[27-19-am] Genes, biosynthesis 1 | The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[27-19-am]Genes, biosynthesis 1

Thu. Mar 27, 2025 8:30 AM - 10:11 AM JST
Thu. Mar 27, 2025 11:30 PM - 1:11 AM UTC

Room 19 (FUKUOKA SUNPALACE: Palace RoomA [2F])

Chair: Kenichi Matsuda, Shinji Kishimoto

8:30 AM - 8:42 AM JST(11:30 PM - 11:42 PM UTC)

[27-19-am01S]Elaborate substrate recognition mechanism by equilibrium and selection in chlorflavonin biosynthesis

○Sho Furumura¹, Taro Ozaki¹, Yohei Morishita¹, Akihiro Sugawara¹, Teigo Asai¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)

8:42 AM - 8:54 AM JST(11:42 PM - 11:54 PM UTC)

[27-19-am02S]Prediction modeling for macrolide ring size by structural comparison of thioesterases

○Yuto Homma¹, Yohei Morishita¹, Taro Ozaki¹, Teigo Asai¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)

8:54 AM - 9:06 AM JST(11:54 PM - 12:06 AM UTC)

[27-19-am03S]Investigation of promoters and genetic loci for precursor gene expression to improve the production of α-amanitin precursor in Aspergillus oryzae

○Toko Negishi¹, Taro Ozaki¹, Akihiro Sugawara¹, Yohei Morishita¹, Teigo Asai¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)

9:06 AM - 9:18 AM JST(12:06 AM - 12:18 AM UTC)

[27-19-am04]Functional analysis of cytochrome P450 enzymes involved in benzylisoquinoline alkaloid biosynthesis in Eschscholzia californica

Momoka Nakashima¹, Reo Sone¹, Haruki Yanai¹, Kenji Miura², Nobukazu Shitan¹, ○Yasuyuki Yamada¹ (1. Kobe Pharm. Univ., 2. Inst. Life Environ. Sci. Univ. Tsukuba)

9:18 AM - 9:23 AM JST(12:18 AM - 12:23 AM UTC)

Break

9:23 AM - 9:35 AM JST(12:23 AM - 12:35 AM UTC)

[27-19-am05]Biosynthetic incorporation of non-native aryl acid building blocks into peptide products using engineered adenylation domains

○Funihiro ISHIKAWA¹, Maya Nohara¹, Akimasa Miyanaga^2,3, Satoki Kuramoto¹, Natsuki Miyano¹, Shumpei Asamizu⁴, Fumitaka Kudo², Hiroyasu Onaka⁵, Tadashi Eguchi², Genzoh Tanabe¹ (1. Faculty of Pharmacy, Kindai University, 2. Institute of Science Tokyo, 3. Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 4. Engineering Biology Research Center, Kobe University, 5. Department of Life Science, Faculty of Science, Gakushuin University)

9:35 AM - 9:47 AM JST(12:35 AM - 12:47 AM UTC)

[27-19-am06]Uncovering the formation mechanism of a polycyclic structure with an unusual alkenyl ether moiety in the biosynthesis of macrodiolide antibiotic

Reona Suzuki¹, ○Hayama Tsutsumi^1,2, Akihiro Ishii¹, Ayano Komaki³, Yuka Yamakawa³, Yoshihiro Watanabe^1,2, Tomohiro Suzuki¹, Masato Iwatsuki^1,2, Tomoyasu Hirose^1,2, Sunazuka Toshiaki^1,2, Yuki Inahashi^1,2 (1. Grad. Sch. Infection Cont. Sci., Kitasato Univ., 2. Ōmura Inst. Kitasato Univ., 3. Sch. Science. Kitasato Univ.)

9:47 AM - 9:59 AM JST(12:47 AM - 12:59 AM UTC)

[27-19-am07S]Functional analysis of a novel oxidase ActVA-ORF3 involved in actinorhodin biosynthesis with AlphaFold

○Susumu Watari¹, Makoto Hashimoto^2,3, Kazuki Ishikawa^3,4, Takuya Kumamoto⁵, Hideaki Kakeya¹, Koji Ichinose^2,3 (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Fac. Pharm Musashino Univ., 3. Res. Inst. Pharm. Sci. Musashino Univ., 4. Fac. Pharm. Sci.Teikyo Heisei Univ., 5. Grad. Sch. Biomed. Health Sci. Hiroshima Univ.)

9:59 AM - 10:11 AM JST(12:59 AM - 1:11 AM UTC)

[27-19-am08S]Genome mining directed to the discovery of bioactive natural products

○Teruhisa Manome¹, Ryusuke Nakada¹, Aya Yoshimura¹, Toshiyuki Wakimoto¹ (1. Grad. Sch. Pharm. Sci., Hokkaido Univ.)

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