Session Details
[27P-pm]Medicinal Chemistry, bioactive materials 2
Thu. Mar 27, 2025 1:30 PM - 5:00 PM JST
Thu. Mar 27, 2025 4:30 AM - 8:00 AM UTC
Thu. Mar 27, 2025 4:30 AM - 8:00 AM UTC
Poster (MARINE MESSE FUKUOKA Hall B: Exhibition Room [1F])
[27P-pm131]Development of a chemically stable MAIT cell ligand inspired by key structures of natural ligands
○Ryosuke Takasaki1, Emi Ito2,3, Masamichi Nagae2,3, Yuki Takahashi1, Takuro Matsuoka1, Wakana Yasue1, Norihito Arichi1, Hiroaki Ohno1, Sho Yamasaki2,3, Shinsuke Inuki1,4 (1. Graduate School of Pharmaceutical Sciences, Kyoto Univ., 2. Research Institute for Microbial Diseases, Osaka Univ., 3. Immunology Frontier Research Center (IFReC), Osaka Univ., 4. Graduate School of Biomedical Sciences, Tokushima Univ.)
[27P-pm132]Expansion of existing diminazene scaffold library and QSAR model for modulation of MALAT1 Triple Helix
○Shinya Suzuki1,2, Justin G Martyr3, Emily Swanson2, Daniel S Garcia2, Martina Zafferani2, Zhengguo Cai2, Amanda E Hargrove2,3 (1. TORAY Industries, Inc., 2. Department of Chemistry, Duke University, 3. Department of Biochemistry, Duke University School of Medicine)
[27P-pm133]Research on the discovery of a novel photoimmunotherapy drug based on a HER2-binding peptide
○Takuya Otani1, Matias Rey2, Hiroaki Suga2, Hirofumi Hanaoka1 (1. NIR-PIT Res. Inst., Kansai Med. Univ., 2. Grad. Sch. Sci., UTokyo)
[27P-pm134]In silico discovery of selective inhibitors against Na+/H+ exchange transporter (NHE5)
○Yusei Shinohara1, Kashin Morimoto2, Yuki Komiya2, Itasu Ninomiya3, Yoshio Endo4, Takahisa Takino5, Hisatsugu Yamada1, Yoshihiro Uto1 (1. Grad. Sch. Tech. Ind. Soc. Sci., Tokushima Univ., 2. Grad. Sch. of Adv. Sci. and Tech. Innov., Tokushima Univ., 3. Director of Central Med. Ctr. and Dept. Surg., Fukui Pref. Hosp., 4. Cancer Res. Inst., Kanazawa Univ., 5. Inst. of Liberal Arts and Sci., Kanazawa Univ.)
[27P-pm135S]Structure-Activity Relationship of Matrine type Alkaloids Part 37;
Syntheshis and Evaluation of Antinociception of 4-(trifluoromethylphenyl)piperidine Derivatives
○Yuki Takahashi1, Yamato Takahashi1, Yuki Matsumoto1, Melanny Ika Sulistyowaty1,2, Taichi Sugimoto3, Ryota Moriwaki1, Ryota Sasaki1, Hiroyoshi Teramoto1, Takayasu Yamauchi1 (1. Hoshi Univ., 2. Airlangga Univ., 3. Grad. Sch. Pharm. Sci., Hoshi Univ.)
[27P-pm136S]Development of Novel Colchicine Derivatives to Improve Cancer-Targeting Capability
○Mana Nagai1, Takayuki Ohkuri2, Kazuki Yamamoto1, Satoshi Ichikawa1 (1. Grad. Sch. Pharm. Sci., Hokkaido Univ., 2. Asahikawa Medical Univ.)
[27P-pm137S]Synthesis and Structure-Activity Relationship Studies of Novel Balanol Analogs
○Sana Ishijima1, Arisa Katsumi1, Hiroki Yonezawa1, Akihiro Nagao1, Kenji Arimitsu1, Naoyoshi Maezaki1, Yoshimi Hirokawa1 (1. Faculty of Pharm., Osaka Ohtani Univ.)
