[S21] Structure-Membrane Permeability-Excretion Transporter Substrate Correlation Aimed at the Drug Discovery of Middle-Molecule Natural Product Derivatives."

5:54 PM - 6:11 PM JST(8:54 AM - 9:11 AM UTC)

[S21-4] Evaluation of whether middle molecules are substrates for P-gp using P-gp-overexpressing cells

○Hitoshi Kashiwagi¹, Hayata Yamada², Kenta Ojiya², Yuki Sato¹, Shunsuke Nashimoto¹, Mizuki Watanabe¹, Tomoyasu Hirose^3,4, Masato Iwatsuki^3,4, Toshiaki Sunazuka^3,4, Kayoko Kanamitsu⁵, Mayumi Ishii⁵, Eri Watanabe⁵, Hiroyuki Miyachi⁵, Yoh Takekuma⁶, Mitsuru Sugawara^1,6 (1. Fac. Pharm. Sci., Hokkaido Univ., 2. Sch. Pharm. Sci. Pharm., Hokkaido Univ., 3. Grad. Sch. Infect. Cont. Sci., Kitasato Univ., 4. Ōmura Satoshi Mem. Inst., Kitasato Univ., 5. Drug Discovery Initiative, Tokyo Univ., 6. Dept. Pharm., Hokkaido Univ. Hosp.)