways of mesenchymal stromal cells to maintain their stemness
○Fuki Kumagai1, Hikaru Tsutsumi1, Ayana Ueno1, Ayano Kuga1, Miyu Kozaki 1, Tadokoro Maho1, Kana Endo 1, Satori Kaname1, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Medical Biophysics, Kobe Univ., 2. Biochem & Mol. Biol., the Rockefeller Univ.)
[2P-579]Elucidation of Akt-mediated suppression of ES cells conversion to 2-cell-like cells
○Asuka Furuta1, Toshinobu Nakamura1 (1. Nagahama Institute of Bio-Science and Technology)
[2P-580]Analysis of self-renewal mechanism in STAT3ER expressing ES cells
○Kaito Tomonaga1, Jin Fujita1, Atsushi Ueda2, Kousuke Uranishi3, Tadayuki Akagi1 (1. Fukuoka institute of technology., 2. Tokai Univ., 3. Saitama Medical Univ.)
[2P-581]SFRP1/2 support normal and malignant HSPCs without effects on WNT pathway of blood cells
○Ayana Ueno1, Fuki Kumagai1, Hikaru Tsutsumi1, Ayano Kuga1, Miyu Kozaki1, Manaka Fujieda1, Yuto Sakurai1, Aika Morimoto1, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Medical Biophysics, Kobe Univ., 2. Biochem. & Mol. Biol., the Rockefeller Univ.)
[2P-582]Generation of Tetraploid Human iPS Cells by Polyethylene Glycol-Mediated Cell Fusion
○KAI ZHANG1,2, Ittetsu Nakajima1,2, Tomoko Kato-Inui1, Yuichiro Miyaoka1,2,3 (1. Tokyo Metropolitan Institute of Medical Science, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 3. Graduate School of Humanities and Sciences, Ochanomizu University)
[2P-583]Zebrafish RhoH promotes hematopoietic stem cell formation in response to PI3K signaling.
○Ryuji Takeda1, Yuto Hirakawa2, Amane Harada3, Kotaro Ichikawa3, Isao Kobayashi1 (1. Fac. of Biol. Sci. & Tech., Inst. of Sci. Eng., Kanazawa Univ., 2. Div. of Nat. Sys., Grad. Sch. of Nat. Sci., Kanazawa Univ., 3. Div. of Biol. Sci. & Tech., Grad. Sch. of Nat. Sci., Kanazawa Univ.)
[2P-584]PI3K/AKT signaling maintains multipotency of hematopoietic stem/progenitor cells during hematopoietic induction of human iPS cells
○Amane Harada1, Yusuke Hata1, Hikaru Asahi2, Makiko Meguro3, Shinichi Horike3, Isao Kobayashi2 (1. Div. of Biol. Sci. & Tech., Grad. Sch. of Nat. Sci., Kanazawa Univ., 2. Fac. of Biol. Sci. & Tech., Inst. of Sci. Eng., Kanazawa Univ., 3. Res. Cent. for Exp. Model. of Human Dis., Div. of Integ. Omics Res.)
[2P-585]Characterization of Erythroid and Hematopoietic Cells in Daphnia magna: a Novel Model Organism for Hematopoiesis
○Momoko Hatta1, Hitoshi Miyakawa2, Yutaka Takeuchi1, Isao Kobayashi1 (1. Fac. of Biol. Sci. & Tech., Inst. of Sci. Eng., Kanazawa Univ., 2. Cent. for Biosci. Res. Edu., Utsunomiya Univ.)
[2P-586]Poised Enhancer Methylation Defines Mesenchymal Stem Cell Potency and Senescence Resistance
Keiko Hiraki-Kamon1, Atsushi Wada2, Takashi Suyama3, Yumi Matsuzaki4,3, ○Hidemasa Kato1 (1. Ehime university, 2. Solallis Bio Inc., 3. PuREC Inc., 4. Shimane university)
[2P-587]Analysis of Primary Ciliary Signaling in Human Brain Organoid Regionalization
○Issei S Shimada1, Yoichi Kato1 (1. Nagoya City University)
[2P-588]Attempting artificial patterning of human iPSC-derived limb progenitor-like cells
○Kiichi Matsumoto1, Yuna Hattori1, Ken-Ichi Wada2, Shoma Kuriyama1, Yoko Yamanishi3, Yuji Atsuta4 (1. Grad. Sch. Sys. Life Sci., Kyushu Univ, 2. Inst. Mat. Chem. Eng., Kyushu Univ, 3. Grad. Sch. Eng., Dept. Mech. Eng., Kyushu Univ, 4. Grad. Sch. Sci., Dept. Biol., Kyushu Univ)
[2P-589(2AS-08-03)]Developing a novel cell isolation method enabling single-cell-based 3D spatial omics
○Nozomi Hojo1, Katsuyuki Shiroguchi1 (1. RIKEN Center for Biosystems Dynamics Research)
[2P-590]Comparative Glycomics Analysis of Enchytraeids to Elucidate Mechanisms Underlying Reproduction and Regeneration
○Chikako Yoshida-Noro1, Naoko Goto-Inoue2, Minoru Saito3, Masaki Kurogochi4, Junichi Furukawa4 (1. Nihon University Medical School, 2. BRS Nihon University, 3. CHS Nihon University, 4. iGCORE Nagoya University)
[2P-591]Establishment of skin gland-derived organoid in brown bear
○Ryosuke Kobayashi1, Kyogo Hagino2, Narumi Takahashi2, Naoki Takahashi1, Takafumi Watanabe1, Yojiro Yanagawa3, Jumpei Tomiyasu4 (1. Rakuno Gakuen University, 2. Noboribetsu Bear Park, 3. Hokkaido University, 4. Obihiro University of Agriculture and Veterinary)
[2P-592]mRNA localization analysis toward elucidating novel regulatory mechanisms of protein expression
○Rika Nishimura1,2, Tatsuya Yamakawa2, Ippei Yoshino2, Megumi Kumazaki2, Tsuyoshi Tabata2, Mio Iwasaki2 (1. Graduate School of Medicine, Kyoto Univ. , 2. Center for iPS Cell Research and Application (CiRA), Kyoto Univ.)
[2P-593]Establishment of a developmentally integrated human neuromuscular junction model derived from neuro-mesodermal progenitors
○Makoto Motono1, Hidemasa Kato2, Yoichi Kondo1 (1. Osaka Medical and Pharmaceutical University, 2. Ehime University)
[2P-594]Escargot, a member of Snail family transcription factors, regulates the timing of differentiation from neuroepithelial to neural stem cells in the Drosophila visual center
○Mire Shimizu1, Anna Saito, Takumi Suzuki2 (1. Ibaraki Univ., 2. Ibaraki Univ)
[2P-595]Functional analysis of mTOR complexes in central nervous system development
○Rina Sasaki1, Noriaki Sasai1, Takuma Shinozuka1 (1. Nara Institute of Science and Technology)
[2P-596]Olfactory epithelium differentiation from mouse embryonic stem cells
○Momoha Ito1, Mototsugi Eiraku2, Saori Hada (1. Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, 2. DEPARTMENT OF BIOSYSTEMS SCIENCE LAB. OF DEVELOPMENTAL SYSTEMS)
[2P-597]An Ets family transcription factor suppresses endothelial-mesenchymal transition and contributes to the maintenance of vascular integrity
○Yasuhiro Yoshimatsu1,2,4, Kentaro Maeda2, Yusuke Watanabe3, Tomohiro Shiiya1, Shiori Kimuro4, Hiroyuki Sugimoto5, Osamu Nakagawa3, Tetsuro Watabe4, Masanori Hirashima1 (1. Niigata Univ., 2. Tokyo Univ. Pharm. & Life Sci., 3. NCVC Res. Inst., 4. Inst. Sci. Tokyo, 5. Dokkyo Med. Univ.)
[2P-598]Regulation of male fertility by ecdysone signaling and stress responses in the accessory gland of Drosophila melanogaster
○Nachi Kinoshita1, Shinichi Otsune1, Kanon Oue2, Hideki Nakagoshi1 (1. Grad. Sch. Envir. Life, Natl. Sci. Tech., Okayama Univ., 2. Sch. Sci., Okayama Univ.)
[2P-599]Identification of functional target genes regulated by the sex-determining gene Sry in mice
○Suzune Furuhashi1,2, Iku Tsuchiya1,2, Maika Ozeki1, Miho Terao1, Shuji Takada1,2 (1. Department of Systems Developmental Biology, National Center for Child Health and Development, 2. Department of NCCHD Child Health and Development, Graduate School of Medical and Dental Science, Institute of Science Tokyo)
[2P-600]Mechanisms of Sox9 expression by its distal enhancer in mouse sex differentiation
○Karin Sugiyama1,2, Iku Tsuchiya1,3, Aki Oishi1,3, Yuki Matsumura1, Mika Hirabayashi1, Miho Terao1, Tomomi Sato2, Shuji Takada1,3 (1. National Center for Child Health and Development, Department of Systems Developmental Biology, 2. Graduate School of Nanobioscience, Yokohama City University, 3. Department of NCCHD Child Health and Development, Graduate School of Medical and Dental Science, Institute of Science Tokyo)
[2P-601]Scx+/Sox9+ Progenitors and Mechanical Cues Coordinate the Spatial Differentiation Gradient of the Annulus Fibrosus
○Shigenori Miura1, Jie Zhang1, Yuya Morimoto2, Haruhiko Akiyama3, Chisa Shukunami1 (1. Hiroshima Univ, 2. Waseda Univ, 3. Gifu Univ)
[2P-602]Identification of a novel gene set that induces direct reprogramming of human pancreatic β cells
○Hideki Endoh1, Ruslan Deviatiiarov 1, Oleg Gusev 1, Keishiro Nishimura1, Haruka Odagiri2,1, Yohichi Yasunami1, Hideo Saotome1, Yasushi Okazaki1, Masahito Matsumoto1 (1. Juntendo Univ., 2. Sekisui chemical Co., LTD)
[2P-603]Functional analysis of genes that enhance the direct reprogramming of human pancreatic β cells using non-viral transfection method.
○Haruka Odagiri1,2, Hideki Endoh1, Takaya Oshita2, Yukio Ueno2, Park Giri2, Ruslan Deviatiiarov1, Oleg Gusev1, Keishiro Nishimura1, Hideo Saotome1, Yasushi Okazaki1, Masahito Matsumoto1 (1. DRC., Grad.Sch.of Med., Juntendo Univ., 2. R&D Center , Sekisui Chemical Co.,Ltd.)
[2P-604]Combination of factors that enhance differentiation and maturation into insulin-producing cells by direct reprogramming
○Keishiro Nishimura1, Hideki Endoh1, Ruslan Deviatiiarov1, Oleg Gusev1, Hideo Saotome1, Yasushi Okazaki1, Masahito Matsumoto1 (1. IDRC., Grad.Sch.of Med., Juntendo Univ.)
[2P-605]A Novel in vivo Direct Reprogramming Model Reverses Diabetes via Insulin Induction in Transgenic Mice
○Saundra Yvonne Schlesinger1, Jastin Edrian Cocuangco Revilleza1, Seiya Mizuno2, Keishiro Nishimura1, Mika Suhara1, Satoru Takahashi2, Yasushi Okazaki1, Masahito Matsumoto1 (1. Juntendo University, 2. University of Tsukuba)
[2P-606]The role of KIF11 on the osteoblast differentiation induced by BMP4 via regulation by RUNX2
○Jastin Edrian Cocuangco Revilleza1, Saundra Yvonne Schlesinger1, Yosuke Mizuno2, Tsuyoshi Sato4, Peter C. Gray3, Yasushi Okazaki1, Masahito Matsumoto1 (1. Juntendo University, 2. Saitama Medical University, 3. The Salk Institute for Biological Studies, 4. Kyushu Dental university)
[2P-607(2AS-05-04)]Nectin-1 regulates neural stem cell function in hypothalamic tanycytes
○Tatsuhiro Shimizu1, Yoshimi Takai1 (1. Kobe Univ.)
[2P-608]Functional analysis of the transcription factor Dve in Drosophila nephrocytes
○Natsuo Sakuma1, Hideki Nakagoshi1 (1. Grad. Sch. Envir. Life, Natl. Sci. Tech., Okayama Univ.)
[2P-609]Analysis of novel chondrogenic differentiation regulatory factors using small molecule compound
○Takako Abe1, Hironori Hojo2,3, Toshiya Hayano4, Yuichi Tei1,3,5, Shimohata Nobuyuki1 (1. Graduate School of Health Innovation, Kanagawa University of Human Services, 2. Graduate School of Dentistry, Osaka University, 3. Graduate School of Medicine, University of Tokyo, 4. College of Life Sciences, Ritsumeikan University, 5. Graduate School of Engineering, University of Tokyo)
[2P-610]The Process of Differentiation into Microglia During the Early Embryonic Development.
○Mizuki Ono1, Yuki Hattori1 (1. Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University)
[2P-611]Pparδ-mediated cellular energy metabolism drives lipid droplets formation to facilitate C2C12 myoblast differentiation
○Rumana Mahzabin1, Satoko Hyashi1, Habib Md Rezwanul1, Yukako Tokutake1, Shinichi Yonekura1 (1. Graduate School of Medicine, Science and Technology, Shinshu University)
[2P-612]Elucidation of the Transdifferentiation Effect of Neuregulin1 on α- to β-cells in Type 1 Diabetes
○Izumi Mitsutake1, Minami Yoshikai1, Nobuhito Goda1 (1. Waseda University)
[2P-613]Differential roles of Smad2 and Smad3 in mediating the TGF-β1 effects on mesenchymal stem cells
○YUN MAN LIAO1, YING WEN WANG1, CHING WEI LUO1 (1. National Yang Ming Chiao Tung University)
[2P-614]Failure of embryonic development related to maternal age is caused by dysregulated uterine muscle contractions.
○Misuzu Okuno1,2, Yoko Ueda2, Kyoko Mochida2, Chihiro Matsuno2, Yasumasa Bessho3, Chiharu Kimura-Yoshida2, Isao Matsuo2 (1. Osaka Univ, 2. Osaka women's and children's Hosp, 3. NAIST biological science)
[2P-615]Early Ribosome Biogenesis Inhibition by CX-5461 in Pre-implantation Mouse Embryos Alters Nucleolar Structure and Affects Long-Term Metabolic Outcomes
○JANNATUL FERDOUS JHARNA1, Kishigami Satoshi 1 (1. University of Yamanashi)
[2P-616]Analysis of conserved genetic mechanisms underlying temperature tolerance in plants and animals using C. elegans
○Sakura Sengoku1,2, Akane Ohta1,2, Teruaki Taji3, Atsushi Kuhara1,2,4 (1. Graduate School of Natural Science, Konan University, 2. Institute for Integrative Neurobiology, Konan University, 3. Faculty of Life Science, Faculty of Agriculture, Tokyo University of Agriculture, 4. AMED-PRIME, Japan Agency for Medical Research and Development)
[2P-617]Controllability of the gene regulatory network in zebrafish embryogenesis
○Kanghee Cho1, Jiyeon Park1, Junil Kim1 (1. Soongsil University)
[2P-618]The transcriptional regulation of the Tbx6 gene to elucidate the mesoderm development from the neuro-mesodermal progenitors.
○Sou Hazaki1, Hitomi Suzuki1, Yuta Chigi1, Kaori Tanaka2, Akihito Harada2, Yasuyuki Ohkawa2, Tatsuya Takemoto1 (1. Laboratory of Embryology, Institute of Advanced Medical Sciences, Tokushima University, 2. Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University)
[2P-619]Spatio-temporal analysis of the localization of Hr-Eph1 mRNA to the PVC/CAB of ascidian embryos
○Ayumi Yoshikawa1, Naohito Takatori1 (1. Tokyo Metropolitan Univ. Graduate School of Science)
[2P-620]Effects of endoplasmic reticulum stress induction by tunicamycin on the nucleolus in mouse preimplantation embryos.
○Masahiro Horizoe1, Taiga Kayanuma2, Bari MD wasim3, Satoshi Kishigami1,2,3,4 (1. Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi , 2. Graduate School of Medical, Engineering and Agricultural Sciences, Yamanashi University, Department of Life and Environmental Sciences, 3. Faculty of Life and Environmental Sciences, University of Yamanashi, 4. Center for Advanced Assisted Reproductive Technologies, University of Yamanashi, Yamanashi)
[2P-621]Live imaging and single-cell tracking of a mouse early embryo with Next-Generation SPIM
○Go Shioi1, Tomonobu M Watanabe1, Ko Sugawara2, Shuichi Onami2 (1. RIKEN BDR Lab. Comprehensive Bioimaging, 2. RIKEN BDR Lab. Developmental Dynamics)
[2P-622]Human iPSC-Derived Neural Crest Cell as a 3D Model for Deciphering Collective Cell Migration Dynamics
○ITSUKI MISAKI1, MOTOTUGU EIRAKU1 (1. Kyoto University)
[2P-623(2PS-03-05)]Mechanisms and impact of diploidization in mouse haploid embryos during preimplantation development
○Koya Shimabukuro1, PAN Tao1, Natsumi Taira2, Miho Ohsugi1,2 (1. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 2. Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
[2P-624]Temporal Transcriptome Analysis of Placental-Complemented Parthenogenetic Embryos
○Genki Tsukinokisawa1, Makoto Kashima2, Shinpei Yamaguchi1 (1. Graduate School, Toho University, 2. Toho University)
[2P-625]Apoptosis-independent Elimination of Unfit Cells in Mouse Peri-implantation Embryos
○Rui Shibata1, Masakazu Hashimoto2, Hiroshi sasaki1 (1. Osaka University, 2. Fukushima Med.Univ.,Cell Sci.)
[2P-626]Effect of epigenetic memory on tissue-specific chimeric contribution of iPS cells
○Misa Ohori1, Mami Oikawa1, Tomoyuki Yamaguchi1 (1. Laboratory of Regenerative Medicine, Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)
[2P-627]Spatiotemporal Regulation of Germ Plasm Formation in medaka
○Ami Aita1, Chika Fujimori2, Toshiya Nishimura1 (1. Div. of Marine Life Sci., Grad. Sch of Fish. Sci., Hokkaido Univ., 2. Div. of Biol. Sci., Faculty of Sci., Hokkaido Univ)
[2P-628]Nuclear protein asymmetry between maternal and paternal pronuclei underlies zygotic totipotency
○Marino Maemura1, Ayaka Kakihara2, Masaki Matsumoto2, Azusa Inoue1, Yu-ichi Tsukada3 (1. RIKEN. IMS, 2. Dept. Omics Sys. Biol., Grad. Sch. Med. Dent. Sci., Niigata Univ., 3. INAMORI Front. Res. Ctr., Kyushu Univ.)
[2P-629]Comparative analysis of TCA cycle-related proteins involved in sperm activation between nematodes and mice
○Suzuka Nomura1, Ayane Takemura1, Yoshihiro Shimada1, Kenji Miyado2, Arata Honda3, Junya Ito4, Atsuko Kageyama4, Tatsuya Yamamoto5, Honoo Satake5, Koichiro Kako6, Akiyoshi Fukamizu6, Yukiko Karuo7, Masaaki Omote7, Hitoshi Nishimura1 (1. Dept. Lif. Sci., Fac. Sci. Eng., Setsunan Univ., 2. NCCHD, 3. Ctr. Dev. Adv. Med. Tech., Jichi Med. Univ., 4. Sch. Vet. Med., Azabu Univ., 5. SUNBOR, 6. TARA, Tsukuba Univ., 7. Fac. Pharm. Sci., Setsunan Univ.)
[2P-630]BMP15 Gene Editing Leads to Preantral Follicle Arrest and Granulosa Cell Subpopulation Absence in Pig Ovaries
○Meina Xu1, Xinxin Lv2, Delin Mo1, Yaosheng Chen1, xiaohong Liu1, Jinming Guo1, Alian Liao1, Yiran Mo2 (1. Sun Yat-Sen University, 2. Annoroad Gene Technology)
[2P-631]The effect of hormonal environment on mouse external genitalia development
○Yuki Korenaga1, Kosei Tanaka1, Hikari Mizoguchi1, Mako Ishikawa1, Shota Hatsuki1, Kenji Toyota2, Shinichi Miyagawa1 (1. Tokyo University of Science, 2. Hiroshima University)
[2P-632]MOV10L1 S818I Mutant Mouse, a Model of Male Infertility, Provides New Insights into piRNA-Mediated Regulation of Spermatogenesis
○Yanling Wei1, Ryuki Shimada2,4, Naoki Takeda3, Kimi Araki3, Shigeki Hirakata1, Soichiro Yamanaka1,5, Kei-ichiro Ishiguro2,4, Mikiko Siomi1 (1. Department of Biological Science, Faculty of Science, The University of Tokyo, 2. Institute of Molecular Embryology and Genetics (IMEG), Kumamoto university, 3. Institute of Resource Development and Analysis, Kumamoto University, 4. Graduate School of Medicine, Chiba University, 5. Department of Molecular Biology, Hamamatsu University School of Medicine)
[2P-633]Functional Analysis of CCDC9 and CCDC9B in mouse spermiogenesis
○Frederick Soetandar1, Yosuke Fukutani1, Yukiko U. Inoue2, Takayoshi Inoue2, Takanari Inoue3, Kyosuke Shinohara1 (1. Tokyo University of Agriculture and Technology, Department of Biotechnology and Life Science, Tokyo, Japan, 2. National Center of Neurology and Psychiatry, 3. Johns Hopkins University)
[2P-634]Divergence of UBAP2Z and UBAP2W in the embryonic gonads of the Japanese quail
○Daichi Hodota1, Shusei Mizushima1,2, Tomoe Kobayashi3, Makoto Matsuyama3, Asato Kuroiwa1,2 (1. Grad. Sch. of Life Sci., Hokkaido Univ., 2. Fac. of Sci., Hokkaido Univ., 3. Div. Mol. Genet., Shigei Med. Res. Inst.)