[27P-pm138S]Mutational Analysis of HBV Core Protein-Derived Peptide for the Development of HBV Capsid Assembly Inhibiters
○Kazuma Takeda1, Sayuri Takeo2, Kohei Sato1, Nobuyuki Mase1, Kenji Nakashima3, Masaru Yokoyama4, Tetsuro Suzuki3, Tetsuo Narumi1,2 (1. Fac. Eng., Shizuoka Univ., 2. Grad. Sch. Med. Photonics, Shizuoka Univ., 3. Hamamatsu Univ. School Med., 4. NIID)
[27P-pm139]Synthetic study of Mirabegron related compound
○Haruaki Ishiyama1, Hinata Takamatsu1 (1. Grad. Sch. Pharm. Sci., Ohu Univ)
[27P-pm140]Synthesis and histone deacetylase inhibition of 4-aliphatic substituted 1,4-dihydropyridine compounds.
○Chisato Onozawa1, Mirika Mizuma1, Yoshinori Okuno1, Shigeki Isomura1, Miho Sawada2, Yukihiro Itoh2, Takayoshi Suzuki2, Yasuo Sato1 (1. Yokohama Uni of Pharm., 2. SANKEN, Osaka Uni.)
[27P-pm141]Inhibition of histone deacetylase by Chennat-type 1,4-dihydropyridinne compounds.
○Kurumi Yamamoto1, Shion Ohno1, Yoshinori Okuno1, Shigeki Isomura1, Miho Sawada2, Yukihiro Itoh2, Takayoshi Suzuki2, Yasuo Sato1 (1. Yokohama University of Pharmacy, 2. SANKEN, Osaka University)
[27P-pm142]Study on the search of novel anti-cancer drug resistance-overcoming compound from soil fungus
○Tadahiro Etoh1, Huma Hiki1, Hiromi Torii1, Kurumi Ayabe1, Yong Pil Kim1,2 (1. Iryo Sosei Univ., 2. Iryo Sosei Univ. Postgraduate School of Life Science and Engineering)
[27P-pm143]Investigation for anionic-type fullerene derivatives with antimicrobial activity
○Hiroki Kataoka1, Tomoyuki Ohe2, Seiji Yamasaki3, Kunihiko Nishino3, Jun-ichi Yamagishi1,3 (1. Nihon Pharm. Univ., 2. Fac. Pharm., Keio Univ., 3. SANKEN, Osaka Univ.)
[27P-pm144]Large scale chemical screening identified compounds that impairs nuclear localization of the ependymoma-associated ZFTA-RELA fusion protein and NF-κB activation.
Masaki Ishii1, Naoki Suto2, Kazuaki Katakawa1,3, Kosho Makino1, Sachiko Toma-Fukai4, Shunsuke Sueki1, Masashiro Anada1, Hirotatsu Kojima2, ○Shinya Ohata1 (1. Res. Instit. Pharm. Sci., Facul. Pharm., Musashino Univ., 2. DDI, Univ. Tokyo, 3. Shonan Univ. Med. Sci., 4. NAIST)
[27P-pm145]Synthesis and activity evaluation of labdanes searching for COMT-activated compounds
○Hiroaki Saito1, Koki Iwashige1, Keiya Tsukamoto1, Manami Hirano1, Naoki Oikawa1, Hiroshi Iijima1, Taketo Uchiyama1 (1. School of Phamacy, Nihon Univ.)
[27P-pm146S]Activity classification of in-house compounds using machine learning against human glioblastoma cells.
Shuhei Nakao1, ○Yuki Uemichi1, Seina Yasuda1, Miyuki Mabuchi1, Shuji Nagano1, Yoshihiro Uesawa2, Tadashi Shimizu1 (1. Sch. Pharm. Hyogo Medical Univ., 2. Meiji Pharmaceutical Univ.)
