Session Details
[27P-am]Medicinal Chemistry, bioactive materials 1
Thu. Mar 27, 2025 8:30 AM - 12:00 PM JST
Thu. Mar 27, 2025 11:30 PM - 3:00 AM UTC
Thu. Mar 27, 2025 11:30 PM - 3:00 AM UTC
Poster (MARINE MESSE FUKUOKA Hall B: Exhibition Room [1F])
[27P-am111S]Evaluation of the effect of introducing disubstituted amino acids into the hydrophilic region of amphipathic peptides on cell membrane permeability.
○Sakurako Imoto1, Takuma Kato1, Akiko Asano1, Mitsunobu Doi1 (1. Facul. Pharm. Osaka. Med. Pharm. Univ.)
[27P-am112S]Evaluation of the effects of introducing α,α-disubstituted amino acids into hydrophobic cell penetrating peptides TP1
○Rika Tatsumi1, Takuma Kato1, Akiko Asano1, Mitsunobu Doi1 (1. Facul. Pharm. Osaka Med. Pharm. Univ.)
[27P-am113S]Altered metabolism of bioactive lipids based on intramuscular administration of myostatin inhibitory peptides in young and adult mice.
○Natsuki Nishikawa1, Rina Tamaki1, Minori Nishikawa1, Katsuya Morito1, Kazuki Nagasawa1, Kentaro Takayama1 (1. Kyoto Pharm. Univ.)
[27P-am114S]Fluorescent labeling of cellular antigens in response to “human orthogonal enzymes”
○Akihiro Koga1, Akihiro Kuroda1, Yuji Miyazaki1, Ryosuke Kaneko2, Teruki Nii2, Akihiro Kishimura2,3, Takeshi Mori2, Yoshiki Katayama2,3 (1. Grad. School of Systems Life Sciences, Kyushu Univ., 2. Grad. School of Engineering, Kyushu Univ., 3. Center for Molecular Systems, Kyushu Univ.)
[27P-am115S]Development of fluorescent ubiquitinated artificial substrates for UPS activity detection
○Ryo Ozawa1, Mitsuyasu Kawaguchi1, Yuhei Ohta1, Naoya Ieda2, Hidehiko Nakagawa1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Grad. Sch. Pharm. Sci., Hokkaido Univ.)
[27P-am116S]Examination of cell adhesion between HUVEC and HL-60 and the inhibitory effect of SLeX-related substances
○Honoka Nishioka1, Hiyori Ozawa1, Kawano Susumu1, Kazi Hiroaki1 (1. Pharm. Shujitsu Univ.)
[27P-am117S]Utilization of the new analog of cortistatin A for mechanistic study
○Yuri Fujimoto1, Yuta Nakamura2, Hanami Suzuki2, Nao Kitamura1, Yuya Kizaki1, Rio Wakasugi1, Takako Kaneko-Kawano1,2, Naoyuki Kotoku1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Coll. Pharm. Sci., Ritsumeikan Univ.)
[27P-am118]Evaluation of peptide secondary structure and cell membrane permeability by Introducing disubstituted amino acids into amphipathic helical peptide C18AA
○Takuma Kato1, Go Ofuka1, Ryota Kobayashi1, Akiko Asano1, Mitsunobu Doi1 (1. Facul. Pharm, Osaka Med. Pharm. Univ.)
[27P-am119]Development of a bicyclic MT1-MMP binding peptide/IR700 conjugate for photoimmunotherapy
○NAOYA KONDO1, HIROFUMI HANAOKA1 (1. NIR-PIT Res. Inst., Kansai Med. Univ.)
[27P-am120S]Development of a novel cancer imaging method targeting the Cystine transporter (xCT)
○Keiya Endo1, Yasuteru Urano1,2 (1. Grad. Sch. Med., Univ. Tokyo, 2. Grad. Sch. Pharm. Sci., Univ. Tokyo)
[27P-am121]Targeting pancreatic cancer with novel nicolaioidesin C derivatives: molecular mechanism, in vitro and in vivo evaluation
○Suresh Awale1, Takeyoshi Yamazaki2, Nguyen Duy Phan2, Juthamart Maneenet1, Tsutomu Fujii2, Takuya Okada3, Naoki Toyooka3 (1. Institute of Natural Medicine, University of Toyama, 2. Department of Surgery and Science, University of Toyama, 3. Faculty of Engineering, University of Toyama)
[27P-am122]Development of selective SPP inhibitors
○Hidetomo Yokoo1, Yumi Itoh2, Tomomi Hishinuma2, Toru Okamoto2, Yosuke Demizu1,3,4 (1. NIHS, 2. Grad. Sch., Juntendo Univ., 3. Grad. Sch., Yokohama City Univ., 4. Grad. Sch., Okayama Univ.)