[2P-635]Further maturation of PGC-like cells derived from male rat ES cells
○Hiroki Kojima1,2, Mami Oikawa1, Tomoyuki Yamaguchi1, Toshihiro Kobayashi2,3 (1. Tokyo University of Pharmacy and Life Sciencessity, 2. National Institute for Physiological Sciences, 3. The University of Tokyo)
[2P-636]Priming Epigenetic Landscape at Promoters through Gonocyte Genome Reprogramming
○Peilin Li1, Tatsuya Fujisawa1, Haruka Narita1, Yuta Uneme1,2, Takuma Izawa2, Masahide Seki3, Mengwen Hu4, Ryohei Narumi5, Yuta Otobe6, Satoshi H. Namekawa4, Shehroz S. Khan7, James R. Davie8, Hikari Yoshitane6, Yutaka Suzuki3, Jun Adachi5, Ahmed Ashraf9, Azusa Inoue10, Mikiko C. Siomi1,2, Soichiro Yamanaka1,11 (1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2. Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo, 3. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4. Department of Microbiology and Molecular Genetics, University of California, Davis, 5. Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, 6. Circadiain Clock Project, Tokyo Metropolitan Institute of Medical Science, 7. KITE, University Health Network, 8. Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 9. Department of Electrical and Computer Engineering, University of Manitoba, 10. Laboratory for Epigenome Inheritance, RIKEN Center for Integrative Medical Sciences, 11. Department of Molecular Biology, Hamamatsu University School of Medicine)
[2P-637]Identification of a shared molecular basis of sperm exocytotic activation in nematodes and mice
○kanta yamamoto1, Mitsuki Shimamoto1, Runa Nakasone1, Nonoka Inadu1, Yoshihiro Shimada1, Haruhiko Miyata2, Masahito Ikawa2, Hitoshi Nishimura1 (1. Dept.Lif.Sci.,Fac.Sci.Eng.,Setsunan Univ., 2. Osaka Univ.,RIMD)
[2P-638]Roles of ROS Production and mTOR Pathway in Oocyte Maturation, Aging, and Apoptosis in Xenopus laevis
○Himena Hagino1, Kanami Doi1, Yamato Miyamoto1, Kenichi Sato1 (1. Kyoto Sangyo University)
[2P-639]The Role of Uroplakin Ⅲ in the Ovulation and Maturation Process of Xenopus oocytes
○Kanami Doi1, Himena Hagino1, Yamato Miyamoto1, Keisuke Nakajima2, Kenichi Sato1 (1. Kyoto Sangyo University, 2. Hiroshima University)
[2P-640]Elucidation of the Regulatory Mechanism of Oogenesis by Class I Histone Deacetylase HDA-3 in the Gonads of Caenorhabditis elegans
○Tomoki Mimura Mimura1, Soma Tani1, Shotaro Yamanaka2, Yukihiko Kubota2, Masahiro Ito1 (1. Graduate School of Life Sciences, Ritsumeikan University, 2. Department of Bioinformatics, College of Life Sciences, Ritsumeikan University)
[2P-641]Two-step telomere-dependent regulation of centromere positioning required for sister kinetochore association in fission yeast meiosis
○Alimul Islam1, Yamamoto Ayumu1,2 (1. Graduate School of Science and Technology, Shizuoka University, Japan, 2. Faculty of Science, Shizuoka University, Japan)
[2P-642]Distinct foci formation by different phosphorylation statuses around Ser307 of mouse HORMAD1
○Hiroshi Kogo1, Manami Fujiwara1, Makoto Matsuyama2, Akiko Iizuka-Kogo1, Hanako Yamamoto1, Maiko Ikezawa1, Toshiyuki Matsuzaki1 (1. Gunma Univ., 2. Shigei Med. Res. Inst.)
[2P-643]Heterochromatin Protein 6 suppresses heat-induced germ cell differentiation defects in Drosophila testes
○Junki Watanabe1, Hayato Okumura2, Mika Toyoda2, Hideki Yoshida3, Masanori Mukai1,2 (1. Grad. Sch. of Nat. Sci., Biol., Konan Univ., 2. Fac. of Sci., Dept. of Biol., Konan Univ., 3. Dept. of Appl. Biol., Kyoto Inst. of Tech.)
[2P-644]Study on the mechanism of apicobasal polarity change in apical-out bovine uterine gland spheroids in vitro
○Miyu Takahashi1, Youske Sugino1, Kaede Ito1, Kohei Kawano1, Koji Kimura1 (1. Graduate School of Environmental, Life, Natural Science and Technology, Okayama University)
[2P-645]Possible Involvement of Testis-Specific, Cytoplasmic Poly(A) Polymerase PAPOLB/TPAP in the Stability of Haploid-Specific mRNAs
○Kazuma Yamazawa1, Tomohiro Kobayashi1, Shin-ichi Kashiwabara1 (1. Inst. of Life Envir. Sci., Univ. of Tsukuba)
[2P-646]Acquired Intestinal Heat Stress Tolerance Mediated by Ovarian/Intestinal Tissue Interactions in Drosophila
○hayato kikuoka1, namika matsumoto1, ayaha tanaka2, naoya yoshida2, junki watanabe1, masanori mukai1,2, shuhei tuji2 (1. Grad. Sch. of Nat. Sci., Konan Univ., 2. Dept. of Biol., Fac. of Sci. and Eng., Konan Univ.)
[2P-647]Possible involvement of hnRNP family proteins in the global translational repression during murine spermatogenesis
○Heita Maeda1, Hideto Tanaka1, Yuka Isono1, Shin-ichi Kashiwabara1 (1. Inst. of Life Envir. Sci., Univ. of Tsukuba)
[2P-648]TRECK-mediated xenogeneic endometrial epithelial cell replacement in immunodeficient mice
○Kana Hayakawa1, Naoaki Mizuno1, Zeng Shihan1, Motohito Goto2, Riichi Takahashi2, Yoshiakira Kanai3, Masami Kanai Azuma1 (1. Institute of Science Tokyo, 2. Central Institute for Experimental Medicine and Life Science, 3. The University of Tokyo)
[2P-649]Role of mTOR signalling pathway in lacrimal gland
development
○Mahiro Murakami1, Takayoshi Sakai1, Manabu Sakai2 (1. The University of Osaka, Department of Rehabilitation for Orofacial Disorders, Graduate School of Dentistry, 2. Tenri University, Faculty of Health Care, Department of Clinical Laboratory Science)
[2P-650]Analysis of an inducible large Mafs-deficient mouse model to elucidate the switching mechanism of myofiber types
○Shunya Sadaki1, Tatsuya Matsumoto1, Ryosuke Tsuji1, Haruka Kanamaru1, Ryoto Iwai1, Takuto Hayashi2, Takehito Sugasawa1, Masafumi Muratani1, Takashi Kudo1, Satoru Takahashi1, Ryo Fujita1 (1. University of Tsukuba, 2. Institut Necker Enfants Malades)
[2P-651]Prototyping CoMBI 3D imaging system for detecting fluorescence.
○Yuki Tajika1 (1. Gunma Prefectural College of Health Science)
[2P-652]PERICYTE- EXOSOMES STIMULATED BY JAGGED-1 FACILITATES ANGIOGENESIS THROUGH ENDOTHELIAL CELL PROLIFERATION
○VISHNUVARDHINIDUTT KASI1, Yasuyuki Hanada1, Honami Ogoh1, Semanti Halder1, Koichi Nishiyama1 (1. Department of Vascular and Cellular Dynamics, Faculty of Medicine, University of Miyazaki)
[2P-653]Single-Cell Gene Expression Analysis of the Cnidarian Hydra vulgaris by using fixation-based cell dissociation methods
○Qihang Su1, Koryu Kin1, Etsuo A Susaki1,2,3 (1. Department of Biochemistry and Systems Biomedicine, Graduate School of Medicine, Juntendo University, 2. Nakatani Biomedical Spatialomics Hub, Graduate School of Medicine, Juntendo University, 3. Institute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST))
[2P-654]Intra- and inter-species comparative genomic and epigenomic analyses of Hydra vulgaris toward elucidating aging mechanisms
○Kaoruko Nojiri1, Koryu Kin2, Akimasa Someya3, Kazuharu Arakawa4, Etsuo Susaki1,2 (1. Juntendo University, Faculty of Medicine, 2. Juntendo University, Graduate School of Medicine, Department of Biochemistry and Systems Medical Science, 3. Juntendo University, Faculty of Pharmacy, Department of Molecular Biology, 4. Keio University, Graduate School of Media and Governance)
[2P-655]Establishment of a live zebrafish embryo genotyping method and its application
○Yosuke Aihara1, Yusuke Kamachi1 (1. Kochi University of Technology)
[2P-656]Comparative assessment of various fluorescent protein variants in zebrafish embryos
○Aiko Ichinose1, Tomohiro Kanzaki1, Yusuke Kamachi1 (1. Kochi university of technology)
[2P-657]Collagen XII polarizes cells and controls their migration direction to promote tendon regeneration.
○Kei Fujihara1, Yayoi Izu1 (1. Department of Comparative Cell Biology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University)
[2P-658]Function of Fusobacterium-exposed macrophages in ovarian cancer
○Ryosuke Sonobe1, Miho Suzuki1, Keiko Shinjo1, Yutaka Kondo1 (1. Nagoya Univ.)
[2P-659]Bacterial Selection in the C. elegans Gut Mediated by D-Amino Acid Metabolic Enzymes
○Yasuaki Saitoh1, Tian Autumn Qiu2 (1. School of Pharmacy, Kitasato University, 2. Department of Chemistry, Michigan State University)
[2P-660]Evaluation of the Effects of Fecal Microbiota Transplantation on Gut Microbiota Composition and Metabolic Pathways in Lethally Irradiated Mice
○Takamasa Nagai1, Kanako Yamanouchi1, Karin Kakihara2, Masaru Yamaguchi3, Takakiyo Tsujiguchi4, Mitsuru Chiba1 (1. Dept. of Biosci. & Lab. Med., Grad. Sch. of Health Sci., Univ. of Hirosaki, 2. Dept. of MedTech., Sch. of Health Sci., Univ. of Hirosaki, 3. Dept. of Radio. Sci., Grad. Sch. of Health Sci., Univ. of Hirosaki, 4. Educ. Center Disas. Radiat. Emer. Med., Univ. of Hirosaki)
[2P-661]Isolation and Analysis of Genes Involved in Plant Growth-Promoting Activities of Pseudomonas sp. Y132
○Rinon Kanai1, Hiroto Satake2, Hazuki Kurashita2, Takashi Ano1,2, Masahiro Okanami1,2 (1. Grad.Sch.Biol.Ortd.Sci.Technol.,Kindai Univ., 2. Fac.Biol.Ortd.Sci.Technol.,Kindai Univ.)
[2P-662]Intestinal microbiota disruption by psychological stress-induced Paneth cell damage is associated with depression-like behaviors
○Yuna Abe1, Yuki Yokoi1,2,3, Miyuki Ikeda2, Kanta Harasawa1, Miu Ihara1, Shuya Ohira1,2,3, Kiminori Nakamura1,2,3 (1. Innate Immunity Lab., Grad. Sch. of Life Sci., Hokkaido Univ., 2. Innate Immunity Lab., Sch. of Sci., Hokkaido Univ., 3. Innate Immunity Lab., Faculty of Adv. Life Sci., Hokkaido Univ.)
[2P-663]Development of a Novel Co-culture Method for Intestinal Organoids and Gut Bacteria
○Kota Yanagisawa1,2, Mikako Takahashi3, Toyoyuki Hashimoto3, Nobuo Sasaki1 (1. Institute for Molecular and Cellular Regulation, Gunma University, 2. Course of Medical Sciences in Graduate School of Medicine, 3. Future Strategy Department Business Development Group Technology Research Laboratory Shimazu Corporation)
[2P-664]Indole regulates cytoskeletal functions and virulence in the human parasite Entamoeba histolytica.
Eva Zanditenas1, Meirav Trebicz Geffen1, Yumiko Saito-Nakano2, Seiki Kobayashi2, Hajime Hisaeda2, Tomoyoshi Nozaki3, Yuanning Guo4, Haguy Wolfenson4, ○SERGE ANKRI1 (1. Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel, 2. Department of Parasitology, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan, 3. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4. Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion– Israel Institute of Technology, Haifa, Israel.)
[2P-665]Circadian phenotypes in 3q29 deletion syndrome associated with psychiatric disorders
○Akira Yoshino1, Hotaka Fukushima1, Takanobu Nakazawa1, Daiki Miura1 (1. Tokyo University of Agriculture Graduate School of Life Sciences Department of Bioscience)
[2P-666]Biophysical Mechanisms of DNA Damage-Induced Sleep Disruption in Aging and Neurodegeneration
○Masashi Tabuchi1, Natalia Pokaleva1, Alexa Zarjetskiy1, Samira Xhaferi2, Prema Singaravel2, Jackson Taylor2 (1. Case Western Reserve University School of Medicine, 2. Cleveland State University)
[2P-667]The role of chaperone-kinase interaction in sleep homeostasis
○Daiki Komine1, Minori Masaki1, Shinya Nakata1, Kei Nishida1, Hiromasa Funato1,2, Masashi Yanagisawa1 (1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 2. Dept. of Anatomy, Faculty of Medicine, Toho university)
[2P-668]Heterotopic changes in Sonic Hedgehog expression during amniote brain evolution
○Shoyo Tainaka1, Sayaka Tojima1, Tadashi Nomura1,2 (1. Applied Biology, Kyoto Institute of Technology, 2. Center for Social and BioMedical Engineering, Kyoto Institute of Technology)
[2P-669]Developmental and evolutionary roles of mammalian-specific alanine repeat in Lhx2 protein
○Reon Ikeda1, Sayaka Tojima1, Tadashi Nomura1,2 (1. Applied Biology, Kyoto Instite of Technology, 2. Center for Social and BioMedical Engineering, Kyoto Institute of Technology)
[2P-670]An extracellular matrix protein laminin-411 and its derivative fragment/peptide enhance myelin membrane formation in oligodendrocytes
○Binri Sasaki1, Momo Oishi1, Tomoka Aoki1, Mai Hyodo1, Nanako Yamada1, Hitomi Misawa1, Kiyotoshi Sekiguchi2, Keisuke Hamada3, Yuji Yamada3, Yamato Kikkawa3, Motoyoshi Nomizu3, Nobuharu Suzuki1 (1. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 2. Division for Matrixome Research and Application, Institute for Protein Research, Osaka University., 3. Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science)
[2P-671]Induction of Aggrecan expression by neural activity drives perineuronal net formation
○Kentaro Nakayama1, Ayumu Mubuchi1, Shinji Miyata1 (1. Tokyo University of Agriculture and Technology)
[2P-672]The role of CRMPs in promoting neurite outgrowth induced by retinoic acid (RA) in SH-SY5Y cells
○Masaomi Tomita1, Asumi Kataoka1, Takuto Kudo2, Ritusko Ohtani-Kaneko1,2 (1. Toyo University Graduate School of Life Science, 2. Toyo University of Life Science)
[2P-673]Gender-related enhancement of BMP signaling inhibited adult neurogenesis in mouse models of Alzheimer's disease
○XINGYU SU1, Rina Takayanagi1, Hiroki Maeda1, Takaomi C Saido2, Toshio Ohshima1 (1. Waseda University, 2. RIKEN Center for Brain Science)
[2P-674]Axon Targeting and Synapse Formation in the Drosophila Visual System
○Satoko Hakeda-Suzuki1, Mingyue Li2, Jiro Osaka2, Takashi Suzuki2 (1. Yokohama National University, 2. Institute of Science Tokyo)
[2P-675]The role of the BAR domain protein pacsin 1 in podosome formation and function during growth cone migration
○JIANZHEN LI1 (1. RIKEN Center for Brain Science)
[2P-676]Search for proteins that define the critical period of neuronal circuit plasticity
○Yukiya Narita1, Akari Kuroishi1, Suzuki Takashi1 (1. Life Science and Technology, Tokyo Institute of Technology)
[2P-677]Control of hypothalamic POMC neurogenic niche and its remodelling
○Kyoji Ohyama1, Rina Ogawa1, Aya Ogawa1, Yuuki Arai1, Aki Masui1, Shoichiro Omura1, Hideyuki Maeda2, Tokiharu Takahashi1 (1. Tokyo Medical University, 2. Osaka University)
[2P-678]KMT2E Dysregulation Causes Transcriptomic Shifts in ODLURO Syndrome
○Sandra Somuah-Asante1, Sae Fukuda1, Rune Sakurai1, Joseph A. Gogos2, Jun Mukai1 (1. Research and Development Center for Precision Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., 2. Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY, United States)
[2P-679]Physiological role of micronuclear propagation to microglia
○Fuminori Tsuruta1 (1. Inst. of Life and Env. Sci., Univ. of Tsukuba)
[2P-680]RNA binding domains of Fragile X Mental Retardation Protein are important for formation of neuronal transport granules involving LLPS
○Kanae Yoshizawa1, Momo Kubo1, Maho Ishiyama1, Yukio Sasaki1 (1. Yokohama City Univ.)
[2P-681]Developmental regulation of microglial distribution in the cortex and its functional implications
○Kazutaka Nishizawa1, Yuki Hattori1 (1. Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University)
[2P-682]Route-dependent priming of microglial precursors for pallial infiltration
○Hisa Asai1, Yuki Hattori1 (1. Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University)
[2P-683]Strict Regulation of Fyn Kinase Activity is Critical for Proper Neuronal Migration during Cerebral Cortical Development.
○Yoshiaki V. Nishimura1, Shiho Ito2, Takeshi Kawauchi2,3 (1. Tohoku Med. and Pharm. Univ., 2. Kyoto Univ., 3. Keio Univ.)
[2P-684]Pituitary structure abnormalities of Notch4 knockout mice
○Kenji Tanigaki1 (1. Shiga Medical Center)
[2P-685]Explorations and analysis on the neuronal groups showing a specialized behavior in the left and right brains of zebrafish, Xenopus and mouse
Natsumi Kouno1, Chihane Mori2, Haruki Nakatani2, Makoto Mochii1,2, Hiroko Yukinaga1,2, Hiroaki Nakagomi2, ○Kohei Hatta1,2 (1. Grad. Sch. of Sci., Univ. of Hyogo, 2. Dept. of Sci., Univ. of Hyogo)
[2P-686]Analysis of the cell production mechanism that determines the differentiation of deep neurons in the cerebral cortex
○Shoko Yoshizawa1,2, Carina Hanashima1,2 (1. Waseda Univ., 2. Grad. School of Waseda Univ.)
[2P-687]Which of "The Usual Suspects" governs extracellular adenosine production in mouse retina?
○Ryutaro Ishii1,2, Keisuke Sakurai3, Marina Sanaki Matsumiya2, Masafumi Muratani1, Shohei Morikawa4, Nao Hosomi2,5, Kenichi Kimura2, Hiromi Yanagisawa2 (1. University of Tsukuba, Institute of Medicine , 2. University of Tsukuba, Life Science Center for Survival Dynamics, TARA, 3. University of Tsukuba, Institute of Life and Environmental Sciences, 4. University of Tsukuba, Department of Ophthalmology, 5. University of Tsukuba, PhD Program in Human Biology)
[2P-688]Developmental Changes in Spindle Burst Activity and Cortical Maturation in Newborn Mice
○Sota Yamazaki1,2, Yumiko Hatanaka1, Sachine Yoshida3, Akiyo Natsubori4 (1. Developmental Neuroscience, Tokyo Metropolitan Institute of Medical Science, 2. Developmental Neurology, Graduate School of Medical and Dental Sciences, Niigata University, 3. Department of Anatomy, Faculty of Medicine, Toho University, 4. Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science)
[2P-689]Requirement for auditory inputs in the morphological development of layer 4 neuron in the auditory cortex
○Aoi Nohara1,2, Hayato Saito1,2, Carina Hanashima1,2 (1. Waseda Univ., 2. Grad. School of Waseda Univ.)
