[S21] Structure-Membrane Permeability-Excretion Transporter Substrate Correlation Aimed at the Drug Discovery of Middle-Molecule Natural Product Derivatives." | The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

Session Details

Symposium

[S21]Structure-Membrane Permeability-Excretion Transporter Substrate Correlation Aimed at the Drug Discovery of Middle-Molecule Natural Product Derivatives."

Thu. Mar 27, 2025 5:00 PM - 6:30 PM JST
Thu. Mar 27, 2025 8:00 AM - 9:30 AM UTC

Room 14 (Fukuoka International Congress Center: 405+406 [4F])

Organizer: HIROYUKI MIYACHI (drug discovery initiative, Tokyo Univ.), KATSUMI MAENAKA (Facul. Pharm. Sci., Hokkaido Univ. / Grad. Sch. Pharm. Sci., Kyushu Univ.)

5:00 PM - 5:03 PM JST(8:00 AM - 8:03 AM UTC)

趣旨説明：宮地弘幸（東大院薬　創薬機構）

5:03 PM - 5:20 PM JST(8:03 AM - 8:20 AM UTC)

[S21-1]Synthesis of bottromycin derivatives to improve the membrane permeability and transporter substrate properties

○Masato Iwatsuki^1,2, Tomoyasu Hirose^1,2, Toshiaki Sunazuka^1,2 (1. Grad. Sch. Infect. Cont. Sci., , Kitasato Univ., 2. Ōmura Satoshi Mem. Inst., Kitasato Univ.)

5:20 PM - 5:37 PM JST(8:20 AM - 8:37 AM UTC)

[S21-2]Study of the relationship between membrane permeability and three-dimensional structure of cyclopropane-based conformationally controlled cyclic peptides

○Mizuki Watanabe¹, Yuki Yamazaki¹, Yuta Takashima¹, Satoshi Shuto¹ (1. Fac. Pharm. Sci., Hokkaido Univ.)

5:37 PM - 5:54 PM JST(8:37 AM - 8:54 AM UTC)

[S21-3]Analysis of membrane permeation mechanism of cyclic peptides based on simulation of permeation process across lipid bilayer

○Masatake Sugita^1,2 (1. Dept. of Computer Science, Science Tokyo, 2. MIDL, Science Tokyo)

5:54 PM - 6:11 PM JST(8:54 AM - 9:11 AM UTC)

[S21-4]Evaluation of whether middle molecules are substrates for P-gp using P-gp-overexpressing cells

○Hitoshi Kashiwagi¹, Hayata Yamada², Kenta Ojiya², Yuki Sato¹, Shunsuke Nashimoto¹, Mizuki Watanabe¹, Tomoyasu Hirose^3,4, Masato Iwatsuki^3,4, Toshiaki Sunazuka^3,4, Kayoko Kanamitsu⁵, Mayumi Ishii⁵, Eri Watanabe⁵, Hiroyuki Miyachi⁵, Yoh Takekuma⁶, Mitsuru Sugawara^1,6 (1. Fac. Pharm. Sci., Hokkaido Univ., 2. Sch. Pharm. Sci. Pharm., Hokkaido Univ., 3. Grad. Sch. Infect. Cont. Sci., Kitasato Univ., 4. Ōmura Satoshi Mem. Inst., Kitasato Univ., 5. Drug Discovery Initiative, Tokyo Univ., 6. Dept. Pharm., Hokkaido Univ. Hosp.)

6:11 PM - 6:28 PM JST(9:11 AM - 9:28 AM UTC)

[S21-5]Structural basis for P-gp substrate recognition for medium-sized molecules

○Takeshi Murata¹ (1. Science/Chiba Univ.)

6:28 PM - 6:30 PM JST(9:28 AM - 9:30 AM UTC)

まとめ：前仲勝実（北大院薬）

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