[27P-am123]Systematic synthesis of carbon-branched iminosugars and structure-activity relationships for inhibition against various glycosidases.
○Atsushi Kato1, Takahisa Masukawa1, Suzuka Yamamoto1, Kousuke Yoshimura1, Yuna Shimadate1, Atsumi Taguchi1 (1. Department of Hospital Pharmacy, University of Toyama)
[27P-am124S]Synthesis and biological evolution of C-alkyl-DAB delivetives for Gaucher disease
○Suzuka Yamamoto1, Atsumi Taguchi1, Atsushi Kato1 (1. Department of Hospital Pharmacy)
[27P-am125S]In silico design of peptide-based inhibitors targeting intracellular protein-protein interactions
○Minami Fujita1,2, Yosuke Demizu1,2 (1. Grad. Sch. Med. Life Sci., Yokohama City Univ., 2. NIHS)
[27P-am126]Design and Formulation Development of Shape-changing Polyvinyl alcohol/Cassava Fiber Composite 3D-Printing via Powder Melt Extrusion
○Kasidit Dokhom1, Baramee Chanabodeechalermrung1, Tanpong Chaiwarit1, Pensak Jantrawut1 (1. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University)
[27P-am127S]Design, Synthesis, and Anticancer Activity of Calixarene-Peptide Hybrids for Inducing Programmed Cell Death in Cancer Cells
○Saki Sekiguchi1, Toshifumi Tojo1, Shin Aoki1,2,3 (1. Faculty of Pharmaceutical Science, Tokyo University of Science, 2. Reseach Institute for Biomedical Science, Tokyo University of Science, 3. Reseach Institute for Science & Technology, Tokyo University of Science)
[27P-am128]Divergent synthesis of aliphatic trifluoromethyl ketones from alkenes and bromotrifluoroacetone under photocatalysis
○Satoshi Mizuta1, Tomoko Yamaguchi1, Takeshi Ishikawa2, Masaharu Iwasaki3 (1. Grad. Sch. Biomed. Sci., Nagasaki Univ., 2. Grad. Sch. Sci. Eng., Kagoshima Univ., 3. RIMD., Osaka Univ.)
[27P-am129S]Design and Synthesis of Bis(borono)-Macrocyclic Polyamine Carriers for Boron Neutron Capture Therapy
○Wakana Yoshida1, Hiroki Ueda2, Tomohiro Tanaka3, Toshifumi Tojo1, Yoshinori Sakurai2, Minoru Suzuki2, Shin Aoki1 (1. Fac. Pharm. Sci., Tokyo Univ. of Sci., 2. Institute for Integrated Radiation and Nuclear Sci., Kyoto Univ., 3. Graduate School of Med., Dentistry and Pharm. Sci., Okayama Univ.)
[27P-am130S]De novo design of PROTAC linker to improve cell membrane permeability based on a data-driven method
○Yuki Murakami1, Shoichi Ishida1, Masateru Ohta2, Teruki Honma2, Yosuke Demizu1,3, Kei Terayama1 (1. Grad. Sch. Med. Life Sci., Yokohama City Univ., 2. RIKEN, 3. NIHS)
[27P-am131]Effect of human serum albumin on NO release from SNPiP, a novel cardiac drug
○Shigeo NAKAMURA1, Kyoko TAKAHASHI1, Yoshihiko KAKINUMA1 (1. Nippon Medical School)
[27P-am132S]Myostatin-Selective Inactivation by Novel Hydrophilic Photooxygenation Agent–D-Peptide Conjugates
○Jo Yamamoto1, Kaoru Ikekawa2, Shuko Amber Murano2, Hideyuki Okamoto1,2, Sho Konno1,2, Akihiro Taguchi1,2, Atsuhiko Taniguchi1,2, Yoshio Hayashi2,3 (1. Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 2. Grad. Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 3. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)
[27P-am133]Syntheses of 2-azolylethyl-1alpha,25-dihydroxy-19-norvitamin D3
○MASASHI Takano1, Atsushi Kittaka1, Toshie Fujishima1 (1. Fac. of Pharm. Sci., Teikyo Univ.)