[2P-690]Analysis of mutants exhibiting defects in the integration of olfactory and temperature information in C. elegans
○Kenshin Irie1, Yanshu Zhang2, Asuka Takeishi1,3 (1. Graduate School of Science, Kobe University, 2. RIKEN Center for Brain Science, 3. CREST, JST)
[2P-691]Distinct roles of the mushroom body in short- and long-term courtship memory in Drosophila
○Yusei Hiruma1, Takaomi Sakai1 (1. Tokyo Metropolitan University Graduate School)
[2P-692(2PS-16-08)]Analysis of the temperature sensing mechanism by multiple thermo-receptors in a single thermosensory neuron and the significance of the presence of multiple thermo-receptors.
○Nanako Kanamura1,2, Akane Ohta1,2, Yuki Sato1,2, Akira Kawanabe3, Yuichiro Fujiwara4,3, Atsushi Kuhara1,2,5 (1. Graduate School of Natural Science, Konan University, Kobe, Japan, 2. Institute for Integrative Neurobiology, Konan University, Kobe, Japan, 3. Faculty of Medicine, Kagawa University, Kagawa, 4. Graduate School of Biomedical and Health Sciences (Medical), Hiroshima University, Hiroshima, Japan, 5. PRIME, AMED)
[2P-693]The roles of indole-containing metabolites of intestinal bacterial origin, and nuclear receptor CAR in the development of social brain in adolescence
○Ryuya Narita1, Takashi Kondo2, Keiko Abe3, Akihito Yasuoka1 (1. Dep Hum Nutri., Seitoku Univ., 2. RIKEN Cent Med Sci., 3. Dep App Biol Chem., Grad Sch Agric Life Sci., Univ. Tokyo)
[2P-694]Autism model mice exhibit distinctive social interaction of others and grooming behaviors
○Aika Sakamoto1, Yukino Chiba2, Nagisa Sakuma2, Aika Shoda2, Kaede Yamagishi2, Takamasa Yoshida3, Tomohiro Nagata4, Shigeo Uchino1,2 (1. Teikyo Univ.Grad School, 2. Teikyo Univ., 3. Teikyo Univ.Sch.Med, 4. Teikyo Univ.Sch.Sci.Eng)
[2P-695(2AS-18-05)]Regulation of Memory by Neuropeptide FMRFamide under Aging and Nutritional Conditions in Drosophila
○ZIHAO GAO1, Suzuna Kimura1, Sizhe Lyu1, Motoyuki Itoh1, Ayako Tonoki1 (1. Chiba University)
[2P-696]Social experience-dependent modulation of male courtship behavior involves altered K+ channel dynamics in a courtship trigger neuron
○Akari Kabasawa1,2, Daniel J Rindner2, Kenta Tomihara2, Yusuke Hara2, Daisuke Yamamoto2, Kosei Sato1,2 (1. University of Hyogo, Graduate School of Science., 2. National Institute of Information and Communications Technology (NICT))
[2P-697]Dopamine-dependent plasticity causes male courtship suppression by confinement stress in a small space in Drosophila
○Tomohito Sato1, Takaomi Sakai1 (1. Tokyo Metropolitan University)
[2P-698]Unsupervised Machine Learning Analysis of Gustatory Neural Activity for Host Plant Selection in Swallowtail Butterflies
○Katsuhisa Ozaki1, Juri Nishioka2 (1. JT Biohistory Research Hall, 2. Kyoto Prefectural Momoyama Senior High School)
[2P-699(2PS-06-03)]Gene Regulation Around E-box Motifs Involved in Alcohol Tolerance and Consumption
○Yoshiatsu Aomine1, Koki Sakurai1, Jun Adachi2, Tom Macpherson1, Takaaki Ozawa1, Yoichi Miyamoto2, Yoshihiro Yoneda3, Masahiro Oka2, Takatoshi Hikida1 (1. The Univ. of Osaka, 2. Nat. Inst. Biomedical Innovation (NIBN), 3. Res. Found. for Microbial Diseases of Osaka Univ.)
[2P-700]Effects of ice-binding protein on olfactory response and adaptation after cold exposure in Caenorhabditis elegans
○Ayano Kawamura1, Masahiro Kuramochi1 (1. Graduate School of Science and Engineering, Ibaraki University)
[2P-701]Functional and molecular signature of the astrocyte subset stabilizing memory
○Aoi Kuwahara1,2, Ken-ichi Dewa1, Kodai Kaseda1,2, Jun Nagai1 (1. RIKEN CBS, 2. Waseda Univ.)
[2P-702]Measurement of intracellular Ca2+ dynamics in ependymal cells of the ascidian larval trunk using fluorescent Ca2+ indicator proteins
○Maasa Kondo1, Nanako Okawa1,2, Takehiro G Kusakabe1, Kohei Onuma3, Atsushi Kuhara1, Tatsushi Yokoyama4, Masayuki Sakamoto4 (1. Inst. for Integr. Neurobiol.,Grad. Sch. of Nat. Sci., Konan Univ., 2. Div. Biol. Sci.,Grad. Sch. Sci.,Kyoto Univ., 3. Div. Agric. & Life Sci.,Grad. Sch. Nat. Sci.,Shimane Univ., 4. Grad. Sch. of Biostudies.,Kyoto Univ.)
[2P-703]Involvement of the cGAS-STING Pathway in the Pathogenesis of GLUT1 Deficiency and a Novel Therapeutic Strategy by its Inhibition
○Nobuyuki Aruga1,2, Shimbo hiroko1,3, Shoko Tamura1, Shinobu Hirai1 (1. Tokyo Metropolitan Institute of Medical Science, 2. Institute of Science Tokyo, 3. Kanagawa Children's Medical Center)
[2P-704(2AS-03-02)]Molecular mechanism of UNC13A dysregulation as a convergent outcome of functional loss of ALS-associated RNA-binding proteins
○Yasuaki Watanabe1,2, Naoki Suzuki1,3, Tadashi Nakagawa2,4, Masaki Hosogane2, Tetsuya Akiyama1, Satoru Morimoto6,7, Hideyuki Okano6,7, Masashi Aoki1, Keiko Nakayama2,5 (1. Department of Neurology, Graduate School of Medicine, Tohoku University,, 2. Division of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, 3. Department of Rehabilitation Medicine, Graduate School of Medicine, Tohoku University, 4. Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 5. Research Infrastructure Management Center, Institute of Science Tokyo, 6. Keio University Regenerative Medicine Research Center (KRM), 7. Division of Neurodegenerative Disease Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology)
[2P-705]Multi-modal Omics Analysis Reveals Molecular machineries regulating Epileptogenesis in Hemimegalencephaly
○Hosaka Ayane1, Miyashita Satoshi1, Nao Tabe1, Keiya Iijima2, Kaoru Yagita3, Masaki Takao3, Shinichiro Taya4, Masaki Iwasaki2, Mikio Hoshino1 (1. Department of Biochemistry & Cellular Biology, National institute of neuroscience, National Center of Neurology and Psychiatry, 2. Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, 3. Department of Clinical Laboratory and Internal Medicine, , National Center Hospital, National Center of Neurology and Psychiatry, 4. Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS), Fujita Health University)
[2P-706]Knockdown of a tardive dyskinesia target VMAT-1 by CRISPR-Cas13 inhibits astrocytic behavior
○Mami Akiyama1, Hideji Yako1, Junji Yamauchi1 (1. Tokyo University of Pharmacy and Life Sciences)
[2P-707]Development of an open-type neuronal cell culture device for enriching axonal compartments
○Bingbing Wang1, Hiromi Takahashi2, Asako Otomo2,3, Shinji Hadano2,3, Hiroshi Kimura1,3 (1. Dept. of Mech., Tokai Univ. Sch. Eng., 2. Dept. of Physiol., Tokai Univ. Sch. Med., 3. MNTC, Tokai Univ.)
[2P-708(2PS-06-01)]The analysis of the epigenetic mechanisms underlying stress susceptibility in a mouse model of chronic social defeat stress-induced depression
○Sayaka Yamaguchi1,2, Shusaku Uchida3, Yusuke Kishi1,2 (1. Department of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Laboratory of Molecular Neurobiology, Institute for Quantitative Biosciences, The University of Tokyo, 3. Department of Integrative Stress Science, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo)
[2P-709]Development of a quantification method for LINE-1 ORF0 expression and its application to postmortem brain samples
○Kazunari Mizuno1, Yutaka Nakachi1, Wataru Ukai2, Takao Ishii3, Eri Hashimoto2, Kazuya Iwamoto1, Miki Bundo1 (1. Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, 2. Department of Neuropsychiatry, Sapporo Medical University, School of Medicine, 3. Department of Occupational Therapy, Sapporo Medical University School of Health Sciences)
[2P-710]Functional Analysis of Claudin-11 in Oligodendrocyte-related Disorders and Identification of a Novel Binding Partner, Shroom-2
○Sakurako Kobayashi1, Junji Yamauchi1 (1. Tokyo University of Pharmacy & Life Science)
[2P-711]Elucidation of the Mechanism of Mental Illness Prevention by Voluntary Exercise
○Sena Uchida1,2, Jonghyuk Park1,3, Hiroko Shimbo1, Shoko Tamura1, Tomoe Nishimura4, Shinobu Hirai1 (1. Metabolic Regulation Group, Tokyo Metropolitan Institute of Medical Sciences, 2. Department of Biological Sciences, Ochanomizu Univ., 3. Laboratory of Exercise Physiology, Department of Food Design, Nitobe Bunka College, 4. Center of Basic Technology Research, Tokyo Metropolitan Institute of Medical Sciences)
[2P-712]Molecular and Cellular Biological Analysis of the Neurodegenerative Disease-Associated Hikeshi/C11ORF73 p.Pro173Leu Variant
○Minori Minegishi1, Hideji Yako1, Junji Yamauchi1 (1. Laboratory of Molecular Neurology, Tokyo University of Pharmacy and Life Sciences)
[2P-713]Astrocytic Cathepsin D truncates a-synuclein and promotes Lewy neurite-like aggregation in neurons
○Kota Ohashi1, Hiromu Shojima1, Naoki Hisamoto1, Kunihiro Matsumoto1, Hiroshi Hanahusa1 (1. Nagoya Univ.)
[2P-714]DGCR8 Function and Microglial "Individuality": Insights from Cell Imaging Analysis
○Mayuko Arai1, Takaaki Watanabe1, Toshiyasu Taniguchi1 (1. Dept. of Mol. Life Sci., Sch., of Med., Tokai Univ.)
[2P-715]Targeting DGCR8 to eliminate extrachromosomal oncogene amplifications (DMs): A novel cancer therapy
○Yurina Yoshida1, Takaaki Watanabe1, Toshiyasu Taniguchi1 (1. Tokai University School of Medicine, Department of Molecular Life Science)
[2P-716]Novel functions of the RNA-binding protein DGCR8 in stress responses and genome stability
○Takaaki Watanabe1, Toshiyasu Taniguchi1 (1. Dept. of Mol. Life Sci., Sch., of Med., Tokai Univ.)
[2P-717]Analysis of the DGCR8-dependent regulatory network underlying UV-induced R-loop formation
○yukiko tanaka1, Takaaki Watanabe1, Toshiyasu Taniguchi1 (1. Tokai University School of Medicine,Department of Molecular Life Science)
[2P-718]Analysis of the blue light damage response mechanism in ophthalmology and dermatology via a novel oxidative stress regulation function of DGCR8/Drosha
○Hidehiro Nagaoka1, Takaaki Watanabe1, Toshiyasu Taniguchi1 (1. Tokai University)
[2P-719]Disruption of Sphingolipid Metabolism as a Risk Factor for Parkinson’s Disease:Analysis Using a PLA2G6/GBA1 Double Knockout Model
○Mai Shimizu1, Kahori Shiba-Fukushima2, Ryota Kasahara2, Emi Tokuda3, Yoshiki Miura3, Hui-Yi Liu4, Chun-Feng Liu4, Jun-Yi Liu5, Nobutaka Hattori1,2, Yuzuru Imai1,2 (1. Department of Neurology, Juntendo University, Graduate School of Medicine , 2. Research for Parkinson's Disease, Juntendo University, Graduate School of Medicine, 3. Laboratory of Proteomics and Biomolecular Science, Juntendo University, Graduate School of Medicine, 4. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China, 5. Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China)
[2P-720]Effect of NAD+ metabolism changes associated with aging and obesity on Alzheimer's disease pathology
○Ayaka Nakamura1, Tomoko Wakabayashi1,2, Takeshi Iwatsubo1 (1. Tokyo Univ., 2. Meiji Pharmaceutical Univ.)
[2P-721]Impact of a TDP-43 nonsense mutation in ALS on RNA binding and phase separation in iPSC-derived motor neurons
○Yusaku Kasuga1, Asako Otomo2, Akira Katayama3, Kaneyoshi Yamamoto1, Shinji Hadano2, Akira Ishiguro1 (1. Hosei Univ., 2. Tokai Univ., 3. Japan Medical Univ.)
[2P-722]Phospholipid flippase ATP8A2 modulates inhibitory neurotransmission in hippocampal neurons
○Muneyuki Kawase1, Shu Tokunaga1, Hishashi Oishi2, Takashi Sakurai3, Mitsuharu Hattori1 (1. Nagoya City Univ. Grad. Sch. Pharmaceut. Sci., Dept. Biomed. Sci., 2. Nagoya City Univ. Grad. Sch. Med. Sci., Dept. Comparative Exp. Med., 3. Juntendo Univ. Grad. Sch. Med., Dept. Cell. Mol. Pharmacol.,)
[2P-723]The feasibility of genome editing-mediated gene-silencing therapy for DRPLA
○Taisuke Kato1, Sho Kitahara2, Yuka Mitsuhashi2, Kobayashi Kenta3, Onodera Osamu2 (1. Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 2. Department of Neurology, Brain Research Institute, Niigata University, 3. Department of Viral Vector Development, National Institute for Physiological Science)
[2P-724]Microglial CRMP4 Deficiency Attenuates Dopaminergic Neuronal Death in a 6-OHDA-Induced Mouse Model of Parkinson's Disease
○Ryo Asahina1, Leo Shimizu1, Toshio Ohshima1 (1. Waseda Univ. Life science and Medical Bioscience)
[2P-725]Investigating the Contribution of AQP4 Localization to the Suppressive Effect of Gamma Frequency Sensory Stimulation on Brain Injury
○Kanon Hayashi1 (1. Ochanomizu University, Tokyo, Japan)
[2P-726]IBMX and Forskolin Co-Treatment Protects Against MDMA-induced Neurotoxicity via cAMP-Mediated Suppression of Apoptosis and Autophagy
○Yuan-Shieh Huang1 (1. Department and Graduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan)
[2P-727]Enteric neuronal and glial hyperactivity in irritable bowel syndrome
○Ken Ueda1, Kazuki Harada2, Yuri Osuga Yoshiike1, Hiromu Monai3, Takashi Tsuboi1 (1. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan, 2. Health and Environmental Risk Division, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki 305-8506, Japan, 3. Department of Biology, Faculty of Science, Ochanomizu University, Ohtsuka, Bunkyo, Tokyo 112-8610, Japan)
[2P-728]Mapping Seizures in Space: Spatial Transcriptomics of Region-Specific Epileptiform Activity
○Kutter Hine1, Alexis Given1, Lance Peterson1, Kevin Lumene1, Wendi Rivera1, Benjamin Riley1, Tyler Bowman1, Benjamin Blaine1, R. Ryley Parrish1, Matthew H. Bailey1 (1. BYU)
[2P-729]Integrated Stress Response in ALS model mice is affected by a nonstructural protein S derived from sandfly fever Sicilian viruses (SFSV-NSs)
○Kaoru Suzuki1, Haruki Kimura1,2, Hitomi Tsuiji3, Shintaro Iwasaki4,5, Takuhiro Ito6, Yoshiho Ikeuchi1,2,7 (1. Institute of Industrial Science, 2. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 3. Faculty of Pharmacy, Musashino University, 4. Pioneering Research Institute, RIKEN, 5. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 6. Center for Integrative Medical Sciences, RIKEN, 7. Institute for AI and Beyond, The University of Tokyo)
[2P-730]Effect of hormones on pathogenesis of Alzheimer's desease.
○Masanori ITO1, Riho ARAKI2 (1. Gifu Univ. Med. Neurophysiology, 2. Gifu Univ. Med.)
[2P-731]Changes in the activity of enteric neurons and glial cells in GFAP-Cre calcineurin B1fl/fl mice suffering from maldigestion and malabsorption
○Mizuki Nishino1, Naohide Hirashima1, Masahiko Tanaka1 (1. Nagoya City University Graduate School of Pharmaceutical Sciences)
[2P-732]Chromogranin B, a neuron-derived secreted protein, induces the apoptosis of oligodendrocyte-lineage cells
○Nanako Yamada1, Momona Yamada1, Reina Oono1, Binri Sasaki1, Akira Yoshimoto1, Ryunosuke Ohkawa1, Nobuharu Suzuki1 (1. Department of Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[2P-733]Transcriptomic Landscape of Microglia in Mouse Models of Social Dysfunction and Oxytocin-Mediated Recover
○Masafumi Tsurutani1, Haruaki Sato1, Mitsue Hagihara1, Kazunari Miyamichi1 (1. RIKEN BDR)
[2P-734]Analysis of osteoclast differentiation mediated by IGF binding protein signaling
○Takashi Izawa1, Yusaku Hamada1, Gohji Kozaki1, Yuri Yoshikawa1, Hiroshi Kamioka1 (1. Okayama Univ.)
[2P-735]Possible pre-metazoan function of the hematopoietic cell differentiation suppressor CEBPα
○Riho Kodera1, Mami Inoue1, Seitaro Denbo2, Ayato Hino2, Yosuke Nagahata3, Hiroshi Kawamoto4, Hiroshi Suga1 (1. Prefectural University of Hiroshima, 2. PUH Graduate School , 3. IBE, 4. Kyoto Univ.)
[2P-736]Evaluation of immunosuppressive phenotype on tumor-associated macrophages in pancreatic cancer
○Waka Mochizuki1, Kuniyuki Kawano1,2, Hiroshi Okuda1, Juri Ichikawa1, Shingo Kato3, Michito Hamada4, Satoru Takahashi5, Shin Maeda2, Tomohiko Tamura1,6 (1. Department of Immunology, Yokohama City University, 2. Department of Gastroenterology, Yokohama City University, 3. Department of Clinical Cancer Genomics, Yokohama City University Hospital, 4. Center for Medical Science, Ibaraki Prefectural University of Health Sciences, 5. Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 6. Advanced Medical Research Center, Yokohama City University)
[2P-737(2PS-12-05)]Roles of TfR1-mediated iron metabolism in the initiation of T-lineage program
○Hiroyuki Hosokawa1 (1. Tokai Univ.)
[2P-738]The role of IκBNS in the pathogenesis of murine autoimmune gastritis
○Koki Awaka1, Kaito Tatsuno2, Kana Takahashi1, Maki Touma1 (1. Department of Life and Food Sciences, Graduate School of Science and Technology, Niigata University , 2. Faculty of Science, Niigata University)
[2P-739(2PS-15-08)]Coordinated control of infected-cell clearance and tissue repair by host immune modulator CD5L in viral infection
○Satoko Arai1, Natsumi Maehara1, Toru Miyazaki1 (1. The Institute for AIM Medicine)
[2P-740]Sterilization Stability of Autoantibody Adsorbents Using Denatured Antigens as Ligands
○Midori Futami1, Ryozan Tokunaga1, Masaya Kamo1, Eri Kurozumi1 (1. Okayama Univ. Sci.)
[2P-741]Potential of secretory leukocyte protease inhibitor (SLPI) as a novel biomarker for inflammatory bowel disease
○Sotaro Ozaka1,2, Yomei Kagoshima1,2, Yoko Kudo2, Kanako Ito2, Ekronarongchai Supanuch1, Nozomi Sachi1, Masaaki Okamoto1, Naganori Kamiyama1,3, Tatsuhito Umeki1, Shohei Terashi2, Kazuhiro Mizukami2, Takashi Kobayashi1,3 (1. Oita University, Faculty of Medicine, Department of Infectious Disease Control, 2. Oita University, Faculty of Medicine, Department of Gastroenterology, 3. Oita University)
[2P-742]The transcription factor IRF6 orchestrates cellular interaction networks between skin and immune cells
○Maki Miyauchi Yada1,2, Yuki Takakura3, Takahisa Miyao2, Naho Hagiwara2, Akira Kinoshita4, Nobuko Akiyama1,2, Tetsuro Kobayashi5, Taishin Akiyama1,2 (1. Immunobiology, Graduate School of Medical Life Science, Yokohama City University, 2. Laboratory for Immune Homeostasis, RIKEN Center of Integrative Medical Sciences, 3. Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 4. Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University, 5. Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences)
[2P-743]The transcription factor Nrf3 promotes MHC-I degradation for cancer immunosuppression
○Ayaka Ishibashi1, Ayuka Makino1, Miki Nukushina1, Tsuyoshi Waku2, Akira Kobayashi1 (1. Grad. Sch. Life and Med. Sci., Doshisha Univ., 2. Fac. Life. and. Med. Sci., Doshisha Univ.)