[27P-pm147S]Evaluation of anticancer activity of azelastine against glioblastoma cells.
Yuki Uemichi1, ○Seina Yasuda1, Miyuki Mabuchi1, Shuhei Nakao1, Shuji Nagano1, Tadashi Shimizu1 (1. Sch. Pharm. Hyogo Medical Univ.)
[27P-pm148S]Computational analysis of chemical features and mechanisms of compounds with anti-aging effects
○Futaba Sakaguchi1, Miku Tanaka1, Satoko Namba1, Yohei Kamijo1, Tatsuma Shoji2, Norihiro Kikuchi2, Yoshihiro Yamanishi1 (1. Nagoya Univ., 2. FRACORA Co., Ltd.)
[27P-pm149S]Exploration of osteosarcoma treatment drug candidates using machine learning
Shuhei Nakao1, ○Riria Yajima1, Yuki Uemichi1, Miyuki Mabuchi1, Shuji Nagano1, Yoshihiro Uesawa2, Tadashi Shimizu1 (1. Sch. Pharm. Hyogo Medical Univ., 2. Meiji Pharmaceutical Univ.)
[27P-pm150]NC-DEL Technology: Selective Cleavable Hairpin DELs and their Applications in DEL
○Takehiko Inohana1, Kaori Okumura1, Shin Itoh1, Masahiro Kamaura1, Takeshi Nanya1, Masako Tanabe1, Kenji Goryo1, Jun Hayashida1 (1. Nissan Chemical Corporation)
[27P-pm151]Development of anti-cancer medicine using indene as a fundamental structure
○Hirofumi Shimomura1, Kiyofumi Wanibuchi2, Mitsuru Shoji2, Shunji Hayashi1 (1. Sch. Med., Kitasato Univ., 2. Yokohama Univ. Pharm.)
[27P-pm152]The antioxidant activity and skin penetration of pterostilbene derivatives and its transfersome
○FENGLIN YEN1, Liu Cheng-yu2, Teng Wei-Lin3, Wu Tzu-Hui4 (1. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, 2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 3. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, 4. Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, Taiwan)
[27P-pm155S]Synthesis of 4'-substituted carbocyclic nucleosides for anti-SARS-CoV-2 agents
○Kuto Kato1, Kaho Ishijima1, Nati Watanabe1, Yuki Odanaka2, Shinichiro Hattori3, Nobuyo Kuwata3, Hiroaki Mitsuya3, Kiju Konno1 (1. Department of Pharm. Sci., International University of Health and Welfare, 2. Sch. Pharm., Showa Univ., 3. National Center for Global Health and Medicine Research Institute)
[27P-pm153S]Development of water-soluble anti-VZV agents based on acyclovir as a lead compound; focusing on improvement of solubility
○Haruna Konno1, Yutaka Tatano1, Kiju Konno1 (1. Department of Pharm. Sci., International University of Health and Welfare)
[27P-pm154S]Synthesis of carbovir derivatives for the therapeutics of adenovirus infection
○Shion Nishiduka1, Eri Hasegawa1, Takuya Ogawa1, Kiju Konno1 (1. Department of Pharm. Sci., International University of Health and Welfare)
[27P-pm156S]Development of vitamin D derivative Dcha-20 as a rodenticide
○Chiharu Ogura1, Kana Okamura1, Kazuki Takeda2, Satoru Nagaoka3, Hiroyuki Kagechika4, Aya Tanatani1 (1. Fac. Sci., Ochanomizu Univ., 2. Sch. Vet. Med., Kitasato Univ., 3. Daimaru Compound Chemical CO., LTD., 4. Lab. Biomater. Bioeng., Inst. Integ. Res., Inst. Science Tokyo)
[27P-pm157]Evaluation of Tyrosinase Inhibitory Activity of Hydroxycinnamic Acid Derivatives
○Takuma Okusawa1, Koichi Shikama1, Jun Takayama1, Meiyan Xuan1, Atsushi Kato2, Takeshi Sakamoto1 (1. Josai University, 2. Pharmacy Department of the University of Toyama Hospital)
[27P-pm158]Studies on Structure-Activity Relationship of ferulic acid derivatives between antioxidative effects and cytoprotective effects against oxidative stress
○Koichi Shikama1, Jun Takayama1, Meiyan Xuan1, Hirokazu Matsuzaki1, Bo Yuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai. Univ.)
