The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

Sponsored by AMED『A Project focused on Developing Key Evaluation Technology aiming  at Industrialization of Regenerative Medicine and Gene Therapies（Development of Platform Technology for Advanced Drug Discovery Support Tools through Application of Regenerative Medicine）』
Organizer: Kazuo Takayama (CiRA, Kyoto Univ), Daiju Yamazaki (NIHS)

Fifteen years have passed since Dr. Donald Ingber's 2010 report on the lung-on-a-chip (lung MPS) in Science, marking a milestone in microphysiological system (MPS) technology. Since then, MPS technology has advanced rapidly, opening up possibilities for emulating human organ functions outside the body. This trend is increasingly influencing drug discovery research across both pharmaceutical industries and academic institutions. However, a critical question remains: fifteen years on, has MPS truly proven useful in drug discovery research? To explore the current state of MPS application in drug discovery, this symposium gathers talented researchers from pharmaceutical and academic sectors who are at the forefront of MPS research and application. Through these presentations, we aim to clarify the extent of drug discovery research achievable with today's MPS technology and identify the elements still needed to enhance its practical application in the future. Additionally, we would like to discuss the regulatory science research required to support MPS-based drug discovery and foster collaborative awareness among industry, government, and academia to drive MPS research and application forward.