[2P-744(2PS-12-06)]The role of mevalonate metabolism in inflammatory memory of macrophages
○Seonghyeon Hong1, Tomoaki Koga1, Naofumi Funagura1,2, Tomoaki Inazumi3, Yukihiko Sugimoto3, Mitsuyoshi Nakao1 (1. Dept. of Med. Cell Bio., Inst. of Mol. Embryo. and Gene., Kumamoto Univ., 2. Dept. of Ophthalmol., Fac. of Life Sci., Kumamoto Univ., 3. Dept. of Pharm. Biochem., Fac. of Life Sci., Kumamoto Univ.)
[2P-745]Bioreactor development using chicken eggs for useful antibody production and its evaluation method
○Kana Harada1 (1. Hiroshima university)
[2P-746]The protective effect of ellagic acid against pulmonary dysfunction is mediated via suppression of the IL-17/NF-κB/MMP9 axis
○Li Shao1,2, Shaokang Wang1, Jingming Shi2 (1. school of public health,Southeast University, 2. School of Medicine, Xizang Minzu University)
[2P-747]L-PGDS-PGD2-DP1 axis controls the phagocytic activity of CD36+ MG/MΦs which emerge in the ischemic area after stroke
○Akiko Doi1,2, Aya Narita1, Hideaki Nishie3, Yu Fukuda3, Tomohiro Matsuyama2, Takayuki Nakagomi1,2 (1. Institute for Advanced Medical Sciences, Hyogo Medical University, 2. Department of Therapeutic Progress in Brain Diseases, Hyogo Medical University, 3. Nippon Zoki Pharmaceutical Co., Ltd.)
[2P-748]Fgf21 promotes central immune tolerance and prevents autoimmune responses by maintaining medullary thymic epithelial cell function
○Yuki Masuda1, Yoshiaki Nakayama1, Hiroshi Hasegawa1, Morichika Konishi1 (1. Kobe Pharm. Univ.)
[2P-749]The Nr4a family in T cell regulates MASH
○Daisuke Aki1, Akihiko Yoshimura2 (1. Wakayama Medical University, 2. Tokyo University of Science)
[2P-750]Reactivity of autologous serum IgG to the gut microbes in pediatric ulcerative colitis
○Nafisa Tabassum1, Haruyuki Nakayama Imaohji1, Munyeshyaka Emmanuel1, Ayano Tada1, Tateo Kondo 2, Sonoko Kondo2, Takashi Kusaka2, Tomomi Kuwahara1 (1. Department of Microbiology, Faculty of Medicine, Kagawa University, 2. Department of Pediatrics, Faculty of Medicine, Kagawa University)
[2P-751]Oxidative stress promotes the expression of Mfa1 fimbriae in Phocaeicola vulgatus
○Emmanuel Munyeshyaka1, Haruyuki Imaohji1, Hisashi Yamasaki2, Ayano Tada1, Nafisa Tabasum1, Tomomi Kuwahara1 (1. Kagawa University, 2. Hyogo Med. Univ)
[2P-752]Comparative Analysis of Anti-Inflammatory Flavones in Chrysanthemum indicum Capitula Using Primary Cultured Rat Hepatocytes
Keita Minamisaka1, ○Airi Fujii1,2,3, Cheng Li1, Yuto Nishidono4, Saki Shirako1, Teruhisa Kawamura1, Yukinobu Ikeya2, Mikio Nishizawa1 (1. College of Life Sciences Ritsumeikan Univ., 2. Ritsumeikan Univ., 3. College of Pharmaceutical Sciences Doshisha Women’s College of Liberal Arts, 4. College of Pharmaceutical Sciences Ritsumeikan Univ.)
[2P-753]Optimization of a high-efficiency transfection method for the establishment of metabolically competent THP-1 cells.
○Yutaro Oishi1, Hiroki Koyama1, Kouichi Kurose1 (1. Tokyo University of Marine Science and Technology)
[2P-754]Efficient Extraction and Allergenicity Assessment of Proteins from Tenebrio molitor for Food Resource Utilization
○Shumma Aoki1, Hiroki Koyama1, Kuniyoshi Simakura1, Kouichi Kurose1 (1. Tokyo University of Marine Science and Technology)
[2P-755]Exploration of LPS-responsive gene markers in THP-1 cells based on RNA-Seq analysis and its application to a novel endotoxin testing method
○Moeri Okada1, Hiroki Koyama1, Kouichi Kurose1 (1. Tokyo University of Marine Science and Technology)
[2P-756]PD-1 suppresses inflammatory responses elicited by de novo genome mutagenesis in mice
○Yoshiya Kakimoto1, Ilamangai Nagaretnam1, Fuka Takeuchi2, Toshiaki Shigeoka1, Akihiko Ito2, Yasumasa Ishida1 (1. Nara Institute of Science and Technology, 2. Kindai University Faculty of Medicine)
[2P-757]The role of IκBNS in the differentiation of helper T cell subsets that regulate the germinal center reaction
○Yuna Ota1, Shoki Kanno1, Maki Touma1 (1. Department of Life and Food Sciences, Graduate School of Science and Technology, Niigata University)
[2P-758]The role of IκBNS in the anti-inflammatory function of innate-type Bregs
○Karin Yamazaki1, Tomoya Takahashi1, Maki Touma1 (1. Department of Life and Food Sciences, Graduate School of Science and Technology, Niigata University)
[2P-759]The Effect of von Willebrand Factor on Platelet Thrombus Formation in Sinusoidal Obstruction Syndrome
○Morisada Hayakawa1,2, Yuji Kashiwakura1,2, Hiroko Hayakawa1,3, Nemekhbayar Baatartsogt1, Tsukasa Ohmori1,2 (1. Dept of Biochem・ Sch of Med・Jichi Med Univ, 2. Cent for Gene Ther Res・Jichi Med Univ, 3. Cent for Cyto Res・Jichi Med Univ)
[2P-760]The Role of MK2/MK3 Kinase in the Airway Inflammation
○Hiroko Hayakawa1,2, Morisada Hayakawa1,3, Yasumitsu Nagao4, Tsukasa Ohmori1,3 (1. Dept of Biochem・Sch of Med・Jichi Med Univ, 2. Cent for Cyto Res・Jichi Med Univ, 3. Cent for Gene Ther Res・Jichi Med Univ, 4. Cent for Exp Med・Jichi Med Univ)
[2P-761]Mechanistic Analysis of UBA1 Mutation–Driven Inflammation in a VEXAS Syndrome Cell Model
○Tomoyuki Mukai1, Yuma Sakamoto1, Nobuyasu Baba1, Masanori Iseki1 (1. Kawasaki Medical School)
[2P-762]Investigation of murine gastric organoid culture for the pathological analysis of autoimmune gastris
○Yusaku Kato1, Ayane Wada1, Maki Touma1 (1. Department of Life and food sciences, Graduate School of Science and Technology, Niigata University)
[2P-763]IFN-γ production in co-culture of 293T cells and human NK cells
○Yasuhiro Omata1, Yuko Hayakawa1, Kojiro Sato1 (1. Jichi Medical University)
[2P-764]Identification of Individual Immune Phenotypes through Time-Series Analysis of Salivary sIgA Concentrations: Implications for Personalized Health Monitoring
○Yu Akiyama1, Takahiro Shiga1, Hirotaka Minagawa1, Ikuo Shiratori1 (1. NEC Solution Innovators, Ltd.)
[2P-765]Investigation of the Mechanism of IL-3-Mediated Priming of Mouse Basophils
○Konoka Tanimoto1, Hajime Karasuyama1, Kensuke Miyake1 (1. Institute of Science Tokyo)
[2P-766]Zinc Ion–Mediated ROS Signaling Drives T Cell Homing and Exacerbates Skin Inflammation
○Ji-Ae Lee1, Juhyun Shin1, Jeong Won Park1, Seon Young Kim1, Hyuk Soon Kim1 (1. Dong-A University)
[2P-767]Frontotemporal dementia gene progranulin deficiency induces autoimmune liver disease via glucosylceramide accumulation
○Chiharu Tanaka1, Shiho Sakai1, Mari Goto2, Yasunori Miyamoto3, Kei Hashimoto3 (1. Graduate School of Humanities and Sciences, Ochanomizu Univ., 2. Teikyo Univ., 3. Insutitute for Human Life Science, Ochanomizu Univ.)
[2P-768]Evaluation of the NLRP3 inflammasome inhibitory effect of herbal extracts
○Rina Shibata1, Sunao Kobayashi2, Kaho Mizuno2, Nao Tsuchida1, Tadayoshi Karasawa3, Masafumi Takahashi3, Fumitake Kawanishi1,2 (1. Dep. of Biotechnology and Pharmaceutical Eng., Grad. Sch. of Eng., Toyama Prefectural Univ., 2. Dep. of Pharmaceutical Eng., Faculty of Eng., Toyama Prefectural Univ., 3. Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical Univ.)
[2P-769]Elucidating the molecular mechanism by which iron enhances inflammatory signaling
○Suzu Yoshitomo1,2, Ayato Maeda1,2, Akihiro Nita2, Toshiro Moroishi2 (1. 1.Department of Molecular and Medical Pharmacology, Faculty of Life Sciences, Kumamoto University, 2. 2.Division of Cellular Dynamics, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo)
[2P-770]Macrophage Scavenger Receptor 1-Mediated Phagocytosis of Lactic Acid Bacteria, Enterococcus faecalis EF-2001
○Yuki Kubota1,2, Takumi Tsuboya2, Marina Murakami2, Shuichiro Uehara1, Shigeo Suzuki2 (1. Department of Pediatric Surgery, Nihon University School of Medicine, 2. NIHON BERUMU CO., LTD.)
[2P-771]Screening and functional evaluation of plant extract targeting inflammatory responses of T cells and surrounding tissue cells for skin immune regulation
○Yoshiho Akiyama1, Yoshino Kaige2, Masatoshi Takeiri1, Keiko Arai1, Kenji Takemoto3, Masataka Asagiri3, Keiko Iwaisako4, Osamu Ohno2, Yoshihide Kimura1 (1. IVY Cosmetics Corporation, 2. Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 3. Department of Pharmacology, Yamaguchi University Graduate School of Medicine, 4. Department of Medical Life Systems Faculty of Life and Medical Sciences Doshisha University)
[2P-772]Immune Priming via Or56a-Dependent Olfactory Activation Enhances Survival in Drosophila
○JIAXUAN ZHAO1, Akira Ito1, Takahiro Chihara1,2 (1. Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Japan., 2. Program of Basic Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Japan.)
[2P-773]Development of a droplet-based FLASH-seq workflow for complete genome analysis of single SARS-CoV-2 particles
○Hiroko Matsunaga1, Chia-Ling Lin2, Sho Miyamoto4, Koki Numakura2,4, Misato Okudaira1, Tadaki Suzuki4, Haruko Takeyama1,2,3 (1. Res. Org. Nano Life Innov., Waseda Univ., 2. Grad. Sch. Adv. Sci. Eng., Waseda Univ., 3. Inst. Adv. Res. Biosyst. Dynam., Waseda Res. Inst. Sci. Eng., Waseda Univ., 4. Dept. Of Infect. Dis. Pathol., NIID, JIHS)
[2P-774]Comprehensive Analysis of Conserved Protein Structures Among Distantly Related Viruses Through Network Clustering Using Node2Vec and DBSCAN
○Takara Doteuchi1, Manabu Igarashi2, Daiki Koge1, Takashi Abe1 (1. Graduate School of Science and Technology, Niigata University, 2. Hokkaido University International Institute for Zoonosis Control)
[2P-775]Development of a method for estimating virus taxonomy using deep learning
○Kenshi Moriya1, Daiki Koge1, Takashi Abe1 (1. Graduate School of Science and Technology, Niigata University)
[2P-776]Unveiling host-specific oligonucleotides in viral genomes using Random Forest
○Kazuki Ohwa1, Daiki Koge1, Takashi Abe1 (1. Graduate School of Science and Technology, Niigata University)
[2P-777]The effect of the stability of Dengue Virus Serotype 3 Envelope Protein Domain Ⅲ on its immunogenicity
○Yuma Tanaka1, Md. Din Islam1, Tomonori Saotome2, Takeshi Kurosu3, Yutaka Kuroda1 (1. Tokyo University of Agriculture and Technology, 2. National Institute of Technology (KOSEN), Oyama College, 3. National Institute of Infectious Diseases)
[2P-778]Analyses of chicken innate immune responses to viral pathogens
○SHIHYUAN CHENG1, Satoko Kobayashi 1, Kennosuke Ichikawa2, Tenkai Watanabe1,3, Takumi Terada1, Ryo Ezaki 1, Mei Matsuzaki1, Yuko Uchida4, Hiroyuki Horiuchi 1,3 (1. Graduate School of Integrated Sciences for Life, Hiroshima University, 2. The Roslin Institute, University of Edinburgh, 3. Hiroshima University Genome Editing Innovation Center, 4. National Institute of Animal Health, NARO)
[2P-779(2PS-15-07)]Mechanistic Investigation of LC-Plasma-Induced Innate Immune Memory
○CHANG TANG1, Reno Otuka1, Kenta Jounai1, Hiroshi Ishii2, Tetsuro Matano3 (1. Kirin Holdings Company, Limited., 2. Japan Insititute of Health Security, National Institute of Infectious Diseases, 3. Japan Insititute of Health Security, National Institute of Infectious Diseases)
[2P-780]Neutrophil adhesion to pulmonary vessels impairs blood flow in COVID-19
○Hiroshi Ueki1,2, I-Hsuan Wang3, Maki Kiso2, Kenta Horie4, Shun Iida5, Sotaro Mine5, Hsu Hung-Wei3, Wu Chen-Hui3, Masaki Imai1, Tadaki Suzuki5, Wataru Kamitani6, Eiryo Kawakami4, Yoshihiro Kawaoka1,3,7 (1. Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, 2. Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 3. Institute of Biomedical Sciences, Academia Sinica, 4. Department of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, 5. Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan, 6. Department of Infectious Diseases and Host Defense, Gunma University Graduate School of Medicine, Gunma, Japan, 7. Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin-Madison)
[2P-781]Environmental factors in the replication of the Archetype and PML-type JC polyomavirus
○Ryoko Enomoto1, Zhiping Chen1, Souichi Nukuzuma1, Yoh-ichi Tagawa1 (1. School of Life Science and Technology, Institute of Science Tokyo)
[2P-782(2PS-09-05)]AMP-Atlas: AI-Driven Discovery and Evolutionary Optimization of Antimicrobial Peptides
○Yuki Otani1,2, Daisuke Koga1, Tae Ugaki1, Yasunari Wakizaka1, Hideyuki Shimizu1,2 (1. Institute of Integrated Research, Instiute of Sceince Tokyo, 2. Graduate School of Medical and Dental Science, Institute of Science)
[2P-783]A cap-dependent endonuclease inhibitor acts as a potent antiviral agent against La Crosse virus infection
○Kei Konishi1,2, Yoshiyuki Taoda3, Manabu Igarashi2, Takao Shishido1, Kazuya Yasuo3, Yasuko Orba4,5,2, Hirofumi Sawa4,5, Michihito Sasaki4,2, Akihiko Sato1,2,4 (1. Laboratory for Drug Discovery & Disease Research, Shionogi & Co., Ltd., 2. International Institute for Zoonosis Control, Hokkaido University, 3. Laboratory for Medicinal Chemistry Research, Shionogi & Co., Ltd., 4. Institute for Vaccine Research and Development, Hokkaido University, 5. One Health Research Center, Hokkaido University)
[2P-784]Role of Residue 421 in the L Protein of Respiratory Syncytial Virus in Transcription and Replication
○Tatsuki Takahashi1, Sodbayasgalan Amarbayasgalan1, Yoshiro Sugiura1, Shiori Ueno1,2, Enkhjin Dorjsuren1, Kenta Shimizu1, Wataru Kamitani1 (1. Gunma Univ., 2. National Institute of Infectious Diseases)
[2P-785(2PS-15-06)]Genome-wide screening for host cell factors involved in Oz virus infection
○Yuta Homma1,3, Nanami Yamamoto2,3, Hideki Tani4, Haruhiko Isawa3, Kohji Noguchi2,3, Masayoshi Fukasawa3,2, Toshiyuki Yamaji1,3 (1. Fac. Pharm., Juntendo Univ., 2. Grad. Sch. Pharm Sci., Tokyo Univ. Sci., 3. Nat. Inst. Infectious Diseases, JIHS, 4. Toyama Inst. Health)
[2P-786]Development of a Rapid Visual Detection Method for A Influenza Viruses Using DNA Aptamer
○Eri Hamada1 (1. NECSolution Innovators)
[2P-787]Development of Neuraminidase Aptamers for Broad Detection of Influenza A Virus
○Yuna Imaizumi1, Yukitoshi Katayama1, Toshiki Sekiya2, Tomomi Kawakita2, Naoki Nomura2, Eri Hamada1, Hiroshi Kida2, Hirofumi Sawa2,3, Masashi Shingai2, Katsunori Horii1 (1. NEC Solution Innovators, Ltd., 2. Hokkaido University International Institute for Zoonosis Control, 3. Hokkaido University, Institute for Vaccine Research and Development)
[2P-788]Evaluation of Caenorhabditis elegans as a model organism for Dirofilaria immitis in Aedes aegypti
○Tatsuki Kuramoto1,2, Motoki Sasaki1, Shinya Fukumoto2 (1. Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2. Department of Veterinary Medicine, Rakuno Gakuen University)
[2P-789]Strand structure of DNA impurities in recombinant adeno-associated virus capsids
○Kyoko Masumi Koizumi1, Emi Ito Kudo1, Yuan Yuzhe1, Keisuke Yusa1, Kazuhisa Uchida1 (1. Kobe University)
[2P-790]Characterization of Ynnan orbivirus and Fako virus isolated from field-collected mosquitoes in Zambia
○Takuma Ariizumi1, Bernard Hang’ombe2, Michihito Sasaki1,3, Hirofumi Sawa3, Yasuko Orba1,3 (1. IIZC, Hokkaido Univ., 2. School of Veterinary and Medicine, University of Zambia, 3. IVRed. Hokkaido Univ.)