[27P-pm159]C2-trimethoxyphenoxy chromone derivatives exhibited lipid-lowering effects via lipophage pathway
Yi-Han Chang1, Ming-Yu Tsai1, Yun-Wen Chen2, ○Hsin-Yi Hung1 (1. School of Pharmacy, College of Medicine, National Cheng Kung University, 2. Department of Pharmacology, College of Medicine, National Cheng Kung University)
[27P-pm160]Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives as anti-neurodegenerative agents.
○Satsawat Visansirikul1,2, Suthira Yanaso3, Yingrak Boondam Chuayboon4,5, Kanjanawadee Prasittisa6, Brompoj Prutthiwanasan1,2, Sumet Chongruchiroj7,8, Kittisak Sripha1,2 (1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand., 2. Unit of Compounds Library for Drug Discovery Mahidol University, Bangkok, 10400, Thailand., 3. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences Huachiew Chalermprakiet University, Samut Prakan 10540, Thailand., 4. Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand., 5. Centre of Biopharmaceutical Science for Healthy Ageing, Mahidol University, Bangkok 10400, Thailand., 6. Division of Science, Faculty of Education, Nakhon Phanom University, Nakhon Phanom 48000, Thailand., 7. Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand., 8. Molecular Simulations in Drug Discovery, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.)
[27P-pm161S]Improved synthesis of neurotrophic banglene
○Masaki Inoue1, Kenichi Harada1, Yuichiro Kusumoto1, Miwa Kubo1, Yoshiyasu Fukuyama1 (1. Pharm. Sci., Tokushima Bunri Univ.)
[27P-pm162S]Synthesis of azole derivatives for the discovery of novel pharmacokinetic boosters
○Chisaki Hanada1, Shoki Hoshikawa1, Koki Kimura1, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Masaaki Omote1, Makoto Kataoka1, Kentaro Kawai1 (1. Fac. Pharm. Sci., Setsunan Univ.)
[27P-pm163]Synthesis of Ferulic Acid Derivatives and Structure-Activity Relationship by Measuring DPPH Free Radical Scavenging Capacity
○Yuta Muraoka1, Koichi Shikama1, Jun Takayama1, Meiyan Xuan1, Hirokazu Matsuzaki1, Bo Yuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai Univ)
[27P-pm167]DNA photocleavage activity of zinc complexes with viaryl moiety as photosensitizer
○Yoshimi Ichimaru1, Koichi Kato1, Hiromasa Kurosaki2, Masaaki Kurihiara1 (1. Fac. Pharm. Sci., Shonan Univ. Med. Sci., 2. Coll. Pharm., Kinjo Gakuin Univ.)
[27P-pm164S]Design, synthesis and biological activity of novel aminoethylphenol derivatives as ceramide equivalents
○Yuya Moriguchi1, Shoki Hoshikawa1, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Masaaki Omote1, Kazuyuki Kitatani1, Kentaro Kawai1 (1. Fac. pharm. Sci., Setsunan Univ.,)
[27P-pm168S]Development of PROTACs targeting lipocalin-type prostaglandin D2 synthase
○Hinata Osawa1,2, Norihito Shibata2, Kosuke Aritake3, Yosuke Demizu1,2,4 (1. Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ., 2. NIHS., 3. Daiichi. Univ. Pharm., 4. Grad. Sch. Med. Life Sci., Yokohama City Univ.)
