Session Details
[S20]Artificial enzymes and molecular assembly using metals open up new avenues of pharmaceutical sciences
Thu. Mar 27, 2025 5:00 PM - 6:30 PM JST
Thu. Mar 27, 2025 8:00 AM - 9:30 AM UTC
Thu. Mar 27, 2025 8:00 AM - 9:30 AM UTC
Room 13 (Fukuoka International Congress Center: 402+403 [4F])
Organizer: Seiji Komeda (Fac. Pharm. Sci., Suzuka Univ. Med. Sci; Grad. Sch. Pharm., Suzuka Univ. Med. Sci.), Shin Aoki (Fac. Pham Sci., Tokyo Univ. Science; Res. Inst. Sci. Tech. (RIST), Tokyo Univ. Sci.; Res. Inst. Biomed. Sci. (RIBS), Tokyo Univ. Sci.)
Living organisms have acquired the ability to efficiently take in metal ions, which are essential for maintaining life, and utilize them as biomolecules. Transition metal ions are found in various biological phenomena, and many of the metal ions play a role in the active centers of enzymes. There is active research being conducted on drug discovery targeting these biologically relevant metals and on artificial enzymes that mimic the active centers of enzymes. In addition, transition metal ions and their complexes can control and assemble the structures of biomolecules through electrostatic attraction and covalent interaction. This symposium will discuss the latest findings on artificial enzymes with metals as their active centers and molecular assembly phenomena arising from the interactions between metal complexes and biomolecules, and consider their applications to drug discovery and life science researches in pharmaceutical sciences.
オーガナイザー挨拶：米田 誠治1,2（1. 鈴鹿医療大薬、2. 鈴鹿医療大院薬）
[S20-1]Simple designing of artificial mononuculear metalloenzymes
○Nobutaka Fujieda1 (1. Grad. Sch. Agric., Osaka Metro. Univ.)
[S20-2]Oxidative functionalization of non-natural substrates by cytochrome P450s using enzymatic function-modulating molecules
○Shinya Ariyasu1, Kai Yonemura1, Yusaku Kodama1, Yuya Yokoyama1, Chie Kasai1, Hiroshi Sugimoto2, Yuichiro Aiba1, Osami Shoji1 (1. Grad. Sch. Sci., Nagoya Univ., 2. RIKEN SPring-8 Cent.)
[S20-3]Development of designer enzymes for concerted uses with biological molecules
○Yasunori Okamoto1,2,3 (1. ExCELLS, 2. Inst. Mol. Sci., 3. Grad. Univ. Adv. Stud.)
[S20-4]Diverse DNA assembly states formed from liquid-liquid phase separation by an anti-tumor platinum complex
○Ryu Tashiro1, Takuma Yamada2, Masako Uemura1,2, Seiji Komeda1,2 (1. Fac. Pharm. Sci., Suzuka Univ. Med. Sci., 2. Grad. Sch. Pharm. Sci., Suzuka Univ. Med. Sci.)
[S20-5]Design, synthesis, and evaluation of artificial catalyses based on combinatorial multicomponent assembly
○Shin Aoki1,2,3 (1. Fac. Pharm. Sci., Tokyo Univ. Sci., 2. Res. Inst. Sci. Tech. (RIST), Tokyo Univ. Sci., 3. Res. Inst. Biomed. Sci. (RIBS), Tokyo Univ. Sci.)