[2P-791]An endogenous viral element suppresses replication and transmission of an insect-specific virus in naturally infected mosquitoes
○Yasutsugu Suzuki1, Artem Baidaliuk2, Yuu Sekii1, Irish Coleen Asin1, Pascal Piesen3, Etienne Simon-Loriere2, Kozo Watanabe1 (1. CMES, Ehime University, 2. G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, 3. Department of Medical Microbiology, Radboud University Medical Center)
[2P-792]R59G variant of Fibroblast growth factor 11 increases inhibition of FXRα-mediated-hepatitis B virus gene expression and its protein stability
○Mi So Seong1,2, Jeong Ah Jang1, Hyun Jin Jeong1, JaeHun Cheong1 (1. Department of Molecular Biology, Pusan National University, 2. Institute for Future Earth(IFE), Pusan National University)
[2P-793]Investigation of blood glucose suppression methods using highly efficient adenovirus infection
○Naoto Obayashi1, Akira Kurisaki1, Hitomi Takada1 (1. Nara Institute of Science and Technology)
[2P-794]Analysis of a PEVE-related Sequence Detected in Planarians from Japanese Rivers
○Shiori Kasho1, Fuki Yamanaka1, Hiroko Kobayashi2, Masayuki Horie3,4, Kan Fujino1, Satoshi Taharaguchi1 (1. Laboratory of Microbiology, School of Veterinary Medicine, Azabu University, 2. Research Institute for Microbial Diseases, Osaka University, 3. Laboratory of Veterinary Microbiology, Graduate School of Veterinary Science, Osaka Metropolitan University, 4. Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University)
[2P-795]Autophagy-Mediated Enhancement of Dengue Virus Replication in Aedes aegypti: The Role of AaFIP200 and AaAtg9
○Wei-Ting Liu1, Chi-Han Chiu2, Wu-Chun Tu3,4, Cheng-Chen Chen2,5 (1. Department of Entomology, National Chung Hsing University, Taichung, Taiwan, 2. Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan, 3. National Mosquito-Borne Diseases Control Research Center, National Health Research Institutes, Kaohsiung, Taiwan, 4. School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, Indonesia, 5. Department of Tropical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan)
[2P-796]Characterization of autophagy-related proteins involved in SARS-CoV-2 replication
○Itsuki Anzai1, Tokiko Watanabe1,2,3 (1. RIMD, The University of Osaka, 2. CiDER, The University of Osaka, 3. CAMaD, The University of Osaka)
[2P-797]Development of mouse-adapted virus for establishing an Orthohantavirus infection murine model
○Atsuko Inoue1,2, Rio Harada1,3, Cassia Sousa Moraes1,3, Kaito Maeda1,3, Motohito Goto4, Yukari Itakura1, Shinji Saito1, Kumiko Yoshimatsu3,5, Gabriel Gonzalez1, Yasuko Orba1,6, Katsumi Maenaka1,2,6,7,8, Mamoru Ito4, Makoto Suematsu4, Hirofumi Sawa1,6,9, Koshiro Tabata1 (1. Institute for Vaccine Research and Development, Hokkaido University, 2. Faculty of Pharmaceutical Science, Graduate School of Life Science, Hokkaido University, 3. Graduate School of Infectious Diseases, Hokkaido University, 4. Central Institute for Experimental Medicine and Life Science, Japan, 5. Institute for Genetic Medicine, Hokkaido University, 6. International Institute for Zoonosis Control, Hokkaido University, 7. Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, 8. Global Station for Biosurfaces and Drug Discovery, Hokkaido University, 9. One Health Research Center, Hokkaido University)
[2P-798]Phage Breeding via Coevolution Expands Host Range and Enhances Infection Efficiency of Staphylococcus aureus Phages
○Wakana Noro1, Hayato Matsuki1, Masahiro Oodaira1, Tomohiro Nakamura1,2, Junpei Fujiki1, Hidetomo Iwano1 (1. Rakuno Gakuen University, 2. National Institute of Infectious Diseases)
[2P-799]Establishment of a High-Throughput Plate-Reader–Based Neutralization Assay for Orthoflaviviruses
○Kaito Maeda1, Atsuko Inoue1,2, Chinatsu Nakamura1, Yukari Itakura1, Shinji Saito1, Shintaro Kobayashi1,3,4, Yasuko Orba1,4, Hirofumi Sawa1,4,5, Koshiro Tabata1 (1. Institute for Vaccine Research and Development, Hokkaido University, Japan, 2. Faculty of Pharmaceutical Science, Graduate School of Life Science, Hokkaido University, Japan, 3. Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Japan, 4. International Institute for Zoonosis Control, Hokkaido University, Japan, 5. One Health Research Center, Hokkaido University, Japan)
[2P-800]Transcriptomic Analysis of Cells Co-infected with Hepatitis B and Hepatitis D Viruses.
○Coco Okamura1,2, Masashi Iwamoto3, Koichi Watashi3, Masamichi Muramatsu4, Moto Kimura1, Wataru Sugiura1, Shawichi Iwamuro2, Junko Takeuchi1,2 (1. JIHS, 2. Toho Univ., 3. JIHS/NIID, 4. KBIC)
[2P-801]Mechanism of senolytic drugs in kidney tissue of old mice
○Masataka Murakawa1,3, Noriyuki Okudaira1, Takao Susa1, Miho Akimoto1, Yoshifuru Tamura3, Masayoshi Iiduka1,2, Shigeru Shibata3, Mimi Tamamori-Adachi1 (1. Teikyo Univ. of Med. Dep Biochem, 2. Teikyo Univ. of Med. Dep Int Med, 3. Teikyo Univ. of Med. Dep Int Med. Div Neph)
[2P-802]Possible involvement of BAF in base excision repair
○Haruka Kikuchi1, Yuna Sugiyama1, Yuki Matsuo1, Shiho Nakatsukasa1, Namiko Noma1, Taro Mannen1, Shinji Ito2, Ryotaro Nishi3, Toshiya Hayano1 (1. Ritsumeikan Univ., 2. Kyoto Univ., 3. Tokyo Univ. of Tech.)
[2P-803]Possible involvement of BAF in nucleotide excision repair
○Shiho Nakatsukasa1, Kota Kamei1, Yuki Matsuo1, Haruka Kikuchi1, Namiko Noma1, Taro Mannen1, Toshiya Hayano1, Shinji Ito2, Ryotaro Nishi3 (1. Ritsumeikan University, 2. Kyoto Univ. Grad. Sch. of Med, 3. Tokyo Univ. of Tech. Col. of Biosci. and Biotech)
[2P-804]Possible involvement of BAF in repair of DNA double-strand breaks(DSB)
○Yuki Matsuo1, Tetsu Hirai1, Namiko Noma1, Taro Mannnen1, Shinji Ito2, Ryotaro Nishi3, Toshiya Hayano1 (1. Ritsumeikan Univ. Col. of Life Sci., 2. Kyoto Univ. Grad. Sch. of Med., 3. Tokyo Univ. of Tech. Col. of Biosci. and Biotech.)
[2P-805]Fluorescent Labeling and Undecalcified Histomorphometry Reveal Enhanced Bone Repair via Vascularized Grafts
○CHEN YONG HUANG1, Tzu-Hui Chu1, Yu-Chi Lo2, Hsin-Yu Shu1, Xin-Lin Lai1, Min-Hung Liaong1, Jia-Fwu Shyu1 (1. College of Medicine National Defense Medical University, 2. Graduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University)
[2P-806(2PS-10-02)]Mechanisms of aging caused by glucocorticoids
○Noriyuki Okudaira1, Misato Terahara1, Masaki Kobayashi1, Masataka Murakawa1, Takao Susa1, Miho Akimoto1, Masayoshi Iizuka2,1, Mimi Adachi1 (1. Teikyo Univ. of Med. Dep Biochem, 2. Teikyo Univ. of Med. Dep Int Med)
[2P-807]mTORC1 control of growth and lifespan through chromatin remodeling
○Takafumi Ogawa1,2, T. Keith Blackwell2, Masaki Mizunuma1 (1. Hiroshima Univ., 2. Harvard Med. Sch.)
[2P-808(2PS-10-06)]Dnmt3a overexpression disrupts skeletal muscle homeostasis, promotes an aging-like phenotype
○Yasutomi Kamei1, Mamoru Oyabu1, Yuto Ohira1, Kiyoshi Yoshioka2, Runa Kawaguchi1, Atsushi Kubo3, Yukino Hatazawa1, Hinako Yukitoshi1, Huascar Pedro Ortuste Quiroga4, Naoki Horii4, Fumihito Miura5, Hiromitsu Araki5, Masaki Okano4, Izuho Hatada6, Hitoshi Gotoh7, Tatsuya Yoshizawa7, So-ichiro Fukada3, Yoshihiro Ogawa5, Takashi Ito5, Kengo Ishihara8, Yusuke Ono4 (1. Kyoto Prefectural University, 2. Institute for Research on Productive Aging, 3. Osaka University, 4. Kumamoto University, 5. Kyushu University , 6. Gunma University, 7. Kyoto Prefectural University of Medicine, 8. Ryukoku University)
[2P-809(2AS-05-06)]A new function of an ATG gene in the regulation of cold-inducible diapause in C. elegans
○Makoto Horikawa Horikawa1, Shuhei Nakamura1 (1. Nara Med. Univ., Dept. Biochem.)
[2P-810]Temporal Analysis of Age-Associated Gene Glipr1 Expression During Mouse Liver Development
○Ryosuke Oguma1,3, Yasunori Fujita1, Yoshitaka Kondo2, Kanae Ando3, Akihito Ishigami1,3 (1. Molecular and Cellular Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 2. Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 3. Department of Biological Sciences, Tokyo Metropolitan University)
[2P-811]Treatment with resveratrol, a SIRT1 activator, attenuates age-related skin thinning in mice.
○Fuka Tamura1, Ryusuke Hosoda1, Iyori Nojima1, Atsushi Kuno1 (1. Department of Pharmacology, Sapporo Medical University School of Medicine)
[2P-812]Tissue-Specific Lifespan Analysis of the Histone Deacetylase HDA-2 in Caenorhabditis elegans
○Souma Tani1, Yukihiko Kubota2, Kosuke Hamaya2, Yuto Hida2, Masahiro Ito1,2 (1. Graduate school of Life Sciences, Ritsumeikan univ., 2. College of Life Sciences, Ritsumeikan Univ.)
[2P-813]Decline in Nutrient Uptake and Metabolic Function in Cellular Senescence Models of Human iPSC-Derived Intestinal Organoid
○Tatsuhiro Ayabe1, Yu Takahashi2, I-Ting Lee2, Takeshi Kokubo1, Yoshio Yamauchi2, Ryuichiro Sato2 (1. Kirin Holdings Company, Limited, 2. The University of Tokyo)
[2P-814]The expression of Menin in epidermal keratinocytes may regulate cellular senescence
○Miyuki Omori-Miyake1, Ryosuke Kawakami2, Jun Muto3, Takeshi Imamura2, Masakatsu Yamashita1,4 (1. Dept. of Infections and Host Defenses, Ehime Univ., 2. Dept. of Molecular Medicine for Pathogenesis, Ehime Univ., 3. Dept. of Dermatology, Ehime Univ., 4. Dept. of Immunology, Ehime Univ.)
[2P-815]Comprehensive metabolite changes in mouse epididymis with aging
○Ryusei Maeda1, Keisuke Masuda1, Reiri Koga1, Sakura Nakamitsu1, Satohiro Nakao1, Naomi Nakagata2, Toru Takeo1 (1. Div. of Reproductive Enginnering, CARD, Kumamoto University, 2. Div. of Reproductive Enginnering, CARD, Kumamoto Univ. ²Div. of Reprod. Biol. Innov. CARD, Kumamoto Univ)
[2P-816]Molecular Markers of Cerebrovascular Aging Revealed by Single-Cell Metabolomics and Continuous Modeling
○Yuya Sato1, Kazuhiro Takara2,3, Yuto Nose1, Hiroyasu Kidoya2, Hitoshi Iuchi6, Michiaki Hamada7, Toru Asahi1,4, Kosuke Kataoka5 (1. Grad. Sch. of Adv. Sci. Eng., Waseda Univ., 2. Dept. of Integ. Vasc. Biol., Faculty of Med. Sci., Univ. of Fukui, 3. Tenure-Track Prog. for Innovative Res., Univ. of Fukui, 4. Dept. of Comp. Res. Org., Waseda Univ., 5. Grad. Sch. Eng., Tokyo Univ. of Agric. and Tech., 6. Waseda Res. Inst. Sci. Eng., Waseda Univ., Tokyo, Japan, 7. Cell. Mol. Biotech. Res. Inst. (CMB), Natl. Inst. Adv. Ind. Sci. Technol. (AIST), Tokyo, Japan)
[2P-817]Investigation of mechanisms underlying sarcopenia induced by aging and SIRT1 suppression through acetylome and transcriptome analyses
○Ryusuke Hosoda1, Ryo Numazawa1, Ryuta Nakashima1, Naotoshi Iwahara2, Iyori Nojima1, Atsushi Kuno1 (1. Department of Pharmacology, Sapporo Medical University School of Medicine, 2. Department of Neurology, Sapporo Medical University School of Medicine)
[2P-818]ESE-3 suppresses SASP in cellular senescence
○Yukiko Fumoto1,2, Makoto Fujikawa2, Yuichiro Katayama2, Tomoichiro Miyoshi 1, Fuyuki Ishikawa 2 (1. RIKEN Center for Integrative Medical Sciences, 2. Kyoto University, Graduate School of Biostudies)
[2P-819]Development of Mechanical Assays for Cancer Organoid Response to Deformations
○Makiko Arai1, Satoru Okuda1 (1. Kanazawa University)
[2P-820]The Adaptor Protein Crk Is Essential for Hydrogel-Induced Cancer Stemness in Neuroblastoma
○Yuya Miyamoto1, Masumi Tsuda2,3, Lei Wang2,3, Yoshitaka Oda2, Zen-ichi Tanei2,5, Jian Ping Gong3,4, Shinya Tanaka2,3,5 (1. Sch. of Med 6th Grade, Hokkaido Univ., 2. Dep. of Cancer Pathol., Fac. of Med., Hokkaido Univ., 3. WPI-ICReDD, Hokkaido Univ., 4. Lab. of Soft and Matter, Fac. of Adv. Life Science, Hokkaido Univ., 5. Dep. of Surg. Pathol., Hokkaido Univ. Hospital.)
[2P-821]Tumor-Derived Secreted Proteins Facilitate Fusobacterium nucleatum Biofilm Formation in the Oral Cancer Microenvironment
○Siqi Chen1, Natsumi Fujiwara2, Yasuhiro Mouri1, Yasusei Kudo1 (1. Tokushima University Graduate School of Biomedical Sciences, Department of Oral Bioscience, 2. Tokushima University Graduate School of Biomedical Sciences, Department of Oral Health Care Management)
[2P-822]Evaluation of Combined Effects of GLO I and XIAP Inhibitors in Cultured Lung Cancer Cells
○Genta Uchishiro1, Ryoko Takasawa1 (1. Facul. Pharm. Sci., Tokyo Univ. Sci.)
[2P-823(2PS-16-02)]Light Scattering Spectrum as a New Tool for Single-Cell Quantitative Analysis of Tumors
○Fuka Takeuchi1, Yuka Tsuri2, Yuichi Kimura3, Takashi Nagaoka4, Yoichiroh Hosokawa2,5, Akihiko Ito1 (1. Dept. Pathol., Fac. Med., Kindai Univ., 2. Div. of Materials Sci., NAIST, 3. Fac. of Inform., Cyber Inform. Inst., Kindai Univ., 4. Dept. of Computational Sys. Biology, Fac. of Biology-Oriented Sci., & Tech., Kindai Univ., 5. Medilux Research Center, NAIST)
[2P-824]Synthesis of natural product analogues for novel therapeutics for T-cell acute lymphoblastic leukemia
○Kensuke Yanada1, Tomoya Higashi1, Tomoki Hosoya1, Humiya Seki2,3, Tetsuyuki Akashi4, Nobuo Kitada1,5, Takashi Hirano1, Takahiko Hara2,3, Shingo Dan4, Shojirou Maki1,6 (1. Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, 2. Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 3. Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 4. Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japan Foundation for Cancer Research, 5. The University of Electro-Communications, Center for Environmental Safety and Health Management, 6. The University of Electro-Communications, Center for Neuroscience and Biomedical Engineering)
[2P-825]Drug-responsive behavioral changes of BCR-ABL-associated interacting proteins and alterations in signal transduction mechanisms
○Yosei Yamauchi1, Takanori Nakamura1, Hidetaka Kosako2, Mikihiko Naito3, Tatsuya Sawasaki1 (1. Proteo-Science Center, Ehime University, 2. Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3. Graduate School of Pharmaceutical Sciences, The University of Tokyo)
[2P-826]RPS19, a major Diamond-Blackfan anemia-causative gene product, prevents cellular transformation by counteracting SET oncoprotein-mediated attenuation of p53 activity
○Ryoma Kokubo1, Hiroki Fujiyama1, Takuya Takafuji1, Tohru Kiyono2, Yoko Katsuki1, Kazumasa Yoshida1, Hidetaka Kosako3, Nozomi Sugimoto1, Masatoshi Fujita1 (1. Department of Cellular Biochemistry, Graduate School of Pharmaceutical Sciendes, Kyushu University, Fukuoka, Japan, 2. Division of Carcinogenesis and Cancer Prevention, National Cancer Research Institute, Tokyo, Japan, 3. Fujii Memorial Institute of Medical Sciences, Tokushima University)
[2P-827]TRPC6 as a potential therapeutic target for metastasis and angiogenesis in bladder cancer
○Wei-Han Yen1, Chien-Rui Lai1, Hui-Kung Ting2, Ying Chen1 (1. National Defense Medical University, 2. Tri-Service General Hospital)
[2P-828]USP1 Suppression Regulates Cell Growth in BAP1-Mutated Malignant Mesothelioma
○Miki Takahashi1, Koya Suzuki1,2,3, Shinichi Kiyonari4, Kirara Kobayashi1, Takashi Miida5, Hiroshi Murakami6, Yoshitaka Sekido7, Yuko Murakami-Tonami1,3 (1. Tokyo Univ. Tech. Grad Sch. Bionics, 2. Adv. Comp. Res. Org., Teikyo Univ., 3. Juntendo Univ. Med., 4. Kitasato Univ. Med., 5. Fac. Med. Sci., Juntendo Univ., 6. Fac. Sci. Eng., Chuo Univ., 7. Div. Cancer. Biol., Aichi Cancer Ctr. Res. Inst)
[2P-829(2PS-17-04)]Evaluation of angiogenesis-inducing capacity of migrasomes using by peptide-modified substrate
○Yuka Iwasaki1, Shogo Saito1, Mina Okochi1 (1. Institute of Science Tokyo)
[2P-830]Functional analysis of ZIC5 in pancreatic cancer survival and drug resistance
○Momona Harada1, Yuki Kashiwaba1, Misaki Okao1, Reiko Satow1 (1. Tokyo University of Pharmacy and Life Sciences)
[2P-831]Targeting ZIC5 increases gemcitabine sensitivity and causes PDAC shrinkage in vivo
○Misuzu Iki1, Takeru Watanabe1, Yuna Aiga1, Kiyoko Fukami1, Reiko Satow1 (1. Tokyo University of Pharmacy and Life Sciences)
[2P-832]Theoretical elucidation of the reversal of win–lose fate in cell competition using a cellular automaton model
○Yudai Nakagawa1, Keisuke Ikawa1, Haruka Hiraoka1, Shizue Ohsawa1 (1. Nagoya University)
[2P-833]Screening for colorectal cancer-associated microproteins translated from small open reading frames within noncoding RNAs
○Hiroshi Kitajima1, Takeshi Niinuma1, Kazuya Ishiguro1, Takasawa Akira2, Yorozu Akira1, Masahiro Kai1, Hiroshi Nakase3, Hiromu Suzuki1 (1. Sapporo medical universityDiv. Mol. Biol., Dept. Biochem., Sapporo Med. Univ. Sch. Med., 2. Div. Tumor Pathol., Dept. Pathol., Asahikawa Med. Univ., 3. Dept. Gastroentrol., Hepatol., Sapporo. Med. Univ., Sch. Med.)
[2P-834]CYD19 as a Novel Therapeutic Agent: Anti-Tumor Mechanisms in Glioblastoma Multiforme
○Chien-Yun Huang1, Jen-Fu Yang2, Ying Chen1 (1. National Defense Medical University, 2. Tri-Service General Hospital)
[2P-835]Caspase-4 promotes DNA repair and radioresistance via nuclear actin dynamics in cancer cells
○Shohei Nagasaka1,2, Tomomitsu Doi2,3, Kunie Obayashi2, Masaoki Kohzaki4, kazuhiro Sumida2,5, Junkoh Yamamoto1, Motoyoshi Endo2 (1. Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 2. Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 3. Department of cellular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 4. Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 5. Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan)
[2P-836]Research on the colorectal tumor suppressing effect of nuclear receptor FXR
○Rin Shinozaki1, Koichiro Kawaguchi1 (1. Kyoto Institute of Technology・Department of Applied Biology)
[2P-837]Altered expression and localization of progesterone receptor accelerate malignant progression endometrial adenocarcinoma
○Natsumi Hamasaki1, Eisaburo Sueoka1, Hiroshi Miyamoto1, Takahiro Yaguchi2 (1. Saga Univ., 2. IUHW)
[2P-838]A YAP/TAZ-CDC6 axis initiates and maintains malignant transformation.
○DAVID NDURU1, Akihiro Nita2, Mayumi Niimura1, Samson Wainaina Ngurari1, Shinya Oki1, Toshiro Moroishi2 (1. Kumamoto Univ., 2. Institute of Science Tokyo.)
[2P-839]RNA-binding protein ARID5A promotes gastrointestinal tumorigenesis through YAP and STAT3 signaling
○Koji Taniguchi1, Kazuya Hamada1, Shugo Tanaka1, Kensuke Nakazono1, Rino Saito1, Sari Iwasaki1, Satoshi Tanaka1 (1. Hokkaido University)
[2P-840]Mechanism of malignant progression of fallopian tube epithelium by sensing extracellular vesicle nucleic acids derived from vaginal bacteria in ovarian cancer
○Eri Inami1, Akira Yokoi1, Kosuke Yoshida1, Yukari Nagao1, Masami Kitagawa1, Takao Yasui2, Shunsuke Kitajima3, Hiroaki Kajiyama1 (1. Dept. of OB/GYN, Grad. Sch. of Med., Nagoya Univ., 2. Sch. of Life Sci. & Tech., Tokyo Inst. of Sci, 3. Cancer Immunotherapy Project, CPM Center, JFCR)
[2P-841]MicroRNA-505-5p/-3p regulates the proliferation, invasion, apoptosis, and temozolomide resistance in mesenchymal glioma stem cells by targeting AUF1
○Souichi Oe1, Rio Kakizaki1, Sumika Sakamoto1, Teruhide Sato1, Mikio Hayashi2, Haruna Isozaki3, Masahiro Nonaka3, Hikaru Iwashita1, Shinichi Hayashi1, Taro Koike1, Ryohei Seki-Omura1, Yousuke Nakano1, Yuki Sato1, Yukie Hirahara4, Masaaki Kitada1 (1. Dept. Anat., Kansai Med. Univ., 2. Dept. Physiol., Kansai Med. Univ., 3. Dept. Neurosurgery, Kansai Med. Univ., 4. Faculty of Nursing, Kansai Med. Univ.)