[27P-pm165S]Development of Novel Aromatic Sulfonamides as Progesterone Receptor Antagonists
○Ayano Ikeda1, Ryosuke Ishida2, Masatoshi Kawahata3, Kosuke Katagiri4, Hiroyuki Kagechika5, Tanatani Aya1 (1. Grad. Sch. Humanities and Sci., Ochanomizu Univ., 2. Grad. Sch. Pharm. Sci., Nagoya City Univ., 3. Fac. Pharm. Sci., Showa Pharma. Univ., 4. Fac. Sci. Eng., Konan Univ., 5. Lab. Biomater. Bioeng., Inst. Integ. Res., Inst. Science Tokyo)
[27P-pm166S]Synthesis and activity evaluation of dibenzyl compounds targeting cancer stem cells
○Rikako Yamashita1, Yukiha Iida1, Sousuke Moriue1, Shinya Kimura1, Masamichi Yamanaka1, Pithi Chanvorachote2, Masashi Yokoya1 (1. Meiji Pharm. Univ., 2. Chulalongkorn Univ.)
[27P-pm169S]Structure-Activity Relationship Study and Mechanistic Elucidation of DIF-1 Targeting Anti-Fibrotic Drug Development for Liver Fibrosis Treatment
○Kaori Inamura1, Akira Ooka1,2, Yuzuki Nagasawa1, Momoka Yamaguchi1,2, Kenji Yamashita1,2, Shin-ya Saito3, Makoto Inai1,2, Tomohisa Ishikawa1,2, Yoshitaka Hamashima1,2 (1. Sch. Pharm. Sci., Univ. of Shizuoka, 2. Grad. Sch. Pharm. Sci., Univ. of Shizuoka, 3. Fac. Vet. Med., Okayama Univ. Sci.)
[27P-pm170]Exploratory research on new derivatives effective against
multidrug-resistant Mycobacterium tuberculosis (2)
Yuya Ichida1, Hiromu Ito1, Hiroyuki Fuchino2, Teruo Kirikae3, Fumiko Kirikae3, ○Ken-ichi Kurihara1 (1. Faculty of Pharm. Sci., Teikyo Heisei Univ., 2. Niigata University of Pharmacy and Medical and Life Sciences, 3. Juntendo Advanced Reseach Institute for Health Science)
[27P-pm171S]Accelerating GPCR-targeted Drug Discovery through Machine Learning
○Tomoya Sakuma1, Hideyuki Shimizu1 (1. Institute of Integrated Research, Institute of Science Tokyo)
[27P-pm172S]Creation of antitrypanosomal compounds based on lignan lactone skeletons
○Marina Tada1, Takehiro Nishimura1, Yuka Tani1, Haruhisa Kikuchi1 (1. Fac. Pharm., Keio Univ.)
[27P-pm173S]A survey and organization of the toxicity prediction models with deep learning
○Zehao Li1, Tadahaya Mizuno1, Shunpei Nemoto1, Hiroyuki Kusuhara1 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)
[27P-pm174]Chemical profile and bioactivities of microwave-assisted hydro-distillation extract from clove buds (Syzygium aromaticum L.)
○YU-CHUN LIN1, CHIN-CHUNG WU1 (1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan)
[27P-pm175S]Synthesis of piperidine derivatives as bacterial MATE-type drug efflux transporter inhibitors
○Naoki Hori1, Shoki Hoshikawa1, Naoki Kobayashi2, Susumu Shinya1, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Masaaki Omote1, Kentaro Kawai1 (1. Faculty of Pharmaceutical Sciences, Setsunan University, 2. Faculty of Agricultural Sciences, Setsunan University)
[27P-pm176S]Characterization of phosphine haloboranes as hydrophobic structures and their application to VDR ligands
○Tsukasa Saito1, Hiroki Saito1, Yu Miyajima1, Takashi Misawa2, Yosuke Demizu2, Hiroyuki Kagechika1, Shinya Fujii1 (1. LBB, Science Tokyo, 2. NIHS)