The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

Sponsored by JSPS
Organizer: Yoshiro Saito, (Grad. Sch. Pharm., Tohoku Univ.)Ken-ichi Yamada, (Grad. Sch. Pharm., Kyushu Univ.) Hozumi Motohashi (Grad. Sch. Med., Tohoku Univ)

In recent years, advances in analytical technology have led to the discovery of novel biological phenomena regulated by redox, and its relation to biological functions and pathology has progressed extensively. In addition to the reactive oxygen species (ROS) and reactive nitrogen species (RNS), which have been actively studied long decade, the existence of a variety of reactive species and supramolecules, such as supersulfur species and metals that are closely related to these reactive species, has become discovered. Molecular-level research on the understanding of the redox environment in the body and its involvement in diseases has progressed dramatically. Since the discovery of "ferroptosis," a cell death involving an iron-dependent lipid peroxidation, diverse its regulating factors have been identified with the development of various analytical methods, and the research has been published in top journals. In this symposium, we will welcome Prof. Marcus Conrad, a leading researcher in ferroptosis research, and hold a joint symposium with the top Japanese researcher in redox supramolecules and ferroptosis research. We would like to discuss the new basic principles of life that are discovered from redox research, their involvement in diseases, toxicology, and development into drug discovery.