[2P-842]Anti-metastatic opportunities by targeting co- and post-translational N-glycosylation
○Yang Shi1,2, Yu Mizote3, Akinobu Honda4, Tadashi Suzuki4, Hideaki Tahara3,5, Naoyuki Taniguchi1, Yoichiro Harada1,2,6 (1. Dept. of Glyco-Oncol. & Med. Biochem., OICI., 2. Dept. of Mol. Oncol., Grad. Sch. of Med., UOsaka., 3. Dept. of Cancer Immunother., OICI, 4. Glycometabolic Biochem. Lab., RIKEN PRI., 5. Ctr for Clinical Res., OICI., 6. iGCORE, Nagoya Univ.)
[2P-843]RNF126 Promotes Peritoneal Dissemination of Ovarian Cancer
○Shiori Mori1, Anh Duc Vu1, Takeharu Sakamoto1 (1. Kansai Medical Univ)
[2P-844]Amino acid depletion-induced immune evasion and cellular senescence in cancer cells
○Honoka Mita1, Kyo Sakai2, Iori Aketa1, Tsuyoshi Waku 2, Akira Kobayashi1 (1. Grad. Sch. Life and Med. Sci., Doshisha Univ., 2. Fac. Life. and. Med. Sci., Doshisha Univ.)
[2P-845]LncRNA MANCR is involved in the malignance of mesenchymal glioma stem cells by regulating CD44 expression.
○Teruhide Sato1, Souichi Oe1, Rio Kakizaki1, Sumika Sakamoto1, Mikio Hayashi2, Haruna Isozaki3, Masahiro Nonaka3, Hikaru Iwashita1, Shinnichi Hayashi1, Taro Koike1, Ryohei Seki-Omura1, Yousuke Nakano1, Yuki Sato1, Yukie Hirahara4, Masaaki Kitada1 (1. Dept. Anat., Kansai Med. Univ., 2. Dept. Physiol., Kansai Med. Univ., 3. Dept. Neurosurgery, Kansai Med. Univ., 4. Faculty of Nursing, Kansai Med. Univ.)
[2P-846]Association between COL6A2-expressing glioma stem cells and microvascular proliferation in glioblastoma.
○Atsuko Takamura1, Masumi Tsuda2,3, Lei Wang2,3, Yoshitaka Oda2, Zen-ichi Tanei2,5, Jian Ping Gong3,4, Shinya Tanaka2,3,5 (1. Sch. of Med 5th Grade, Hokkaido Univ., 2. Dep. of Cancer Pathol., Fac. of Med., Hokkaido Univ., 3. WPI-ICReDD, Hokkaido Univ., 4. Lab. of Soft and Matter, Fac. of Adv. Life Science, Hokkaido Univ., 5. Dep. of Surg. Pathol., Hokkaido Univ. Hosp.)
[2P-847]HDAC5, an early osimertinib-responsive gene, is a novel therapeutic target for overcoming drug resistance in EGFR-mutant lung cancer.
○Akihiko Ishimura1, Hanbing Lyu1, Ryusuke Suzuki1, Khurelsukh Buyanbat1, Gerelsuren Batbayar2, Makiko Meguro-Horike3, Shin-ichi Horike3, Hidekazu Tsutsui 4, Seiji Yano5, Takeshi Suzuki1 (1. Cancer Res. Inst., Kanazawa univ., 2. Inst. Biol., Mongolian Academy of Sci., 3. Inst. Liberal Art and Sci., Kanazawa univ., 4. School of Materials Sci., Japan Advanced Inst. Sci. and Tech., 5. Dept. Respiratory Med., Fac. Med. Kanazawa univ.)
[2P-848]Development of a co-culture model to study interactions between the periodontal pathogen Porphyromonas gingivalis and head and neck squamous cell carcinoma cells
○Shogo Okazaki Okazaki1, Yurika Nakajima1, Muneaki Tamura1, Kenichi Imai1 (1. Dept. of Microbiol. and Immnol., Sch. of Dent., Nihon Univ.)
[2P-849]Generation of Genetically Modified Schwann Progenitor Cells Derived from NF1 Patients to Investigate the Progression Mechanisms of Malignant Peripheral Nerve Sheath Tumors
○Aoba Nakajima1, Taro Osawa1, Shigeo Otake1, Tatsunori Osone1, Tomoka Takao1, Eiji Nakata2, Masyu Futagawa3, Akira Hirasawa3, Toshifumi Ozaki2, Takeshi Takarada1 (1. Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2. Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 3. Department of Clinical Genetic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
[2P-850]Cancer-type-specific QKI promoter methylation as a driver of colorectal cancer cell vulnerability
○I. Shota S.Ichinose1, M.Karen K.Minowa1, Y.Satoshi S.Yamashita1,2 (1. Maebashi Institute of Technology, Graduate School of Engineering, Department of Biotechnology, 2. Maebashi Institute of Technology, Faculty of Engineering, Department of Biotechnology)
[2P-851]Sulfasalazine-Auranofin Combination Overcomes Ferroptosis Resistance in NSCLC: AI-Driven Prediction of Synergistic Drugs Modulating Transcriptional Networks
○shuran li1, Hao LI2, Yohei Kanamori4, saisai liu5, Toshiro MOROISHI3 (1. Functional Genomics Division, Centre for Life Science Research Support, Kumamoto University, 2. Department of Biomedical Sciences School of Biological and Environmental Sciences Kwansei Gakuin University, 3. DIVISION OF CELLULAR DYNAMICS Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 4. Graduate School of Life Sciences, Kumamoto University, 5. Department of Nuclear Medicine, Ruijin Hospital, Shanghai)
[2P-852]Synergistic targeting of the ARID2-MYC axis by IMiDs and HDAC Inhibitors overcomes intrinsic IMiDs resistance in multiple myeloma cell
○Junichi Yamamoto1, Tomoko Asatsuma-Okumura2, Takumi Ito3, Yoshiko Iwai2, Hiroshi Handa3, Yuki Yamaguchi1 (1. Tokyo Institute of Science, 2. Nippon Medical School, 3. Tokyo Medical University)
[2P-853(2PS-16-09)]Analysis of HER2 Heterogeneity and Associated Phenotypes in Breast Cancer
○Shota Katayama1, Kentaro Semba1,2, Yusuke Yamamoto3, Jun Nakayama4 (1. Dept. of Life Sci. & Med. Biosci., Grad. Sch. of Sci. & Eng., Waseda Univ., 2. TR Ctr., Fukushima Med. Univ., 3. Lab. Integr. Oncol., Natl. Cancer Ctr. Res. Inst., 4. Dept. of Oncogenesis Growth Regulation, Res Inst., Osaka Intl. Cancer Inst.)
[2P-854]Novel Nutrient Sensor METTL7A Suppresses Tumor Growth
○RUNMEI CUI1, Sumire Nakagawa2, Arisa Hoashi2, Chisato Iwabuchi2, Maki Sugaya2, Miyuki Nishida2, Tsuyoshi Osawa1,2 (1. Tokyo Univ., 2. RCAST, Tokyo Univ.)
[2P-855]Functional Analysis of the Human-Specific Gene Notch2NL Using a Glioblastoma Model
○Yuki Yamauchi1, Zhou D. Xuanhao1, Ikuo K. Suzuki1 (1. the University of Tokyo)
[2P-856(2PS-13-08)]Peroxisomal Fatty Acid Metabolism Regulates Cancer Cell Drug Sensitivity
○Naoko Hattori1,4, Hideru Obinata2, Genki Yamagishi1, Kozue Kimura1, Masayuki Tobo1, Satoshi Yamashita3, Toshikazu Ushijima4 (1. Inst. for Molecular and Cellular Regulation, Gunma Univ., 2. Education and Res. Support Ctr., Grad. School of Medicine, Gunma Univ., 3. Faculty of Engineering, Maebashi Institute of Technology, 4. 4)Institute for Advanced Life Sciences, Hoshi Univ.)
[2P-857]Mechanistic Elucidation of ATRX Suppression in Telomerase-Independent Cancers
○Hiroyuki Nara1, Taisei Sadahisa1, Kaichi Kogo1, Kumi Kinoshita1, Yusuke Osato1, So Maezawa1, Mahito Sadaie1 (1. Tokyo University of Science)
[2P-858]Screening of long noncoding RNAs contributing to colorectal cancers using the TCGA dataset; RP11-278A23.1 as a potential modulator of p53 tumor suppression
○Eden Uesugi1, Masayo Kamikokura1, Shoichiro Tange1, Takashi Tokino1, Masashi Idogawa1 (1. Sapporo Med. Univ.)
[2P-859]Elucidation of mechanisms driving cancer malignancy induced by mitochondrial genome mutations
○Sakura Saito1, Kazuto Nakada2, Kaori Ishikawa2 (1. Degree Programs in Life and Earth Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba, 2. Institute of Life and Environmental Sciences, University of Tsukuba)
[2P-860]Effects of changes in the extracellular redox environment mediated by system xc- on the migratory ability of human osteosarcoma cells
○Ryosuke Kusumi1, Ayaki Shirai1, Nahoko Kakihara1, Mitsuhiko Osaki2, Futoshi Okada2, Hideyo Sato1 (1. Graduate School of Health sciences, Niigata University, 2. Division of Experimental Pathology, Tottori University Faculty of Medicine)
[2P-861]Analysis of state transition in Glioblastoma multiforme
○Kunihiro Ozaki1, Ichiyo Shibahara2, Takaaki Yamagiwa1, Tomoki Kiryu1, Tohru Kimura1, Yoichi Sekita1 (1. Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 2. Departments of Neurosurgery, Kitasato University School of Medicine)
[2P-862]Effects of low-molecular weight fucoidan extracts on metabolic state of cancer cells
○Mari Suzuki1, Hiroshi Eto2, Kiichiro Teruya1,3 (1. Grad. Sch. Sys. Life Sci. Kyushu Univ., 2. Daiichi Sangyo Co., Ltd., 3. Fac. Agr. Kyushu Univ.)
[2P-863]The relationship between transient receptor potential vanilloid 4 (TRPV4) and inflammation-related signaling in breast cancer cells
○Takahiro Hamoya1,2, Kiichi Kaminaga2, Daisuke Iizuka2,3, Tatsuhiko Imaoka2,3, Shingo Miyamoto1, Michihiro Mutoh1 (1. Department of Molecular-Targeting Prevention Kyoto Prefectural University of Medicine, 2. Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, 3. Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology)
[2P-864]Deciphering circular extrachromosomal DNA sequences from cancer cells
○Peixun Han1, Yasuhiro Tanizawa2, Atsushi Toyoda3, Yasukazu Nakamura2, Mariko Sasaki1 (1. National Institute of Genetics. Center for Frontier Research, 2. National Institute of Genetics. Department of Informatics, 3. National Institute of Genetics. Department of Genomics and Evolutionary Biology)
[2P-865]Role of the Oxidized-Lipid Receptor G2A (GPR132) in Cell-Fate Determination during the DNA Damage Response
○Qin Simao1, Kazune Minagawa1, Yui Kashihara2, Yosuke Tokai2, Riho Shibata2, Koji Kishimoto3 (1. Tokushima Univ. Grad. Sch. of Sci. and Tech. for Innov. Div. of BioResourse sci., 2. Fac. of Biosci. and Bioind., Tokushima Univ., 3. Tokushima Univ. Grad. Sch. of Tech., Ind. and Social Sci. Div. of Biosci. and Bioind.)
[2P-866]Anticancer activity of cedrol in A-431 human epidermoid carcinoma cells and A-431-derived 3D skin cancer tissues
○You Na Oh1, Soojung Jin1, Jung-ha Park1,2, Hyun Ju Kwon1,2,3 (1. Core-Facility Center for Tissue Regeneration, Dong-eui University, Busan 47340, Korea, 2. Department of Biopharmaceutics, College of Engineering, Dong-eui University, Busan 47340, Korea, 3. Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea)
[2P-867]Synthesis of an Ether-Type SQAP Derivative and Evaluation of Its Anti-Angiogenic Effects
○Shiyori Yanagisawa1, Yukiya Yamano1, Suzuka Higeta1, Kentaroh Tamiya2, Nayuko Akiyama2, Ayano Mohri2, Yushi Kitago2, Nozomi Ishii3, Ichiro Matsuo3, Masahiko Oshige1,2,4, Shinji Katsura1,2,4 (1. Dept. of Envi. Eng. Sci., School of Sci. and Tech., Gunma Univ., 2. Dept. of Food Eng., Gunma Univ., 3. Dept. of Mol. Sci., School of Sci. and Tech., Gunma Univ., 4. GUCFW)
[2P-868]Phenotypic changes of lung cancer cell lines through direct interaction with osteoblasts and bone metastasis
○Kazuki Okada1, Kenji Kokura2, Toshihiko Kishimoto2, Takashi Narai3, Yuji Nakayama4 (1. Toho University Graduate School of Science, Department of Biomolecular Science, 2. Department of Biomolecular Science, Faculty of Science, Toho University, 3. Division of Oral and Maxillofacial Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, 4. Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion,Tottori University)
[2P-869]Cytoplasmic Fluidity and Cancer Cell Dormancy
○Kanon Kitagawa1,2, Roberto Coppo3, Masahiro Inoue3, Kazuhiro Aoki1,2 (1. Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University, 2. Faculty of Science, Kyoto University, 3. Department of Clinical Bio-resource Research and Development, Graduate School of Medicine, Kyoto University)
[2P-870]A pan-cancer single-cell RNA sequencing atlas of tumor-associated macrophages
○Lin Zhang1, Hafumi Nishi1,2, Kengo Kinoshita1 (1. Tohoku Univ., 2. Ochanomizu Univ.)
[2P-871]EDF1 Confers Ferroptosis Resistance and Maintains Glioma Oncogenesis via Protection Against Ribosome Collision
○Abdulrahman Raafat Fathi Mousa1, Tianxiang Zhang1, Yuko Iwasaki1, Hidenori Endo3, Sherif Rashad1,2, Kuniyasu Niizuma1,2,3 (1. Department of Translational Neuroscience, Graduate School of Medicine, Tohoku University, 2. Department of Neurosurgical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 3. Department of Neurosurgery, Graduate School of Medicine, Tohoku University)
[2P-872]Modification of radiation effects by psychosocial stress in tumor-allografted mice
○Yasuharu Ninomiya1, Tatsuhiko Imaoka1, Tetsuo Nakajima1, Takamitsu Morioka1 (1. Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology)
[2P-873]A long-term culture system of Lingual Organoids and its application to Head and Neck Cancer research
○MIHO ISHIKAWA1,2, Hisano Yanagi3, Yusuke Minato4, Kaori Ushida5, Naoya Asai5, Hiroyasu Ito1, Hisayuki Kato6, Ichiro Tateya6, Hideyuki Saya2, Takashi Watanabe2 (1. Department of Clinical laboratory. Fujita Health University Hospital, 2. Oncology Innovation Center. Fujita Health University, 3. Department of Clinical Oncology. Fujita Health University, 4. Center for Infectious Disease Research. Fujita Health University, 5. Department of Pathology. Fujita Health University, 6. Department of Otolaryngology/Head and Neck Surgery. Fujita Health University)
[2P-874]Elucidating Environment-Mediated Radioresistance in Glioma Cell Lines
○Takashi Shimokawa1, Saaya Suzuki1, Alisa Kobayashi1, Takamitsu Masuda1, Koki Kasamatsu1, Taku Inaniwa1 (1. QST, iQMS.)
[2P-875]Bortezomib Restores Venetoclax Sensitivity in AML with Intrinsic and Acquired Resistance
○Chengxi Li1, Toshio Kitamura2,3, Susumu Goyama4, Yutaka Enomoto3 (1. Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, 2. Institute of Biomedical Research Innovation, Foundation for Biomedical Research Innova- tion at Kobe, 3. Division of Molecular Oncology, Graduate School of Frontier Sciences, The University of Tokyo, 4. Molecular Pharmacology of malignant Diseases, Graduate School of Pharma- ceutical Sciences, The University of Tokyo)
[2P-876(2PS-17-02)]Heterogeneity of intraperitoneal extracellular vesicles and evasive function of the liver surface against ovarian cancer peritoneal dissemination
○Risa Hishikawa1, Akira Yokoi1, Kosuke Yoshida1, Kazuhiro Suzuki1, Yukari Nagao1, Eri Inami1, Masami Kitagawa1, Takao Yasui2, Hiroaki Kajiyama1 (1. Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 2. Department of Life Science and Technology, Institute of Science Tokyo)
[2P-877]MicroRNA expression analysis in bladder cancer tissue and its usefulness as a diagnostic marker
○kimiaki takagi1, Toyohiro Yamada1, Yuka Maekawa1, Kenichi Minoshima1, Kentaro Suzuki2, Naruse Azumi3, Shizuku Ueno3, Arizumi Kikuchi3, Yoshifumi Yuto4 (1. Daiyukai General Hospital, Department of Urology, 2. Daiyukai General Hospital, Clinical Laboratory, 3. Daiyukai Research Institute for Medical Science, 4. Kanto Chemical CO. INC.)
[2P-878]Genetic analysis for elucidating disease mechanisms using DNA/RNA derived from eyelid tissues
○Yuichi Tokuda1, Hiroaki Oku2, Akihide Watanabe2, Tomomichi Nakayama2, Kei Tashiro1, Chie Sotozono2, Masakazu Nakano1 (1. Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, 2. Department of Ophthalmology, Kyoto Prefectural University of Medicine)
[2P-879]A novel urinary biomarker for diagnosing bladder cancer
○Jeong-Hun Kang1, Takahito Kawano2, Junichi Inokuchi3, Masaharu Murata2, Masatoshi Eto4 (1. NCVC, 2. Kyushu Univ. Adv. Innovation Center, 3. Ryukyu Univ. Dept. Urol., 4. Kyushu Univ. Dept. Urol.)
[2P-880]Identification of novel diagnostic markers and therapeutic targets in gastric-type endocervical adenocarcinoma through transcriptomic analysis
○Hiroaki Yamada1,2, Akira Yokoi1, Kosuke Yoshida1, Kazuhiro Suzuki1, Hajime Araki1, Risa Hishikawa1, Masami Kitagawa1, Eri Inami1, Naotake Tsuda2, Hiroaki Kajiyama1 (1. Nagoya University Graduate School of Medicine Lecture on Obstetrics and Gynecology, 2. Kurume University Lecture on Obstetrics and Gynecology)
[2P-881]An Integrated Network Approach to Explore Flavonoid Combinations as Anticancer Alternatives
○Koyo Fujisaki1, Hideto Nakai1, Kengo Morohashi1 (1. Chitose Institute of Science and Technology)
[2P-882]Evaluation of the Anticancer Effects of Flavonoid Combinations on Cultured Lung Cancer Cells (A549)
○Hideto Nakai1, Koyo Fujisaki1, Kengo Morohashi1 (1. Chitose Institute of Science and Technology)
[2P-883]Development of a new cancer immunotherapy using inflammation caused by macrophage-phagocytosis of particles of a specific diameter
○Yusuke Ide1, Yoichi Saito2, Yukio Fujiwara3, Yoshitaka Nakanishi2, Yuta Nakashima2,4,5 (1. Fac. Sci. and Tech., Kumamoto Univ., 2. Fac. Advanced Sci. and Tech., Kumamoto Univ., 3. Dept. Cell Pathol., Grad. Sch. Med. Sci., Fac. Life Sci., Kumamoto Univ., 4. Inst. of Industrial Nanomaterials, Kumamoto Univ., 5. FOREST researcher, Japan Sci. and Tech. Agency (JST))
[2P-884]Identification of novel therapeutic targets though Transcriptional analysis of Hemangiosarcoma and Nodular Hyperplasia using Patient-Derived cell strains and Orthotopic Xenograft Models
○YISHAN LIU1, HARU YAMAMOTO1,2, TATSUYA USUI1, KAZUAKI SASAKI1 (1. Tokyo University of Agriculture and Technology, 2. AIRDEC mini)
[2P-885(2AS-11-01)]Analysis of the Impact of Anticancer Drugs on the Gut Microbiota across Multiple Cancer Types: A Case Study of EGFR Inhibitors
○Kyoko Kurihara1,2, Shunsuke A Sakai1,2, Naoko Iida3, Kentaro Sawada4, Satoshi Horasawa3, Takao Fujisawa3,5, Yoshiaki Nakamura3,6, Shun-ichiro Kageyama1, Katsuya Tsuchihara1,2, Riu Yamashita1,7 (1. TI, NCC EPOC, 2. IB, Tokyo Univ., 3. TR, NCCHE, 4. Kushiro Rosai Hospital, 5. HNMO, NCCHE, 6. GO, NCCHE, 7. CBMS, Tokyo Univ.)
[2P-886]Development of a Novel Quantitative Marker for Detecting Fibrotic Stroma Distribution in Colorectal Cancer
○Momoko Shigematsu1, Koji Moriya2, Yuki Sota2, Satsuki Mochizuki2, Hideki Ueno2, Toshiaki Tanaka1 (1. Institute of Science Tokyo, 2. National Defense Medical College Hospital)
[2P-887]A novel cancer therapeutic strategy utilizing extracellular vesicles secreted by senescent cancer cells
○Hikaru Hatano1, Naoya Hasegawa1, Hiyori Iitsuka1, Sogo Aoki1, Kiyoshi Sato1, Hiroyoshi Kawakami1 (1. Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University)
[2P-888]Evaluation of a mesenchymal stem cell-mediated delivery system for anticancer viruses in an ovarian cancer peritoneal dissemination model
○Nao Ogawa1,2, Shugo Shinoda3,2, Emiko Sonoda-Fukuda2, Shuji Kubo2 (1. Dept. of Biomed. Chem., Grad. Sch. of Sci. & Tech., Kwansei Gakuin Univ., 2. Lab. of Mol. & Genetic Therap., Advanced Med. Sci., Hyogo Med. Univ., 3. Dept. of Biologi. Sci., Sch. of Biologi. and Env. Sci., Kwansei Gakuin Univ.)
[2P-889]Therapeutic application of retroviral replicating vector delivery via mesenchymal stem cell in a pulmonary metastasis model of osteosarcoma
○Shugo Shinoda1,2, Nao Ogawa3,2, Emiko Sonoda-Fukuda2, Shuji Kubo2 (1. Dept. of Biologi. Sci., Sch. of Biologi. and Env. Sci., Kwanseigakuin Univ., 2. Lab. of Mol. & Genetic Therap., Advanced Med. Sci., Hyogo Med. Univ., 3. Dept. of Biomed. Chem., Grad. Sch. of Sci. & Tech., Kwanseigakuin Univ.)
[2P-890]Therapeutic silencing of the anti-apoptotic gene TOB1 via siRNA enhances chemotherapy-induced apoptosis in pancreatic and breast cancer models
○Nao Ohmine1, Saori Nishijima1, Akiko Nishiyama1, Risa Ishida1, Kensuke Osada2, Tadashi Yamamoto1 (1. Okinawa Institute of Science and Technology, 2. National Institutes for Quantum Science and Technology)
[2P-891]Alternation of EV-miRNAs by genomic profiles of copy number variations in ovarian cancer
○Hajime Araki1, Akira Yokoi1, Eri Inami1, Hiroaki Yamada1, Risa Hishikawa1, Hiroaki Kajiyama1 (1. Nagoya University Graduate School of Medicine, Obstetrics and Gynecology)
[2P-892]Serine/Glycine-Deficient Diet Enhances the Efficacy of Immune Checkpoint Inhibitors in Treating Colorectal Cancer by Promoting Cytotoxic T Cell Activation
○Lijing Shi1, Yigang Wan1 (1. Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School)
[2P-893(2AS-07-04)]PMR-116, a second generation ribosome biogenesis inhibitor
○Luc Furic1, Rita Ferreira2, Katherine Hannan2, Eric Kusnadi1, Amee George2, Alisee Huglo1, Mitchell Lawrence1, Denis Drygin3, Mustapha Haddach3, Nadine Hein2, Ross Hannan2 (1. Peter Maccallum Cancer Centre, 2. ANU, 3. Pimera)
[2P-894]A multi-stage AI framework for predicting the efficacy of anticancer combination therapy
○Kohei Ota1,2, Hirofumi Aso1, Daisuke Koga1, Hideyuki Shimizu1,2 (1. Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[2P-895]Regulation of Gut Microbiota-Tumor Microenvironment Crosstalk With Traditional Chinese Medicine, Shuyu Wan, Delays Colorectal Adenoma Progression to Colorectal Cancer
○Tianqing sang1, Yigang Wan1 (1. Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University)
[2P-896]A Functionally Distinct Sox2+ Subpopulation Drives Chemoresistance, Metastasis and Intertumoral Heterogeneity in Pancreatic Ductal Adenocarcinoma
○Shigekazu Murakami1,2, Haruna Fujimori1, Rie Shibuya Takahashi1, Jun Yasuda1, Naoki Asano1, Chunling Yi2 (1. Miyagi Cancer Center Research Institute, 2. Georgetown Univ.)
[2P-897]The effect of DACH1 transcription factor expression on blood vessels in lung tumor
○Sato Koki1, Shimbori Takumi1, Iguchi Kanae2, Hayasaka Haruko1,2,3 (1. Dept. Sci. Grad. Sch. Sci. Eng. Kindai Univ., 2. Dept. Life Sci. Fac. Sci. Eng. Kindai Univ., 3. Res. Inst. of Sci. and Tech. Kindai Univ.)
[2P-898]Toward Precision Oncology: Establishing and Characterizing Oral Cancer Patient-Derived Organoid/Xenograft Models
○Xuhong Zhang1, Ri Sho2, Kuniaki Chida3, Kazuya Kurakami3, Masayoshi Souri2, Yuya Soma1, Hidekazu Nohara4, Tsukasa Ito3, Tsuneo Konta2 (1. Dept. of Biochem. & Mol Biol., Yamagata Univ. Grad. Sch. of Med. Sci., 2. Dept. of Pub. Health & Hygiene, Yamagata Univ. Grad. Sch. of Med. Sci., 3. Dept. of Otolaryngology, Head & Neck Surg., Yamagata Univ. Faculty of Med., 4. Lab. Animal Cent., Inst. for Prom. of Med. Sci. Res.)
[2P-899(2PS-16-07)]Quantitative Analysis of Pancreatic Cancer Heterogeneity through Persister Cells
○YUXIAO YANG1,2, YUHANG LIU1, Yuta Uneme1, Chikako Shibata1, Takaaki Furukawa1, Reo Maruyama1,3, Kenichi Miyata1,3 (1. Division of Cancer Epigenomics, Cancer Institute, JFCR, 2. Graduate School of Medical and Dental Sciences, 3. NEXT-Ganken, JFCR)
[2P-900]Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations
○Misaki Kosaka1, Yoshimi Okamoto1, Haruka Hirose1,2, Teppei Shimamura1, Hiroshi Nishina1 (1. Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 2. Laboratory of Computational Life Science, National Cancer Center Research Institute)
[2P-901]The p53–p53PAD5 Pathway Contributes to Tumor Promotion in Liver Cancer
○Musashi Kagaya1,2, Naoya Kobayashi2,3, Krishnaraj Jayaraman2, Tatsuki Yamamoto2,4, Kiyono Aoki2, Tomoko Tazima2, Yukiko Sakaguti2, Yuko Tabata2, Daisuke Shiokawa5, Masahiro Yamamoto6, Shotaro Yamano7, Takuya Matsuo1, Rieko Ohki2 (1. Kitasato University, 2. National Cancer Center, 3. Science Tokyo University, 4. Chiba University, 5. Ehime University, 6. Kumamoto University, 7. National Institute of Occupational Safety and Health)
[2P-902]Increased expression of KRT23 in Japanese sporadic colorectal cancer and its tumor-promoting characteristics.
○Yumi Furuichi1, Kensuke Kumamoto2, Keiichi Okano1 (1. Gastroenterological Surgery, Kagawa University, 2. Genome Medical Science and Medical Genetics, Kagawa University)
[2P-903]Tumor Microenvironment Analysis of Colorectal Carcinoma in Adenoma Using Single-Cell Spatial Multi-Omics
○Mamoru Arai1, Junko Zenkoh1, Tomoko Dai3, Masayuki Noguchi2, Yutaka Suzuki1, Ayako Suzuki1 (1. Dept. Computational Biology and Medical Sciences, Grad. Sch. Frontier Sci., Univ. Tokyo, 2. Shonan Kamakura Gen. Hosp., 3. Dept. Diag. Pathol., Inst. Med., Univ. Tsukuba)
[2P-904]Technical challenges and optimization in the analysis of intratumoral microbiota in colorectal cancer
○Fukutoshi Shirai1, Hayato Takihara1, Yosuke Tajima2, Toshifumi Wakai2, Shujiro Okuda1 (1. Niigata Univ. Grad. Sch. Med. Dent. Sci. Medical AI center, 2. Niigata Univ. Grad. Sch. Med. Dent. Sci. Digestive and General Surgery)
[2P-905]Characterization of Akt–PAK binding domains and their potential in suppressing cancer malignancy
○Itsuki Senoo1, Azumi Urata1, Hiroaki Nagano2, Keisuke Onishi3, Yukiko Gotoh2, Maiko Higuchi1 (1. Rikkyo University, 2. Graduate School of Pharmaceutical Sciences, University of Tokyo, 3. Faculty of Engineering, University of Tokyo)
[2P-906]Arginine Deprivation Enhances Venetoclax-Induced Apoptosis via the Integrated Stress Response in acute myeloid leukemia
○mizuki fukase1, fumiaki sato2, kaori saito2, yusuke iwasaki1, yoko tabe2 (1. Hoshi Univ., 2. Juntendo Univ.)
[2P-907]Elucidation of Tumor Microenvironment (TME) Factors Hindering Antibody Drug Delivery in Pancreatic Cancer Compared Analysis with Colorectal Cancer and Overcoming Strategies
○Yuki Tsuji1,2, Takahiro Anzai3, Hirobumi Fuchigami2, Masahiro Yasunaga1,2 (1. The University of Tokyo, 2. National Cancer Center, 3. Gunma National College of Technology)
[2P-908]The potential inhibition of angiogenesis in colorectal cancer by tomato lectin
○Chizuru Sone1, Yoko Nakanishi2, Yukari Hirotani2, Shinobu Masuda2, Kayoko Sasaki-Fukatsu1 (1. Dept. of Food Sci. Nutr., Grad. Sch. of Home Eco., Kyoritsu Wom. Univ. , 2. Div. of Onco. Pathol., Dept. of Pathol. and Microbiol., Nihon Univ. Sch. of Med.)
[2P-909]“Analysis of physiological functions of two insulin receptor isoforms in mice”
○Saho Ishizuka1, Wataru Fujii2, Fumihiko Hakuno3, Hiroki Nishi1 (1. Dept of Life Sci, Grad Sch of Sci Eng, Saitama Univ, 2. Dept of Vet Med Sci, Grad Sch of Agri Life Sci, The Univ of Tokyo, 3. Dept of Anim Res Sci, Grad Sch of Agri Life Sci, The Univ of Tokyo)
[2P-910]MED1’s nuclear receptor binding ability impacts on hepatic lipid metabolism
○Koya Kawaguchi1, Momoka Sawada1, Hanayo Watanabe1, Manaka Fujieda1, Aika Morimoto1, Yuto Sakurai1, Kyoka Imoto1, Robert G. Roeder2, Natsumi Hasegawa1, Mitsuhiro Ito1,2 (1. Medical Biophysics, Kobe Univ., 2. Biochem & Mol. Biol., the Rockefeller Univ.)
[2P-911]Egg yolk protein vitellogenin, increased in the embryo due to probiotic supplementation in hens, promotes skeletal muscle growth in cultured chicken muscle cells
○Yu Adachi1, Jewoo Lee1, Tsubasa Irie2, Takumi Nishiuchi3, Hirokuni Miyamoto4,5, Hiroaki Kodama4, Naruki Sato1,2 (1. Chiba University, Graduate School of Sience and Engineering, 2. Chiba University, Faculty of Science , 3. ReCEMHD, 4. Chiba University, Graduate School of Horticulture, 5. RIKEN IMS)
[2P-912]MetDeeCINE: Deciphering Metabolic Regulation through Deep Learning and Multi-Omics
○Takumi Ito1,2, Satoshi Ohno1, Yiran Wang3, Shinya Kuroda3,4, Hideyuki Shimizu1,2 (1. Department of AI Systems Medicine, M&D Data Science Center, Institute of integrated research, Institute of Science Tokyo, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 3. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4. Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
[2P-913]High-throughput and Sensitive Urine Metabolomic Profiling Using a Sheathless Interface for Multisegment Injection-Capillary Electrophoresis–Mass Spectrometry for Verification of Tobacco Smoking Status
○Momo Sato1,2, Zachary Kroezen4, Yuushi Kamei2, Tomoyoshi Soga3, Philip Britz-McKibbin4, Akiyoshi Hirayama1,2 (1. Keio Univ.・Media and Governance, 2. Keio Univ.・IAB, 3. Keio Univ.・WPI-Bio2Q, 4. McMaster Univ.)
[2P-914]Elucidation of the Srebf1-mediated hypoxic response of pancreatic β cells
○Takenari Sato1, Tomonori Tsuyama2, Kazuya Yamagata2,3 (1. Kumamoto university Graduate School of Medical Sciences, 2. Kumamoto Univ. Center for Metabolic Regulation of Healthy Aging, 3. Kumamoto University Faculty of Life Sciences)
[2P-915]Impact of chronic vitamin C deficiency on liver and sex-related differences in mouse
○Yukari Mitsumaru1,2, Ayami Sato3, Koji Fukui2, Yoshitaka kondo1, Akihito Ishigami1 (1. Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 2. Department of Systems Engineering and Science, Shibaura Institute of Technology, 3. Department of Nutritional Sciences, Faculty of Health and Sports Sciences, Toyo University)
[2P-916]Effect on metabolics in transcription factor PARIS knock out mouse.
○JOOJOO YANG1 (1. Tokyo University of Science)
[2P-917]Globin digest, acidic protease hydrolysate, promotes multi-stage skeletal muscle differentiation and enhances muscle function
○Misa Nakai1, Liqing Zang1,2, Kazutake Fukada2,3, Keiichi Ishido4, Norihiro Nishimura 1,2, Yasuhito Shimada2,5 (1. Graduate School of Regional Innovation Studies, Mie University, 2. Zebrafish Drug Screening Center, 3. ROHTO Pharmaceutical Co., Ltd., 4. MGP Pharma Inc. , 5. Department of Integrative Pharmacology, Graduate School of Medicine, Mie University)
[2P-918]Analysis of Gut Microbiota Profiles in Athletes
○Nao Nomoto1,2, Misaki Kaito1, Doshun Ito1, Wakana Takagi1, Koichi Fujita3, Nobuo Sasaki1, Eiji Miyauchi1 (1. Laboratory of Mucosal Ecosystem Design, The Institute for Molecular and Cellular Regulation, Gunma University., 2. Department of Medicine, School of Medicine,Gunma University., 3. Sports Health Communication, Inc.)
[2P-919]Effect of intravenous administration of nicotinamide mononucleotide on blood glucose levels
○Jun Ichikawa1, Keisuke Yaku1, Takashi Nakagawa1 (1. Department of Molecular and Medical Pharmacology, University of Toyama)
[2P-920(2PS-05-05)]High-fat diet-induced lipotoxicity exacerbates obstructive lung disease via IGF-1-Akt suppression
Choyo Ogasawara1, Hirofumi Nohara1, Tomoki Kishimoto1, Keisuke Kawano1, Kenji Watanabe2, Kentaro Oniki3, Yukio Fujiwara4, Ryunosuke Nakashima1, Shunsuke Kamei1, Noriki Takahashi1, Megumi Hayashi1, Ayami Fukuyama1, Mai Uemura1, Kota Nakajima1, Keiko Ueno-Shuto5, Junji Saruwatari3, Yoichi Mizukami2, Mary Ann Suico1,6, Hirofumi Kai1, ○Tsuyoshi Shuto1,6 (1. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2. Cent. Gene Res., Sci. Res. Cent., Yamaguchi Univ., 3. Pharmacol. Therap., Grad. Sch. Pharm. Sci., Kumamoto Univ., 4. Cell Pathol., Grad. Sch. Med. Sci., Kumamoto Univ., 5. Pharmacol., Facul. Pharm. Sci., Sojo Univ., 6. Glob. Cent. Nat. Res. Sci., Facul. Life Sci., Kumamoto Univ.)
[2P-921]Basic study on the impact of muscle atrophy on liver pathology
○YAN ZHAO1, Takuya Kuwashiro1, Akiko Takano1, RASHEDA PERVEEN1, Hirokazu Takahashi1 (1. Saga University Department of Medicine)
[2P-922]Glutamine-polyamine metabolic axis promotes tumor growth.
○Mayu Asao1,2, Rummei Cui1,2, Chisato Iwabuchi1, Xu Bo1, Tomoya Matsushita1,2, Maki Sugaya1, Kazuyuki Yamagata1, Sho Aki1,2,3, Tsuyoshi Osawa1,2 (1. Dept. of Integrative Nutriomics and Oncology RCAST, Univ. of Tokyo, 2. Dept. Eng., Univ. of Tokyo, 3. Premium Res. Inst. for Human Metaverse, Osaka Univ.)
[2P-923]Endothelial cell-specific LAT1 knockout facilitates vascular normalization by promoting metabolism of sulfur-containing amino acids.
○Jun-chi Suehiro1, Hiroyuki Sakurai1 (1. Kyorin University)
[2P-924]Intestinal lipid metabolism controls sexual dimorphic effects of dietary restriction in Drosophila
○Mei Yakushiji1, Hinako Fukatsu2, Yi-Hui Hu3, Keiichi Koizumi4,5, Kazutaka Akagi4,5 (1. Sch. of Pharm. and Pharma. Sci, Univ. of Toyama, 2. Grad. Sch. of Med. and Pharma. Sci., Univ. of Toyama, 3. Grad. Sch. of Pharma-Med. Sci., Univ. of Toyama, 4. Inst. of Nat. Med., Univ. of Toyama, 5. Res. Cent. of Pre-Dis. Sci., Univ. of Toyama)
[2P-925]Role of HMGB2 in Glucose Metabolism: Hmgb2 KO Mice Exhibit Lean Non-Obese Insulin Resistance
○Tomoko Tanaka1, Yuriko Hamaguchi1, Hidetaka Morinaga2, Shohta Kodama1, Toshihiko Yanase3 (1. Dep. of Regen. Med. & Transplant., Fukuoka Univ., 2. Dep. of Endocrinol. & Diabetes Mellit., Fukuoka Univ., 3. Muta Hosp.)
[2P-926]ZFP90 deficiency promotes MASLD progression through inflammatory and metabolic dysregulation
○Seongjoon Park1, Toshimitsu Komatsu1, Isao Shimokawa1,2 (1. Nagasaki University, 2. SAGL)
[2P-927]Elucidating the mechanisms of GLS-mediated autophagy induced by dietary restriction in Drosophila intestine
○Yi-Hui Hu1, Mei Yakushiji2, Keiichi Koizumi3,4, Kazutaka Akagi3,4 (1. Grad. Sch. Pharma-Med. Sci., Univ. of Toyama, 2. Sch. of Pharma. and Pharma. Sci., Univ. of Toyama, 3. Inst. of Nat. Med., Univ. of Toyama, 4. Res. Cent. of Pre-Dis. Sci., Univ. of Toyama)
[2P-928]The Role of Excretion under Excessive Protein Intake in Drosophila
○Miyu Kubota1,2, Ayano Oi1, Obata Fumiaki1,2 (1. RIKEN BDR, 2. Kyoto Univ.)
[2P-929]Inhibitory Effects of Food Digestion Products on Inflammation
between Adipocytes and Macrophages
○Masaya Yabe1, Shinsuke Mohri1, Eri Mukai1 (1. Ritsumeikan Univ.)
[2P-930]β–Aminoisobutyric acid (BAIBA), an exercise–derived metabolite, protects against doxorubicin–induced cardiomyopathy via functional mitochondrial restoration in mice
○Ryo Numazawa1, Yuki Tatekoshi1,2, Ryusuke Hosoda1, Iyori Nojima1, Tatsuya Sato2,3, Yukika Saga1, Koki Abe1,2, Hidemichi Kouzu2, Toshifumi Ogawa2,3, Toshiyuki Yano2, Atsushi Kuno1,2 (1. 1.Department of Pharmacology, Sapporo Medical University School of Medicine, 2. 2.Division of Cardiovascular-Kidney-Metabolic Medicine, Department of Internal Medicine, 3. 3.Division of Cellular Physiology and Signal Transduction, Department of Physiology, Sapporo Medical University School of Medicine)
[2P-931]Renal GSTA1/2 expression is sensitive to testosterone-mediated regulation in male mice
○Youngseo Park1, Herin Hwang1, Se-Yeong Jeon1, Doug-Young Ryu1 (1. Seoul national university)
[2P-932]The inflammatory effects of maternal high-fat diet during pregnancy
○Haruka Yamazaki1, Yoshiyuki Kasahara1, Chihiro Yoshida1, Yoshitaka Kimura1, Masatoshi Saito1 (1. Tohoku University Scholl of Medicine Disability Science Maternal and Fetal Therapeutics)
[2P-933]Effects of a high-fat diet during pregnancy on offspring health and disease risk in mice
○Chihiro Yoshida1, Yoshiyuki Kasahara1, Yoshitaka Kimura1, Masatoshi Saito1 (1. Dept. of Maternal and Fetal Therapeutics, Grad. Sch. of Med., Tohoku Univ.)
[2P-934]Probiotic A supplementation alleviates hepatic lipid accumulation in a mouse model of metabolic dysfunction-associated steatotic liver disease
○bogyeong LEE1, Gwang-woong GO1 (1. Hanyang Univ.)
[2P-935]Effects of NF1 Gene Mutations on Cell Proliferation and
Neurofibromin Expression in Patients with Neurofibromatosis Type 1
○Shunsuke Fujikawa1, Misa Yamamoto1, Riyo Koganemaru1, Tomoko Kondo1 (1. Yamaguchi Univ.)
[2P-936]Investigation of a novel treatment for Neurofibromatosis type 1: The impact of simultaneous inhibition of tumor proliferation and mast cells within the tumor on cell growth.
○Riyo Koganemaru1, Misa Yamamoto1, Shunsuke Fujikawa1, Tomoko Kondo1, Yuichi Yoshida2 (1. Yamaguchi Univ., 2. Tottori Univ.)
[2P-937]Analysis of the association between amino acid mutations in BRCA1 and related proteins and disease
○Ayaka Ide1, Kei Yura1,2 (1. Ochanomizu Univ., 2. Waseda Univ.)
[2P-938]Single-Cell Level Profiling of Genome Editing by CRISPR-Cas9 in Tetraploid Human iPS Cells
○Kayoko Shinozaki1,2, Lanyu Huang1,2, Go Takahashi3, Ito Saburo4, Yuichiro Miyaoka1,2,5 (1. Reg. Med. Project, Tokyo Met. Inst., 2. Grad. Sch. of Med and Dent Sci., Science Tokyo, 3. Department of Animal Sci., Faculty of Agri., Tokyo Univ. of Agri, 4. Yamaha Motor Co., Ltd., 5. Grad. Sch. of Hum. and Sci. Ochanomizu Univ)
[2P-939]Effects of LAMP2 Deficiency on Autophagy in Danon Disease
○Tomo Shiota1, Kiichi Nakahira2, Minako Yamaoka1, Mai Makino3, Shuhei Nakamura3,4, Kazuma Sugie1,4 (1. Nara med univ. Dept of Neurology., 2. Nara med univ. Dept of Pharmacology., 3. Nara med univ. Dept of Biochemistry., 4. Nara med univ. Center for Autophagy and Anti-Aging Research.)
[2P-940]Elucidation of Malignant Transformation Mechanisms and Therapeutic Compound Screening Using Patient-Derived iPS Cells in Neurofibromatosis Type 1
○Taro Osawa1, Eiji Nakata2, Aoba Nakajima1, Tatsunori Osone1, Shigeo Otake1, Mashu Futagawa3, Tomoka Takao1, Akira Hirasawa3, Toshifumi Ozaki 2, Takeshi Takarada1 (1. Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2. Department Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 3. Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
[2P-941]Establishment and characterization of model mice deficient in aldehyde metabolizing enzymes with complete human mutations
○Yoshihiro Tamaki1, Jun Nakamura2, Aya Kawai1, Kazunori Shiraishi1, Toshiya Okada2, Masanobu Kawanishi1 (1. Graduate School of Science, Osaka Metropolitan University, 2. Graduate School of Veterinary, Osaka Metropolitan University)
[2P-942]Functional Analyses of X-linked Alport syndrome rats using the rGONAD method
○Masumi Namba1, Tomoe Kobayashi1, Mayumi Kohno1, Hiroaki Hiramatsu1, Takayuki Koyano1, Makoto Matsuyama 1 (1. Shigei Medical Reserch Institute)
[2P-943]A novel pathogenic missense variant of TAB2 from parental mosaicism identified in a Japanese patient with mitral valve regurgitation, joint laxity, and hearing loss.
○Yumi Enomoto1, Nobuhiko Okamoto2, Yuiko Hasegawa2, Kumiko Yanagi1, Taiga Aoki1, Masahiko Yamamori1, Tadashi Kaname1,3 (1. National Center for Child Health and Development, 2. Osaka Women's and Children's Hospital, 3. Tohoku Univ.)
[2P-944]Suppression of the male infertility gene Kansl1l induces primary cilia elongation in renal tubules.
○Tomoko Kagiya1, Shunji Itoh2, Ikuji Hatamura2 (1. Dept. of Health Sci., Kansai Univ. of Health Sci., 2. Grad. Sch., Kansai Univ. of Health Sci.)
[2P-945]CTG repeat expansion-induced splicing alterations in a mouse model of Fuchs endothelial corneal dystrophy
○Taichi Yuasa1, Naoki Okumura1, Hayato Tsutsumi1, Suguru Ito1, Ayaka Izumi2, Yuki Oyama3, Masahito Ikawa3,4, Noriko Koizumi1 (1. Faculty of Life and Medical Sciences, Doshisha University, 2. ActualEyes Inc., 3. Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, 4. Graduate School of Pharmaceutical Sciences, Osaka University)
[2P-946]Functional Impact of a Novel SGSH (N-Sulfoglucosamine Sulfohydrolase) Mutation from a Sanfilippo Syndrome Type A Patient
○Akane Yabuki1, Chika Ogura2, Kazuyoshi Itoh2, Shiho Ohno3, Noriyoshi Manabe3, Kiyohiko Angata2, Akira Togayachi1,2,4, Kiyoko Flora Aoki-Kinoshita2,5, Jun-Ichi Furukawa5, Kei-Ichiro Inamori6, Jin-Ichi Inokuchi7, Tadashi Kaname8, Yoshiki Yamaguchi3, Shoko Nishihara1,2 (1. Department of Biosciences, Graduate School of Science and Engineering, Soka Univ., 2. Glycan and Life Systems Integration Center (GaLSIC), Soka Univ., 3. Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical Univ., 4. Department of Science and Engineering for Sustainable Innovation, Faculty of Science and Engineering, Soka Univ., 5. Institute for Glyco-Core Research (iGCORE), Nagoya Univ., 6. Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical Univ., 7. Forefront Research Center, Graduate School of Science, Osaka Univ., 8. Department of Genome Medicine, National Center for Child Health and Development)
[2P-947]Functional Analysis of C-terminal Peptides from Alpha-1 Antitrypsin Variants
○Xiaowen Liang1,2,3, Yonghak Park2,3, Riki Ishibashi2, Fumiko Toyoshima1 (1. Medical Research Laboratory, Institute of Science Tokyo, 2. Institute for Life and Medical Sciences, Kyoto University, 3. Graduate school of biostudies,Kyoto University)
[2P-948]Changes in expression of gene isoforms in Lymphoblastoid cell lines from patients with hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)
○Arisa Igarashi1, Shugo Suwazono2, Sinichiro Kina3, Taiga Aoki1, Yoichi Matsubara1,4, Shingo Kanemura5, Masaki Okumura5, Masato Tsutsui3, Tadashi Kaname1,6 (1. National Center for Child Health and Development, 2. NHO Okinawa National Hospital, 3. Graduate School of Medicine University of the Ryukyus, Department of Phamacology, 4. CRIFM Prenatal Medical Clinic, 5. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6. National Center for Child Health and Development, Allergy Center, Division of Genetic Information Evaluation Support)
[2P-949]Study towards utilization of intractable disease patient data by data linkage between Nanbyo and Shouman DBs in Japan -data item Analysis for Crohn's Disease and Ulcerative Colitis-
○Chisato Yamasaki1, Ryuichi Sakate1, Akinori Moriichi2, Yusuke Mizukami1, Takuya Yamamoto1 (1. National Institutes of Biomedical Innovation, Health and Nutrition(NIBN), 2. National Center for Child Health and Development (NCCHD))
[2P-950]Analysis of the mycotoxin patulin in apple juice using the antibiotic oxytetracycline analytical method
○Shotaro Hirata1,2, Masato Yoshimitsu1 (1. Osaka Institute of Public Health, 2. Tokyo NODAI Research Institute)
[2P-951]Enhancement of saccharification yields from rice straws with a cellulase gene and a cytokinin biosynthesis gene.
○Hotaka Nishimura1, Kano Miura1, Yukihiro Ito1 (1. Tohoku University)
[2P-952]Synthetic gibberellin system reveals root growth regulation by coordinating distant cell layers
○Yuichiro Yagami1, Ryotaro Yamada1, Yuuma Ishikawa2, Kenichiro Itami2,3, Wolf B. Frommer2,4, Shinya Hagihara3, Masayoshi Nakamura2,5 (1. Nagoya Univ., 2. ITbM, Nagoya Univ., 3. RIKEN, 4. HHU Düsseldorf, 5. Saitama Univ.)
[2P-953]Correlation of HAKAI with Blue Light-Dependent Inhibition of Hypocotyl Elongation and m6A RNA Methylation in Arabidopsis thaliana
○Yoshiyo Kato1, Ayano Yasuda1, Takeshi Kanegae1 (1. Dept.Biol.Sci., Tokyo Metropolitan Univ.)
[2P-954]Spatiotemporal Analysis of the Soybean Nodule Symbiosis System
○Yuho Tani1, Chika So1, Hiroko Matsunaga2, Haruko Takeyama1,2,3 (1. Grad. Sch. Adv. Sci. Eng., Waseda Univ., 2. Res. Org. Nano Life Innov., Waseda Univ., 3. Inst. Adv. Res. Biosyst. Dynam., Waseda Res. Inst. Sci. Eng., Waseda Univ.)
[2P-955]Analysis of the relationship between cold tolerance and barley CISP in plants
○Md Maksudul Haque1, Yutaro Okumura1, Shin-ichiro Kidou1,2 (1. Graduate School of Science, Department of Biological Science, Nagoya City University, 2. Research Center for Biological Diversity, Nagoya City University, Japan)
[2P-956]Functional characterization of the salivary gland-specific gene SlSGP1 of Spodoptera litura as a plant defense-suppressing effector
○Hinako Tachibana1, Takuya Uemura1, Ryoka Shimizu1, Gen-ichiro Arimura1 (1. Tokyo University of Science)
[2P-957]Insights into Plant Gravity Sensing Mechanisms Revealed by Single-Particle Analysis of MCA Channels
○Ryusei Shimizu1, Takaaki A. Kobayashi1, Hagino Tatsuya1, Tsukasa Kusakizako1, Kazuko Iida2, Hidetoshi Iida2, Osamu Nureki1 (1. The University of Tokyo, Graduate School of Science, Department of Biological Sciences, 2. Tokyo Gakugei University, Faculty of Education, Department of Life Sciences)
[2P-958]Extracellular secretory pathways of pollutant transport proteins in plants
○Katsuki Igaku1, Minami Yoshida1, Hideyuki Inui1,2 (1. Kobe Univ. , 2. Kobe Univ. Biosig. Res. Ctr.)
[2P-959]Suppression of tomato mosaic virus infection by ectopic gene expression of ethylene response factor NtERF#116
○Satsuki Kanayama1, Nobumitsu Sasaki1,2, Yasuhiko Matsushita1,2 (1. Grad. Sch. of Agr., Tokyo Univ. of Agr. & Tech., 2. Gene Res. Center, Tokyo Univ. of Agr. & Tech.)
[2P-960]Cell death induction by ectopic expression of a gene encoding the constitutively active form of MAPK kinase NtMEK2DD using artificial transcription factor XV
○Miki Yanagi1, Midori Eguchi1, Hiyori Suzuki1, Yuki Fujii2, Nobumitsu Sasaki1,2,3, Yasuhiko Matsushita1,2,3 (1. Grad. Sch. of Agr., Tokyo Univ. of Agr. & Tech., 2. United Grad. Sch. of Agr. Sci., Tokyo Univ. of Agr. & Tech., 3. Gene Res. Center, Tokyo Univ. of Agr. & Tech.)
[2P-961]CqHKT1 and CqSOS1 mediate genotype-dependent Na+ exclusion under high salinity conditions in quinoa
○Yasufumi Kobayashi1, Ryohei Sugita2, Miki Fujita3, Yasuo Yasui4, Yoshinori Murata1, Takuya Ogata1, Yukari Nagatoshi1, Yasunari Fujita5,6 (1. Biological Resources and Post-harvest Division, JIRCAS, 2. Nagoya University, 3. RIKEN CSRS, 4. Kyoto University, 5. Food Program, JIRCAS, 6. University of Tsukuba)
[2P-962]Search for novel effetor protein genes of the rice blast fungus Magnaporthe oryzae
○Ryota Ogawa1, Naomi Miyaji2, Motoki Shimizu2, Ryohei Terauchi2, Koizumi Takahiko1, Kosuke Yamamoto1, Hiromasa Saitoh1 (1. Tokyo University of Agriculture, 2. Iwate Biotechnology Research Center)
[2P-963]PlanDyO: A Metagenomic and Metaepigenomic Platform for Understanding Environmental Response Mechanisms in Plankton Communities
Takeshi Obayashi1,2, Toyonobu Fujii2,3, ○Akane Kitamura2, Gaku Kumano2,4, Minoru Ikeda2,3 (1. Grad. Sch. Info. Sci., Tohoku Univ., 2. WPI-AIMEC, Tohoku Univ., 3. Grad. Sch. Agr. Sci., Tohoku Univ., 4. Grad. Sch. Life Sci., Tohoku Univ.)
[2P-964]PCR-free Environmental DNA Analysis for Detecting Tunicates and Fishes
○Naoki Sugimura2, Toyonobu Fujii3,1, Akane Kitamura1, Gaku Kumano4,1, Minoru Ikeda3,1, Takeshi Obayashi2,1 (1. WPI-AIMEC, Tohoku Univ., 2. Grad. sch. Info. Sci., Tohoku Univ., 3. Grad. Sch. Agr. Sci., Tohoku Univ., 4. Grad. Sch. Life Sci., Tohoku Univ.)
[2P-965]MoG+3.0: Release and Future Directions
○Toyoyuki Takada1, Daiki Usuda1, Masanobu Yamagata1, Tatsuya Kushida1, Hiroshi Masuya1 (1. RIKEN BRC)
[2P-966]Construction of a Multimodal Knowledge Graph toward Drug Repositioning
○Takahide Suzuki1,2,3, Hisashi Shirakawa1, Asuka Inoue1, Hideyuki Shimizu2,3 (1. Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 2. Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 3. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[2P-967]Visualization of Late-Onset Effects of Low-Dose X-ray Irradiation on Cell Cycle
○Ting Xiao1,2, Go Shioi2, Hideaki Fujita3, Tomonobu M Watanabe2,3 (1. The University of Osaka, 2. Laboratory for Comprehensive Bioimaging, RIKEN Center for Biosystems Dynamics Research (BDR), 3. Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University)
[2P-968]Identification of a TCF12 splice site variant in a patient with Kallmann Syndrome
○Erina Suzuki1, Hirohito Shima2, Aki Ueda1, Kazuhiko Nakabayashi3, Keiko Matsubara4, Yoko Kuroki 4,5,6, Junko Kanno2, Maki Fukami1,4 (1. Department of Molecular Endocrinology National Research Institute for Child Health and Development , 2. Department of Pediatrics Tohoku University School of Medicine, 3. Department of Maternal-Fetal Biology, National Center for Child Health and Development, 4. Division of Diversity Research, National Research Institute for Child Health and Development, 5. Department of Genome Medicine National Research Institute for Child Health and Development, 6. Division of Collaborative Research, National Research Institute for Child Health and Development)
[2P-969]AI-driven drug discovery utilizing quantum chemical knowledge: Towards enhanced generalizability in compound-protein interaction prediction based on physical plausibility
○Ryo Ogawa1,2, Takuya Suzuoka1,2, Yuki Otani1,2, Hideyuki Shimizu1,2 (1. Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, 2. Graduate School of Medical and Dental Sciences, Institute of Science Tokyo)
[2P-970]Analysis of Drug Resistance Regulated by the Bacterial Two-Component System
○Junwen Wu1, Akio Abe2 (1. Kitasato University Graduate school of infection control science, 2. Kitasato University Ōmura Satoshi Memorial Institute Laboratory of Bacterial Infection)
[2P-971(2PS-09-04)]Therapeutic Target Discovery for Rare Diseases via Machine Learning Integrating GWAS and TWAS
○Satoko Namba1, Michio Iwata2, Shin-Ichi Nureki3, Noriko Yuyama Otani1, Yoshihiro Yamanishi1 (1. Dept. of Complex Systems Science, Grad. Sch. of Informatics, Nagoya Univ., 2. Dept. of Bioscience and Bioinformatics, Fac. of Comp. Sci. and Systems Eng., Kyushu Inst. of Tech., 3. Dept. of Respiratory Medicine and Infectious Diseases, Fac. of Medicine, Oita Univ.)
[2P-972]Chronic Kidney Disease-Induced Cellular Diversity and Structural Remodeling in the Parathyroid Gland
○Norifumi Tatsumi1, Sahoko Kamejima2, Atsuhiro Sakuma1, Masataka Okabe1 (1. Dept. of Anat., Jikei Univ. Sch. of Med., 2. Div. of Nephrology and Hypertension, Dept. of Internal Med., Jikei Univ. Sch. of Med.)
[2P-974]Neural crest cells are sensitive to radiation-induced DNA damage
○Yasuko Honjo1 (1. Hiroshima Univ.)
[2P-975]Measurements of mechanical properties that determine the higher-order structure of cellular tissue
○Nanami Sakurai1, Hiroshi Y. Yoshikawa1, Ritsuko Morita3, Kazuaki Yoshioka2, Hisamichi Naito2, Takahisa Matsuzaki1 (1. Graduate School of Engineering, The University of Osaka, 2. Department of Vascular Physiology, Kanazawa University, 3. Graduate School of Frontier Biosciences, The University of Osaka)
[2P-976]Gender classification via deep learning of handwritten text images
○Aki Ueda1, Keiko Matsubara1, Kohji Okamura1, Akie Nakamura1, Maki Fukami1 (1. National Research Institute for Child Health and Development)
[2P-977]Trajectory Analysis of Mouse Phenotype Data for Estimating Disease Progression
○Nobuhiko Tanaka1 (1. Shimonoseki City University)
[2P-978]Detection of VBNC Vibrio cholerae from sewage and environmental waters.
○Ayumu Ohno1,2, Priyanka Denny1, Debmalya Mitra1, Goutam Chowdhury4, Kei Kitahara1,2, Suman Kanungo4, Shanta Dutta4, Asish Mukhopadhyay4, Shin-ichi Miyoshi2,3 (1. Collaborative Research Centre of Okayama University for Infectious Diseases in India at ICMR-NIRBI, 2. Research Center for Intestinal Health Science, Okayama Univ., 3. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ., 4. ICMR-NIRBI)
[2P-979]An Efficient Screening Method to Accelerate Antibody Pair Selection in Sandwich ELISA
Soushi Murayama1, ○Ai Tonami2, Koichiro Aoki1, Yasuyuki Kurihara3 (1. Grad. Sch. Sci. Eng. Yokohama Natl. Univ., 2. Col. Eng. Sci. Yokohama Natl. Univ., 3. Fac. Eng. Sci. Yokohama Natl. Univ.)
[2P-980]Elucidating the role of Interleukin-11 in protecting colonic epithelial cells
○Tamami Sutou1,3, Takashi Nishina1, Hiroyasu Nakano2, Yuji Goto3, Katsuhide Okunishi1 (1. Department of Biochemistry, Faculty of Medicine, Toho University, 2. Unit of Host Defense Faculty of Medicine, Toho University, 3. Department of Biology, Faculty of Science, Toho University)
[2P-981]VLCFA-Regulated Lipid Raft Formation and Its Role in Signaling Mechanisms
○ATSUKO HONDA1, MICHIHIRO IGARSHI1 (1. Niigata University)
[2P-982]Differentiation of THP-1-derived dendritic cells and Langerhans cells, and 3D skin tissue construction using these immune cells
○Soojung Jin1, Jinsun Jeong1, Jung-ha Park1,2, Hyun Ju Kwon1,2,3 (1. Core-Facility Center for Tissue Regeneration, Dong-eui University, Busan 47340, Korea, 2. Department of Biopharmaceutics, College of Engineering, Dong-eui University, Busan 47340, Korea, 3. Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea)